{r, results='asis',include=TRUE,echo=FALSE} # if(params$isSlides != "yes"){ # cat("# RNAseq (part 3) # # --- # " # ) # # } # #

The data

In this session we will be reviewing the same data that we used in the first two sessions. This is the data from Christina Leslie’s lab at MSKCC on T-Reg cells and activated T-Reg cells. T-Reg data can be found on the Encode portal here and activated T-Reg data here

I have aligned all FQ to BAM and counted in genes and exons using Rsubread and summariseOverlaps() and then analysed this data for expression changes using DESeq2.

The data

All Gene and Exon counts can be found as .RData obects in data directory

  • Counts in genes can be found at - data/GeneCounts.RData

  • Counts in disjoint exons can be found at - data/ExonCounts.RData

  • Salmon transcript quantification output directories can be found under - data/Salmon/

The data

You can find an excel file of differential expression analysis for this comparison in the data directory.

  • CSV file of differential expression results for activated versus resting T-cells - data/Group_Activated_minus_Resting.csv.

What we will cover

In our last session we will looked at how we can identify changes in gene expression from two separate methods to gene expression estimates and looked a little at the output from comparing differential expression levels using DESeq2.

In this session we will explore a few ways we can evaluate any enrichment for functionally related genes from our differential expression analysis. This helps us address common questions like:

Are genes related to “immune response” enriched in my set of significantly upregulated genes?

Do “cell cycle” genes change more between conditions then other genes?

Gene Sets


What we test and how we test?

There are many options available to us for both functions/pathways/categories (Gene set) we will test and the methods we can use to test these gene sets for enrichment in our analysis (Gene set Enrichment Analysis).

  • Gene set - A named collection of genes.
  • Gene Set enrichment Analysis - GSA - Broad term for correlating a set of genes with a condition/phenotype.
  • Gene Set Enrichment Analysis - GSEA - Broad’s term for correlating a set of genes with a condition/phenotype.

Gene set testing

A frequent step in RNAseq analysis is to test whether any functionally related sets of genes are enriched within our differential expressed genes.

Sources of well curated gene sets include GO consortium (gene’s function, biological process and cellular localization), REACTOME (Biological Pathways) and MsigDB (Computationally and Experimentally derived).

Gene Ontology

The Gene Ontology consortium aims to provide a comprehensive resource of all the currently available knowledge regarding the functions of genes and gene products.

Functional categories of genes are broadly split into three main groups.

  • Molecular functions. - Activity of a gene’s protein product.
  • Biological processes. - Role of gene’s protein product.
  • Cellular components. - Where in cell molecular function of protein product is performed.

Gene Ontology

The three sub categories of gene ontology are arranged in nested, structured graph with gene sets at the top of graph representing more general terms and those at the bottom more specific terms.

Reactome and KEGG

The Reactome and KEGG (Kyoto Encyclopedia of genes and genomes) contains information on genes’ membership and roles in molecular pathways.

These databases focus largely on metabolic and disease pathways, and allow us to investigate our genes in the context of not only functional roles but relative positions within pathways.

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MsigDB

The molecular signatures database (MsigDB) is available from the Broad institute and provides a set of curated gene sets derived from sources such as GO, pathway databases, motif scans and even other experimental sets.

MsigDB databases are widely used in gene set enrichments analysis and are available as plain text, in formats used with the popular Java based gene set enrichment software GSEA. ]

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]

Gene sets in Bioconductor

In R we can access information on these gene sets through database libraries (such as the Org.db.eg we have reviewed) such as GO.db, KEGG.db, reactome.db or by making use of libraries which allows us to our gene sets from parse plain text formats, GSEABase.

library(GO.db)
library(KEGG.db)
library(reactome.db)
library(GSEABase)

Gene sets

We have already reviewed how we can get information on genes using the Org.db packages in our previous sessions.

We can also have access to information on the gene sets themselves using some of the bioconductor resources including GO.db, KEGG.db, reactome.db packages.

Another rich source of gene sets can be found at the Molecular Signature DataBase (MSigDB) database.

MSigDB and Gene Set Collections


GSEA and MSigDB

The GSEA software and MSigDB gene set collections can be found at the Broad’s site

MSigDB

We have access to Human gene sets containing information on:

  • H - hallmark gene sets
  • C1 - positional gene sets
  • C2 - curated gene sets
  • C3 - motif gene sets
  • C4 - computational gene sets
  • C5 - GO gene sets
  • C6 - oncogenic gene sets
  • C7 - immunologic gene sets

MSigDB

The gmt (gene matrix transposed) is a GSEA specific format which is easy to edit and spreadsheet programs.

It contains tab separated space with lines containing gene sets of differing sizes.

GSEAbase

We can read in gene sets in the gmt format using the GSEABase package.

library(GSEABase)

Reading gmt

The GSEABase function getGmt allows us to import our gmt formatted gene set collection into a GeneSetCollection object. In this case we are reading in the Hallmarks gene set with gene symbols which we downloaded from the Broad website.

hallMarks <- getGmt(con = "data/h.all.v7.1.symbols.gmt")
hallMarks
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_HYPOXIA, ..., HALLMARK_PANCREAS_BETA_CELLS (50 total)
##   unique identifiers: JUNB, CXCL2, ..., SRP14 (4383 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)

GeneSetCollection

The GeneSetCollection object can be subset as a list.

hallMarks[1]
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB (1 total)
##   unique identifiers: JUNB, CXCL2, ..., MXD1 (200 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)
hallMarks[[1]]
## setName: HALLMARK_TNFA_SIGNALING_VIA_NFKB 
## geneIds: JUNB, CXCL2, ..., MXD1 (total: 200)
## geneIdType: Null
## collectionType: Null 
## details: use 'details(object)'

GeneSetCollection

We can access the names of gene sets using the names() accessor

names(hallMarks)
##  [1] "HALLMARK_TNFA_SIGNALING_VIA_NFKB"          
##  [2] "HALLMARK_HYPOXIA"                          
##  [3] "HALLMARK_CHOLESTEROL_HOMEOSTASIS"          
##  [4] "HALLMARK_MITOTIC_SPINDLE"                  
##  [5] "HALLMARK_WNT_BETA_CATENIN_SIGNALING"       
##  [6] "HALLMARK_TGF_BETA_SIGNALING"               
##  [7] "HALLMARK_IL6_JAK_STAT3_SIGNALING"          
##  [8] "HALLMARK_DNA_REPAIR"                       
##  [9] "HALLMARK_G2M_CHECKPOINT"                   
## [10] "HALLMARK_APOPTOSIS"                        
## [11] "HALLMARK_NOTCH_SIGNALING"                  
## [12] "HALLMARK_ADIPOGENESIS"                     
## [13] "HALLMARK_ESTROGEN_RESPONSE_EARLY"          
## [14] "HALLMARK_ESTROGEN_RESPONSE_LATE"           
## [15] "HALLMARK_ANDROGEN_RESPONSE"                
## [16] "HALLMARK_MYOGENESIS"                       
## [17] "HALLMARK_PROTEIN_SECRETION"                
## [18] "HALLMARK_INTERFERON_ALPHA_RESPONSE"        
## [19] "HALLMARK_INTERFERON_GAMMA_RESPONSE"        
## [20] "HALLMARK_APICAL_JUNCTION"                  
## [21] "HALLMARK_APICAL_SURFACE"                   
## [22] "HALLMARK_HEDGEHOG_SIGNALING"               
## [23] "HALLMARK_COMPLEMENT"                       
## [24] "HALLMARK_UNFOLDED_PROTEIN_RESPONSE"        
## [25] "HALLMARK_PI3K_AKT_MTOR_SIGNALING"          
## [26] "HALLMARK_MTORC1_SIGNALING"                 
## [27] "HALLMARK_E2F_TARGETS"                      
## [28] "HALLMARK_MYC_TARGETS_V1"                   
## [29] "HALLMARK_MYC_TARGETS_V2"                   
## [30] "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"
## [31] "HALLMARK_INFLAMMATORY_RESPONSE"            
## [32] "HALLMARK_XENOBIOTIC_METABOLISM"            
## [33] "HALLMARK_FATTY_ACID_METABOLISM"            
## [34] "HALLMARK_OXIDATIVE_PHOSPHORYLATION"        
## [35] "HALLMARK_GLYCOLYSIS"                       
## [36] "HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"  
## [37] "HALLMARK_P53_PATHWAY"                      
## [38] "HALLMARK_UV_RESPONSE_UP"                   
## [39] "HALLMARK_UV_RESPONSE_DN"                   
## [40] "HALLMARK_ANGIOGENESIS"                     
## [41] "HALLMARK_HEME_METABOLISM"                  
## [42] "HALLMARK_COAGULATION"                      
## [43] "HALLMARK_IL2_STAT5_SIGNALING"              
## [44] "HALLMARK_BILE_ACID_METABOLISM"             
## [45] "HALLMARK_PEROXISOME"                       
## [46] "HALLMARK_ALLOGRAFT_REJECTION"              
## [47] "HALLMARK_SPERMATOGENESIS"                  
## [48] "HALLMARK_KRAS_SIGNALING_UP"                
## [49] "HALLMARK_KRAS_SIGNALING_DN"                
## [50] "HALLMARK_PANCREAS_BETA_CELLS"

GeneSetCollection

The geneIDs() function returns a list named by gene set with each named element containing the genes (their IDS) contained within that set.

geneIds(hallMarks)[1:3]
## $HALLMARK_TNFA_SIGNALING_VIA_NFKB
##   [1] "JUNB"     "CXCL2"    "ATF3"     "NFKBIA"   "TNFAIP3"  "PTGS2"   
##   [7] "CXCL1"    "IER3"     "CD83"     "CCL20"    "CXCL3"    "MAFF"    
##  [13] "NFKB2"    "TNFAIP2"  "HBEGF"    "KLF6"     "BIRC3"    "PLAUR"   
##  [19] "ZFP36"    "ICAM1"    "JUN"      "EGR3"     "IL1B"     "BCL2A1"  
##  [25] "PPP1R15A" "ZC3H12A"  "SOD2"     "NR4A2"    "IL1A"     "RELB"    
##  [31] "TRAF1"    "BTG2"     "DUSP1"    "MAP3K8"   "ETS2"     "F3"      
##  [37] "SDC4"     "EGR1"     "IL6"      "TNF"      "KDM6B"    "NFKB1"   
##  [43] "LIF"      "PTX3"     "FOSL1"    "NR4A1"    "JAG1"     "CCL4"    
##  [49] "GCH1"     "CCL2"     "RCAN1"    "DUSP2"    "EHD1"     "IER2"    
##  [55] "REL"      "CFLAR"    "RIPK2"    "NFKBIE"   "NR4A3"    "PHLDA1"  
##  [61] "IER5"     "TNFSF9"   "GEM"      "GADD45A"  "CXCL10"   "PLK2"    
##  [67] "BHLHE40"  "EGR2"     "SOCS3"    "SLC2A6"   "PTGER4"   "DUSP5"   
##  [73] "SERPINB2" "NFIL3"    "SERPINE1" "TRIB1"    "TIPARP"   "RELA"    
##  [79] "BIRC2"    "CXCL6"    "LITAF"    "TNFAIP6"  "CD44"     "INHBA"   
##  [85] "PLAU"     "MYC"      "TNFRSF9"  "SGK1"     "TNIP1"    "NAMPT"   
##  [91] "FOSL2"    "PNRC1"    "ID2"      "CD69"     "IL7R"     "EFNA1"   
##  [97] "PHLDA2"   "PFKFB3"   "CCL5"     "YRDC"     "IFNGR2"   "SQSTM1"  
## [103] "BTG3"     "GADD45B"  "KYNU"     "G0S2"     "BTG1"     "MCL1"    
## [109] "VEGFA"    "MAP2K3"   "CDKN1A"   "CCN1"     "TANK"     "IFIT2"   
## [115] "IL18"     "TUBB2A"   "IRF1"     "FOS"      "OLR1"     "RHOB"    
## [121] "AREG"     "NINJ1"    "ZBTB10"   "PLPP3"    "KLF4"     "CXCL11"  
## [127] "SAT1"     "CSF1"     "GPR183"   "PMEPA1"   "PTPRE"    "TLR2"    
## [133] "ACKR3"    "KLF10"    "MARCKS"   "LAMB3"    "CEBPB"    "TRIP10"  
## [139] "F2RL1"    "KLF9"     "LDLR"     "TGIF1"    "RNF19B"   "DRAM1"   
## [145] "B4GALT1"  "DNAJB4"   "CSF2"     "PDE4B"    "SNN"      "PLEK"    
## [151] "STAT5A"   "DENND5A"  "CCND1"    "DDX58"    "SPHK1"    "CD80"    
## [157] "TNFAIP8"  "CCNL1"    "FUT4"     "CCRL2"    "SPSB1"    "TSC22D1" 
## [163] "B4GALT5"  "SIK1"     "CLCF1"    "NFE2L2"   "FOSB"     "PER1"    
## [169] "NFAT5"    "ATP2B1"   "IL12B"    "IL6ST"    "SLC16A6"  "ABCA1"   
## [175] "HES1"     "BCL6"     "IRS2"     "SLC2A3"   "CEBPD"    "IL23A"   
## [181] "SMAD3"    "TAP1"     "MSC"      "IFIH1"    "IL15RA"   "TNIP2"   
## [187] "BCL3"     "PANX1"    "FJX1"     "EDN1"     "EIF1"     "BMP2"    
## [193] "DUSP4"    "PDLIM5"   "ICOSLG"   "GFPT2"    "KLF2"     "TNC"     
## [199] "SERPINB8" "MXD1"    
## 
## $HALLMARK_HYPOXIA
##   [1] "PGK1"     "PDK1"     "GBE1"     "PFKL"     "ALDOA"    "ENO2"    
##   [7] "PGM1"     "NDRG1"    "HK2"      "ALDOC"    "GPI"      "MXI1"    
##  [13] "SLC2A1"   "P4HA1"    "ADM"      "P4HA2"    "ENO1"     "PFKP"    
##  [19] "AK4"      "FAM162A"  "PFKFB3"   "VEGFA"    "BNIP3L"   "TPI1"    
##  [25] "ERO1A"    "KDM3A"    "CCNG2"    "LDHA"     "GYS1"     "GAPDH"   
##  [31] "BHLHE40"  "ANGPTL4"  "JUN"      "SERPINE1" "LOX"      "GCK"     
##  [37] "PPFIA4"   "MAFF"     "DDIT4"    "SLC2A3"   "IGFBP3"   "NFIL3"   
##  [43] "FOS"      "RBPJ"     "HK1"      "CITED2"   "ISG20"    "GALK1"   
##  [49] "WSB1"     "PYGM"     "STC1"     "ZNF292"   "BTG1"     "PLIN2"   
##  [55] "CSRP2"    "VLDLR"    "JMJD6"    "EXT1"     "F3"       "PDK3"    
##  [61] "ANKZF1"   "UGP2"     "ALDOB"    "STC2"     "ERRFI1"   "ENO3"    
##  [67] "PNRC1"    "HMOX1"    "PGF"      "GAPDHS"   "CHST2"    "TMEM45A" 
##  [73] "BCAN"     "ATF3"     "CAV1"     "AMPD3"    "GPC3"     "NDST1"   
##  [79] "IRS2"     "SAP30"    "GAA"      "SDC4"     "STBD1"    "IER3"    
##  [85] "PKLR"     "IGFBP1"   "PLAUR"    "CAVIN3"   "CCN5"     "LARGE1"  
##  [91] "NOCT"     "S100A4"   "RRAGD"    "ZFP36"    "EGFR"     "EDN2"    
##  [97] "IDS"      "CDKN1A"   "RORA"     "DUSP1"    "MIF"      "PPP1R3C" 
## [103] "DPYSL4"   "KDELR3"   "DTNA"     "ADORA2B"  "HS3ST1"   "CAVIN1"  
## [109] "NR3C1"    "KLF6"     "GPC4"     "CCN1"     "TNFAIP3"  "CA12"    
## [115] "HEXA"     "BGN"      "PPP1R15A" "PGM2"     "PIM1"     "PRDX5"   
## [121] "NAGK"     "CDKN1B"   "BRS3"     "TKTL1"    "MT1E"     "ATP7A"   
## [127] "MT2A"     "SDC3"     "TIPARP"   "PKP1"     "ANXA2"    "PGAM2"   
## [133] "DDIT3"    "PRKCA"    "SLC37A4"  "CXCR4"    "EFNA3"    "CP"      
## [139] "KLF7"     "CCN2"     "CHST3"    "TPD52"    "LXN"      "B4GALNT2"
## [145] "PPARGC1A" "BCL2"     "GCNT2"    "HAS1"     "KLHL24"   "SCARB1"  
## [151] "SLC25A1"  "SDC2"     "CASP6"    "VHL"      "FOXO3"    "PDGFB"   
## [157] "B3GALT6"  "SLC2A5"   "SRPX"     "EFNA1"    "GLRX"     "ACKR3"   
## [163] "PAM"      "TGFBI"    "DCN"      "SIAH2"    "PLAC8"    "FBP1"    
## [169] "TPST2"    "PHKG1"    "MYH9"     "CDKN1C"   "GRHPR"    "PCK1"    
## [175] "INHA"     "HSPA5"    "NDST2"    "NEDD4L"   "TPBG"     "XPNPEP1" 
## [181] "IL6"      "SLC6A6"   "MAP3K1"   "LDHC"     "AKAP12"   "TES"     
## [187] "KIF5A"    "LALBA"    "COL5A1"   "GPC1"     "HDLBP"    "ILVBL"   
## [193] "NCAN"     "TGM2"     "ETS1"     "HOXB9"    "SELENBP1" "FOSL2"   
## [199] "SULT2B1"  "TGFB3"   
## 
## $HALLMARK_CHOLESTEROL_HOMEOSTASIS
##  [1] "FDPS"      "CYP51A1"   "IDI1"      "FDFT1"     "DHCR7"     "SQLE"     
##  [7] "HMGCS1"    "NSDHL"     "LSS"       "MVD"       "LDLR"      "TM7SF2"   
## [13] "ALDOC"     "EBP"       "SCD"       "PMVK"      "MVK"       "LPL"      
## [19] "SC5D"      "FADS2"     "HMGCR"     "HSD17B7"   "ANXA13"    "SREBF2"   
## [25] "PCYT2"     "ACSS2"     "ATF3"      "ADH4"      "ETHE1"     "ECH1"     
## [31] "CBS"       "GUSB"      "FASN"      "LGALS3"    "ATF5"      "ANXA5"    
## [37] "TP53INP1"  "CHKA"      "GSTM2"     "ACAT2"     "AVPR1A"    "PLSCR1"   
## [43] "CLU"       "ERRFI1"    "TRIB3"     "CXCL16"    "TNFRSF12A" "ACTG1"    
## [49] "JAG1"      "LGMN"      "FBXO6"     "GPX8"      "PNRC1"     "ANTXR2"   
## [55] "MAL2"      "CD9"       "PPARG"     "GLDC"      "STX5"      "STARD4"   
## [61] "CTNNB1"    "TMEM97"    "NIBAN1"    "PDK3"      "PLAUR"     "SEMA3B"   
## [67] "GNAI1"     "ABCA2"     "ATXN2"     "NFIL3"     "ALCAM"     "FABP5"    
## [73] "S100A11"   "CPEB2"

Human to mouse gene sets

To make use of human gene sets in mouse we can either

  • Use an alternative mouse specific set.
  • Translate relevant set to mouse ortholog names.

gskb

The gskb package holds many pathways and gene sets for mouse genome equivalent to MSigDB.

First we can load the package.

library(gskb)

gskb datasets

The gskb package contains 7 collections of genes.

  • mm_GO - gene sets from Gene Ontology for mouse (Mus musculus).
  • mm_location - Gene sets based on chromosomal location.
  • mm_metabolic - metabolic pathways.
  • mm_miRNA - Target genes of microRNAs, predicted or experimentally verified.
  • mm_pathway - Curated pathways.
  • mm_TF - Transcription factor target genes.
  • mm_other - Everything else.

Accessing gskb data

We access gskb datasets by using the data() function to load into memory the gene set collection of interest.

data(mm_miRNA)
names(mm_miRNA)[1:2]
## [1] "MIRNA_MM_BETEL_MMU-LET-7A" "MIRNA_MM_BETEL_MMU-LET-7B"
mm_miRNA[1]
## $`MIRNA_MM_BETEL_MMU-LET-7A`
##    [1] "MIRNA_MM_BETEL_MMU-LET-7A"                                                                        
##    [2] "BETEL_MMU-LET-7A; Good mirSVR score Conserved; The microRNA.org resource: targets and expression."
##    [3] "NSUN4"                                                                                            
##    [4] "DCX"                                                                                              
##    [5] "KCNK6"                                                                                            
##    [6] "PBX1"                                                                                             
##    [7] "PHF8"                                                                                             
##    [8] "RACGAP1"                                                                                          
##    [9] "EFHD2"                                                                                            
##   [10] "DCBLD2"                                                                                           
##   [11] "CCDC88A"                                                                                          
##   [12] "CEP68"                                                                                            
##   [13] "SLITRK4"                                                                                          
##   [14] "NAA40"                                                                                            
##   [15] "DSCAML1"                                                                                          
##   [16] "ESYT2"                                                                                            
##   [17] "DNAJC21"                                                                                          
##   [18] "CDC27"                                                                                            
##   [19] "CHRAC1"                                                                                           
##   [20] "MYL6"                                                                                             
##   [21] "PRLR"                                                                                             
##   [22] "GUF1"                                                                                             
##   [23] "LCK"                                                                                              
##   [24] "GSDMC"                                                                                            
##   [25] "PTGER1"                                                                                           
##   [26] "CADM1"                                                                                            
##   [27] "DGCR2"                                                                                            
##   [28] "CREM"                                                                                             
##   [29] "PPHLN1"                                                                                           
##   [30] "VWA1"                                                                                             
##   [31] "IPMK"                                                                                             
##   [32] "PTPRO"                                                                                            
##   [33] "MPZL1"                                                                                            
##   [34] "CREB1"                                                                                            
##   [35] "RAVER2"                                                                                           
##   [36] "MED24"                                                                                            
##   [37] "TM9SF3"                                                                                           
##   [38] "BTLA"                                                                                             
##   [39] "TMEM72"                                                                                           
##   [40] "TCEANC"                                                                                           
##   [41] "SLAMF7"                                                                                           
##   [42] "MTM1"                                                                                             
##   [43] "ASB8"                                                                                             
##   [44] "USP4"                                                                                             
##   [45] "LRRFIP1"                                                                                          
##   [46] "E330016L19RIK"                                                                                    
##   [47] "GJC2"                                                                                             
##   [48] "GALNT7"                                                                                           
##   [49] "PDGFC"                                                                                            
##   [50] "GPD2"                                                                                             
##   [51] "EDDM3B"                                                                                           
##   [52] "KLHL4"                                                                                            
##   [53] "C2CD2L"                                                                                           
##   [54] "MKS1"                                                                                             
##   [55] "SBNO1"                                                                                            
##   [56] "RTN3"                                                                                             
##   [57] "EIF4E1B"                                                                                          
##   [58] "ZNFX1"                                                                                            
##   [59] "TMEM164"                                                                                          
##   [60] "PADI3"                                                                                            
##   [61] "PLB1"                                                                                             
##   [62] "SEMA5A"                                                                                           
##   [63] "DNMT3A"                                                                                           
##   [64] "AP1G1"                                                                                            
##   [65] "APH1B"                                                                                            
##   [66] "CSPRS"                                                                                            
##   [67] "PISD-PS3"                                                                                         
##   [68] "2310003H01RIK"                                                                                    
##   [69] "FBXO21"                                                                                           
##   [70] "EYA3"                                                                                             
##   [71] "2810011L19RIK"                                                                                    
##   [72] "MSRA"                                                                                             
##   [73] "SPINK5"                                                                                           
##   [74] "PARVA"                                                                                            
##   [75] "CHAC1"                                                                                            
##   [76] "P4HA2"                                                                                            
##   [77] "LRTM2"                                                                                            
##   [78] "ELOVL7"                                                                                           
##   [79] "ZFP568"                                                                                           
##   [80] "AI504432"                                                                                         
##   [81] "AGK"                                                                                              
##   [82] "SLCO2A1"                                                                                          
##   [83] "SH3PXD2A"                                                                                         
##   [84] "MYBL2"                                                                                            
##   [85] "ANKRD10"                                                                                          
##   [86] "1700052N19RIK"                                                                                    
##   [87] "LIN28B"                                                                                           
##   [88] "RNF24"                                                                                            
##   [89] "ESRRB"                                                                                            
##   [90] "PIGS"                                                                                             
##   [91] "TM6SF2"                                                                                           
##   [92] "SNAP91"                                                                                           
##   [93] "VAT1"                                                                                             
##   [94] "4930480K23RIK"                                                                                    
##   [95] "PQLC1"                                                                                            
##   [96] "ZFP473"                                                                                           
##   [97] "EHMT1"                                                                                            
##   [98] "4632428N05RIK"                                                                                    
##   [99] "1700012B07RIK"                                                                                    
##  [100] "FKBP1A"                                                                                           
##  [101] "SARNP"                                                                                            
##  [102] "ERCC6"                                                                                            
##  [103] "PATZ1"                                                                                            
##  [104] "NCOR1"                                                                                            
##  [105] "LBP"                                                                                              
##  [106] "STON2"                                                                                            
##  [107] "GNS"                                                                                              
##  [108] "DHX57"                                                                                            
##  [109] "5031439G07RIK"                                                                                    
##  [110] "CLVS1"                                                                                            
##  [111] "HECW1"                                                                                            
##  [112] "ZFP12"                                                                                            
##  [113] "GEMIN5"                                                                                           
##  [114] "FKRP"                                                                                             
##  [115] "RABGEF1"                                                                                          
##  [116] "UIMC1"                                                                                            
##  [117] "CPEB3"                                                                                            
##  [118] "VILL"                                                                                             
##  [119] "RRAGD"                                                                                            
##  [120] "GNPDA1"                                                                                           
##  [121] "DNLZ"                                                                                             
##  [122] "COPS8"                                                                                            
##  [123] "VGLL3"                                                                                            
##  [124] "CWF19L2"                                                                                          
##  [125] "CD200R1"                                                                                          
##  [126] "OCRL"                                                                                             
##  [127] "SLC16A6"                                                                                          
##  [128] "GRIN1"                                                                                            
##  [129] "COL23A1"                                                                                          
##  [130] "CEP120"                                                                                           
##  [131] "DZIP1"                                                                                            
##  [132] "4930453N24RIK"                                                                                    
##  [133] "B930041F14RIK"                                                                                    
##  [134] "JUND"                                                                                             
##  [135] "GP5"                                                                                              
##  [136] "B230378P21RIK"                                                                                    
##  [137] "YLPM1"                                                                                            
##  [138] "STXBP5"                                                                                           
##  [139] "LOXL3"                                                                                            
##  [140] "ITGA1"                                                                                            
##  [141] "ZSCAN10"                                                                                          
##  [142] "TSPAN18"                                                                                          
##  [143] "CECR5"                                                                                            
##  [144] "SEC24C"                                                                                           
##  [145] "NOS1AP"                                                                                           
##  [146] "9330162012RIK"                                                                                    
##  [147] "GLRX2"                                                                                            
##  [148] "DYNC1I2"                                                                                          
##  [149] "D130017N08RIK"                                                                                    
##  [150] "TTC9C"                                                                                            
##  [151] "GM5922"                                                                                           
##  [152] "AEN"                                                                                              
##  [153] "PDCD1"                                                                                            
##  [154] "ICMT"                                                                                             
##  [155] "SLC23A2"                                                                                          
##  [156] "EXOG"                                                                                             
##  [157] "DDX19B"                                                                                           
##  [158] "SPTY2D1"                                                                                          
##  [159] "BC017643"                                                                                         
##  [160] "LRRC41"                                                                                           
##  [161] "LRRN3"                                                                                            
##  [162] "AFAP1L2"                                                                                          
##  [163] "ZFP446"                                                                                           
##  [164] "ISCA2"                                                                                            
##  [165] "FUCA2"                                                                                            
##  [166] "SMPD1"                                                                                            
##  [167] "ARMC10"                                                                                           
##  [168] "RCN1"                                                                                             
##  [169] "ANKRD6"                                                                                           
##  [170] "ZFP444"                                                                                           
##  [171] "CYB561D1"                                                                                         
##  [172] "ZFP207"                                                                                           
##  [173] "GPRASP1"                                                                                          
##  [174] "SERTAD2"                                                                                          
##  [175] "PKNOX1"                                                                                           
##  [176] "FNDC3A"                                                                                           
##  [177] "GRIA3"                                                                                            
##  [178] "TTC19"                                                                                            
##  [179] "TRIM11"                                                                                           
##  [180] "DNMT3B"                                                                                           
##  [181] "WIPI1"                                                                                            
##  [182] "GLO1"                                                                                             
##  [183] "DLD"                                                                                              
##  [184] "ZFP282"                                                                                           
##  [185] "ATP2B2"                                                                                           
##  [186] "CASP7"                                                                                            
##  [187] "RAB5B"                                                                                            
##  [188] "SH2B1"                                                                                            
##  [189] "TAS1R3"                                                                                           
##  [190] "DLGAP1"                                                                                           
##  [191] "ZBTB16"                                                                                           
##  [192] "TSPAN32"                                                                                          
##  [193] "PUS1"                                                                                             
##  [194] "TNRC6A"                                                                                           
##  [195] "ACPP"                                                                                             
##  [196] "IDO2"                                                                                             
##  [197] "NPTXR"                                                                                            
##  [198] "AP1B1"                                                                                            
##  [199] "PRKRIP1"                                                                                          
##  [200] "TMPO"                                                                                             
##  [201] "EDA"                                                                                              
##  [202] "TRPM6"                                                                                            
##  [203] "NIPAL3"                                                                                           
##  [204] "FPGS"                                                                                             
##  [205] "VPS18"                                                                                            
##  [206] "TRIM33"                                                                                           
##  [207] "WDHD1"                                                                                            
##  [208] "CEP55"                                                                                            
##  [209] "GMIP"                                                                                             
##  [210] "PPP1R16B"                                                                                         
##  [211] "GSDMC3"                                                                                           
##  [212] "MAPKBP1"                                                                                          
##  [213] "LDB3"                                                                                             
##  [214] "GM2897"                                                                                           
##  [215] "NDOR1"                                                                                            
##  [216] "C030039L03RIK"                                                                                    
##  [217] "DIP2A"                                                                                            
##  [218] "BCL7A"                                                                                            
##  [219] "GM5468"                                                                                           
##  [220] "6030443J06RIK"                                                                                    
##  [221] "D930016D06RIK"                                                                                    
##  [222] "GABPB2"                                                                                           
##  [223] "ARHGEF6"                                                                                          
##  [224] "RALGDS"                                                                                           
##  [225] "ZFP92"                                                                                            
##  [226] "MED1"                                                                                             
##  [227] "A330050B17RIK"                                                                                    
##  [228] "CD34"                                                                                             
##  [229] "GRIK5"                                                                                            
##  [230] "MELA"                                                                                             
##  [231] "YBX2"                                                                                             
##  [232] "PNPLA1"                                                                                           
##  [233] "SLC12A6"                                                                                          
##  [234] "TRIM7"                                                                                            
##  [235] "FAM135A"                                                                                          
##  [236] "BCHE"                                                                                             
##  [237] "NTF5"                                                                                             
##  [238] "WWP1"                                                                                             
##  [239] "NEU4"                                                                                             
##  [240] "ELMO1"                                                                                            
##  [241] "DMTF1"                                                                                            
##  [242] "CDK12"                                                                                            
##  [243] "TULP4"                                                                                            
##  [244] "OIT3"                                                                                             
##  [245] "E130218I03RIK"                                                                                    
##  [246] "GUCY1A2"                                                                                          
##  [247] "1300002E11RIK"                                                                                    
##  [248] "POGK"                                                                                             
##  [249] "TEX21"                                                                                            
##  [250] "USP29"                                                                                            
##  [251] "4833424O15RIK"                                                                                    
##  [252] "TTBK2"                                                                                            
##  [253] "POLQ"                                                                                             
##  [254] "CDC123"                                                                                           
##  [255] "4930417H01RIK"                                                                                    
##  [256] "NCOA7"                                                                                            
##  [257] "STAT3"                                                                                            
##  [258] "MLLT1"                                                                                            
##  [259] "4933411K20RIK"                                                                                    
##  [260] "ELK1"                                                                                             
##  [261] "HORMAD1"                                                                                          
##  [262] "ABCB9"                                                                                            
##  [263] "KLHL23"                                                                                           
##  [264] "SENP7"                                                                                            
##  [265] "SULF1"                                                                                            
##  [266] "TREM1"                                                                                            
##  [267] "MTSS1"                                                                                            
##  [268] "AHCYL2"                                                                                           
##  [269] "TRIM39"                                                                                           
##  [270] "HNRNPD"                                                                                           
##  [271] "SLC34A1"                                                                                          
##  [272] "MAPK8IP3"                                                                                         
##  [273] "GJB5"                                                                                             
##  [274] "RREB1"                                                                                            
##  [275] "ENTPD5"                                                                                           
##  [276] "SLC6A8"                                                                                           
##  [277] "CCDC114"                                                                                          
##  [278] "SLC22A23"                                                                                         
##  [279] "GM9"                                                                                              
##  [280] "SHISA5"                                                                                           
##  [281] "RALB"                                                                                             
##  [282] "L3MBTL4"                                                                                          
##  [283] "FNDC3B"                                                                                           
##  [284] "FGD4"                                                                                             
##  [285] "LIMK2"                                                                                            
##  [286] "PPP1R3B"                                                                                          
##  [287] "DOK3"                                                                                             
##  [288] "MBD1"                                                                                             
##  [289] "AFG3L1"                                                                                           
##  [290] "RARG"                                                                                             
##  [291] "SYNM"                                                                                             
##  [292] "TRHDE"                                                                                            
##  [293] "ASB7"                                                                                             
##  [294] "CRYBG3"                                                                                           
##  [295] "STARD9"                                                                                           
##  [296] "VPS37C"                                                                                           
##  [297] "MAN1A2"                                                                                           
##  [298] "SCARA3"                                                                                           
##  [299] "EPM2AIP1"                                                                                         
##  [300] "SKP2"                                                                                             
##  [301] "DIP2C"                                                                                            
##  [302] "AHR"                                                                                              
##  [303] "KLHL30"                                                                                           
##  [304] "NAA10"                                                                                            
##  [305] "GABPA"                                                                                            
##  [306] "TNKS2"                                                                                            
##  [307] "NUDT13"                                                                                           
##  [308] "2010109I03RIK"                                                                                    
##  [309] "RAMP1"                                                                                            
##  [310] "XKR4"                                                                                             
##  [311] "CLEC16A"                                                                                          
##  [312] "CPN2"                                                                                             
##  [313] "SRR"                                                                                              
##  [314] "AGTR1B"                                                                                           
##  [315] "TLE4"                                                                                             
##  [316] "ZFP655"                                                                                           
##  [317] "MIRG"                                                                                             
##  [318] "ANKRD16"                                                                                          
##  [319] "RDH13"                                                                                            
##  [320] "DPY19L2"                                                                                          
##  [321] "AKT1S1"                                                                                           
##  [322] "CAP1"                                                                                             
##  [323] "A630009H07RIK"                                                                                    
##  [324] "KIF16B"                                                                                           
##  [325] "CHST10"                                                                                           
##  [326] "IGF1"                                                                                             
##  [327] "ADAMTS9"                                                                                          
##  [328] "KIF1B"                                                                                            
##  [329] "NSMCE2"                                                                                           
##  [330] "1700006A11RIK"                                                                                    
##  [331] "HES2"                                                                                             
##  [332] "KIF7"                                                                                             
##  [333] "IL15"                                                                                             
##  [334] "FAM102B"                                                                                          
##  [335] "SOD2"                                                                                             
##  [336] "ZFP763"                                                                                           
##  [337] "TFB2M"                                                                                            
##  [338] "USP47"                                                                                            
##  [339] "ZFP644"                                                                                           
##  [340] "TMEM163"                                                                                          
##  [341] "PTRH2"                                                                                            
##  [342] "CTSB"                                                                                             
##  [343] "TTPAL"                                                                                            
##  [344] "MIR155"                                                                                           
##  [345] "ADRA1B"                                                                                           
##  [346] "CDKN2AIPNL"                                                                                       
##  [347] "NEDD8"                                                                                            
##  [348] "GAD1"                                                                                             
##  [349] "SFPQ"                                                                                             
##  [350] "DNAJC27"                                                                                          
##  [351] "JMJD4"                                                                                            
##  [352] "NEIL3"                                                                                            
##  [353] "UBN2"                                                                                             
##  [354] "ABCC9"                                                                                            
##  [355] "KLHDC8A"                                                                                          
##  [356] "MCTP1"                                                                                            
##  [357] "KLRK1"                                                                                            
##  [358] "COL9A3"                                                                                           
##  [359] "ARMC9"                                                                                            
##  [360] "NCS1"                                                                                             
##  [361] "SERPINA3I"                                                                                        
##  [362] "HARS2"                                                                                            
##  [363] "A830018L16RIK"                                                                                    
##  [364] "OXNAD1"                                                                                           
##  [365] "POM121"                                                                                           
##  [366] "SV2A"                                                                                             
##  [367] "TRIM16"                                                                                           
##  [368] "PTPN14"                                                                                           
##  [369] "TRP63"                                                                                            
##  [370] "NT5M"                                                                                             
##  [371] "AMOT"                                                                                             
##  [372] "NFATC1"                                                                                           
##  [373] "KCNC3"                                                                                            
##  [374] "PHLDB1"                                                                                           
##  [375] "RHOT1"                                                                                            
##  [376] "MYT1"                                                                                             
##  [377] "AW549877"                                                                                         
##  [378] "CLN3"                                                                                             
##  [379] "INTS2"                                                                                            
##  [380] "ZFP422"                                                                                           
##  [381] "CBX5"                                                                                             
##  [382] "BAHCC1"                                                                                           
##  [383] "GSDMC4"                                                                                           
##  [384] "ARID3A"                                                                                           
##  [385] "CAR7"                                                                                             
##  [386] "TAF1D"                                                                                            
##  [387] "CTDSP2"                                                                                           
##  [388] "CACNA1D"                                                                                          
##  [389] "SLAMF6"                                                                                           
##  [390] "IQSEC3"                                                                                           
##  [391] "RASGEF1B"                                                                                         
##  [392] "TMPRSS2"                                                                                          
##  [393] "MAGI2"                                                                                            
##  [394] "KIFC2"                                                                                            
##  [395] "ARHGEF5"                                                                                          
##  [396] "STX17"                                                                                            
##  [397] "SLC10A7"                                                                                          
##  [398] "MEST"                                                                                             
##  [399] "EN1"                                                                                              
##  [400] "6330416G13RIK"                                                                                    
##  [401] "SMAD5"                                                                                            
##  [402] "TXN2"                                                                                             
##  [403] "PDGFRL"                                                                                           
##  [404] "F730016J06RIK"                                                                                    
##  [405] "PGM2L1"                                                                                           
##  [406] "SLC25A28"                                                                                         
##  [407] "TBKBP1"                                                                                           
##  [408] "WDR77"                                                                                            
##  [409] "MCTS2"                                                                                            
##  [410] "1700030J22RIK"                                                                                    
##  [411] "FAM78B"                                                                                           
##  [412] "TMEM231"                                                                                          
##  [413] "OGFOD1"                                                                                           
##  [414] "STK36"                                                                                            
##  [415] "CDYL"                                                                                             
##  [416] "TMEM106C"                                                                                         
##  [417] "UBE2O"                                                                                            
##  [418] "FKBP5"                                                                                            
##  [419] "NXT2"                                                                                             
##  [420] "SART1"                                                                                            
##  [421] "PLXNA2"                                                                                           
##  [422] "HDAC6"                                                                                            
##  [423] "SFT2D2"                                                                                           
##  [424] "SSR1"                                                                                             
##  [425] "STAT5B"                                                                                           
##  [426] "SLA"                                                                                              
##  [427] "RHBDD2"                                                                                           
##  [428] "GYK"                                                                                              
##  [429] "SHC4"                                                                                             
##  [430] "TM6SF1"                                                                                           
##  [431] "HECTD2"                                                                                           
##  [432] "NFYA"                                                                                             
##  [433] "SPTLC2"                                                                                           
##  [434] "TGFBR1"                                                                                           
##  [435] "MCTP2"                                                                                            
##  [436] "COPS7A"                                                                                           
##  [437] "NFAM1"                                                                                            
##  [438] "CPSF4"                                                                                            
##  [439] "DDX20"                                                                                            
##  [440] "B3GNT7"                                                                                           
##  [441] "MTPN"                                                                                             
##  [442] "MED7"                                                                                             
##  [443] "CD2AP"                                                                                            
##  [444] "SH2D2A"                                                                                           
##  [445] "GPAA1"                                                                                            
##  [446] "ARL5A"                                                                                            
##  [447] "CDC34"                                                                                            
##  [448] "SYTL4"                                                                                            
##  [449] "4930579C12RIK"                                                                                    
##  [450] "SLC43A2"                                                                                          
##  [451] "MMD"                                                                                              
##  [452] "PRKRIR"                                                                                           
##  [453] "PA2G4"                                                                                            
##  [454] "LAPTM5"                                                                                           
##  [455] "2700081O15RIK"                                                                                    
##  [456] "E2F6"                                                                                             
##  [457] "TIMP4"                                                                                            
##  [458] "KLHL15"                                                                                           
##  [459] "SHISA9"                                                                                           
##  [460] "PDE12"                                                                                            
##  [461] "ARFRP1"                                                                                           
##  [462] "SPOCK1"                                                                                           
##  [463] "H2AFX"                                                                                            
##  [464] "NPAS3"                                                                                            
##  [465] "1600012H06RIK"                                                                                    
##  [466] "GOLGA7"                                                                                           
##  [467] "KCNC2"                                                                                            
##  [468] "KIF14"                                                                                            
##  [469] "PYGO2"                                                                                            
##  [470] "P2RX4"                                                                                            
##  [471] "HPS3"                                                                                             
##  [472] "CYBA"                                                                                             
##  [473] "UBE2J2"                                                                                           
##  [474] "KCNS2"                                                                                            
##  [475] "9530059O14RIK"                                                                                    
##  [476] "HDX"                                                                                              
##  [477] "NRF1"                                                                                             
##  [478] "NEK9"                                                                                             
##  [479] "EIF2S2"                                                                                           
##  [480] "SECTM1B"                                                                                          
##  [481] "SLC24A6"                                                                                          
##  [482] "SNX27"                                                                                            
##  [483] "IMP4"                                                                                             
##  [484] "DBC1"                                                                                             
##  [485] "COL27A1"                                                                                          
##  [486] "SHANK2"                                                                                           
##  [487] "TRP53BP1"                                                                                         
##  [488] "TMEM143"                                                                                          
##  [489] "ANO2"                                                                                             
##  [490] "FN3K"                                                                                             
##  [491] "UBE2E3"                                                                                           
##  [492] "MPP2"                                                                                             
##  [493] "GTPBP2"                                                                                           
##  [494] "MBNL3"                                                                                            
##  [495] "GM15246"                                                                                          
##  [496] "FBXW11"                                                                                           
##  [497] "HIATL1"                                                                                           
##  [498] "E330032C10RIK"                                                                                    
##  [499] "MBTPS2"                                                                                           
##  [500] "TIMM22"                                                                                           
##  [501] "NPSR1"                                                                                            
##  [502] "B430306N03RIK"                                                                                    
##  [503] "CD93"                                                                                             
##  [504] "ZFP36L1"                                                                                          
##  [505] "VASH2"                                                                                            
##  [506] "2610301B20RIK"                                                                                    
##  [507] "SCYL3"                                                                                            
##  [508] "LRRC58"                                                                                           
##  [509] "HMBOX1"                                                                                           
##  [510] "SYS1"                                                                                             
##  [511] "TNFRSF22"                                                                                         
##  [512] "KCNB2"                                                                                            
##  [513] "CABP2"                                                                                            
##  [514] "KLHL32"                                                                                           
##  [515] "MYADM"                                                                                            
##  [516] "B230206H07RIK"                                                                                    
##  [517] "SYT2"                                                                                             
##  [518] "3110002H16RIK"                                                                                    
##  [519] "ZFP248"                                                                                           
##  [520] "SLC25A3"                                                                                          
##  [521] "SMOC2"                                                                                            
##  [522] "ARHGAP8"                                                                                          
##  [523] "SLC7A14"                                                                                          
##  [524] "MTERFD3"                                                                                          
##  [525] "TTC3"                                                                                             
##  [526] "IKBKG"                                                                                            
##  [527] "JPH4"                                                                                             
##  [528] "MAGT1"                                                                                            
##  [529] "PRR18"                                                                                            
##  [530] "HNRPDL"                                                                                           
##  [531] "MTMR6"                                                                                            
##  [532] "ENY2"                                                                                             
##  [533] "EPB4.1L1"                                                                                         
##  [534] "PDZD3"                                                                                            
##  [535] "SENP2"                                                                                            
##  [536] "RFFL"                                                                                             
##  [537] "FAF2"                                                                                             
##  [538] "RNF13"                                                                                            
##  [539] "MICAL3"                                                                                           
##  [540] "PANX2"                                                                                            
##  [541] "NLRP4C"                                                                                           
##  [542] "GSPT2"                                                                                            
##  [543] "ANKRD54"                                                                                          
##  [544] "TTLL9"                                                                                            
##  [545] "LMBRD1"                                                                                           
##  [546] "DBPHT2"                                                                                           
##  [547] "CLN8"                                                                                             
##  [548] "ZDHHC21"                                                                                          
##  [549] "FAM60A"                                                                                           
##  [550] "PFN2"                                                                                             
##  [551] "AGBL2"                                                                                            
##  [552] "1700112E06RIK"                                                                                    
##  [553] "ZDHHC24"                                                                                          
##  [554] "TEF"                                                                                              
##  [555] "8030462N17RIK"                                                                                    
##  [556] "PPP2R1A"                                                                                          
##  [557] "LPHN3"                                                                                            
##  [558] "LIN7C"                                                                                            
##  [559] "DSC3"                                                                                             
##  [560] "NDST1"                                                                                            
##  [561] "1700047M11RIK"                                                                                    
##  [562] "GRID2IP"                                                                                          
##  [563] "CGGBP1"                                                                                           
##  [564] "WARS"                                                                                             
##  [565] "TXNL4B"                                                                                           
##  [566] "UBE2H"                                                                                            
##  [567] "FRS2"                                                                                             
##  [568] "USP45"                                                                                            
##  [569] "ACSM5"                                                                                            
##  [570] "RUNDC1"                                                                                           
##  [571] "TC2N"                                                                                             
##  [572] "CDADC1"                                                                                           
##  [573] "CCNH"                                                                                             
##  [574] "RPGRIP1"                                                                                          
##  [575] "AU015836"                                                                                         
##  [576] "CXCL12"                                                                                           
##  [577] "ZFP111"                                                                                           
##  [578] "IPCEF1"                                                                                           
##  [579] "ANXA8"                                                                                            
##  [580] "ST3GAL1"                                                                                          
##  [581] "GNA15"                                                                                            
##  [582] "TIFAB"                                                                                            
##  [583] "IGF1R"                                                                                            
##  [584] "MIER2"                                                                                            
##  [585] "GNAL"                                                                                             
##  [586] "VTI1A"                                                                                            
##  [587] "1700026D11RIK"                                                                                    
##  [588] "NF2"                                                                                              
##  [589] "TMEM229B"                                                                                         
##  [590] "HGF"                                                                                              
##  [591] "DHRS13"                                                                                           
##  [592] "ARMC8"                                                                                            
##  [593] "GRAMD3"                                                                                           
##  [594] "DNASE2A"                                                                                          
##  [595] "TECPR2"                                                                                           
##  [596] "SYN3"                                                                                             
##  [597] "EBF4"                                                                                             
##  [598] "B3GAT1"                                                                                           
##  [599] "COL10A1"                                                                                          
##  [600] "PRRT2"                                                                                            
##  [601] "TMEM71"                                                                                           
##  [602] "KLF17"                                                                                            
##  [603] "1500026H17RIK"                                                                                    
##  [604] "RBM33"                                                                                            
##  [605] "CACNB2"                                                                                           
##  [606] "MYL9"                                                                                             
##  [607] "SOX2OT"                                                                                           
##  [608] "ISY1"                                                                                             
##  [609] "AGAP1"                                                                                            
##  [610] "RHBDD1"                                                                                           
##  [611] "USP7"                                                                                             
##  [612] "AOC3"                                                                                             
##  [613] "MCPT2"                                                                                            
##  [614] "SKIL"                                                                                             
##  [615] "SRRM4"                                                                                            
##  [616] "C920008G01RIK"                                                                                    
##  [617] "AA987161"                                                                                         
##  [618] "MOBP"                                                                                             
##  [619] "CWC25"                                                                                            
##  [620] "RUNX3"                                                                                            
##  [621] "ZFP300"                                                                                           
##  [622] "IKZF2"                                                                                            
##  [623] "SLC4A7"                                                                                           
##  [624] "PTBP2"                                                                                            
##  [625] "PDZD7"                                                                                            
##  [626] "MLLT10"                                                                                           
##  [627] "4933437N03RIK"                                                                                    
##  [628] "ZBTB37"                                                                                           
##  [629] "CTTNBP2"                                                                                          
##  [630] "SMAP1"                                                                                            
##  [631] "2810429I04RIK"                                                                                    
##  [632] "PSD2"                                                                                             
##  [633] "AP2B1"                                                                                            
##  [634] "UBE2K"                                                                                            
##  [635] "NTRK2"                                                                                            
##  [636] "USP16"                                                                                            
##  [637] "KRT6A"                                                                                            
##  [638] "2900079G21RIK"                                                                                    
##  [639] "TMOD2"                                                                                            
##  [640] "LBH"                                                                                              
##  [641] "ADAMTS14"                                                                                         
##  [642] "LPAR1"                                                                                            
##  [643] "PIM1"                                                                                             
##  [644] "OSBP2"                                                                                            
##  [645] "NIN"                                                                                              
##  [646] "RHOBTB1"                                                                                          
##  [647] "EPSTI1"                                                                                           
##  [648] "PDZRN3"                                                                                           
##  [649] "1810014B01RIK"                                                                                    
##  [650] "STK35"                                                                                            
##  [651] "AI464131"                                                                                         
##  [652] "A1CF"                                                                                             
##  [653] "KLHDC3"                                                                                           
##  [654] "EIF4EBP2"                                                                                         
##  [655] "WDR92"                                                                                            
##  [656] "SLC2A6"                                                                                           
##  [657] "CSNK1G1"                                                                                          
##  [658] "ZFP512"                                                                                           
##  [659] "FRMD5"                                                                                            
##  [660] "AIG1"                                                                                             
##  [661] "NSD1"                                                                                             
##  [662] "AI854517"                                                                                         
##  [663] "MEF2C"                                                                                            
##  [664] "ACTR2"                                                                                            
##  [665] "COL2A1"                                                                                           
##  [666] "TRIM66"                                                                                           
##  [667] "AP3B2"                                                                                            
##  [668] "ANXA3"                                                                                            
##  [669] "NOSIP"                                                                                            
##  [670] "PGLS"                                                                                             
##  [671] "PDGFRB"                                                                                           
##  [672] "SFMBT2"                                                                                           
##  [673] "GM9054"                                                                                           
##  [674] "LPP"                                                                                              
##  [675] "ZFP668"                                                                                           
##  [676] "HSPBAP1"                                                                                          
##  [677] "NAA30"                                                                                            
##  [678] "D030028A08RIK"                                                                                    
##  [679] "SRGAP2"                                                                                           
##  [680] "2500002B13RIK"                                                                                    
##  [681] "KIRREL3"                                                                                          
##  [682] "WDR37"                                                                                            
##  [683] "TMEM91"                                                                                           
##  [684] "MLST8"                                                                                            
##  [685] "MGLL"                                                                                             
##  [686] "DFFA"                                                                                             
##  [687] "PCYT1B"                                                                                           
##  [688] "IL21"                                                                                             
##  [689] "3110052M02RIK"                                                                                    
##  [690] "RBM14"                                                                                            
##  [691] "MAPK10"                                                                                           
##  [692] "CBX7"                                                                                             
##  [693] "4930555G01RIK"                                                                                    
##  [694] "PSG17"                                                                                            
##  [695] "FUT9"                                                                                             
##  [696] "YME1L1"                                                                                           
##  [697] "BC049352"                                                                                         
##  [698] "ZBTB7B"                                                                                           
##  [699] "METTL4"                                                                                           
##  [700] "ATE1"                                                                                             
##  [701] "ANO5"                                                                                             
##  [702] "FBXW4"                                                                                            
##  [703] "B4GALT6"                                                                                          
##  [704] "ZFP653"                                                                                           
##  [705] "ARRDC3"                                                                                           
##  [706] "PELI1"                                                                                            
##  [707] "VPS13D"                                                                                           
##  [708] "A830012C17RIK"                                                                                    
##  [709] "ARNT2"                                                                                            
##  [710] "TPRN"                                                                                             
##  [711] "HOXD3"                                                                                            
##  [712] "4833417C18RIK"                                                                                    
##  [713] "GK5"                                                                                              
##  [714] "SNHG1"                                                                                            
##  [715] "SERPINB8"                                                                                         
##  [716] "EME2"                                                                                             
##  [717] "DEGS1"                                                                                            
##  [718] "4930422G04RIK"                                                                                    
##  [719] "SPIN1"                                                                                            
##  [720] "ESRRG"                                                                                            
##  [721] "ITCH"                                                                                             
##  [722] "RANBP10"                                                                                          
##  [723] "TRAM1L1"                                                                                          
##  [724] "TSC22D2"                                                                                          
##  [725] "RB1"                                                                                              
##  [726] "SDC3"                                                                                             
##  [727] "ACVR1B"                                                                                           
##  [728] "BATF"                                                                                             
##  [729] "BC046251"                                                                                         
##  [730] "PAQR3"                                                                                            
##  [731] "MAST4"                                                                                            
##  [732] "ELL2"                                                                                             
##  [733] "CCDC116"                                                                                          
##  [734] "MGAT1"                                                                                            
##  [735] "TMEM8B"                                                                                           
##  [736] "B530045E10RIK"                                                                                    
##  [737] "DDX58"                                                                                            
##  [738] "4930533N22RIK"                                                                                    
##  [739] "EZH1"                                                                                             
##  [740] "PIN1"                                                                                             
##  [741] "SYNJ1"                                                                                            
##  [742] "PXK"                                                                                              
##  [743] "FBXL22"                                                                                           
##  [744] "NR1D2"                                                                                            
##  [745] "RHEB"                                                                                             
##  [746] "PARD3B"                                                                                           
##  [747] "RNF167"                                                                                           
##  [748] "RBM11"                                                                                            
##  [749] "GPR174"                                                                                           
##  [750] "KIF3A"                                                                                            
##  [751] "ARMC2"                                                                                            
##  [752] "FKBP6"                                                                                            
##  [753] "TSPAN5"                                                                                           
##  [754] "ZFP710"                                                                                           
##  [755] "SPIN4"                                                                                            
##  [756] "CTTN"                                                                                             
##  [757] "SLC2A8"                                                                                           
##  [758] "ARHGEF12"                                                                                         
##  [759] "PPP2R1B"                                                                                          
##  [760] "C030017K20RIK"                                                                                    
##  [761] "NRP2"                                                                                             
##  [762] "RAB11FIP5"                                                                                        
##  [763] "CCBL2"                                                                                            
##  [764] "DENND5B"                                                                                          
##  [765] "LCOR"                                                                                             
##  [766] "SLC6A1"                                                                                           
##  [767] "4930434J06RIK"                                                                                    
##  [768] "AIRN"                                                                                             
##  [769] "SSH2"                                                                                             
##  [770] "TFAM"                                                                                             
##  [771] "DUSP16"                                                                                           
##  [772] "NOL7"                                                                                             
##  [773] "SCN3B"                                                                                            
##  [774] "GATM"                                                                                             
##  [775] "D430042O09RIK"                                                                                    
##  [776] "DOK4"                                                                                             
##  [777] "CCR9"                                                                                             
##  [778] "SUMF2"                                                                                            
##  [779] "NRBP2"                                                                                            
##  [780] "SH3KBP1"                                                                                          
##  [781] "HIST2H2BE"                                                                                        
##  [782] "UBAP1"                                                                                            
##  [783] "LILRB4"                                                                                           
##  [784] "PIKFYVE"                                                                                          
##  [785] "GM4776"                                                                                           
##  [786] "SGSM2"                                                                                            
##  [787] "PROM2"                                                                                            
##  [788] "ABHD12B"                                                                                          
##  [789] "PPP1R1C"                                                                                          
##  [790] "TSPAN7"                                                                                           
##  [791] "TCF25"                                                                                            
##  [792] "HBA-A2"                                                                                           
##  [793] "FADS1"                                                                                            
##  [794] "CHST1"                                                                                            
##  [795] "AIDA"                                                                                             
##  [796] "FOXP2"                                                                                            
##  [797] "NAIP6"                                                                                            
##  [798] "HMGN3"                                                                                            
##  [799] "CLEC5A"                                                                                           
##  [800] "BC048943"                                                                                         
##  [801] "UFM1"                                                                                             
##  [802] "KCNV1"                                                                                            
##  [803] "STK16"                                                                                            
##  [804] "NOD2"                                                                                             
##  [805] "SUPT7L"                                                                                           
##  [806] "TRMT11"                                                                                           
##  [807] "CAP2"                                                                                             
##  [808] "SYT5"                                                                                             
##  [809] "TPRGL"                                                                                            
##  [810] "SLC37A4"                                                                                          
##  [811] "LPL"                                                                                              
##  [812] "UBOX5"                                                                                            
##  [813] "HAND1"                                                                                            
##  [814] "CHD5"                                                                                             
##  [815] "SYT11"                                                                                            
##  [816] "CEP164"                                                                                           
##  [817] "NPR3"                                                                                             
##  [818] "ACN9"                                                                                             
##  [819] "CCDC127"                                                                                          
##  [820] "OPHN1"                                                                                            
##  [821] "MAN2A1"                                                                                           
##  [822] "SCARB1"                                                                                           
##  [823] "ZFP707"                                                                                           
##  [824] "PSMB5"                                                                                            
##  [825] "NKIRAS2"                                                                                          
##  [826] "HAP1"                                                                                             
##  [827] "PDE1C"                                                                                            
##  [828] "VWCE"                                                                                             
##  [829] "DSC1"                                                                                             
##  [830] "MEA1"                                                                                             
##  [831] "ITSN2"                                                                                            
##  [832] "PPP1R3C"                                                                                          
##  [833] "BNC2"                                                                                             
##  [834] "ABCC10"                                                                                           
##  [835] "LYZL4"                                                                                            
##  [836] "INTS9"                                                                                            
##  [837] "DKK3"                                                                                             
##  [838] "CORO2A"                                                                                           
##  [839] "RHBDL3"                                                                                           
##  [840] "MYRIP"                                                                                            
##  [841] "ZC3H11A"                                                                                          
##  [842] "PRMT6"                                                                                            
##  [843] "SLC7A8"                                                                                           
##  [844] "GM6787"                                                                                           
##  [845] "GM410"                                                                                            
##  [846] "EIF3I"                                                                                            
##  [847] "EBAG9"                                                                                            
##  [848] "TMEM62"                                                                                           
##  [849] "GTPBP1"                                                                                           
##  [850] "CCDC53"                                                                                           
##  [851] "B230110G15RIK"                                                                                    
##  [852] "TPPP"                                                                                             
##  [853] "A930024E05RIK"                                                                                    
##  [854] "KLHL26"                                                                                           
##  [855] "MNT"                                                                                              
##  [856] "PTPRH"                                                                                            
##  [857] "SNPH"                                                                                             
##  [858] "LTB"                                                                                              
##  [859] "TRP53RK"                                                                                          
##  [860] "SKINT3"                                                                                           
##  [861] "ANKS1B"                                                                                           
##  [862] "MAN1A"                                                                                            
##  [863] "ZFP9"                                                                                             
##  [864] "ALX3"                                                                                             
##  [865] "ZFP263"                                                                                           
##  [866] "3010003L21RIK"                                                                                    
##  [867] "ACOX1"                                                                                            
##  [868] "CASP9"                                                                                            
##  [869] "IARS"                                                                                             
##  [870] "CHSY3"                                                                                            
##  [871] "FGF1"                                                                                             
##  [872] "FAM196B"                                                                                          
##  [873] "SBK1"                                                                                             
##  [874] "MALT1"                                                                                            
##  [875] "SMYD5"                                                                                            
##  [876] "LRRTM1"                                                                                           
##  [877] "RAPGEF6"                                                                                          
##  [878] "GM15623"                                                                                          
##  [879] "KLHL20"                                                                                           
##  [880] "MAPRE1"                                                                                           
##  [881] "ZFP329"                                                                                           
##  [882] "STARD3NL"                                                                                         
##  [883] "HTR2C"                                                                                            
##  [884] "CD160"                                                                                            
##  [885] "GNAI3"                                                                                            
##  [886] "BCL2L13"                                                                                          
##  [887] "NT5DC1"                                                                                           
##  [888] "KDM4D"                                                                                            
##  [889] "NCTC1"                                                                                            
##  [890] "ARHGEF16"                                                                                         
##  [891] "ZDHHC3"                                                                                           
##  [892] "ADAM23"                                                                                           
##  [893] "MAVS"                                                                                             
##  [894] "PDE4B"                                                                                            
##  [895] "STIM1"                                                                                            
##  [896] "NVL"                                                                                              
##  [897] "COPS7B"                                                                                           
##  [898] "IGF2AS"                                                                                           
##  [899] "EDNRA"                                                                                            
##  [900] "ZC3H7B"                                                                                           
##  [901] "STAB2"                                                                                            
##  [902] "SMCR7"                                                                                            
##  [903] "NCALD"                                                                                            
##  [904] "CDR2L"                                                                                            
##  [905] "PNPT1"                                                                                            
##  [906] "HIC2"                                                                                             
##  [907] "ARRDC4"                                                                                           
##  [908] "WDR82"                                                                                            
##  [909] "BAIAP2"                                                                                           
##  [910] "ST13"                                                                                             
##  [911] "CNTN2"                                                                                            
##  [912] "SLC6A17"                                                                                          
##  [913] "CWC22"                                                                                            
##  [914] "FAM133B"                                                                                          
##  [915] "CELA1"                                                                                            
##  [916] "TRIM2"                                                                                            
##  [917] "CAMK2D"                                                                                           
##  [918] "UNC5C"                                                                                            
##  [919] "NUDT4"                                                                                            
##  [920] "LCORL"                                                                                            
##  [921] "SLC35A4"                                                                                          
##  [922] "STARD13"                                                                                          
##  [923] "BCAP29"                                                                                           
##  [924] "4930403D09RIK"                                                                                    
##  [925] "IL1F5"                                                                                            
##  [926] "MYOZ2"                                                                                            
##  [927] "ATXN7L3"                                                                                          
##  [928] "HSD3B3"                                                                                           
##  [929] "CCND1"                                                                                            
##  [930] "WDTC1"                                                                                            
##  [931] "TAF9B"                                                                                            
##  [932] "FAM132B"                                                                                          
##  [933] "TAC4"                                                                                             
##  [934] "RPRD2"                                                                                            
##  [935] "SPHKAP"                                                                                           
##  [936] "ZBTB33"                                                                                           
##  [937] "AKT1"                                                                                             
##  [938] "ARID3B"                                                                                           
##  [939] "GPR31C"                                                                                           
##  [940] "NEUROD2"                                                                                          
##  [941] "OGFR"                                                                                             
##  [942] "C230072F16RIK"                                                                                    
##  [943] "EEF1D"                                                                                            
##  [944] "ANKRD40"                                                                                          
##  [945] "6330403A02RIK"                                                                                    
##  [946] "MKL1"                                                                                             
##  [947] "CEP57"                                                                                            
##  [948] "SLC25A22"                                                                                         
##  [949] "OSBPL6"                                                                                           
##  [950] "MED28"                                                                                            
##  [951] "PRKD3"                                                                                            
##  [952] "SRPK2"                                                                                            
##  [953] "NDST3"                                                                                            
##  [954] "ASNSD1"                                                                                           
##  [955] "AHI1"                                                                                             
##  [956] "PTP4A3"                                                                                           
##  [957] "SYNJ2BP"                                                                                          
##  [958] "PKNOX2"                                                                                           
##  [959] "DDO"                                                                                              
##  [960] "ADAM11"                                                                                           
##  [961] "SH3PXD2B"                                                                                         
##  [962] "ADAM12"                                                                                           
##  [963] "MCFD2"                                                                                            
##  [964] "SUV39H1"                                                                                          
##  [965] "CDK18"                                                                                            
##  [966] "GRIA2"                                                                                            
##  [967] "AHRR"                                                                                             
##  [968] "KRTAP5-2"                                                                                         
##  [969] "A430105I19RIK"                                                                                    
##  [970] "RNF32"                                                                                            
##  [971] "SNX30"                                                                                            
##  [972] "D630045J12RIK"                                                                                    
##  [973] "KIF9"                                                                                             
##  [974] "4933407E24RIK"                                                                                    
##  [975] "ABHD14B"                                                                                          
##  [976] "HIF1AN"                                                                                           
##  [977] "ISL1"                                                                                             
##  [978] "SLC29A2"                                                                                          
##  [979] "NOTCH2"                                                                                           
##  [980] "CHRNB4"                                                                                           
##  [981] "LRRIQ3"                                                                                           
##  [982] "RHOH"                                                                                             
##  [983] "ZBTB10"                                                                                           
##  [984] "PLXNB1"                                                                                           
##  [985] "KLHL18"                                                                                           
##  [986] "IL6ST"                                                                                            
##  [987] "TDRD1"                                                                                            
##  [988] "4930428N03RIK"                                                                                    
##  [989] "SLC18A1"                                                                                          
##  [990] "ARNT"                                                                                             
##  [991] "1600014C10RIK"                                                                                    
##  [992] "GCNT3"                                                                                            
##  [993] "ARHGEF15"                                                                                         
##  [994] "LY86"                                                                                             
##  [995] "THOC2"                                                                                            
##  [996] "PYGB"                                                                                             
##  [997] "PTPRN2"                                                                                           
##  [998] "TARBP2"                                                                                           
##  [999] "SFXN3"                                                                                            
## [1000] "TBC1D14"                                                                                          
## [1001] "GM16515"                                                                                          
## [1002] "CLCN3"                                                                                            
## [1003] "TTLL1"                                                                                            
## [1004] "RGS9BP"                                                                                           
## [1005] "ITFG2"                                                                                            
## [1006] "ESYT1"                                                                                            
## [1007] "CTDSPL2"                                                                                          
## [1008] "ATXN1L"                                                                                           
## [1009] "BMF"                                                                                              
## [1010] "ABL1"                                                                                             
## [1011] "SLC2A3"                                                                                           
## [1012] "TRCG1"                                                                                            
## [1013] "MPDZ"                                                                                             
## [1014] "TMEM139"                                                                                          
## [1015] "COL19A1"                                                                                          
## [1016] "UPK1A"                                                                                            
## [1017] "MYCL1"                                                                                            
## [1018] "AAK1"                                                                                             
## [1019] "LNP"                                                                                              
## [1020] "SPAG9"                                                                                            
## [1021] "2700099C18RIK"                                                                                    
## [1022] "RAB11FIP2"                                                                                        
## [1023] "OTUD7B"                                                                                           
## [1024] "POLR3G"                                                                                           
## [1025] "TLN2"                                                                                             
## [1026] "PGAM1"                                                                                            
## [1027] "TSR2"                                                                                             
## [1028] "FABP12"                                                                                           
## [1029] "IRF4"                                                                                             
## [1030] "RFX2"                                                                                             
## [1031] "UHRF2"                                                                                            
## [1032] "ITGA8"                                                                                            
## [1033] "TTPA"                                                                                             
## [1034] "ZFP532"                                                                                           
## [1035] "DOHH"                                                                                             
## [1036] "ART1"                                                                                             
## [1037] "PGS1"                                                                                             
## [1038] "SMCR8"                                                                                            
## [1039] "4933406F09RIK"                                                                                    
## [1040] "ZFP174"                                                                                           
## [1041] "VAV3"                                                                                             
## [1042] "SLC8A1"                                                                                           
## [1043] "IFT80"                                                                                            
## [1044] "ZEB2"                                                                                             
## [1045] "SPEG"                                                                                             
## [1046] "1110051M20RIK"                                                                                    
## [1047] "TGFBRAP1"                                                                                         
## [1048] "SEMA4B"                                                                                           
## [1049] "TMED10"                                                                                           
## [1050] "GM13547"                                                                                          
## [1051] "CRB1"                                                                                             
## [1052] "CRTAP"                                                                                            
## [1053] "ABI1"                                                                                             
## [1054] "AGBL5"                                                                                            
## [1055] "GAS1"                                                                                             
## [1056] "1700095A21RIK"                                                                                    
## [1057] "VRK1"                                                                                             
## [1058] "TMEM129"                                                                                          
## [1059] "MGAT4C"                                                                                           
## [1060] "KCTD10"                                                                                           
## [1061] "DENND4C"                                                                                          
## [1062] "CD83"                                                                                             
## [1063] "RAB6B"                                                                                            
## [1064] "MNAT1"                                                                                            
## [1065] "CLDN19"                                                                                           
## [1066] "1110008L16RIK"                                                                                    
## [1067] "4933427E13RIK"                                                                                    
## [1068] "MEIS2"                                                                                            
## [1069] "RNF169"                                                                                           
## [1070] "FMN1"                                                                                             
## [1071] "ARHGAP25"                                                                                         
## [1072] "TNRC6B"                                                                                           
## [1073] "TMIE"                                                                                             
## [1074] "HRASLS"                                                                                           
## [1075] "PLCD4"                                                                                            
## [1076] "VPS25"                                                                                            
## [1077] "SLC39A14"                                                                                         
## [1078] "ZKSCAN2"                                                                                          
## [1079] "GJC3"                                                                                             
## [1080] "DGKI"                                                                                             
## [1081] "MAPT"                                                                                             
## [1082] "PRPF18"                                                                                           
## [1083] "ZFP618"                                                                                           
## [1084] "IL23R"                                                                                            
## [1085] "AKNAD1"                                                                                           
## [1086] "DST"                                                                                              
## [1087] "UTP23"                                                                                            
## [1088] "CD47"                                                                                             
## [1089] "GIT2"                                                                                             
## [1090] "PLEKHB2"                                                                                          
## [1091] "GM5766"                                                                                           
## [1092] "IGSF9"                                                                                            
## [1093] "CDK19"                                                                                            
## [1094] "SEBOX"                                                                                            
## [1095] "ALX4"                                                                                             
## [1096] "CLCF1"                                                                                            
## [1097] "ENOX1"                                                                                            
## [1098] "PTPN7"                                                                                            
## [1099] "DPAGT1"                                                                                           
## [1100] "HN1L"                                                                                             
## [1101] "ZFP781"                                                                                           
## [1102] "MLEC"                                                                                             
## [1103] "NRAS"                                                                                             
## [1104] "NCAM1"                                                                                            
## [1105] "PROX2"                                                                                            
## [1106] "THSD4"                                                                                            
## [1107] "IMP3"                                                                                             
## [1108] "ALDH6A1"                                                                                          
## [1109] "RNPS1"                                                                                            
## [1110] "BCL2L14"                                                                                          
## [1111] "PLOD1"                                                                                            
## [1112] "HOMER3"                                                                                           
## [1113] "FXYD5"                                                                                            
## [1114] "ZBTB39"                                                                                           
## [1115] "PIK3R4"                                                                                           
## [1116] "EPHB3"                                                                                            
## [1117] "TOM1"                                                                                             
## [1118] "TMEM191C"                                                                                         
## [1119] "DDIT4L"                                                                                           
## [1120] "RBMS3"                                                                                            
## [1121] "UNC13B"                                                                                           
## [1122] "DCAF8"                                                                                            
## [1123] "ZFP275"                                                                                           
## [1124] "DDX5"                                                                                             
## [1125] "GRM6"                                                                                             
## [1126] "ZFP777"                                                                                           
## [1127] "SLC16A1"                                                                                          
## [1128] "NUP50"                                                                                            
## [1129] "OLFR701"                                                                                          
## [1130] "ACER3"                                                                                            
## [1131] "AI846148"                                                                                         
## [1132] "E430024P14RIK"                                                                                    
## [1133] "LARP4B"                                                                                           
## [1134] "DOK6"                                                                                             
## [1135] "SF3B3"                                                                                            
## [1136] "LIG3"                                                                                             
## [1137] "TTC14"                                                                                            
## [1138] "STIL"                                                                                             
## [1139] "TRIB1"                                                                                            
## [1140] "OTUD4"                                                                                            
## [1141] "MED13"                                                                                            
## [1142] "TBL2"                                                                                             
## [1143] "ANGEL2"                                                                                           
## [1144] "POFUT1"                                                                                           
## [1145] "HMGXB3"                                                                                           
## [1146] "GNL3L"                                                                                            
## [1147] "IFNAR1"                                                                                           
## [1148] "MIDN"                                                                                             
## [1149] "1110018G07RIK"                                                                                    
## [1150] "INSR"                                                                                             
## [1151] "CSDE1"                                                                                            
## [1152] "GIGYF1"                                                                                           
## [1153] "CELF1"                                                                                            
## [1154] "1700054K19RIK"                                                                                    
## [1155] "HMGA2"                                                                                            
## [1156] "CCDC155"                                                                                          
## [1157] "HLCS"                                                                                             
## [1158] "TWSG1"                                                                                            
## [1159] "MYD88"                                                                                            
## [1160] "FDX1"                                                                                             
## [1161] "PRKACB"                                                                                           
## [1162] "DAB1"                                                                                             
## [1163] "B4GALT4"                                                                                          
## [1164] "GALP"                                                                                             
## [1165] "TUB"                                                                                              
## [1166] "C1QTNF1"                                                                                          
## [1167] "CYP2C65"                                                                                          
## [1168] "SPATA7"                                                                                           
## [1169] "ZFYVE20"                                                                                          
## [1170] "LYZL6"                                                                                            
## [1171] "JRK"                                                                                              
## [1172] "NRL"                                                                                              
## [1173] "GCNT1"                                                                                            
## [1174] "PRRC1"                                                                                            
## [1175] "A830049A06"                                                                                       
## [1176] "PIGW"                                                                                             
## [1177] "PRKAA2"                                                                                           
## [1178] "FAM174A"                                                                                          
## [1179] "D430020J02RIK"                                                                                    
## [1180] "TTC21B"                                                                                           
## [1181] "CAB39L"                                                                                           
## [1182] "VWA3B"                                                                                            
## [1183] "GOLPH3L"                                                                                          
## [1184] "STX6"                                                                                             
## [1185] "FAHD1"                                                                                            
## [1186] "PLAT"                                                                                             
## [1187] "RASSF3"                                                                                           
## [1188] "ZFP783"                                                                                           
## [1189] "DCAF7"                                                                                            
## [1190] "SLC45A3"                                                                                          
## [1191] "PPP1R3A"                                                                                          
## [1192] "LIMK1"                                                                                            
## [1193] "FGFBP1"                                                                                           
## [1194] "JAGN1"                                                                                            
## [1195] "CD5"                                                                                              
## [1196] "ASPA"                                                                                             
## [1197] "COL16A1"                                                                                          
## [1198] "GLYCTK"                                                                                           
## [1199] "CDH11"                                                                                            
## [1200] "CFLAR"                                                                                            
## [1201] "GM14296"                                                                                          
## [1202] "EPB4.1L5"                                                                                         
## [1203] "PLA2G10"                                                                                          
## [1204] "SLCO3A1"                                                                                          
## [1205] "KRBA1"                                                                                            
## [1206] "NAV2"                                                                                             
## [1207] "UTP18"                                                                                            
## [1208] "TIA1"                                                                                             
## [1209] "APTX"                                                                                             
## [1210] "MAN2A2"                                                                                           
## [1211] "STT3B"                                                                                            
## [1212] "EPS8L3"                                                                                           
## [1213] "NR1I3"                                                                                            
## [1214] "COL9A1"                                                                                           
## [1215] "KCNA4"                                                                                            
## [1216] "GRB10"                                                                                            
## [1217] "RABEPK"                                                                                           
## [1218] "A330050F15RIK"                                                                                    
## [1219] "ANK3"                                                                                             
## [1220] "HVCN1"                                                                                            
## [1221] "UBXN2A"                                                                                           
## [1222] "ZFP146"                                                                                           
## [1223] "HN1"                                                                                              
## [1224] "CSF2RB2"                                                                                          
## [1225] "DTWD2"                                                                                            
## [1226] "4933412E12RIK"                                                                                    
## [1227] "ABAT"                                                                                             
## [1228] "RNF38"                                                                                            
## [1229] "GM807"                                                                                            
## [1230] "GM5524"                                                                                           
## [1231] "PLEKHA2"                                                                                          
## [1232] "SSPN"                                                                                             
## [1233] "BCL2L11"                                                                                          
## [1234] "RPL22"                                                                                            
## [1235] "DNM3"                                                                                             
## [1236] "NUP133"                                                                                           
## [1237] "FAM26E"                                                                                           
## [1238] "ZFP322A"                                                                                          
## [1239] "EFR3A"                                                                                            
## [1240] "ADIPOR2"                                                                                          
## [1241] "RGR"                                                                                              
## [1242] "BRSK2"                                                                                            
## [1243] "MYO3A"                                                                                            
## [1244] "ATP11A"                                                                                           
## [1245] "ARHGAP6"                                                                                          
## [1246] "RNF165"                                                                                           
## [1247] "RRP7A"                                                                                            
## [1248] "RNF216"                                                                                           
## [1249] "FAM149B"                                                                                          
## [1250] "PEX26"                                                                                            
## [1251] "GLCE"                                                                                             
## [1252] "A230108P19RIK"                                                                                    
## [1253] "MAP2K7"                                                                                           
## [1254] "SGPP2"                                                                                            
## [1255] "TOR1AIP2"                                                                                         
## [1256] "CGN"                                                                                              
## [1257] "SGK3"                                                                                             
## [1258] "CNTLN"                                                                                            
## [1259] "SLC25A35"                                                                                         
## [1260] "TMED8"                                                                                            
## [1261] "GPR35"                                                                                            
## [1262] "THOC1"                                                                                            
## [1263] "RSAD2"                                                                                            
## [1264] "ATAD2"                                                                                            
## [1265] "EDEM1"                                                                                            
## [1266] "CELF5"                                                                                            
## [1267] "PITPNC1"                                                                                          
## [1268] "SETD5"                                                                                            
## [1269] "DCP1A"                                                                                            
## [1270] "ARSG"                                                                                             
## [1271] "SCOC"                                                                                             
## [1272] "RFX1"                                                                                             
## [1273] "NUMBL"                                                                                            
## [1274] "KBTBD8"                                                                                           
## [1275] "B4GALNT2"                                                                                         
## [1276] "NF1"                                                                                              
## [1277] "CCDC115"                                                                                          
## [1278] "RASSF7"                                                                                           
## [1279] "CNOT3"                                                                                            
## [1280] "CHRNA3"                                                                                           
## [1281] "4930513N10RIK"                                                                                    
## [1282] "NIPAL1"                                                                                           
## [1283] "GINS1"                                                                                            
## [1284] "HCFC1"                                                                                            
## [1285] "COMMD9"                                                                                           
## [1286] "MPZ"                                                                                              
## [1287] "HSPH1"                                                                                            
## [1288] "LMLN"                                                                                             
## [1289] "ZER1"                                                                                             
## [1290] "KCNAB1"                                                                                           
## [1291] "KPTN"                                                                                             
## [1292] "MYOM1"                                                                                            
## [1293] "CYB561"                                                                                           
## [1294] "4930478P22RIK"                                                                                    
## [1295] "TAT"                                                                                              
## [1296] "PGPEP1"                                                                                           
## [1297] "PER3"                                                                                             
## [1298] "ZCCHC11"                                                                                          
## [1299] "ZMYM5"                                                                                            
## [1300] "1700072I22RIK"                                                                                    
## [1301] "CD200"                                                                                            
## [1302] "ZKSCAN14"                                                                                         
## [1303] "RNF222"                                                                                           
## [1304] "4930435E12RIK"                                                                                    
## [1305] "ACAT1"                                                                                            
## [1306] "SLC35D1"                                                                                          
## [1307] "DSTYK"                                                                                            
## [1308] "CYYR1"                                                                                            
## [1309] "B130046B21RIK"                                                                                    
## [1310] "BLVRA"                                                                                            
## [1311] "RAB11FIP4"                                                                                        
## [1312] "CCNG1"                                                                                            
## [1313] "ZZZ3"                                                                                             
## [1314] "PRICKLE1"                                                                                         
## [1315] "CYP2C39"                                                                                          
## [1316] "RNF144A"                                                                                          
## [1317] "GM4858"                                                                                           
## [1318] "PVT1"                                                                                             
## [1319] "IFT122"                                                                                           
## [1320] "RNF170"                                                                                           
## [1321] "METTL8"                                                                                           
## [1322] "GM597"                                                                                            
## [1323] "ZFP563"                                                                                           
## [1324] "ZCCHC4"                                                                                           
## [1325] "RFTN2"                                                                                            
## [1326] "PRPF39"                                                                                           
## [1327] "1700037H04RIK"                                                                                    
## [1328] "KCNIP3"                                                                                           
## [1329] "PPP1R16A"                                                                                         
## [1330] "WDR13"                                                                                            
## [1331] "PPM1E"                                                                                            
## [1332] "STX11"                                                                                            
## [1333] "PDXK"                                                                                             
## [1334] "ASTE1"                                                                                            
## [1335] "GM10419"                                                                                          
## [1336] "CD276"                                                                                            
## [1337] "CDKL2"                                                                                            
## [1338] "RAPGEFL1"                                                                                         
## [1339] "TJP1"                                                                                             
## [1340] "GM13111"                                                                                          
## [1341] "LRP11"                                                                                            
## [1342] "4930447F24RIK"                                                                                    
## [1343] "PHC2"                                                                                             
## [1344] "EIF2AK3"                                                                                          
## [1345] "SF3A1"                                                                                            
## [1346] "TRIM45"                                                                                           
## [1347] "KCTD1"                                                                                            
## [1348] "DCBLD1"                                                                                           
## [1349] "CHORDC1"                                                                                          
## [1350] "YEATS4"                                                                                           
## [1351] "HERC1"                                                                                            
## [1352] "ERLIN2"                                                                                           
## [1353] "ADRA2A"                                                                                           
## [1354] "BC034902"                                                                                         
## [1355] "SEPP1"                                                                                            
## [1356] "TMPRSS11F"                                                                                        
## [1357] "2810474O19RIK"                                                                                    
## [1358] "COQ3"                                                                                             
## [1359] "CCDC34"                                                                                           
## [1360] "2810006K23RIK"                                                                                    
## [1361] "HSD11B1"                                                                                          
## [1362] "SAMD4B"                                                                                           
## [1363] "BSN"                                                                                              
## [1364] "PKIB"                                                                                             
## [1365] "RECQL"                                                                                            
## [1366] "G630016G05RIK"                                                                                    
## [1367] "ATP6V1G3"                                                                                         
## [1368] "EXOC6B"                                                                                           
## [1369] "ZFYVE26"                                                                                          
## [1370] "SLC8A2"                                                                                           
## [1371] "MMAB"                                                                                             
## [1372] "UBXN4"                                                                                            
## [1373] "METTL14"                                                                                          
## [1374] "HS2ST1"                                                                                           
## [1375] "TMX4"                                                                                             
## [1376] "PPFIBP2"                                                                                          
## [1377] "LRRC16A"                                                                                          
## [1378] "SLC7A13"                                                                                          
## [1379] "GOLPH3"                                                                                           
## [1380] "ARSJ"                                                                                             
## [1381] "GJA5"                                                                                             
## [1382] "ARHGAP19"                                                                                         
## [1383] "RILPL1"                                                                                           
## [1384] "TBXA2R"                                                                                           
## [1385] "BIRC5"                                                                                            
## [1386] "NCKAP1L"                                                                                          
## [1387] "4930451C15RIK"                                                                                    
## [1388] "PSKH1"                                                                                            
## [1389] "SLC25A45"                                                                                         
## [1390] "ZFP398"                                                                                           
## [1391] "PPP2R5C"                                                                                          
## [1392] "FBXW2"                                                                                            
## [1393] "NDUFS1"                                                                                           
## [1394] "SUMF1"                                                                                            
## [1395] "GPATCH2"                                                                                          
## [1396] "PALLD"                                                                                            
## [1397] "HRH3"                                                                                             
## [1398] "ADH6B"                                                                                            
## [1399] "GTF2IRD1"                                                                                         
## [1400] "GM12185"                                                                                          
## [1401] "EME1"                                                                                             
## [1402] "C430049E01RIK"                                                                                    
## [1403] "ATG16L1"                                                                                          
## [1404] "NLRP5"                                                                                            
## [1405] "RBM41"                                                                                            
## [1406] "ANGPTL2"                                                                                          
## [1407] "1810062O18RIK"                                                                                    
## [1408] "SEMA3C"                                                                                           
## [1409] "PCSK2"                                                                                            
## [1410] "CDK1"                                                                                             
## [1411] "KIF21B"                                                                                           
## [1412] "PDLIM7"                                                                                           
## [1413] "WBSCR22"                                                                                          
## [1414] "A330023F24RIK"                                                                                    
## [1415] "BCAT1"                                                                                            
## [1416] "PRPF4"                                                                                            
## [1417] "UMPS"                                                                                             
## [1418] "MYO1H"                                                                                            
## [1419] "GRIN2B"                                                                                           
## [1420] "FIBCD1"                                                                                           
## [1421] "PKD1"                                                                                             
## [1422] "MTMR4"                                                                                            
## [1423] "FNBP1"                                                                                            
## [1424] "9530077C05RIK"                                                                                    
## [1425] "CYB5B"                                                                                            
## [1426] "GM9903"                                                                                           
## [1427] "ERGIC1"                                                                                           
## [1428] "4833420G17RIK"                                                                                    
## [1429] "CDK5R2"                                                                                           
## [1430] "GM5878"                                                                                           
## [1431] "ATP2A3"                                                                                           
## [1432] "SEMA7A"                                                                                           
## [1433] "SCNN1G"                                                                                           
## [1434] "SIK1"                                                                                             
## [1435] "MICAL1"                                                                                           
## [1436] "RGS12"                                                                                            
## [1437] "GM4798"                                                                                           
## [1438] "SCFD1"                                                                                            
## [1439] "ATF7IP2"                                                                                          
## [1440] "PDE10A"                                                                                           
## [1441] "ANKFY1"                                                                                           
## [1442] "SH3D19"                                                                                           
## [1443] "SYN2"                                                                                             
## [1444] "AKNA"                                                                                             
## [1445] "EIF4EBP1"                                                                                         
## [1446] "MED13L"                                                                                           
## [1447] "TOMM70A"                                                                                          
## [1448] "9530026P05RIK"                                                                                    
## [1449] "VWC2L"                                                                                            
## [1450] "RGS11"                                                                                            
## [1451] "NIPSNAP3A"                                                                                        
## [1452] "CEP110"                                                                                           
## [1453] "ZFP407"                                                                                           
## [1454] "SLC9A3R2"                                                                                         
## [1455] "LY6G6E"                                                                                           
## [1456] "AQP6"                                                                                             
## [1457] "D630037F22RIK"                                                                                    
## [1458] "GYS1"                                                                                             
## [1459] "CFH"                                                                                              
## [1460] "MTDH"                                                                                             
## [1461] "FAM115C"                                                                                          
## [1462] "GNG2"                                                                                             
## [1463] "ETOHD2"                                                                                           
## [1464] "TTC28"                                                                                            
## [1465] "SLC24A3"                                                                                          
## [1466] "IGHMBP2"                                                                                          
## [1467] "PLA1A"                                                                                            
## [1468] "PROKR1"                                                                                           
## [1469] "BLK"                                                                                              
## [1470] "KL"                                                                                               
## [1471] "PSD3"                                                                                             
## [1472] "NKX1-2"                                                                                           
## [1473] "DCUN1D4"                                                                                          
## [1474] "SEC14L1"                                                                                          
## [1475] "SBNO2"                                                                                            
## [1476] "STAMBP"                                                                                           
## [1477] "SPATS2L"                                                                                          
## [1478] "NRP1"                                                                                             
## [1479] "H2-OB"                                                                                            
## [1480] "PRR3"                                                                                             
## [1481] "MMP11"                                                                                            
## [1482] "FBXO41"                                                                                           
## [1483] "POMT2"                                                                                            
## [1484] "HMGCS1"                                                                                           
## [1485] "OBFC1"                                                                                            
## [1486] "LARP4"                                                                                            
## [1487] "RIMKLA"                                                                                           
## [1488] "SLAIN2"                                                                                           
## [1489] "IMPACT"                                                                                           
## [1490] "VPS26A"                                                                                           
## [1491] "WDR73"                                                                                            
## [1492] "TMEM57"                                                                                           
## [1493] "FGF5"                                                                                             
## [1494] "GLS"                                                                                              
## [1495] "ARL13B"                                                                                           
## [1496] "KLHDC7A"                                                                                          
## [1497] "SERPINA12"                                                                                        
## [1498] "LFNG"                                                                                             
## [1499] "LRRC4"                                                                                            
## [1500] "ANKRD34A"                                                                                         
## [1501] "GM5134"                                                                                           
## [1502] "TECPR1"                                                                                           
## [1503] "PLP1"                                                                                             
## [1504] "6330408A02RIK"                                                                                    
## [1505] "WASF2"                                                                                            
## [1506] "RPH3A"                                                                                            
## [1507] "PRR9"                                                                                             
## [1508] "TSPAN31"                                                                                          
## [1509] "FOXK1"                                                                                            
## [1510] "IL1RN"                                                                                            
## [1511] "NCOA2"                                                                                            
## [1512] "9430065F17RIK"                                                                                    
## [1513] "ZXDA"                                                                                             
## [1514] "DHRS9"                                                                                            
## [1515] "PRKCB"                                                                                            
## [1516] "N6AMT1"                                                                                           
## [1517] "KCNAB2"                                                                                           
## [1518] "FLAD1"                                                                                            
## [1519] "MTUS2"                                                                                            
## [1520] "FUNDC2"                                                                                           
## [1521] "ZDHHC8"                                                                                           
## [1522] "IPO5"                                                                                             
## [1523] "GGT5"                                                                                             
## [1524] "ATP1A3"                                                                                           
## [1525] "RGS16"                                                                                            
## [1526] "ANO6"                                                                                             
## [1527] "PBX3"                                                                                             
## [1528] "TMEM18"                                                                                           
## [1529] "MAP3K4"                                                                                           
## [1530] "RNFT2"                                                                                            
## [1531] "FADD"                                                                                             
## [1532] "LOX"                                                                                              
## [1533] "SLC2A4"                                                                                           
## [1534] "GALK2"                                                                                            
## [1535] "9330188P03RIK"                                                                                    
## [1536] "DUSP19"                                                                                           
## [1537] "GM14085"                                                                                          
## [1538] "GM10634"                                                                                          
## [1539] "IL4RA"                                                                                            
## [1540] "NEK7"                                                                                             
## [1541] "PAPOLA"                                                                                           
## [1542] "ATG4C"                                                                                            
## [1543] "FICD"                                                                                             
## [1544] "TSPAN2"                                                                                           
## [1545] "0610009O20RIK"                                                                                    
## [1546] "A930011O12RIK"                                                                                    
## [1547] "EIF5A2"                                                                                           
## [1548] "ZNF512B"                                                                                          
## [1549] "GRIK1"                                                                                            
## [1550] "CYTH4"                                                                                            
## [1551] "CACNB4"                                                                                           
## [1552] "2410080I02RIK"                                                                                    
## [1553] "PCDH15"                                                                                           
## [1554] "MSI2"                                                                                             
## [1555] "GRM2"                                                                                             
## [1556] "UBE2B"                                                                                            
## [1557] "KIF5C"                                                                                            
## [1558] "2010002M12RIK"                                                                                    
## [1559] "NRD1"                                                                                             
## [1560] "SCN5A"                                                                                            
## [1561] "MAPK9"                                                                                            
## [1562] "RBM26"                                                                                            
## [1563] "TDGF1"                                                                                            
## [1564] "LMNB2"                                                                                            
## [1565] "BRMS1"                                                                                            
## [1566] "GDNF"                                                                                             
## [1567] "ANAPC5"                                                                                           
## [1568] "ZPBP2"                                                                                            
## [1569] "KCNJ16"                                                                                           
## [1570] "TAB2"                                                                                             
## [1571] "ZFP709"                                                                                           
## [1572] "MSI1"                                                                                             
## [1573] "RBM7"                                                                                             
## [1574] "BMPR1A"                                                                                           
## [1575] "LMBR1"                                                                                            
## [1576] "B3GALT5"                                                                                          
## [1577] "BCL2L1"                                                                                           
## [1578] "KCNK16"                                                                                           
## [1579] "TRAPPC9"                                                                                          
## [1580] "TTLL7"                                                                                            
## [1581] "DOCK5"                                                                                            
## [1582] "WARS2"                                                                                            
## [1583] "ALDH1A3"                                                                                          
## [1584] "ME3"                                                                                              
## [1585] "XIRP1"                                                                                            
## [1586] "YARS2"                                                                                            
## [1587] "PLEKHA6"                                                                                          
## [1588] "NUDCD3"                                                                                           
## [1589] "ETL4"                                                                                             
## [1590] "VDR"                                                                                              
## [1591] "GIMAP8"                                                                                           
## [1592] "RASA2"                                                                                            
## [1593] "PARP14"                                                                                           
## [1594] "SSBP3"                                                                                            
## [1595] "SLC38A1"                                                                                          
## [1596] "4930407I19RIK"                                                                                    
## [1597] "OGDH"                                                                                             
## [1598] "ABR"                                                                                              
## [1599] "MERTK"                                                                                            
## [1600] "TRP53INP1"                                                                                        
## [1601] "PRX"                                                                                              
## [1602] "A430057M04RIK"                                                                                    
## [1603] "TYR"                                                                                              
## [1604] "GOLM1"                                                                                            
## [1605] "KIFAP3"                                                                                           
## [1606] "CCBE1"                                                                                            
## [1607] "FAM163A"                                                                                          
## [1608] "A930015D03RIK"                                                                                    
## [1609] "KDM5D"                                                                                            
## [1610] "EID1"                                                                                             
## [1611] "ARHGEF9"                                                                                          
## [1612] "BC037034"                                                                                         
## [1613] "MMP15"                                                                                            
## [1614] "CLDN23"                                                                                           
## [1615] "CDAN1"                                                                                            
## [1616] "DENND4A"                                                                                          
## [1617] "GM3002"                                                                                           
## [1618] "DNAJB12"                                                                                          
## [1619] "TANC2"                                                                                            
## [1620] "GTF2A1"                                                                                           
## [1621] "GLRX3"                                                                                            
## [1622] "CTLA4"                                                                                            
## [1623] "APAF1"                                                                                            
## [1624] "IGFBP5"                                                                                           
## [1625] "HIC1"                                                                                             
## [1626] "TMEM201"                                                                                          
## [1627] "ILKAP"                                                                                            
## [1628] "LRRCC1"                                                                                           
## [1629] "MESDC2"                                                                                           
## [1630] "CGNL1"                                                                                            
## [1631] "AUH"                                                                                              
## [1632] "APBA1"                                                                                            
## [1633] "SAA2"                                                                                             
## [1634] "ETNK1"                                                                                            
## [1635] "NNT"                                                                                              
## [1636] "6030458C11RIK"                                                                                    
## [1637] "BC039771"                                                                                         
## [1638] "SON"                                                                                              
## [1639] "HSF2BP"                                                                                           
## [1640] "FAM167A"                                                                                          
## [1641] "GRHL2"                                                                                            
## [1642] "BC043934"                                                                                         
## [1643] "ECHS1"                                                                                            
## [1644] "TNFSF18"                                                                                          
## [1645] "ILTIFB"                                                                                           
## [1646] "PLEKHJ1"                                                                                          
## [1647] "KIF18A"                                                                                           
## [1648] "RPS6KB1"                                                                                          
## [1649] "GSDMA2"                                                                                           
## [1650] "BSG"                                                                                              
## [1651] "DUSP9"                                                                                            
## [1652] "1700028D13RIK"                                                                                    
## [1653] "KCTD12B"                                                                                          
## [1654] "UEVLD"                                                                                            
## [1655] "PDPK1"                                                                                            
## [1656] "9330155M09RIK"                                                                                    
## [1657] "LAMP2"                                                                                            
## [1658] "TRPS1"                                                                                            
## [1659] "SFRS18"                                                                                           
## [1660] "EPHB1"                                                                                            
## [1661] "JAK3"                                                                                             
## [1662] "MBTD1"                                                                                            
## [1663] "GATA5"                                                                                            
## [1664] "OLFR1502"                                                                                         
## [1665] "SEC24A"                                                                                           
## [1666] "ZSCAN12"                                                                                          
## [1667] "ABHD13"                                                                                           
## [1668] "UNC5D"                                                                                            
## [1669] "REEP5"                                                                                            
## [1670] "FGF23"                                                                                            
## [1671] "EIF1AD"                                                                                           
## [1672] "CYP4F15"                                                                                          
## [1673] "NEO1"                                                                                             
## [1674] "GPR157"                                                                                           
## [1675] "ASB12"                                                                                            
## [1676] "RALGAPB"                                                                                          
## [1677] "HEY2"                                                                                             
## [1678] "RNF39"                                                                                            
## [1679] "CLDN2"                                                                                            
## [1680] "TET2"                                                                                             
## [1681] "C530047H08RIK"                                                                                    
## [1682] "PTPN22"                                                                                           
## [1683] "PLD2"                                                                                             
## [1684] "TPSAB1"                                                                                           
## [1685] "FAM96A"                                                                                           
## [1686] "ADAMTSL3"                                                                                         
## [1687] "EXOC2"                                                                                            
## [1688] "CALM1"                                                                                            
## [1689] "NUDT8"                                                                                            
## [1690] "SPCS3"                                                                                            
## [1691] "RUFY2"                                                                                            
## [1692] "TPP1"                                                                                             
## [1693] "ZFHX4"                                                                                            
## [1694] "CHST3"                                                                                            
## [1695] "BRWD1"                                                                                            
## [1696] "DONSON"                                                                                           
## [1697] "CD3E"                                                                                             
## [1698] "ARHGEF18"                                                                                         
## [1699] "SHC1"                                                                                             
## [1700] "AF366264"                                                                                         
## [1701] "GPRC5A"                                                                                           
## [1702] "RAPGEF1"                                                                                          
## [1703] "ZFP740"                                                                                           
## [1704] "ZFP759"                                                                                           
## [1705] "PXDN"                                                                                             
## [1706] "TES"                                                                                              
## [1707] "TCERG1"                                                                                           
## [1708] "SLCO5A1"                                                                                          
## [1709] "RORA"                                                                                             
## [1710] "CAPN6"                                                                                            
## [1711] "SMARCC1"                                                                                          
## [1712] "WDR76"                                                                                            
## [1713] "ABCC5"                                                                                            
## [1714] "NTN3"                                                                                             
## [1715] "ZFP7"                                                                                             
## [1716] "5430435G22RIK"                                                                                    
## [1717] "ZFP719"                                                                                           
## [1718] "SMYD4"                                                                                            
## [1719] "I730028E13RIK"                                                                                    
## [1720] "PTPRG"                                                                                            
## [1721] "STRA13"                                                                                           
## [1722] "YAP1"                                                                                             
## [1723] "SCML2"                                                                                            
## [1724] "VPS37B"                                                                                           
## [1725] "MICALL1"                                                                                          
## [1726] "AARS2"                                                                                            
## [1727] "TXK"                                                                                              
## [1728] "ZFP608"                                                                                           
## [1729] "GAA"                                                                                              
## [1730] "NECAP2"                                                                                           
## [1731] "TNFRSF1B"                                                                                         
## [1732] "SH2D7"                                                                                            
## [1733] "CCDC25"                                                                                           
## [1734] "IP6K2"                                                                                            
## [1735] "A930012L18RIK"                                                                                    
## [1736] "LRRC15"                                                                                           
## [1737] "LRCH1"                                                                                            
## [1738] "GPR63"                                                                                            
## [1739] "CDH26"                                                                                            
## [1740] "NACC2"                                                                                            
## [1741] "UGGT1"                                                                                            
## [1742] "CLPB"                                                                                             
## [1743] "SEMA3G"                                                                                           
## [1744] "CYTH3"                                                                                            
## [1745] "TMED7"                                                                                            
## [1746] "INPP4A"                                                                                           
## [1747] "PLCG1"                                                                                            
## [1748] "EXOC8"                                                                                            
## [1749] "HYAL1"                                                                                            
## [1750] "TMEM194"                                                                                          
## [1751] "RAB3D"                                                                                            
## [1752] "1600020E01RIK"                                                                                    
## [1753] "C130074G19RIK"                                                                                    
## [1754] "RND3"                                                                                             
## [1755] "2810459M11RIK"                                                                                    
## [1756] "PRKCQ"                                                                                            
## [1757] "GP49A"                                                                                            
## [1758] "PFKFB2"                                                                                           
## [1759] "FAM131B"                                                                                          
## [1760] "NRARP"                                                                                            
## [1761] "GM7457"                                                                                           
## [1762] "NRCAM"                                                                                            
## [1763] "GSDMCL-PS"                                                                                        
## [1764] "PRDX6"                                                                                            
## [1765] "GM10389"                                                                                          
## [1766] "POLDIP3"                                                                                          
## [1767] "STK11IP"                                                                                          
## [1768] "ATAD5"                                                                                            
## [1769] "ACVR2A"                                                                                           
## [1770] "ITIH5"                                                                                            
## [1771] "IL17RD"                                                                                           
## [1772] "AMBRA1"                                                                                           
## [1773] "NECAP1"                                                                                           
## [1774] "ZFP276"                                                                                           
## [1775] "FUT10"                                                                                            
## [1776] "GRAMD1B"                                                                                          
## [1777] "NR6A1"                                                                                            
## [1778] "LRP2BP"                                                                                           
## [1779] "TRIM21"                                                                                           
## [1780] "ZFP516"                                                                                           
## [1781] "C330008G21RIK"                                                                                    
## [1782] "MLLT6"                                                                                            
## [1783] "BC021767"                                                                                         
## [1784] "ANKIB1"                                                                                           
## [1785] "PGR15L"                                                                                           
## [1786] "A430078G23RIK"                                                                                    
## [1787] "DAAM2"                                                                                            
## [1788] "STX3"                                                                                             
## [1789] "TMEM161B"                                                                                         
## [1790] "C3AR1"                                                                                            
## [1791] "ATP6V1A"                                                                                          
## [1792] "MRPS15"                                                                                           
## [1793] "PKIG"                                                                                             
## [1794] "FES"                                                                                              
## [1795] "RAP1GAP2"                                                                                         
## [1796] "MARVELD3"                                                                                         
## [1797] "HSDL1"                                                                                            
## [1798] "IFFO2"                                                                                            
## [1799] "SEC16A"                                                                                           
## [1800] "FMO9"                                                                                             
## [1801] "MRPL17"                                                                                           
## [1802] "CHD3"                                                                                             
## [1803] "ZSWIM4"                                                                                           
## [1804] "SLC11A1"                                                                                          
## [1805] "HNRNPA1"                                                                                          
## [1806] "NUP210"                                                                                           
## [1807] "DPP3"                                                                                             
## [1808] "ADRBK2"                                                                                           
## [1809] "9430021M05RIK"                                                                                    
## [1810] "LGI1"                                                                                             
## [1811] "D930048N14RIK"                                                                                    
## [1812] "CTSO"                                                                                             
## [1813] "CALU"                                                                                             
## [1814] "NIPBL"                                                                                            
## [1815] "CASKIN1"                                                                                          
## [1816] "BTRC"                                                                                             
## [1817] "SLMAP"                                                                                            
## [1818] "D830032E09RIK"                                                                                    
## [1819] "JAM3"                                                                                             
## [1820] "RGS19"                                                                                            
## [1821] "FBXO27"                                                                                           
## [1822] "VAMP1"                                                                                            
## [1823] "CER1"                                                                                             
## [1824] "2410003L11RIK"                                                                                    
## [1825] "TMC7"                                                                                             
## [1826] "DOLPP1"                                                                                           
## [1827] "MIER3"                                                                                            
## [1828] "IL1R1"                                                                                            
## [1829] "SLC25A4"                                                                                          
## [1830] "TRIB2"                                                                                            
## [1831] "ARHGAP4"                                                                                          
## [1832] "PPP1R12C"                                                                                         
## [1833] "SAA4"                                                                                             
## [1834] "ITGA9"                                                                                            
## [1835] "BRAF"                                                                                             
## [1836] "MZF1"                                                                                             
## [1837] "C2"                                                                                               
## [1838] "PIGQ"                                                                                             
## [1839] "AP1M2"                                                                                            
## [1840] "BMP3"                                                                                             
## [1841] "ZFP593"                                                                                           
## [1842] "EHHADH"                                                                                           
## [1843] "ANO10"                                                                                            
## [1844] "ABL2"                                                                                             
## [1845] "ASCL1"                                                                                            
## [1846] "DBX2"                                                                                             
## [1847] "NUAK1"                                                                                            
## [1848] "GUCY1A3"                                                                                          
## [1849] "NOVA1"                                                                                            
## [1850] "4930544L04RIK"                                                                                    
## [1851] "MECP2"                                                                                            
## [1852] "HEATR5A"                                                                                          
## [1853] "MTX2"                                                                                             
## [1854] "APOL6"                                                                                            
## [1855] "RNF220"                                                                                           
## [1856] "EXOSC9"                                                                                           
## [1857] "B930082K07RIK"                                                                                    
## [1858] "GRPEL2"                                                                                           
## [1859] "SRCAP"                                                                                            
## [1860] "CPA4"                                                                                             
## [1861] "TMEM115"                                                                                          
## [1862] "GM4876"                                                                                           
## [1863] "MOV10"                                                                                            
## [1864] "CEP192"                                                                                           
## [1865] "ATG2B"                                                                                            
## [1866] "FAM102A"                                                                                          
## [1867] "1700099I09RIK"                                                                                    
## [1868] "CEP170"                                                                                           
## [1869] "GM3896"                                                                                           
## [1870] "EXOC5"                                                                                            
## [1871] "INTU"                                                                                             
## [1872] "ZFP862"                                                                                           
## [1873] "TMEM167"                                                                                          
## [1874] "DMD"                                                                                              
## [1875] "RRAS"                                                                                             
## [1876] "GM867"                                                                                            
## [1877] "DSCAM"                                                                                            
## [1878] "IGF2BP1"                                                                                          
## [1879] "ZFP652"                                                                                           
## [1880] "NEUROG3"                                                                                          
## [1881] "GXYLT1"                                                                                           
## [1882] "2610042L04RIK"                                                                                    
## [1883] "TRAK1"                                                                                            
## [1884] "AI854703"                                                                                         
## [1885] "LRRC18"                                                                                           
## [1886] "L3MBTL2"                                                                                          
## [1887] "ZFP71-RS1"                                                                                        
## [1888] "4632433K11RIK"                                                                                    
## [1889] "GGTA1"                                                                                            
## [1890] "LMOD1"                                                                                            
## [1891] "SLFN1"                                                                                            
## [1892] "HMGCLL1"                                                                                          
## [1893] "ZFP28"                                                                                            
## [1894] "CSNK1E"                                                                                           
## [1895] "3010001F23RIK"                                                                                    
## [1896] "FNDC5"                                                                                            
## [1897] "NECAB1"                                                                                           
## [1898] "RBM22"                                                                                            
## [1899] "LACTB2"                                                                                           
## [1900] "KPNA1"                                                                                            
## [1901] "C8A"                                                                                              
## [1902] "ZFP622"                                                                                           
## [1903] "ATIC"                                                                                             
## [1904] "PRRX1"                                                                                            
## [1905] "SUSD1"                                                                                            
## [1906] "LRRC2"                                                                                            
## [1907] "4931408C20RIK"                                                                                    
## [1908] "MAP4K5"                                                                                           
## [1909] "MYH8"                                                                                             
## [1910] "9330111N05RIK"                                                                                    
## [1911] "CNOT1"                                                                                            
## [1912] "ARPP19"                                                                                           
## [1913] "NHSL1"                                                                                            
## [1914] "FOXN2"                                                                                            
## [1915] "D2HGDH"                                                                                           
## [1916] "2810407C02RIK"                                                                                    
## [1917] "WHSC1L1"                                                                                          
## [1918] "RSRC1"                                                                                            
## [1919] "ADARB2"                                                                                           
## [1920] "CASC4"                                                                                            
## [1921] "IGFBP4"                                                                                           
## [1922] "LDOC1L"                                                                                           
## [1923] "GPR56"                                                                                            
## [1924] "HAS3"                                                                                             
## [1925] "FAM120B"                                                                                          
## [1926] "ACTR1B"                                                                                           
## [1927] "HOMER2"                                                                                           
## [1928] "SLC36A1"                                                                                          
## [1929] "AP3S2"                                                                                            
## [1930] "B630005N14RIK"                                                                                    
## [1931] "TMC1"                                                                                             
## [1932] "EPB4.1"                                                                                           
## [1933] "FAM19A1"                                                                                          
## [1934] "PDIK1L"                                                                                           
## [1935] "SUSD2"                                                                                            
## [1936] "DCAF10"                                                                                           
## [1937] "MED6"                                                                                             
## [1938] "E030013I19RIK"                                                                                    
## [1939] "EGR3"                                                                                             
## [1940] "SURF4"                                                                                            
## [1941] "BICD1"                                                                                            
## [1942] "REPIN1"                                                                                           
## [1943] "PATL1"                                                                                            
## [1944] "D14ABB1E"                                                                                         
## [1945] "MAT2B"                                                                                            
## [1946] "ADRA2B"                                                                                           
## [1947] "TTC24"                                                                                            
## [1948] "ATF7IP"                                                                                           
## [1949] "LASP1"                                                                                            
## [1950] "ASTN2"                                                                                            
## [1951] "RBM20"                                                                                            
## [1952] "CTNS"                                                                                             
## [1953] "FAM175B"                                                                                          
## [1954] "UBE2D3"                                                                                           
## [1955] "CAR1"                                                                                             
## [1956] "TRAF6"                                                                                            
## [1957] "G630025P09RIK"                                                                                    
## [1958] "LTA4H"                                                                                            
## [1959] "PTK2"                                                                                             
## [1960] "POLD3"                                                                                            
## [1961] "PHACTR4"                                                                                          
## [1962] "SCD1"                                                                                             
## [1963] "B3GAT2"                                                                                           
## [1964] "MS4A8A"                                                                                           
## [1965] "LYVE1"                                                                                            
## [1966] "CCDC148"                                                                                          
## [1967] "NR2C2"                                                                                            
## [1968] "MPL"                                                                                              
## [1969] "SYNPO2L"                                                                                          
## [1970] "GNB4"                                                                                             
## [1971] "ZF12"                                                                                             
## [1972] "TRIM26"                                                                                           
## [1973] "ASAH2"                                                                                            
## [1974] "GSR"                                                                                              
## [1975] "ST7"                                                                                              
## [1976] "D630033O11RIK"                                                                                    
## [1977] "SP100"                                                                                            
## [1978] "TET3"                                                                                             
## [1979] "CNR2"                                                                                             
## [1980] "TM4SF5"                                                                                           
## [1981] "DTX4"                                                                                             
## [1982] "KCNK5"                                                                                            
## [1983] "ETV5"                                                                                             
## [1984] "PKHD1"                                                                                            
## [1985] "AP2A1"                                                                                            
## [1986] "KLF3"                                                                                             
## [1987] "SMS"                                                                                              
## [1988] "RAB27B"                                                                                           
## [1989] "AA536875"                                                                                         
## [1990] "MIPEP"                                                                                            
## [1991] "ZFP488"                                                                                           
## [1992] "PRKAB2"                                                                                           
## [1993] "CDC6"                                                                                             
## [1994] "CSMD1"                                                                                            
## [1995] "AW011738"                                                                                         
## [1996] "NLGN1"                                                                                            
## [1997] "PRDM1"                                                                                            
## [1998] "SHPRH"                                                                                            
## [1999] "MEIS3"                                                                                            
## [2000] "BC052688"                                                                                         
## [2001] "POLE4"                                                                                            
## [2002] "MYH10"                                                                                            
## [2003] "BTBD7"                                                                                            
## [2004] "CSF3R"                                                                                            
## [2005] "SLC39A2"                                                                                          
## [2006] "OLFR536"                                                                                          
## [2007] "USP3"                                                                                             
## [2008] "LMF1"                                                                                             
## [2009] "TRAF4"                                                                                            
## [2010] "ABCB10"                                                                                           
## [2011] "LARS2"                                                                                            
## [2012] "ZFP871"                                                                                           
## [2013] "ACOT11"                                                                                           
## [2014] "STAM"                                                                                             
## [2015] "2310022A10RIK"                                                                                    
## [2016] "SMARCD1"                                                                                          
## [2017] "IL2"                                                                                              
## [2018] "GM15800"                                                                                          
## [2019] "SNF8"                                                                                             
## [2020] "LMX1A"                                                                                            
## [2021] "DYM"                                                                                              
## [2022] "SCD2"                                                                                             
## [2023] "MYCBP2"                                                                                           
## [2024] "4930581F22RIK"                                                                                    
## [2025] "RAB11B"                                                                                           
## [2026] "GPS1"                                                                                             
## [2027] "SLC35F4"                                                                                          
## [2028] "ASPH"                                                                                             
## [2029] "SPRN"                                                                                             
## [2030] "ONECUT1"                                                                                          
## [2031] "SLC38A8"                                                                                          
## [2032] "FATE1"                                                                                            
## [2033] "EHD1"                                                                                             
## [2034] "MYO5A"                                                                                            
## [2035] "SLC15A2"                                                                                          
## [2036] "CASK"                                                                                             
## [2037] "TNRC6C"                                                                                           
## [2038] "DHRS7C"                                                                                           
## [2039] "TMEM215"                                                                                          
## [2040] "ADAMTS19"                                                                                         
## [2041] "DDX10"                                                                                            
## [2042] "FRK"                                                                                              
## [2043] "PMP22"                                                                                            
## [2044] "1200014J11RIK"                                                                                    
## [2045] "RUSC2"                                                                                            
## [2046] "KLF12"                                                                                            
## [2047] "AMZ2"                                                                                             
## [2048] "PGAM5"                                                                                            
## [2049] "KCNJ15"                                                                                           
## [2050] "EFR3B"                                                                                            
## [2051] "FMN2"                                                                                             
## [2052] "NARS2"                                                                                            
## [2053] "AFF4"                                                                                             
## [2054] "WSB2"                                                                                             
## [2055] "NPHP4"                                                                                            
## [2056] "IL4I1"                                                                                            
## [2057] "HMGXB4"                                                                                           
## [2058] "NPLOC4"                                                                                           
## [2059] "SLC38A7"                                                                                          
## [2060] "ZFP185"                                                                                           
## [2061] "NLK"                                                                                              
## [2062] "CNP"                                                                                              
## [2063] "CPLX3"                                                                                            
## [2064] "GM6583"                                                                                           
## [2065] "DNM3OS"                                                                                           
## [2066] "SGCG"                                                                                             
## [2067] "CLEC4A1"                                                                                          
## [2068] "A630020A06"                                                                                       
## [2069] "MTMR7"                                                                                            
## [2070] "TMEM161A"                                                                                         
## [2071] "ACP1"                                                                                             
## [2072] "SLC4A8"                                                                                           
## [2073] "SPSB4"                                                                                            
## [2074] "CKLF"                                                                                             
## [2075] "TEAD3"                                                                                            
## [2076] "RIMS3"                                                                                            
## [2077] "PTK7"                                                                                             
## [2078] "APC2"                                                                                             
## [2079] "SLC28A2"                                                                                          
## [2080] "NUCB1"                                                                                            
## [2081] "VMN2R10"                                                                                          
## [2082] "4732465J04RIK"                                                                                    
## [2083] "ATAD1"                                                                                            
## [2084] "PEX5"                                                                                             
## [2085] "C230081A13RIK"                                                                                    
## [2086] "ZBTB20"                                                                                           
## [2087] "GORASP1"                                                                                          
## [2088] "MTOR"                                                                                             
## [2089] "FAM43A"                                                                                           
## [2090] "AP3M2"                                                                                            
## [2091] "TKTL2"                                                                                            
## [2092] "ST8SIA6"                                                                                          
## [2093] "ANKRD52"                                                                                          
## [2094] "LMAN1"                                                                                            
## [2095] "KEG1"                                                                                             
## [2096] "CLCN6"                                                                                            
## [2097] "LRRC8D"                                                                                           
## [2098] "LRFN4"                                                                                            
## [2099] "NHLRC2"                                                                                           
## [2100] "INADL"                                                                                            
## [2101] "DLC1"                                                                                             
## [2102] "UVRAG"                                                                                            
## [2103] "OVGP1"                                                                                            
## [2104] "DDOST"                                                                                            
## [2105] "SLC38A6"                                                                                          
## [2106] "AGTR2"                                                                                            
## [2107] "EPHA1"                                                                                            
## [2108] "HEG1"                                                                                             
## [2109] "MTCH2"                                                                                            
## [2110] "MPI"                                                                                              
## [2111] "NAT10"                                                                                            
## [2112] "PHF3"                                                                                             
## [2113] "AR"                                                                                               
## [2114] "ZFAND2A"                                                                                          
## [2115] "SLC13A4"                                                                                          
## [2116] "LRP1B"                                                                                            
## [2117] "NSG2"                                                                                             
## [2118] "E030003E18RIK"                                                                                    
## [2119] "PRTG"                                                                                             
## [2120] "GKAP1"                                                                                            
## [2121] "SDR42E1"                                                                                          
## [2122] "EPHA8"                                                                                            
## [2123] "GM16499"                                                                                          
## [2124] "TRPM1"                                                                                            
## [2125] "USP20"                                                                                            
## [2126] "CMAH"                                                                                             
## [2127] "CAMK4"                                                                                            
## [2128] "ITGA4"                                                                                            
## [2129] "CD200R3"                                                                                          
## [2130] "TNFSF10"                                                                                          
## [2131] "ORMDL1"                                                                                           
## [2132] "LOC627891"                                                                                        
## [2133] "FBXW17"                                                                                           
## [2134] "PRRG3"                                                                                            
## [2135] "PRDM5"                                                                                            
## [2136] "PALM2"                                                                                            
## [2137] "TAOK1"                                                                                            
## [2138] "BTF3L4"                                                                                           
## [2139] "EPX"                                                                                              
## [2140] "PPP1R2"                                                                                           
## [2141] "HS6ST2"                                                                                           
## [2142] "HSPA14"                                                                                           
## [2143] "SERINC4"                                                                                          
## [2144] "WIPF2"                                                                                            
## [2145] "ZKSCAN17"                                                                                         
## [2146] "ZFP68"                                                                                            
## [2147] "PTGS2"                                                                                            
## [2148] "GM4793"                                                                                           
## [2149] "PTK6"                                                                                             
## [2150] "BAHD1"                                                                                            
## [2151] "ATR"                                                                                              
## [2152] "NPC2"                                                                                             
## [2153] "OBSCN"                                                                                            
## [2154] "GPR155"                                                                                           
## [2155] "SMUG1"                                                                                            
## [2156] "CAPNS1"                                                                                           
## [2157] "FBXL5"                                                                                            
## [2158] "EPHB2"                                                                                            
## [2159] "ROBO2"                                                                                            
## [2160] "PARP9"                                                                                            
## [2161] "1700016L04RIK"                                                                                    
## [2162] "CHM"                                                                                              
## [2163] "INTS4"                                                                                            
## [2164] "2210408F21RIK"                                                                                    
## [2165] "C920021L13RIK"                                                                                    
## [2166] "ARID1B"                                                                                           
## [2167] "ELOVL1"                                                                                           
## [2168] "HDAC11"                                                                                           
## [2169] "PARD6G"                                                                                           
## [2170] "SLC2A13"                                                                                          
## [2171] "GPR137B"                                                                                          
## [2172] "GSDMC2"                                                                                           
## [2173] "FTSJ1"                                                                                            
## [2174] "MACROD2"                                                                                          
## [2175] "CREG1"                                                                                            
## [2176] "ADAM28"                                                                                           
## [2177] "TLN1"                                                                                             
## [2178] "2310014L17RIK"                                                                                    
## [2179] "NAP1L1"                                                                                           
## [2180] "PIGN"                                                                                             
## [2181] "CSPG5"                                                                                            
## [2182] "PPP2R3A"                                                                                          
## [2183] "VWA5A"                                                                                            
## [2184] "TTLL12"                                                                                           
## [2185] "CLDN1"                                                                                            
## [2186] "KLHL24"                                                                                           
## [2187] "ADAM22"                                                                                           
## [2188] "NEU3"                                                                                             
## [2189] "PLD6"                                                                                             
## [2190] "NIPAL4"                                                                                           
## [2191] "RNF130"                                                                                           
## [2192] "RASSF4"                                                                                           
## [2193] "PCNXL2"                                                                                           
## [2194] "FANCC"                                                                                            
## [2195] "GAD2"                                                                                             
## [2196] "ACER2"                                                                                            
## [2197] "9230117E06RIK"                                                                                    
## [2198] "PLA2G4D"                                                                                          
## [2199] "CRB2"                                                                                             
## [2200] "UBE2E1"                                                                                           
## [2201] "TMEM104"                                                                                          
## [2202] "CX3CR1"                                                                                           
## [2203] "GUCA1B"                                                                                           
## [2204] "NRXN2"                                                                                            
## [2205] "ATG9A"                                                                                            
## [2206] "MGA"                                                                                              
## [2207] "LGR5"                                                                                             
## [2208] "RGS2"                                                                                             
## [2209] "ATF6B"                                                                                            
## [2210] "BTG2"                                                                                             
## [2211] "ZCCHC6"                                                                                           
## [2212] "PNMA2"                                                                                            
## [2213] "TMEM79"                                                                                           
## [2214] "DVL3"                                                                                             
## [2215] "ADH6-PS1"                                                                                         
## [2216] "1700020I14RIK"                                                                                    
## [2217] "NUP214"                                                                                           
## [2218] "1700001C19RIK"                                                                                    
## [2219] "GFM2"                                                                                             
## [2220] "SH3YL1"                                                                                           
## [2221] "PI4KA"                                                                                            
## [2222] "DDB1"                                                                                             
## [2223] "FAM178A"                                                                                          
## [2224] "ZBTB46"                                                                                           
## [2225] "TNNI3K"                                                                                           
## [2226] "MEG3"                                                                                             
## [2227] "FAR2"                                                                                             
## [2228] "FCHSD2"                                                                                           
## [2229] "PIAS4"                                                                                            
## [2230] "TCTE2"                                                                                            
## [2231] "PEX6"                                                                                             
## [2232] "FOXO1"                                                                                            
## [2233] "4930425L21RIK"                                                                                    
## [2234] "KCNA1"                                                                                            
## [2235] "PTCD3"                                                                                            
## [2236] "4930529M08RIK"                                                                                    
## [2237] "TRPM5"                                                                                            
## [2238] "CPLX4"                                                                                            
## [2239] "CD28"                                                                                             
## [2240] "PEG10"                                                                                            
## [2241] "LYNX1"                                                                                            
## [2242] "HOXB4"                                                                                            
## [2243] "NPEPL1"                                                                                           
## [2244] "E130309D14RIK"                                                                                    
## [2245] "DENND3"                                                                                           
## [2246] "GRIP2"                                                                                            
## [2247] "AGPAT5"                                                                                           
## [2248] "PTPRM"                                                                                            
## [2249] "TXNDC5"                                                                                           
## [2250] "ZFP456"                                                                                           
## [2251] "TNFSF13B"                                                                                         
## [2252] "EXOC3"                                                                                            
## [2253] "DUSP28"                                                                                           
## [2254] "GPRC5C"                                                                                           
## [2255] "RICTOR"                                                                                           
## [2256] "PIF1"                                                                                             
## [2257] "IFT57"                                                                                            
## [2258] "STEAP2"                                                                                           
## [2259] "DNAJC18"                                                                                          
## [2260] "CAMK1D"                                                                                           
## [2261] "PPM1A"                                                                                            
## [2262] "BC037704"                                                                                         
## [2263] "BYSL"                                                                                             
## [2264] "NAA15"                                                                                            
## [2265] "PLEKHA4"                                                                                          
## [2266] "SCAI"                                                                                             
## [2267] "GM13139"                                                                                          
## [2268] "ZFP597"                                                                                           
## [2269] "HMCN1"                                                                                            
## [2270] "ZFP160"                                                                                           
## [2271] "ARHGAP29"                                                                                         
## [2272] "DNAJC12"                                                                                          
## [2273] "TXNDC11"                                                                                          
## [2274] "ATP10B"                                                                                           
## [2275] "FRY"                                                                                              
## [2276] "TUBA1B"                                                                                           
## [2277] "2010111I01RIK"                                                                                    
## [2278] "LOXL4"                                                                                            
## [2279] "ERC2"                                                                                             
## [2280] "4932438A13RIK"                                                                                    
## [2281] "1110057K04RIK"                                                                                    
## [2282] "PGAP3"                                                                                            
## [2283] "PLEK2"                                                                                            
## [2284] "NARG2"                                                                                            
## [2285] "GPX7"                                                                                             
## [2286] "AFF1"                                                                                             
## [2287] "ZBP1"                                                                                             
## [2288] "SMOK4A"                                                                                           
## [2289] "ZFP11"                                                                                            
## [2290] "MANEAL"                                                                                           
## [2291] "COL4A1"                                                                                           
## [2292] "CCDC78"                                                                                           
## [2293] "ACSS1"                                                                                            
## [2294] "LSM14A"                                                                                           
## [2295] "ZFP280B"                                                                                          
## [2296] "SLC19A2"                                                                                          
## [2297] "COL4A2"                                                                                           
## [2298] "NYNRIN"                                                                                           
## [2299] "BRCC3"                                                                                            
## [2300] "EP300"                                                                                            
## [2301] "CPNE7"                                                                                            
## [2302] "DENND1A"                                                                                          
## [2303] "ASCL3"                                                                                            
## [2304] "LIFR"                                                                                             
## [2305] "TRAPPC5"                                                                                          
## [2306] "UHRF1BP1"                                                                                         
## [2307] "FMR1"                                                                                             
## [2308] "STK40"                                                                                            
## [2309] "SLC41A2"                                                                                          
## [2310] "ZBTB43"                                                                                           
## [2311] "RAB11FIP1"                                                                                        
## [2312] "ADAMTS20"                                                                                         
## [2313] "RNMT"                                                                                             
## [2314] "MTMR2"                                                                                            
## [2315] "ENC1"                                                                                             
## [2316] "VMN1R58"                                                                                          
## [2317] "ASAH1"                                                                                            
## [2318] "KLHL12"                                                                                           
## [2319] "COL6A2"                                                                                           
## [2320] "CD209E"                                                                                           
## [2321] "MAGI1"                                                                                            
## [2322] "GNAO1"                                                                                            
## [2323] "TRPM3"                                                                                            
## [2324] "GOLGA7B"                                                                                          
## [2325] "DPY19L1"                                                                                          
## [2326] "GM5108"                                                                                           
## [2327] "CALD1"                                                                                            
## [2328] "IER3IP1"                                                                                          
## [2329] "UGP2"                                                                                             
## [2330] "GML"                                                                                              
## [2331] "SYT1"                                                                                             
## [2332] "CWF19L1"                                                                                          
## [2333] "DICER1"                                                                                           
## [2334] "LIMD1"                                                                                            
## [2335] "SLC7A1"                                                                                           
## [2336] "SOX11"                                                                                            
## [2337] "ST8SIA2"                                                                                          
## [2338] "DNAJB11"                                                                                          
## [2339] "SNAP29"                                                                                           
## [2340] "4930532M18RIK"                                                                                    
## [2341] "A530054K11RIK"                                                                                    
## [2342] "CADM3"                                                                                            
## [2343] "IDS"                                                                                              
## [2344] "ISLR2"                                                                                            
## [2345] "MAP3K3"                                                                                           
## [2346] "BRCA1"                                                                                            
## [2347] "NID1"                                                                                             
## [2348] "PRODH"                                                                                            
## [2349] "AGPAT1"                                                                                           
## [2350] "RINL"                                                                                             
## [2351] "MAPK1"                                                                                            
## [2352] "FUBP1"                                                                                            
## [2353] "SYPL2"                                                                                            
## [2354] "PID1"                                                                                             
## [2355] "GM13476"                                                                                          
## [2356] "9930013L23RIK"                                                                                    
## [2357] "BCL7C"                                                                                            
## [2358] "UHRF1BP1L"                                                                                        
## [2359] "9530051G07RIK"                                                                                    
## [2360] "CEBPD"                                                                                            
## [2361] "IGF2BP2"                                                                                          
## [2362] "HIST1H2AC"                                                                                        
## [2363] "MPG"                                                                                              
## [2364] "LYST"                                                                                             
## [2365] "APBB1IP"                                                                                          
## [2366] "MED20"                                                                                            
## [2367] "4931406H21RIK"                                                                                    
## [2368] "MELK"                                                                                             
## [2369] "SUCLG2"                                                                                           
## [2370] "FAM84B"                                                                                           
## [2371] "ZFP462"                                                                                           
## [2372] "PSME3"                                                                                            
## [2373] "BC068157"                                                                                         
## [2374] "4931406C07RIK"                                                                                    
## [2375] "SMCR7L"                                                                                           
## [2376] "CRP"                                                                                              
## [2377] "AQP2"                                                                                             
## [2378] "RPGRIP1L"                                                                                         
## [2379] "CELF2"                                                                                            
## [2380] "SLC24A2"                                                                                          
## [2381] "FAM117A"                                                                                          
## [2382] "GM16432"                                                                                          
## [2383] "5730588L14RIK"                                                                                    
## [2384] "LOC545966"                                                                                        
## [2385] "MAN2B1"                                                                                           
## [2386] "N28178"                                                                                           
## [2387] "RFNG"                                                                                             
## [2388] "PTPRD"                                                                                            
## [2389] "ZC3HAV1"                                                                                          
## [2390] "KHK"                                                                                              
## [2391] "LSM11"                                                                                            
## [2392] "SNRNP48"                                                                                          
## [2393] "FEV"                                                                                              
## [2394] "KLF6"                                                                                             
## [2395] "PITPNM3"                                                                                          
## [2396] "RPRML"                                                                                            
## [2397] "B230325K18RIK"                                                                                    
## [2398] "SLC9A1"                                                                                           
## [2399] "AKAP8"                                                                                            
## [2400] "ATXN3"                                                                                            
## [2401] "COMMD2"                                                                                           
## [2402] "PLA2G15"                                                                                          
## [2403] "CDK6"                                                                                             
## [2404] "FIGNL1"                                                                                           
## [2405] "GRK1"                                                                                             
## [2406] "SULT4A1"                                                                                          
## [2407] "GM6999"                                                                                           
## [2408] "NKAIN2"                                                                                           
## [2409] "DIO2"                                                                                             
## [2410] "CSRNP2"                                                                                           
## [2411] "ZIK1"                                                                                             
## [2412] "SDHAF2"                                                                                           
## [2413] "GCK"                                                                                              
## [2414] "PPAPDC2"                                                                                          
## [2415] "IPO9"                                                                                             
## [2416] "KCNK18"                                                                                           
## [2417] "PPIL2"                                                                                            
## [2418] "LSAMP"                                                                                            
## [2419] "VPS13A"                                                                                           
## [2420] "UCHL3"                                                                                            
## [2421] "GM6086"                                                                                           
## [2422] "VPS13C"                                                                                           
## [2423] "FGF15"                                                                                            
## [2424] "HCN1"                                                                                             
## [2425] "IQCK"                                                                                             
## [2426] "ZFP30"                                                                                            
## [2427] "RPAP1"                                                                                            
## [2428] "NME1"                                                                                             
## [2429] "RCL1"                                                                                             
## [2430] "FBLN5"                                                                                            
## [2431] "PPM1D"                                                                                            
## [2432] "BTBD3"                                                                                            
## [2433] "SCN8A"                                                                                            
## [2434] "4930523C07RIK"                                                                                    
## [2435] "GDAP1L1"                                                                                          
## [2436] "ALKBH1"                                                                                           
## [2437] "CYP3A41A"                                                                                         
## [2438] "PSG29"                                                                                            
## [2439] "CXCR2"                                                                                            
## [2440] "SLC26A9"                                                                                          
## [2441] "TMEM177"                                                                                          
## [2442] "PIBF1"                                                                                            
## [2443] "MED15"                                                                                            
## [2444] "PRPS2"                                                                                            
## [2445] "PPP1R9A"                                                                                          
## [2446] "HSD3B2"                                                                                           
## [2447] "SLC11A2"                                                                                          
## [2448] "CORO1C"                                                                                           
## [2449] "CSNK1D"                                                                                           
## [2450] "POT1B"                                                                                            
## [2451] "2700089E24RIK"                                                                                    
## [2452] "GABRA4"                                                                                           
## [2453] "DVL2"                                                                                             
## [2454] "COPZ1"                                                                                            
## [2455] "RSF1"                                                                                             
## [2456] "TAF5"                                                                                             
## [2457] "PHYHIP"                                                                                           
## [2458] "CD164"                                                                                            
## [2459] "CCDC97"                                                                                           
## [2460] "ENTPD6"                                                                                           
## [2461] "RXFP3"                                                                                            
## [2462] "UBE2J1"                                                                                           
## [2463] "CALCR"                                                                                            
## [2464] "PLCXD3"                                                                                           
## [2465] "CASP12"                                                                                           
## [2466] "PHF20L1"                                                                                          
## [2467] "ZFP831"                                                                                           
## [2468] "KCNK3"                                                                                            
## [2469] "PMM2"                                                                                             
## [2470] "PCCB"                                                                                             
## [2471] "NDRG1"                                                                                            
## [2472] "PTPRJ"                                                                                            
## [2473] "RPF2"                                                                                             
## [2474] "D730039F16RIK"                                                                                    
## [2475] "BB287469"                                                                                         
## [2476] "BRPF3"                                                                                            
## [2477] "BRD8"                                                                                             
## [2478] "DUSP6"                                                                                            
## [2479] "CASC3"                                                                                            
## [2480] "C330018A13RIK"                                                                                    
## [2481] "DUSP7"                                                                                            
## [2482] "SIK2"                                                                                             
## [2483] "NGP"                                                                                              
## [2484] "TAF8"                                                                                             
## [2485] "CLINT1"                                                                                           
## [2486] "TBATA"                                                                                            
## [2487] "PLA2G4C"                                                                                          
## [2488] "TMEM125"                                                                                          
## [2489] "4930417O13RIK"                                                                                    
## [2490] "CYLD"                                                                                             
## [2491] "CD96"                                                                                             
## [2492] "STYX"                                                                                             
## [2493] "NAPG"                                                                                             
## [2494] "OPCML"                                                                                            
## [2495] "USP8"                                                                                             
## [2496] "TAF4B"                                                                                            
## [2497] "CYTH1"                                                                                            
## [2498] "AJAP1"                                                                                            
## [2499] "CDC23"                                                                                            
## [2500] "ORAI1"                                                                                            
## [2501] "SEL1L3"                                                                                           
## [2502] "TRIM71"                                                                                           
## [2503] "HNRNPM"                                                                                           
## [2504] "PMAIP1"                                                                                           
## [2505] "SSTR3"                                                                                            
## [2506] "CLCC1"                                                                                            
## [2507] "SORT1"                                                                                            
## [2508] "GM3696"                                                                                           
## [2509] "SRRM1"                                                                                            
## [2510] "COL3A1"                                                                                           
## [2511] "GABRB3"                                                                                           
## [2512] "ZFP433"                                                                                           
## [2513] "ZFP712"                                                                                           
## [2514] "STXBP4"                                                                                           
## [2515] "XK"                                                                                               
## [2516] "SIT1"                                                                                             
## [2517] "KDELR3"                                                                                           
## [2518] "4933404I11RIK"                                                                                    
## [2519] "CD99L2"                                                                                           
## [2520] "PDGFB"                                                                                            
## [2521] "CCDC39"                                                                                           
## [2522] "AOX1"                                                                                             
## [2523] "PLA2G2F"                                                                                          
## [2524] "FUZ"                                                                                              
## [2525] "CPN1"                                                                                             
## [2526] "ANGPTL3"                                                                                          
## [2527] "KCNQ2"                                                                                            
## [2528] "OSTM1"                                                                                            
## [2529] "IPO8"                                                                                             
## [2530] "KCNC1"                                                                                            
## [2531] "DNAHC5"                                                                                           
## [2532] "5430400D12RIK"                                                                                    
## [2533] "SEH1L"                                                                                            
## [2534] "SPON2"                                                                                            
## [2535] "RFX5"                                                                                             
## [2536] "PRR5L"                                                                                            
## [2537] "RRAGC"                                                                                            
## [2538] "PPTC7"                                                                                            
## [2539] "LAIR1"                                                                                            
## [2540] "RP1"                                                                                              
## [2541] "IARS2"                                                                                            
## [2542] "MRPL34"                                                                                           
## [2543] "XPO7"                                                                                             
## [2544] "IL22"                                                                                             
## [2545] "AP3D1"                                                                                            
## [2546] "GOLGA2"                                                                                           
## [2547] "IL20RB"                                                                                           
## [2548] "FASTKD1"                                                                                          
## [2549] "SLC39A8"                                                                                          
## [2550] "TBC1D13"                                                                                          
## [2551] "5430425J12RIK"                                                                                    
## [2552] "CDC25B"                                                                                           
## [2553] "FREM2"                                                                                            
## [2554] "MAMDC2"                                                                                           
## [2555] "GM10516"                                                                                          
## [2556] "SOX9"                                                                                             
## [2557] "LANCL2"                                                                                           
## [2558] "HTR5A"                                                                                            
## [2559] "B130024G19RIK"                                                                                    
## [2560] "ZFP526"                                                                                           
## [2561] "A330009N23RIK"                                                                                    
## [2562] "BCL7B"                                                                                            
## [2563] "SALL3"                                                                                            
## [2564] "KBTBD11"                                                                                          
## [2565] "SEC63"                                                                                            
## [2566] "CIAPIN1"                                                                                          
## [2567] "GM11194"                                                                                          
## [2568] "AKAP10"                                                                                           
## [2569] "MLLT3"                                                                                            
## [2570] "GPR165"                                                                                           
## [2571] "CYP2J6"                                                                                           
## [2572] "PCSK7"                                                                                            
## [2573] "CNR1"                                                                                             
## [2574] "SLC6A6"                                                                                           
## [2575] "FOXR1"                                                                                            
## [2576] "CPNE5"                                                                                            
## [2577] "RAB33B"                                                                                           
## [2578] "S100A1"                                                                                           
## [2579] "VAMP3"                                                                                            
## [2580] "1700066B19RIK"                                                                                    
## [2581] "SGCB"                                                                                             
## [2582] "YPEL2"                                                                                            
## [2583] "C2CD2"                                                                                            
## [2584] "GRM7"                                                                                             
## [2585] "GABRG2"                                                                                           
## [2586] "E2F2"                                                                                             
## [2587] "TGIF2"                                                                                            
## [2588] "SMG1"                                                                                             
## [2589] "FOXK2"                                                                                            
## [2590] "WNT9B"                                                                                            
## [2591] "TTC23L"                                                                                           
## [2592] "A530072M11RIK"                                                                                    
## [2593] "SEMA4F"                                                                                           
## [2594] "REEP1"                                                                                            
## [2595] "RELN"                                                                                             
## [2596] "RAD54L2"                                                                                          
## [2597] "WFDC5"                                                                                            
## [2598] "AWAT2"                                                                                            
## [2599] "CLN5"                                                                                             
## [2600] "FAT4"                                                                                             
## [2601] "SHISA6"                                                                                           
## [2602] "HK2"                                                                                              
## [2603] "RAG1"                                                                                             
## [2604] "ANAPC1"                                                                                           
## [2605] "PSTK"                                                                                             
## [2606] "KCNJ10"                                                                                           
## [2607] "TNFRSF23"                                                                                         
## [2608] "MTF1"                                                                                             
## [2609] "4930506M07RIK"                                                                                    
## [2610] "NIPSNAP1"                                                                                         
## [2611] "ZFP697"                                                                                           
## [2612] "RRM2"                                                                                             
## [2613] "TRIM42"                                                                                           
## [2614] "1700029F12RIK"                                                                                    
## [2615] "RTP1"                                                                                             
## [2616] "ADAMTS6"                                                                                          
## [2617] "P4HTM"                                                                                            
## [2618] "PSMD2"                                                                                            
## [2619] "LMAN2"                                                                                            
## [2620] "CHKA"                                                                                             
## [2621] "CCND2"                                                                                            
## [2622] "ERO1L"                                                                                            
## [2623] "SLC15A1"                                                                                          
## [2624] "CACNA1E"                                                                                          
## [2625] "CHAF1B"                                                                                           
## [2626] "RAB37"                                                                                            
## [2627] "ZMYM6"                                                                                            
## [2628] "NTM"                                                                                              
## [2629] "4930402D18RIK"                                                                                    
## [2630] "KLRC2"                                                                                            
## [2631] "XCR1"                                                                                             
## [2632] "B230354K17RIK"                                                                                    
## [2633] "SDK1"                                                                                             
## [2634] "REEP4"                                                                                            
## [2635] "CPT1C"                                                                                            
## [2636] "NFKB2"                                                                                            
## [2637] "LMTK2"                                                                                            
## [2638] "DOT1L"                                                                                            
## [2639] "HIST1H2BE"                                                                                        
## [2640] "KCTD7"                                                                                            
## [2641] "4921513I03RIK"                                                                                    
## [2642] "TOB2"                                                                                             
## [2643] "TMED4"                                                                                            
## [2644] "INTS12"                                                                                           
## [2645] "KCND3"                                                                                            
## [2646] "UGGT2"                                                                                            
## [2647] "SHPK"                                                                                             
## [2648] "MRPL19"                                                                                           
## [2649] "OLFR121"                                                                                          
## [2650] "TEAD1"                                                                                            
## [2651] "PDCD7"                                                                                            
## [2652] "TSEN34"                                                                                           
## [2653] "RHOBTB2"                                                                                          
## [2654] "DGCR14"                                                                                           
## [2655] "BC058420"                                                                                         
## [2656] "DTNB"                                                                                             
## [2657] "LEPROTL1"                                                                                         
## [2658] "SPRYD4"                                                                                           
## [2659] "SPRY4"                                                                                            
## [2660] "AFAP1"                                                                                            
## [2661] "GABPB1"                                                                                           
## [2662] "TMEM214"                                                                                          
## [2663] "LEP"                                                                                              
## [2664] "BFSP2"                                                                                            
## [2665] "TBX19"                                                                                            
## [2666] "GLB1"                                                                                             
## [2667] "HDGFRP3"                                                                                          
## [2668] "PNP"                                                                                              
## [2669] "BHLHA15"                                                                                          
## [2670] "BOD1L"                                                                                            
## [2671] "E2F7"                                                                                             
## [2672] "GYPC"                                                                                             
## [2673] "D230017M19RIK"                                                                                    
## [2674] "CRLF3"                                                                                            
## [2675] "PYCR1"                                                                                            
## [2676] "DOCK2"                                                                                            
## [2677] "RABGAP1L"                                                                                         
## [2678] "ZFAND3"                                                                                           
## [2679] "ZRANB2"                                                                                           
## [2680] "LAMC3"                                                                                            
## [2681] "BIK"                                                                                              
## [2682] "CRK"                                                                                              
## [2683] "EPHA4"                                                                                            
## [2684] "NXNL1"                                                                                            
## [2685] "PIGV"                                                                                             
## [2686] "ARFGEF2"                                                                                          
## [2687] "SH3BGRL2"                                                                                         
## [2688] "TDO2"                                                                                             
## [2689] "ZCCHC5"                                                                                           
## [2690] "4933413J09RIK"                                                                                    
## [2691] "GM6498"                                                                                           
## [2692] "A230051N06RIK"                                                                                    
## [2693] "3110082I17RIK"                                                                                    
## [2694] "KLHL5"                                                                                            
## [2695] "9530052C20RIK"                                                                                    
## [2696] "SDK2"                                                                                             
## [2697] "MAOA"                                                                                             
## [2698] "UGT3A1"                                                                                           
## [2699] "CHD7"                                                                                             
## [2700] "WNT9A"                                                                                            
## [2701] "CAT"                                                                                              
## [2702] "GABRA3"                                                                                           
## [2703] "FAM110B"                                                                                          
## [2704] "3110006O06RIK"                                                                                    
## [2705] "TRIM67"                                                                                           
## [2706] "4933415F23RIK"                                                                                    
## [2707] "CYP2C38"                                                                                          
## [2708] "SLC30A4"                                                                                          
## [2709] "KHDRBS2"                                                                                          
## [2710] "ZFP120"                                                                                           
## [2711] "2810047C21RIK1"                                                                                   
## [2712] "NSUN2"                                                                                            
## [2713] "ABCB7"                                                                                            
## [2714] "FAM57A"                                                                                           
## [2715] "BCKDK"                                                                                            
## [2716] "HSD3B6"                                                                                           
## [2717] "4921536K21RIK"                                                                                    
## [2718] "FOXN4"                                                                                            
## [2719] "GPCPD1"                                                                                           
## [2720] "4930524L23RIK"                                                                                    
## [2721] "MS4A18"                                                                                           
## [2722] "FGR"                                                                                              
## [2723] "HIST3H2BA"                                                                                        
## [2724] "CHD9"                                                                                             
## [2725] "1700029H14RIK"                                                                                    
## [2726] "RAI14"                                                                                            
## [2727] "ELAC1"                                                                                            
## [2728] "FAM194A"                                                                                          
## [2729] "DPP6"                                                                                             
## [2730] "EIF5B"                                                                                            
## [2731] "CALM4"                                                                                            
## [2732] "PIGU"                                                                                             
## [2733] "ING5"                                                                                             
## [2734] "A330008L17RIK"                                                                                    
## [2735] "FAM13B"                                                                                           
## [2736] "COPA"                                                                                             
## [2737] "PLAA"                                                                                             
## [2738] "IL10"                                                                                             
## [2739] "F13A1"                                                                                            
## [2740] "A930009E05RIK"                                                                                    
## [2741] "SAMD8"                                                                                            
## [2742] "ARCN1"                                                                                            
## [2743] "TMEFF2"                                                                                           
## [2744] "KPNA7"                                                                                            
## [2745] "SLC43A1"                                                                                          
## [2746] "RAD23B"                                                                                           
## [2747] "WDR33"                                                                                            
## [2748] "USP49"                                                                                            
## [2749] "CSTF3"                                                                                            
## [2750] "CENPL"                                                                                            
## [2751] "1810013L24RIK"                                                                                    
## [2752] "GABRB2"                                                                                           
## [2753] "PTGDS"                                                                                            
## [2754] "DNAHC7B"                                                                                          
## [2755] "FREM1"                                                                                            
## [2756] "DOCK9"                                                                                            
## [2757] "RMND1"                                                                                            
## [2758] "TMEM29"                                                                                           
## [2759] "FOXJ3"                                                                                            
## [2760] "ZKSCAN1"                                                                                          
## [2761] "FAM160B2"                                                                                         
## [2762] "ITPKC"                                                                                            
## [2763] "ABCB11"                                                                                           
## [2764] "4933417D19RIK"                                                                                    
## [2765] "GPR137B-PS"                                                                                       
## [2766] "CCNL2"                                                                                            
## [2767] "GNB3"                                                                                             
## [2768] "SFXN5"                                                                                            
## [2769] "APH1C"                                                                                            
## [2770] "CYB5R4"                                                                                           
## [2771] "GM5101"                                                                                           
## [2772] "CC2D1A"                                                                                           
## [2773] "LIN52"                                                                                            
## [2774] "RASGRP4"                                                                                          
## [2775] "C820005J03RIK"                                                                                    
## [2776] "GALNT1"                                                                                           
## [2777] "2310035C23RIK"                                                                                    
## [2778] "RIAN"                                                                                             
## [2779] "IKZF4"                                                                                            
## [2780] "FADS3"                                                                                            
## [2781] "PROSC"                                                                                            
## [2782] "FLYWCH1"                                                                                          
## [2783] "RGS9"                                                                                             
## [2784] "OCIAD1"                                                                                           
## [2785] "EPS8L1"                                                                                           
## [2786] "SDC2"                                                                                             
## [2787] "ZFP113"                                                                                           
## [2788] "SLC16A14"                                                                                         
## [2789] "COL5A3"                                                                                           
## [2790] "MAP2K5"                                                                                           
## [2791] "STAT2"                                                                                            
## [2792] "ZFP553"                                                                                           
## [2793] "METTL6"                                                                                           
## [2794] "SENP1"                                                                                            
## [2795] "BPHL"                                                                                             
## [2796] "TMEM47"                                                                                           
## [2797] "CENPC1"                                                                                           
## [2798] "STARD5"                                                                                           
## [2799] "9430020K01RIK"                                                                                    
## [2800] "NKAIN3"                                                                                           
## [2801] "TCAM1"                                                                                            
## [2802] "CCL22"                                                                                            
## [2803] "GM7729"                                                                                           
## [2804] "ERMAP"                                                                                            
## [2805] "DPP9"                                                                                             
## [2806] "TERF2IP"                                                                                          
## [2807] "GJE1"                                                                                             
## [2808] "VRK2"                                                                                             
## [2809] "HELQ"                                                                                             
## [2810] "MMGT1"                                                                                            
## [2811] "PACS2"                                                                                            
## [2812] "SERINC1"                                                                                          
## [2813] "USP9X"                                                                                            
## [2814] "GPR123"                                                                                           
## [2815] "N4BP2L2"                                                                                          
## [2816] "CDS1"                                                                                             
## [2817] "2210016L21RIK"                                                                                    
## [2818] "GGA3"                                                                                             
## [2819] "BC016579"                                                                                         
## [2820] "COG8"                                                                                             
## [2821] "VPS13B"                                                                                           
## [2822] "RLIM"                                                                                             
## [2823] "CNIH"                                                                                             
## [2824] "NUP188"                                                                                           
## [2825] "ABCE1"                                                                                            
## [2826] "DAD1"                                                                                             
## [2827] "GNAQ"                                                                                             
## [2828] "TMEM130"                                                                                          
## [2829] "GDF6"                                                                                             
## [2830] "CASP4"                                                                                            
## [2831] "RELL1"                                                                                            
## [2832] "SLC19A1"                                                                                          
## [2833] "CCDC163"                                                                                          
## [2834] "ANKRD44"                                                                                          
## [2835] "NSA2"                                                                                             
## [2836] "CAR2"                                                                                             
## [2837] "SLC29A3"                                                                                          
## [2838] "HBEGF"                                                                                            
## [2839] "SLC7A11"                                                                                          
## [2840] "ACSS2"                                                                                            
## [2841] "MRPS25"                                                                                           
## [2842] "PGM3"                                                                                             
## [2843] "MEGF10"                                                                                           
## [2844] "SMURF1"                                                                                           
## [2845] "ZFP362"                                                                                           
## [2846] "TERT"                                                                                             
## [2847] "SLC34A2"                                                                                          
## [2848] "SLC20A1"                                                                                          
## [2849] "FAM13C"                                                                                           
## [2850] "DSCR3"                                                                                            
## [2851] "CREG2"                                                                                            
## [2852] "TAB1"                                                                                             
## [2853] "PHLPP2"                                                                                           
## [2854] "GALNT2"                                                                                           
## [2855] "ROCK2"                                                                                            
## [2856] "ORAOV1"                                                                                           
## [2857] "AP3M1"                                                                                            
## [2858] "OSGIN2"                                                                                           
## [2859] "WNT1"                                                                                             
## [2860] "APOBEC2"                                                                                          
## [2861] "L3MBTL3"                                                                                          
## [2862] "ONECUT2"                                                                                          
## [2863] "RSBN1L"                                                                                           
## [2864] "IGSF11"                                                                                           
## [2865] "MURC"                                                                                             
## [2866] "B230120H23RIK"                                                                                    
## [2867] "NFIA"                                                                                             
## [2868] "SIPA1L1"                                                                                          
## [2869] "D930028M14RIK"                                                                                    
## [2870] "MUC3"                                                                                             
## [2871] "LPAR2"                                                                                            
## [2872] "PKP1"                                                                                             
## [2873] "RGS8"                                                                                             
## [2874] "1700016G14RIK"                                                                                    
## [2875] "4930543N07RIK"                                                                                    
## [2876] "IGF2"                                                                                             
## [2877] "SRPX2"                                                                                            
## [2878] "NFRKB"                                                                                            
## [2879] "NQO1"                                                                                             
## [2880] "PASK"                                                                                             
## [2881] "TSC1"                                                                                             
## [2882] "SIRT7"                                                                                            
## [2883] "1700018B24RIK"                                                                                    
## [2884] "B230307C23RIK"                                                                                    
## [2885] "CBLN4"                                                                                            
## [2886] "CAMK2A"                                                                                           
## [2887] "1700055N04RIK"                                                                                    
## [2888] "MTHFR"                                                                                            
## [2889] "FBXW10"                                                                                           
## [2890] "ZFP748"                                                                                           
## [2891] "KYNU"                                                                                             
## [2892] "PAPPA"                                                                                            
## [2893] "RPS24"                                                                                            
## [2894] "CRAMP1L"                                                                                          
## [2895] "DDX21"                                                                                            
## [2896] "CSMD2"                                                                                            
## [2897] "ZFP523"                                                                                           
## [2898] "ITGAV"                                                                                            
## [2899] "4921529L05RIK"                                                                                    
## [2900] "UBXN1"                                                                                            
## [2901] "GAS8"                                                                                             
## [2902] "TPBPA"                                                                                            
## [2903] "EPPK1"                                                                                            
## [2904] "GM1070"                                                                                           
## [2905] "NTN1"                                                                                             
## [2906] "TROVE2"                                                                                           
## [2907] "COL22A1"                                                                                          
## [2908] "TNFAIP3"                                                                                          
## [2909] "RFC3"                                                                                             
## [2910] "ROBO1"                                                                                            
## [2911] "HRAS1"                                                                                            
## [2912] "CNN1"                                                                                             
## [2913] "GRIP1"                                                                                            
## [2914] "GABRD"                                                                                            
## [2915] "DOCK4"                                                                                            
## [2916] "GFOD1"                                                                                            
## [2917] "HAT1"                                                                                             
## [2918] "PFKFB4"                                                                                           
## [2919] "PIP4K2B"                                                                                          
## [2920] "RAB8B"                                                                                            
## [2921] "HAS2"                                                                                             
## [2922] "C920009B18RIK"                                                                                    
## [2923] "FNTB"                                                                                             
## [2924] "BC048559"                                                                                         
## [2925] "PLCE1"                                                                                            
## [2926] "DOPEY2"                                                                                           
## [2927] "NPHP3"                                                                                            
## [2928] "ELAVL1"                                                                                           
## [2929] "MRPL50"                                                                                           
## [2930] "2010012O05RIK"                                                                                    
## [2931] "MED9"                                                                                             
## [2932] "4933431K23RIK"                                                                                    
## [2933] "FAM126A"                                                                                          
## [2934] "ELF5"                                                                                             
## [2935] "MED25"                                                                                            
## [2936] "CAMK2B"                                                                                           
## [2937] "BRDT"                                                                                             
## [2938] "ZFR2"                                                                                             
## [2939] "MEX3A"                                                                                            
## [2940] "KDM4C"                                                                                            
## [2941] "ADARB1"                                                                                           
## [2942] "PMPCA"                                                                                            
## [2943] "ARPP21"                                                                                           
## [2944] "BNIP1"                                                                                            
## [2945] "EFCAB8"                                                                                           
## [2946] "ATAD3A"                                                                                           
## [2947] "RASSF8"                                                                                           
## [2948] "SLC31A2"                                                                                          
## [2949] "GM15053"                                                                                          
## [2950] "A830011K09RIK"                                                                                    
## [2951] "IDI2"                                                                                             
## [2952] "TYW1"                                                                                             
## [2953] "ABHD10"                                                                                           
## [2954] "PRAMEL1"                                                                                          
## [2955] "TMEM30A"                                                                                          
## [2956] "MMP12"                                                                                            
## [2957] "FGF16"                                                                                            
## [2958] "CHD4"                                                                                             
## [2959] "PARVG"                                                                                            
## [2960] "ARHGAP11A"                                                                                        
## [2961] "ONECUT3"                                                                                          
## [2962] "SSBP2"                                                                                            
## [2963] "MLL3"                                                                                             
## [2964] "DCLK1"                                                                                            
## [2965] "STX8"                                                                                             
## [2966] "BC049265"                                                                                         
## [2967] "VOPP1"                                                                                            
## [2968] "HK1"                                                                                              
## [2969] "RNF111"                                                                                           
## [2970] "SOCS7"                                                                                            
## [2971] "PLXNC1"                                                                                           
## [2972] "TMED5"                                                                                            
## [2973] "FBXO42"                                                                                           
## [2974] "CAR12"                                                                                            
## [2975] "WDR35"                                                                                            
## [2976] "LARGE"                                                                                            
## [2977] "ZBTB22"                                                                                           
## [2978] "RDH1"                                                                                             
## [2979] "ZBTB49"                                                                                           
## [2980] "ITSN1"                                                                                            
## [2981] "AI197445"                                                                                         
## [2982] "MFRP"                                                                                             
## [2983] "GM904"                                                                                            
## [2984] "ATL2"                                                                                             
## [2985] "MKRN2"                                                                                            
## [2986] "MSRB3"                                                                                            
## [2987] "PIR"                                                                                              
## [2988] "ELP2"                                                                                             
## [2989] "ZFP91"                                                                                            
## [2990] "KRT26"                                                                                            
## [2991] "CPD"                                                                                              
## [2992] "TMEM116"                                                                                          
## [2993] "TMEM170"                                                                                          
## [2994] "TLK1"                                                                                             
## [2995] "SH2D4A"                                                                                           
## [2996] "NUP98"                                                                                            
## [2997] "CXX1C"                                                                                            
## [2998] "IDH2"                                                                                             
## [2999] "SERPINA4-PS1"                                                                                     
## [3000] "CNPY1"                                                                                            
## [3001] "F730048M01RIK"                                                                                    
## [3002] "GTF3C2"                                                                                           
## [3003] "5430416O09RIK"                                                                                    
## [3004] "AQP1"                                                                                             
## [3005] "PTCD1"                                                                                            
## [3006] "NPC1"                                                                                             
## [3007] "GM5784"                                                                                           
## [3008] "PSG26"                                                                                            
## [3009] "GM13262"                                                                                          
## [3010] "CD274"                                                                                            
## [3011] "OSBPL8"                                                                                           
## [3012] "RBMX"                                                                                             
## [3013] "MCPH1"                                                                                            
## [3014] "LRRC59"                                                                                           
## [3015] "EXT2"                                                                                             
## [3016] "PSG25"                                                                                            
## [3017] "DMRTA1"                                                                                           
## [3018] "GM1653"                                                                                           
## [3019] "GDPD4"                                                                                            
## [3020] "GM5166"                                                                                           
## [3021] "ADCY10"                                                                                           
## [3022] "F730311O21RIK"                                                                                    
## [3023] "1810009N23RIK"                                                                                    
## [3024] "TTC39B"                                                                                           
## [3025] "FAM101B"                                                                                          
## [3026] "1110059G10RIK"                                                                                    
## [3027] "POP5"                                                                                             
## [3028] "PAX1"                                                                                             
## [3029] "MBNL1"                                                                                            
## [3030] "EFTUD1"                                                                                           
## [3031] "STMN2"                                                                                            
## [3032] "ZFP664"                                                                                           
## [3033] "AKAP6"                                                                                            
## [3034] "ZBTB40"                                                                                           
## [3035] "ZFP106"                                                                                           
## [3036] "CAPZA2"                                                                                           
## [3037] "FAM73A"                                                                                           
## [3038] "RASL12"                                                                                           
## [3039] "EFNB3"                                                                                            
## [3040] "ELOVL3"                                                                                           
## [3041] "GGPS1"                                                                                            
## [3042] "GM5643"                                                                                           
## [3043] "FAM115A"                                                                                          
## [3044] "ARC"                                                                                              
## [3045] "LYSMD3"                                                                                           
## [3046] "GLTPD1"                                                                                           
## [3047] "TMEM180"                                                                                          
## [3048] "AI593442"                                                                                         
## [3049] "SLCO1A4"                                                                                          
## [3050] "CHFR"                                                                                             
## [3051] "UBFD1"                                                                                            
## [3052] "KPNA6"                                                                                            
## [3053] "GRID2"                                                                                            
## [3054] "DMP1"                                                                                             
## [3055] "MYO1B"                                                                                            
## [3056] "EGLN2"                                                                                            
## [3057] "SRGAP3"                                                                                           
## [3058] "E230001N04RIK"                                                                                    
## [3059] "2310069G16RIK"                                                                                    
## [3060] "9530053A07RIK"                                                                                    
## [3061] "TMX3"                                                                                             
## [3062] "CCDC15"                                                                                           
## [3063] "TSPAN3"                                                                                           
## [3064] "MUM1L1"                                                                                           
## [3065] "LRRC9"                                                                                            
## [3066] "FOXL1"                                                                                            
## [3067] "USP22"                                                                                            
## [3068] "MED10"                                                                                            
## [3069] "PRPH2"                                                                                            
## [3070] "ZFP334"                                                                                           
## [3071] "P2RY4"                                                                                            
## [3072] "CDH12"                                                                                            
## [3073] "4933424M12RIK"                                                                                    
## [3074] "DUSP11"                                                                                           
## [3075] "UBXN2B"                                                                                           
## [3076] "1200011I18RIK"                                                                                    
## [3077] "RNGTT"                                                                                            
## [3078] "OPN1MW"                                                                                           
## [3079] "PCGF3"                                                                                            
## [3080] "CSNK2A2"                                                                                          
## [3081] "DYNLT3"                                                                                           
## [3082] "SLC10A5"                                                                                          
## [3083] "ATPAF1"                                                                                           
## [3084] "TCF23"                                                                                            
## [3085] "C330005M16RIK"                                                                                    
## [3086] "KCNH1"                                                                                            
## [3087] "CHD6"                                                                                             
## [3088] "CAR10"                                                                                            
## [3089] "NT5E"                                                                                             
## [3090] "CCDC42"                                                                                           
## [3091] "VAMP7"                                                                                            
## [3092] "TRAF3IP2"                                                                                         
## [3093] "9430016H08RIK"                                                                                    
## [3094] "CCDC3"                                                                                            
## [3095] "SLC9A3"                                                                                           
## [3096] "D930020B18RIK"                                                                                    
## [3097] "VPS26B"                                                                                           
## [3098] "IQSEC2"                                                                                           
## [3099] "COMMD7"                                                                                           
## [3100] "CCDC158"                                                                                          
## [3101] "THBD"                                                                                             
## [3102] "OMP"                                                                                              
## [3103] "DDX24"                                                                                            
## [3104] "PLN"                                                                                              
## [3105] "G730013B05RIK"                                                                                    
## [3106] "MPP7"                                                                                             
## [3107] "FNBP1L"                                                                                           
## [3108] "SMAP2"                                                                                            
## [3109] "SH2D1B1"                                                                                          
## [3110] "TMEM98"                                                                                           
## [3111] "GM5478"                                                                                           
## [3112] "NAT8L"                                                                                            
## [3113] "POMP"                                                                                             
## [3114] "SHC2"                                                                                             
## [3115] "HMG20A"                                                                                           
## [3116] "WNT3A"                                                                                            
## [3117] "SECTM1A"                                                                                          
## [3118] "LRP8"                                                                                             
## [3119] "ZC3H10"                                                                                           
## [3120] "ZFP397"                                                                                           
## [3121] "ST5"                                                                                              
## [3122] "ADC"                                                                                              
## [3123] "ESR2"                                                                                             
## [3124] "MESDC1"                                                                                           
## [3125] "RHOJ"                                                                                             
## [3126] "NACC1"                                                                                            
## [3127] "MAN1B1"                                                                                           
## [3128] "SCLT1"                                                                                            
## [3129] "IMPAD1"                                                                                           
## [3130] "QARS"                                                                                             
## [3131] "ZFP689"                                                                                           
## [3132] "COG2"                                                                                             
## [3133] "BCAM"                                                                                             
## [3134] "BRIP1"                                                                                            
## [3135] "SACM1L"                                                                                           
## [3136] "TTF1"                                                                                             
## [3137] "GM4890"                                                                                           
## [3138] "ATP1A2"                                                                                           
## [3139] "CXXC4"                                                                                            
## [3140] "STK24"                                                                                            
## [3141] "ERF"                                                                                              
## [3142] "KLHL2"                                                                                            
## [3143] "PLEKHG5"                                                                                          
## [3144] "WBSCR17"                                                                                          
## [3145] "QSOX1"                                                                                            
## [3146] "LRRC55"                                                                                           
## [3147] "UBA2"                                                                                             
## [3148] "E330009J07RIK"                                                                                    
## [3149] "TCRB-J"                                                                                           
## [3150] "PRKX"                                                                                             
## [3151] "BRI3"                                                                                             
## [3152] "ST8SIA1"                                                                                          
## [3153] "2010110K18RIK"                                                                                    
## [3154] "CD226"                                                                                            
## [3155] "MED29"                                                                                            
## [3156] "TYROBP"                                                                                           
## [3157] "GM15401"                                                                                          
## [3158] "MRGPRA3"                                                                                          
## [3159] "GPR55"                                                                                            
## [3160] "1700073E17RIK"                                                                                    
## [3161] "MSR1"                                                                                             
## [3162] "4930547E14RIK"                                                                                    
## [3163] "RGP1"                                                                                             
## [3164] "C330004P14RIK"                                                                                    
## [3165] "COL4A5"                                                                                           
## [3166] "LPCAT2"                                                                                           
## [3167] "CYP2J9"                                                                                           
## [3168] "CHST2"                                                                                            
## [3169] "D930048G16RIK"                                                                                    
## [3170] "SVIP"                                                                                             
## [3171] "D11WSU47E"                                                                                        
## [3172] "FAM20B"                                                                                           
## [3173] "LNX1"                                                                                             
## [3174] "PTRF"                                                                                             
## [3175] "WNT10A"                                                                                           
## [3176] "SLC27A4"                                                                                          
## [3177] "PPARGC1A"

Translating to human

An alternative is that we translate our human MSigDB collection to mouse gene set, and throw away terms specific to human (such as chromosome location).

Thankfully someone already did just this for us (and they also do regular updates).

We can find mouse translations from human here and we can load the RDS object directly into our session.

Mm.H <- readRDS("Mm.h.all.v7.1.entrez.rds")
class(Mm.H)
## [1] "list"

Translating to human

This contains a named list gene sets converted to mouse Entrez IDs.

Mm.H
## $HALLMARK_TNFA_SIGNALING_VIA_NFKB
##   [1] "11303"  "11304"  "27403"  "268379" "74591"  "11305"  "12778"  "11839" 
##   [9] "11910"  "67972"  "11941"  "320707" "381290" "14595"  "56336"  "12044" 
##  [17] "12047"  "12045"  "12046"  "12051"  "12053"  "20893"  "11797"  "11796" 
##  [25] "17951"  "17952"  "17940"  "17948"  "12156"  "12226"  "194735" "436199"
##  [33] "12227"  "12228"  "20293"  "20296"  "20292"  "20306"  "20297"  "20303" 
##  [41] "20304"  "16007"  "14219"  "12443"  "12444"  "12445"  "56706"  "56036" 
##  [49] "54199"  "12505"  "12515"  "12519"  "12522"  "12575"  "12608"  "12609" 
##  [57] "12633"  "56708"  "12977"  "12981"  "14825"  "20310"  "330122" "20309" 
##  [65] "15945"  "56066"  "20311"  "230073" "19347"  "320560" "67035"  "71712" 
##  [73] "19252"  "319520" "13537"  "240672" "13614"  "13636"  "13653"  "13654" 
##  [81] "13655"  "13660"  "57440"  "98878"  "259300" "20918"  "68969"  "23872" 
##  [89] "14063"  "14066"  "14221"  "14281"  "14282"  "14283"  "14284"  "14345" 
##  [97] "14373"  "13197"  "23882"  "17873"  "14528"  "14579"  "14584"  "321019"
## [105] "15200"  "15205"  "15894"  "15898"  "50723"  "230623" "230613" "329918"
## [113] "15902"  "15936"  "15937"  "15939"  "71586"  "15958"  "15959"  "667370"
## [121] "15980"  "16160"  "16169"  "16173"  "16175"  "16176"  "83430"  "16193" 
## [129] "16195"  "16197"  "16323"  "16324"  "16362"  "384783" "16369"  "16367" 
## [137] "16449"  "16450"  "16476"  "16477"  "16478"  "216850" "22290"  "21847" 
## [145] "16598"  "16600"  "16596"  "236537" "23849"  "16601"  "70789"  "16780" 
## [153] "16835"  "22359"  "16878"  "56722"  "17133"  "26397"  "26399"  "26410" 
## [161] "17118"  "17210"  "17681"  "17119"  "17869"  "107771" "59027"  "54446" 
## [169] "18024"  "18030"  "18033"  "18034"  "18035"  "18037"  "18081"  "15370" 
## [177] "18227"  "18124"  "108078" "381816" "55991"  "208098" "18578"  "238871"
## [185] "110385" "18577"  "56376"  "67399"  "18626"  "18627"  "170768" "18640" 
## [193] "18639"  "270198" "21664"  "22113"  "18792"  "18793"  "56193"  "20620" 
## [201] "67916"  "65112"  "108767" "17872"  "19219"  "19225"  "19224"  "19267" 
## [209] "19262"  "19288"  "54720"  "19696"  "19697"  "19698"  "11852"  "192656"
## [217] "75234"  "30945"  "20229"  "20971"  "18788"  "20725"  "18787"  "20393" 
## [225] "17691"  "235344" "104681" "20527"  "20525"  "227659" "17127"  "17126" 
## [233] "20621"  "12702"  "20656"  "20698"  "74646"  "211949" "18412"  "20850" 
## [241] "20851"  "21353"  "21354"  "21815"  "99929"  "24088"  "21923"  "21926" 
## [249] "21928"  "21929"  "21930"  "106869" "21942"  "21950"  "57783"  "231130"
## [257] "22029"  "211770" "106628" "21807"  "22151"  "227613" "73710"  "22154" 
## [265] "22153"  "22152"  "545486" "67951"  "22339"  "230734" "229055" "230738"
## [273] "22695" 
## 
## $HALLMARK_HYPOXIA
##   [1] "12778"     "11535"     "11541"     "11540"     "11639"     "56248"    
##   [7] "83397"     "11674"     "79459"     "353204"    "230163"    "11676"    
##  [13] "11717"     "57875"     "52231"     "12306"     "11910"     "11977"    
##  [19] "11979"     "117592"    "14422"     "12032"     "12043"     "12111"    
##  [25] "20893"     "12177"     "100043324" "12209"     "12226"     "194735"   
##  [31] "436199"    "12227"     "76459"     "12368"     "12389"     "19285"    
##  [37] "109042"    "20324"     "16007"     "14219"     "22403"     "12452"    
##  [43] "12575"     "12576"     "12577"     "54371"     "60322"     "53374"    
##  [49] "17684"     "12831"     "12829"     "12828"     "107581"    "53867"    
##  [55] "71355"     "94216"     "373864"    "12824"     "12825"     "12826"    
##  [61] "12827"     "12830"     "12832"     "12836"     "12842"     "12843"    
##  [67] "12870"     "15203"     "13008"     "12767"     "13179"     "13198"    
##  [73] "74747"     "26757"     "12933"     "22240"     "12934"     "13527"    
##  [79] "13528"     "19252"     "319520"    "13615"     "13636"     "13638"    
##  [85] "13649"     "13869"     "13866"     "13867"     "13806"     "433182"   
##  [91] "13807"     "13808"     "50527"     "74155"     "23871"     "14042"    
##  [97] "14066"     "70186"     "14121"     "14120"     "14281"     "14284"    
## [103] "56484"     "14387"     "69983"     "14635"     "14433"     "100039229"
## [109] "100042427" "100042025" "622339"    "14447"     "74185"     "103988"   
## [115] "14538"     "93692"     "14733"     "14734"     "14735"     "23888"    
## [121] "14751"     "76238"     "14936"     "232493"    "15116"     "110611"   
## [127] "211208"    "245598"    "15211"     "15212"     "15275"     "15277"    
## [133] "216019"    "212032"    "15368"     "15417"     "15427"     "15476"    
## [139] "14828"     "15481"     "15482"     "15512"     "193740"    "15931"    
## [145] "15937"     "16006"     "16009"     "16011"     "16193"     "216136"   
## [151] "16322"     "384783"    "16369"     "16367"     "57444"     "68048"    
## [157] "229504"    "107817"    "16476"     "16477"     "16478"     "105785"   
## [163] "66913"     "68137"     "104263"    "108829"    "277250"    "16572"    
## [169] "16573"     "16574"     "23849"     "93691"     "75785"     "16770"    
## [175] "16795"     "228366"    "16828"     "16833"     "16948"     "17035"    
## [181] "17133"     "26401"     "17319"     "17748"     "17750"     "17859"    
## [187] "17886"     "17880"     "17883"     "17882"     "17879"     "17885"    
## [193] "17884"     "544791"    "71960"     "77579"     "140781"    "668940"   
## [199] "17888"     "56174"     "13004"     "17988"     "15531"     "83398"    
## [205] "17423"     "83814"     "18030"     "12457"     "14815"     "18451"    
## [211] "18452"     "18484"     "18534"     "74551"     "18591"     "228026"   
## [217] "236900"    "170768"    "18640"     "18639"     "270198"    "18641"    
## [223] "56421"     "18642"     "56012"     "18648"     "18654"     "18655"    
## [229] "18663"     "72157"     "226041"    "66681"     "70974"     "18682"    
## [235] "18712"     "223775"    "18770"     "18772"     "231507"    "18793"    
## [241] "11520"     "108767"    "19017"     "68507"     "327814"    "233977"   
## [247] "17872"     "53412"     "54683"     "18750"     "18751"     "18752"    
## [253] "19309"     "110078"    "110095"    "19664"     "19883"     "52187"    
## [259] "54170"     "20198"     "268686"    "60406"     "50724"     "20778"    
## [265] "12492"     "15529"     "20970"     "20971"     "20342"     "20341"    
## [271] "18787"     "20439"     "13358"     "20525"     "20528"     "20527"    
## [277] "56485"     "435818"    "14385"     "21366"     "51795"     "52331"    
## [283] "20855"     "20856"     "54200"     "100043194" "76971"     "638251"   
## [289] "434121"    "629203"    "434264"    "629219"    "20859"     "21753"    
## [295] "236749"    "245376"    "21809"     "21810"     "21817"     "331046"   
## [301] "99929"     "83553"     "74419"     "21881"     "56277"     "69457"    
## [307] "21929"     "21983"     "21985"     "21991"     "22022"     "216558"   
## [313] "22339"     "22346"     "22359"     "16835"     "78889"     "170750"   
## [319] "22695"     "30046"     "109263"   
## 
## $HALLMARK_CHOLESTEROL_HOMEOSTASIS
##   [1] "11305"     "224530"    "110460"    "60525"     "11465"     "11461"    
##   [7] "26876"     "69117"     "100417514" "11522"     "11529"     "11532"    
##  [13] "11658"     "11676"     "71914"     "69787"     "11747"     "11910"    
##  [19] "107503"    "20239"     "54140"     "12411"     "12527"     "12660"    
##  [25] "12759"     "231207"    "12387"     "16480"     "66102"     "13121"    
##  [31] "13360"     "13595"     "51798"     "74155"     "66071"     "16592"    
##  [37] "56473"     "76267"     "60527"     "228151"    "14104"     "50762"    
##  [43] "230903"    "14137"     "110196"    "104174"    "14677"     "14678"    
##  [49] "14679"     "69590"     "68312"     "14862"     "14863"     "14864"    
##  [55] "14867"     "14866"     "14865"     "110006"    "15357"     "208715"   
##  [61] "15360"     "15490"     "319554"    "16449"     "16450"     "16835"    
##  [67] "22359"     "16854"     "19141"     "16956"     "16987"     "105853"   
##  [73] "192156"    "17855"     "18030"     "63913"     "18194"     "68671"    
##  [79] "236900"    "18793"     "22038"     "18828"     "78459"     "68603"    
##  [85] "108767"    "19016"     "20195"     "277089"    "235293"    "20250"    
##  [91] "20249"     "30049"     "329065"    "20347"     "20775"     "20788"    
##  [97] "20787"     "170459"    "56389"     "73166"     "69071"     "27279"    
## [103] "60599"     "228775"   
## 
## $HALLMARK_MITOTIC_SPINDLE
##   [1] "11308"     "329165"    "11350"     "11352"     "109934"    "110279"   
##   [7] "60595"     "11472"     "109711"    "11474"     "75547"     "236266"   
##  [13] "74018"     "68743"     "11789"     "106952"    "212285"    "11845"    
##  [19] "211673"    "99371"     "76932"     "78514"     "71544"     "71302"    
##  [25] "544817"    "214137"    "171207"    "117600"    "259302"    "11855"    
##  [31] "232906"    "192662"    "213498"    "69632"     "16800"     "71704"    
##  [37] "54126"     "73341"     "68724"     "67166"     "66615"     "20878"    
##  [43] "12927"     "12125"     "30948"     "11799"     "12190"     "12235"    
##  [49] "12345"     "108686"    "68339"     "12442"     "12488"     "217232"   
##  [55] "12540"     "226751"    "217866"    "240505"    "104445"    "104252"   
##  [61] "56699"     "12534"     "214444"    "229841"    "108000"    "219103"   
##  [67] "21461"     "21462"     "100041352" "12009"     "17120"     "70799"    
##  [73] "16328"     "74360"     "74470"     "75786"     "76707"     "76499"    
##  [79] "56430"     "269713"    "81910"     "26920"     "216846"    "54141"    
##  [85] "104318"    "27373"     "13043"     "19158"     "19157"     "19159"    
##  [91] "13383"     "23859"     "13385"     "53310"     "218977"    "94176"    
##  [97] "330662"    "68813"     "238130"    "208869"    "13518"     "13424"    
## [103] "110082"    "110084"    "327954"    "110350"    "330355"    "13411"    
## [109] "237806"    "69926"     "627872"    "68097"     "13605"     "269587"   
## [115] "13822"     "105988"    "22350"     "17698"     "19684"     "223254"   
## [121] "227377"    "67141"     "224014"    "14163"     "13998"     "26382"    
## [127] "30938"     "192176"    "286940"    "68794"     "14086"     "238021"   
## [133] "276919"    "227753"    "20259"     "11567"     "22349"     "15185"    
## [139] "56233"     "320191"    "16151"     "77963"     "170833"    "16319"    
## [145] "16443"     "20403"     "23924"     "231912"    "74187"     "16551"    
## [151] "209737"    "207607"    "16561"     "16560"     "240641"    "110033"   
## [157] "71819"     "73804"     "16563"     "16569"     "16568"     "16570"    
## [163] "383592"    "16571"     "16573"     "16582"     "16572"     "16574"    
## [169] "16579"     "16593"     "16594"     "74764"     "208628"    "268958"   
## [175] "73647"     "170725"    "12333"     "12334"     "70394"     "16798"    
## [181] "50523"     "16897"     "217325"    "16906"     "16907"     "16905"    
## [187] "72416"     "270058"    "26403"     "269881"    "234878"    "338372"   
## [193] "13589"     "17118"     "232944"    "226778"    "100043566" "100043665"
## [199] "620736"    "628475"    "381937"    "545926"    "100043638" "13728"    
## [205] "17318"     "23947"     "68041"     "77579"     "71960"     "17880"    
## [211] "17886"     "17883"     "17882"     "17879"     "17885"     "17884"    
## [217] "544791"    "140781"    "668940"    "17888"     "71602"     "17916"    
## [223] "17925"     "17973"     "17974"     "67052"     "18003"     "18005"    
## [229] "56349"     "18015"     "18080"     "18129"     "18128"     "18132"    
## [235] "18131"     "101706"    "108907"    "94190"     "18472"     "72333"    
## [241] "76073"     "18536"     "18541"     "56376"     "67399"     "208084"   
## [247] "18764"     "329064"    "101497"    "18817"     "232314"    "233406"   
## [253] "277360"    "109294"    "19303"     "226407"    "227800"    "29809"    
## [259] "338346"    "26934"     "19765"     "56705"     "74334"     "217944"   
## [265] "192786"    "76089"     "218397"    "114713"    "19414"     "226525"   
## [271] "69601"     "240057"    "19687"     "23912"     "214952"    "59040"    
## [277] "78757"     "19877"     "19878"     "66406"     "72776"     "53860"    
## [283] "71774"     "110380"    "24061"     "140557"    "13006"     "70099"    
## [289] "234214"    "20662"     "20740"     "20739"     "20742"     "20743"    
## [295] "80297"     "20741"     "237860"    "231637"    "20853"     "232533"   
## [301] "106504"    "223697"    "104027"    "381921"    "216965"    "330177"   
## [307] "108903"    "21844"     "24001"     "228012"    "24086"     "21973"    
## [313] "72119"     "223435"    "545156"    "64930"     "22137"     "22145"    
## [319] "22143"     "22144"     "22147"     "22146"     "22142"     "53857"    
## [325] "238463"    "56427"     "74237"     "259279"    "233276"    "328580"   
## [331] "22294"     "22330"     "83767"     "242687"    "73178"     "22376"    
## [337] "22627"    
## 
## $HALLMARK_WNT_BETA_CATENIN_SIGNALING
##  [1] "11491"  "12005"  "12006"  "12444"  "12443"  "12445"  "27373"  "104318"
##  [9] "12387"  "16480"  "26965"  "13380"  "234130" "13388"  "54485"  "13543" 
## [17] "13544"  "13542"  "27412"  "14296"  "212398" "14362"  "57265"  "14369" 
## [25] "14370"  "14367"  "14677"  "14678"  "14679"  "232232" "15182"  "15184" 
## [33] "56233"  "208727" "15213"  "15214"  "16449"  "16450"  "14534"  "18519" 
## [41] "16842"  "103806" "433586" "17869"  "107771" "20602"  "20185"  "59287" 
## [49] "93960"  "18128"  "18129"  "18132"  "18131"  "18222"  "19015"  "19165" 
## [57] "19206"  "19207"  "19664"  "27401"  "21414"  "22059"  "22408"  "22419" 
## [65] "22418"  "22420" 
## 
## $HALLMARK_TGF_BETA_SIGNALING
##   [1] "11477"  "11789"  "94246"  "29815"  "12156"  "12166"  "12168"  "12550" 
##   [9] "12560"  "12561"  "107951" "12577"  "12387"  "16480"  "13805"  "14225" 
##  [17] "14226"  "14272"  "18550"  "18553"  "18551"  "18552"  "433759" "15182" 
##  [25] "15181"  "15258"  "15257"  "15259"  "15901"  "15902"  "15903"  "15980" 
##  [33] "16477"  "16476"  "16478"  "21847"  "320202" "13590"  "16997"  "268977"
##  [41] "108075" "26409"  "20602"  "20185"  "18121"  "65112"  "19042"  "232941"
##  [49] "19045"  "19047"  "434233" "17872"  "106572" "19334"  "11848"  "67653" 
##  [57] "11853"  "18787"  "20481"  "20482"  "20515"  "20516"  "17125"  "17129" 
##  [65] "55994"  "17127"  "17126"  "17130"  "17131"  "75788"  "66313"  "20742" 
##  [73] "20743"  "80297"  "20740"  "20741"  "21803"  "21812"  "11479"  "269275"
##  [81] "21815"  "21825"  "21828"  "12845"  "21827"  "21872"  "21873"  "27375" 
##  [89] "94093"  "21848"  "66105"  "73318"  "56550"  "381534" "97064"  "11798" 
##  [97] "17951"  "17952"  "17940"  "17948" 
## 
## $HALLMARK_IL6_JAK_STAT3_SIGNALING
##   [1] "232345" "17837"  "17836"  "104681" "232400" "11287"  "11479"  "269275"
##   [9] "21812"  "11482"  "12018"  "12402"  "20306"  "20292"  "20293"  "20296" 
##  [17] "12768"  "12770"  "12475"  "12491"  "12494"  "12182"  "12505"  "12527" 
##  [25] "12804"  "57914"  "12977"  "12981"  "12982"  "16188"  "12984"  "12983" 
##  [33] "16190"  "12986"  "14825"  "20310"  "330122" "20309"  "15945"  "56066" 
##  [41] "55985"  "17329"  "21673"  "50498"  "14102"  "79201"  "14784"  "71520" 
##  [49] "23897"  "15368"  "15975"  "15979"  "15980"  "16155"  "16161"  "16164" 
##  [57] "16169"  "16172"  "50905"  "16182"  "16176"  "16177"  "16178"  "16184" 
##  [65] "16186"  "16193"  "16195"  "16196"  "16199"  "16326"  "16362"  "16391" 
##  [73] "16401"  "104099" "16416"  "16476"  "16477"  "16478"  "16847"  "16994" 
##  [81] "17000"  "26410"  "17874"  "18414"  "16880"  "54635"  "56744"  "320207"
##  [89] "18712"  "223775" "18780"  "19246"  "19247"  "19255"  "19692"  "19693" 
##  [97] "12703"  "12702"  "56324"  "20846"  "20848"  "20849"  "20847"  "21803" 
## [105] "24088"  "21926"  "27279"  "21937"  "21938"  "94185"  "54721"  "16451" 
## [113] "16452" 
## 
## $HALLMARK_DNA_REPAIR
##   [1] "223921"    "11486"     "11512"     "11513"     "11514"     "224129"   
##   [7] "104110"    "210044"    "432530"    "56436"     "100043022" "76850"    
##  [13] "236511"    "239528"    "214150"    "11636"     "56248"     "11639"    
##  [19] "21681"     "56009"     "100043227" "100043231" "100043239" "100043292"
##  [25] "100861880" "70988"     "435615"    "100043224" "100043235" "100043247"
##  [31] "637578"    "100861901" "627488"    "667692"    "100861891" "11821"    
##  [37] "54208"     "57278"     "84004"     "27061"     "66162"     "66653"    
##  [43] "76025"     "218630"    "72269"     "26370"     "98985"     "22169"    
##  [49] "12856"     "228410"    "13135"     "67665"     "13194"     "107986"   
##  [55] "94223"     "27369"     "110074"    "59022"     "68969"     "20918"    
##  [61] "13716"     "27224"     "13870"     "70333"     "13871"     "13872"    
##  [67] "50505"     "22592"     "71991"     "14156"     "105446"    "23918"    
##  [73] "625249"    "54722"     "235459"    "229906"    "98053"     "14884"    
##  [79] "209357"    "66467"     "70239"     "14923"     "15163"     "15452"    
##  [85] "23917"     "100042069" "16434"     "16881"     "70456"     "268395"   
##  [91] "18100"     "68092"     "58202"     "57314"     "27632"     "74164"    
##  [97] "18102"     "79059"     "56520"     "230103"    "18160"     "50773"    
## [103] "103850"    "107569"    "68106"     "68219"     "74167"     "18538"    
## [109] "18540"     "18578"     "238871"    "110385"    "18577"     "18588"    
## [115] "78600"     "667034"    "18950"     "18968"     "18969"     "18970"    
## [121] "18971"     "67967"     "69745"     "105948585" "66979"     "80905"    
## [127] "56626"     "20016"     "20018"     "66136"     "20020"     "20021"    
## [133] "69241"     "66420"     "69833"     "67710"     "245841"    "69920"    
## [139] "20022"     "17749"     "74414"     "69870"     "107939"    "19075"    
## [145] "19361"     "19365"     "66679"     "56044"     "56438"     "100043674"
## [151] "19823"     "19714"     "19718"     "69263"     "106344"    "72151"    
## [157] "67897"     "19891"     "68240"     "382985"    "20135"     "66406"    
## [163] "53378"     "53421"     "57743"     "75062"     "17129"     "55994"    
## [169] "227644"    "330959"    "67996"     "57317"     "20833"     "20908"    
## [175] "20922"     "100041294" "20924"     "20930"     "24075"     "216185"   
## [181] "66464"     "99730"     "21341"     "21343"     "108143"    "102216272"
## [187] "21357"     "57813"     "56334"     "100862175" "22059"     "22088"    
## [193] "22171"     "22247"     "68134"     "236733"    "14479"     "22258"    
## [199] "66914"     "72749"     "330192"    "194309"    "22591"     "69020"    
## [205] "52696"    
## 
## $HALLMARK_G2M_CHECKPOINT
##   [1] "11350"     "11352"     "11702"     "100041585" "238247"    "94246"    
##   [7] "107503"    "22589"     "20878"     "20877"     "20871"     "12021"    
##  [13] "12051"     "11799"     "12190"     "12235"     "12237"     "26885"    
##  [19] "12412"     "12428"     "12442"     "12443"     "12444"     "12445"    
##  [25] "12449"     "12455"     "107995"    "12530"     "12531"     "217232"   
##  [31] "12544"     "23834"     "12545"     "12534"     "12567"     "12576"    
##  [37] "12580"     "72391"     "12615"     "229841"    "108000"    "27221"    
##  [43] "12649"     "234852"    "54124"     "624855"    "66197"     "13018"    
##  [49] "26965"     "26554"     "99375"     "72584"     "75717"     "27214"    
##  [55] "68278"     "53817"     "245474"    "13405"     "22288"     "13497"    
##  [61] "13486"     "21915"     "13555"     "242705"    "13557"     "104394"   
##  [67] "13559"     "13640"     "13645"     "105988"    "14030"     "26909"    
##  [73] "14056"     "14055"     "14088"     "67141"     "71375"     "27041"    
##  [79] "272551"    "14852"     "14853"     "15270"     "319173"    "621893"   
##  [85] "319176"    "319191"    "319162"    "232440"    "319171"    "15267"    
##  [91] "319192"    "319163"    "319164"    "319165"    "319166"    "319167"   
##  [97] "319168"    "319169"    "319170"    "665433"    "319172"    "51788"    
## [103] "77605"     "319184"    "68024"     "319179"    "319180"    "319181"   
## [109] "319183"    "319185"    "319186"    "319187"    "319188"    "319189"   
## [115] "78303"     "319182"    "319190"    "665596"    "665622"    "15251"    
## [121] "13819"     "15260"     "15361"     "111241"    "15364"     "15354"    
## [127] "619829"    "15331"     "100042405" "625514"    "115488195" "15366"    
## [133] "71653"     "11991"     "51810"     "209448"    "15481"     "15482"    
## [139] "193740"    "14828"     "15512"     "15511"     "15574"     "210554"   
## [145] "16201"     "20744"     "16319"     "15374"     "23924"     "231912"   
## [151] "16551"     "209737"    "207607"    "240641"    "110033"    "71819"    
## [157] "73804"     "16563"     "16571"     "16573"     "16582"     "16572"    
## [163] "16574"     "67956"     "76464"     "16647"     "100043906" "16211"    
## [169] "98386"     "16882"     "16906"     "16907"     "16905"     "56150"    
## [175] "65964"     "26416"     "19094"     "17118"     "17216"     "17215"    
## [181] "17218"     "17219"     "17268"     "17536"     "17345"     "17420"    
## [187] "17750"     "17748"     "17765"     "17865"     "17864"     "17869"    
## [193] "107771"    "50927"     "17975"     "67052"     "18005"     "70769"    
## [199] "18129"     "18128"     "18132"     "18131"     "107823"    "18193"    
## [205] "234135"    "101706"    "18141"     "78482"     "269966"    "108907"   
## [211] "18263"     "18286"     "26429"     "56452"     "18472"     "52033"    
## [217] "100710"    "71521"     "18817"     "20873"     "18854"     "18969"    
## [223] "18973"     "77782"     "233406"    "19076"     "27374"     "19134"    
## [229] "30939"     "19290"     "19291"     "26934"     "19357"     "19359"    
## [235] "19366"     "226525"    "69601"     "240057"    "19650"     "19651"    
## [241] "56275"     "102902673" "19891"     "73086"     "56613"     "60406"    
## [247] "50724"     "71514"     "20496"     "20495"     "20497"     "105727"   
## [253] "11987"     "11989"     "11988"     "20539"     "17127"     "17126"    
## [259] "20588"     "68094"     "24061"     "140557"    "14211"     "70099"    
## [265] "20641"     "20775"     "110809"    "14105"     "20382"     "245492"   
## [271] "268996"    "20842"     "20843"     "50878"     "20460"     "16765"    
## [277] "20937"     "56403"     "74326"     "21335"     "210106"    "21781"    
## [283] "21803"     "21887"     "21888"     "21885"     "21917"     "212999"   
## [289] "238799"    "21969"     "72960"     "21973"     "72119"     "20462"    
## [295] "22036"     "78733"     "22137"     "68612"     "77891"     "80914"    
## [301] "22245"     "19704"     "22427"     "103573"    "231386"   
## 
## $HALLMARK_APOPTOSIS
##   [1] "11518"     "27360"     "11519"     "72168"     "11732"     "16952"    
##   [7] "11820"     "11910"     "54140"     "12028"     "27061"     "12042"    
##  [13] "12048"     "12049"     "12125"     "12050"     "12111"     "12122"    
##  [19] "12124"     "11796"     "11797"     "17951"     "17952"     "17940"    
##  [25] "17948"     "171543"    "12156"     "12177"     "100043324" "12189"    
##  [31] "12227"     "436199"    "194735"    "12226"     "12228"     "12362"    
##  [37] "12366"     "12367"     "12363"     "12368"     "12369"     "12370"    
##  [43] "12371"     "12389"     "12427"     "12443"     "12444"     "12445"    
##  [49] "12475"     "12481"     "12494"     "12182"     "12505"     "12515"    
##  [55] "12531"     "12566"     "12575"     "12576"     "12633"     "12759"    
##  [61] "12914"     "328572"    "107869"    "12387"     "16480"     "74256"    
##  [67] "223453"    "65111"     "13179"     "13198"     "13347"     "66593"    
##  [73] "15502"     "100037258" "74006"     "99586"     "13595"     "13655"    
##  [79] "13730"     "13807"     "433182"    "13806"     "13808"     "13866"    
##  [85] "13869"     "13649"     "13867"     "13874"     "225363"    "14061"    
##  [91] "14062"     "14102"     "79201"     "14103"     "14149"     "235180"   
##  [97] "13197"     "23882"     "17873"     "14528"     "14676"     "14775"    
## [103] "14778"     "75512"     "14780"     "625249"    "227753"    "20259"    
## [109] "11567"     "22349"     "14782"     "14863"     "14864"     "14867"    
## [115] "14862"     "14865"     "14866"     "68312"     "14919"     "245650"   
## [121] "14958"     "15234"     "97165"     "15368"     "15507"     "15937"    
## [127] "66141"     "68713"     "80876"     "74482"     "213002"    "69147"    
## [133] "73835"     "15977"     "15979"     "16004"     "16012"     "16173"    
## [139] "16175"     "16176"     "16193"     "16362"     "57444"     "68048"    
## [145] "229504"    "16476"     "16477"     "16478"     "16668"     "16842"    
## [151] "16854"     "16905"     "16906"     "16907"     "17022"     "228355"   
## [157] "17210"     "17314"     "17390"     "18003"     "380684"    "18040"    
## [163] "18479"     "18481"     "224105"    "18569"     "18596"     "18595"    
## [169] "18611"     "18791"     "18796"     "18797"     "18798"     "18795"    
## [175] "229791"    "58801"     "225849"    "26932"     "19058"     "19059"    
## [181] "19063"     "18646"     "19164"     "19165"     "14083"     "19401"    
## [187] "218772"    "19411"     "19697"     "67442"     "11852"     "214952"   
## [193] "59040"     "24014"     "19877"     "19878"     "20229"     "20230"    
## [199] "235293"    "20515"     "20516"     "17131"     "17130"     "20655"    
## [205] "20656"     "20740"     "20739"     "18412"     "21354"     "21808"    
## [211] "21814"     "21857"     "21858"     "21859"     "21926"     "27279"    
## [217] "22035"     "21973"     "12257"     "56338"     "22334"     "22390"    
## [223] "11798"    
## 
## $HALLMARK_NOTCH_SIGNALING
##  [1] "226548"    "109689"    "216869"    "12443"     "12444"     "12445"    
##  [7] "26965"     "13388"     "54485"     "14357"     "207521"    "74198"    
## [13] "103583"    "12234"     "14362"     "57265"     "14369"     "14367"    
## [19] "14370"     "15205"     "56198"     "15214"     "16449"     "16450"    
## [25] "14534"     "18519"     "16848"     "17305"     "19719"     "270118"   
## [31] "18128"     "18129"     "18132"     "18131"     "19015"     "18750"    
## [37] "18751"     "18752"     "19165"     "66340"     "56438"     "100043674"
## [43] "19823"     "60406"     "50724"     "21402"     "54613"     "21416"    
## [49] "21415"     "22413"     "22418"     "22419"    
## 
## $HALLMARK_ADIPOGENESIS
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "74610"     "52538"     "11363"     "11364"     "11409"     "104112"   
##  [13] "11429"     "11430"     "11512"     "11513"     "11514"     "224129"   
##  [19] "104110"    "210044"    "432530"    "246747"    "11450"     "68465"    
##  [25] "28169"     "68262"     "26926"     "11637"     "11669"     "72535"    
##  [31] "19378"     "26358"     "11668"     "56847"     "11674"     "79459"    
##  [37] "353204"    "11600"     "57875"     "11804"     "11816"     "11836"    
##  [43] "109880"    "110157"    "11861"     "56298"     "73991"     "109168"   
##  [49] "11933"     "28080"     "116848"    "12039"     "94044"     "12053"    
##  [55] "12266"     "12268"     "15139"     "12359"     "19285"     "20324"    
##  [61] "109042"    "12452"     "12476"     "68498"     "66205"     "12491"    
##  [67] "12580"     "103172"    "12675"     "16150"     "12683"     "14311"    
##  [73] "69574"     "66588"     "12819"     "12822"     "12826"     "12829"    
##  [79] "12828"     "107581"    "53867"     "71355"     "94216"     "373864"   
##  [85] "12824"     "12825"     "12827"     "12830"     "12831"     "12832"    
##  [91] "12836"     "12842"     "12843"     "230027"    "52064"     "67914"    
##  [97] "12861"     "66142"     "78174"     "12868"     "12896"     "12908"    
## [103] "12647"     "12974"     "71832"     "66445"     "13120"     "13119"    
## [109] "81906"     "666168"    "13118"     "230639"    "435802"    "100040843"
## [115] "13117"     "277753"    "13171"     "13202"     "67460"     "13350"    
## [121] "13360"     "66375"     "209183"    "216820"    "235339"    "13382"    
## [127] "27362"     "66148"     "67171"     "51798"     "93747"     "232089"   
## [133] "170439"    "18606"     "209558"    "18605"     "13850"     "26379"    
## [139] "23943"     "110826"    "11770"     "18857"     "21884"     "14085"    
## [145] "14366"     "23881"     "13197"     "23882"     "74185"     "66092"    
## [151] "14732"     "102247"    "231510"    "14571"     "268566"    "14778"    
## [157] "75512"     "14780"     "625249"    "17713"     "15107"     "227095"   
## [163] "80888"     "15926"     "269951"    "67834"     "15929"     "243996"   
## [169] "15979"     "76614"     "16404"     "16400"     "209378"    "16443"    
## [175] "20403"     "67767"     "16775"     "16776"     "16774"     "16846"    
## [181] "16880"     "18414"     "16890"     "14792"     "16956"     "17001"    
## [187] "225028"    "26412"     "26411"     "399510"    "72039"     "17448"    
## [193] "17436"     "109264"    "107029"    "23945"     "66447"     "108958"   
## [199] "77037"     "27395"     "67247"     "66112"     "56428"     "107589"   
## [205] "109019"    "69917"     "68202"     "70316"     "102634451" "66916"    
## [211] "68349"     "69721"     "18107"     "18108"     "27047"     "18405"    
## [217] "18406"     "18407"     "18569"     "18618"     "56273"     "170768"   
## [223] "18640"     "18639"     "270198"    "18641"     "72157"     "226041"   
## [229] "102693"    "16922"     "223775"    "18712"     "11520"     "18984"    
## [235] "19016"     "19043"     "232941"    "108954"    "11757"     "50907"    
## [241] "69956"     "19218"     "110391"    "19376"     "13476"     "70335"    
## [247] "57264"     "57263"     "67442"     "66878"     "67809"     "29864"    
## [253] "68750"     "20168"     "68653"     "20778"     "12492"     "20280"    
## [259] "67680"     "66052"     "20509"     "116914"    "20514"     "13358"    
## [265] "27376"     "26457"     "26569"     "330064"    "217430"    "20618"    
## [271] "20655"     "20411"     "268301"    "13602"     "59010"     "16651"    
## [277] "20850"     "20851"     "13830"     "229277"    "56451"     "20887"    
## [283] "53315"     "57429"     "57430"     "215895"    "21351"     "21353"    
## [289] "21881"     "74419"     "83553"     "22057"     "22117"     "246221"   
## [295] "22190"     "22187"     "56085"     "54609"     "94232"     "22245"    
## [301] "80914"     "22228"     "66152"     "66594"     "22273"     "22272"    
## [307] "22340"     "22628"     "22629"    
## 
## $HALLMARK_ESTROGEN_RESPONSE_EARLY
##   [1] "268860"    "27410"     "381072"    "268379"    "67928"     "320631"   
##   [7] "233810"    "54608"     "226251"    "231148"    "319713"    "432530"   
##  [13] "11514"     "11512"     "11515"     "27360"     "11518"     "11519"    
##  [19] "17355"     "93736"     "11640"     "67689"     "73458"     "621603"   
##  [25] "23802"     "71790"     "11828"     "11835"     "11839"     "56350"    
##  [31] "142688"    "14595"     "12017"     "58208"     "14025"     "12043"    
##  [37] "20893"     "233016"    "76459"     "12308"     "12311"     "54598"    
##  [43] "76025"     "12398"     "12395"     "12396"     "22403"     "12443"    
##  [49] "12444"     "12445"     "12505"     "12614"     "53883"     "107934"   
##  [55] "212862"    "99712"     "12700"     "53624"     "69454"     "20315"    
##  [61] "232174"    "546726"    "97998"     "13360"     "71412"     "28200"    
##  [67] "20148"     "50768"     "243362"    "236920"    "67117"     "13655"    
##  [73] "13709"     "13710"     "54326"     "68801"     "71946"     "77411"    
##  [79] "207920"    "98952"     "223254"    "227377"    "14104"     "69169"    
##  [85] "14137"     "14200"     "14228"     "14229"     "286940"    "192176"   
##  [91] "68794"     "14281"     "17300"     "14234"     "14302"     "14389"    
##  [97] "14585"     "14609"     "414089"    "11605"     "268527"    "381157"   
## [103] "15205"     "15460"     "80888"     "16001"     "16010"     "50905"    
## [109] "16195"     "16324"     "16323"     "101490"    "229504"    "68048"    
## [115] "57444"     "217837"    "16452"     "54721"     "16451"     "71529"    
## [121] "241769"    "16529"     "193796"    "76804"     "230674"    "21847"    
## [127] "16600"     "16598"     "69540"     "16663"     "16665"     "16668"    
## [133] "16669"     "16691"     "16763"     "16206"     "269473"    "320398"   
## [139] "17762"     "328329"    "56527"     "17776"     "76199"     "327987"   
## [145] "23989"     "243864"    "266815"    "75007"     "171531"    "77015"    
## [151] "223726"    "381269"    "17695"     "17829"     "17863"     "18432"    
## [157] "17864"     "17865"     "17869"     "107771"    "226101"    "26903"    
## [163] "83762"     "78914"     "78286"     "260315"    "215690"    "17965"    
## [169] "20602"     "20185"     "18166"     "268903"    "56488"     "237082"   
## [175] "56177"     "229759"    "99543"     "13603"     "107586"    "18426"    
## [181] "18442"     "57385"     "23972"     "23971"     "53318"     "59020"    
## [187] "18631"     "18667"     "225845"    "58801"     "27205"     "105675"   
## [193] "76453"     "64292"     "19329"     "106572"    "19334"     "268480"   
## [199] "19401"     "218772"    "19411"     "19419"     "240168"    "225182"   
## [205] "52250"     "225362"    "19713"     "66270"     "73296"     "11854"    
## [211] "20112"     "110651"    "20111"     "67071"     "107094"    "20778"    
## [217] "12492"     "20276"     "67815"     "103655"    "380683"    "20347"    
## [223] "55948"     "24056"     "20439"     "20501"     "116914"    "20509"    
## [229] "20510"     "55963"     "20520"     "56517"     "30805"     "94249"    
## [235] "238384"    "13521"     "231583"    "26458"     "225579"    "20525"    
## [241] "20528"     "20527"     "224674"    "56857"     "106957"    "11988"    
## [247] "11989"     "11987"     "20539"     "26941"     "65962"     "69226"    
## [253] "20675"     "20681"     "20682"     "20856"     "54200"     "100043194"
## [259] "76971"     "638251"    "434121"    "629203"    "434264"    "629219"   
## [265] "20859"     "225115"    "319613"    "20972"     "171180"    "74694"    
## [271] "21420"     "21784"     "21786"     "228839"    "21817"     "331046"   
## [277] "207596"    "229595"    "21844"     "24001"     "99929"     "27375"    
## [283] "209497"    "140765"    "50528"     "22057"     "21983"     "21987"    
## [289] "244152"    "230603"    "73710"     "22151"     "22154"     "22153"    
## [295] "227613"    "22152"     "545486"    "67951"     "22234"     "22248"    
## [301] "106840"    "22393"     "211652"    "52357"     "22433"     "22673"    
## 
## $HALLMARK_ESTROGEN_RESPONSE_LATE
##   [1] "27410"     "381072"    "268379"    "67928"     "320631"    "233810"   
##   [7] "54608"     "93732"     "27360"     "11518"     "11519"     "17355"    
##  [13] "93736"     "23795"     "403205"    "11671"     "67689"     "73458"    
##  [19] "621603"    "23802"     "71790"     "11839"     "56350"     "17172"    
##  [25] "11898"     "381290"    "67972"     "11941"     "320707"    "12017"    
##  [31] "53314"     "12043"     "233016"    "12228"     "76459"     "12349"    
##  [37] "56808"     "12293"     "12311"     "54598"     "12389"     "22403"    
##  [43] "12427"     "12443"     "12444"     "12445"     "12505"     "12527"    
##  [49] "107995"    "23834"     "12550"     "12560"     "12561"     "53883"    
##  [55] "12614"     "107934"    "212862"    "99712"     "68947"     "71367"    
##  [61] "12700"     "12709"     "12715"     "69454"     "12864"     "102640946"
##  [67] "12876"     "20315"     "57266"     "232174"    "546726"    "64385"    
##  [73] "106648"    "631304"    "72054"     "70101"     "170716"    "677156"   
##  [79] "320997"    "666168"    "208285"    "435802"    "100040843" "13117"    
##  [85] "67880"     "12409"     "13360"     "71412"     "28200"     "71228"    
##  [91] "13418"     "30045"     "13537"     "67117"     "13655"     "68801"    
##  [97] "54326"     "13731"     "110826"    "16592"     "98952"     "223254"   
## [103] "227377"    "14137"     "14184"     "14228"     "14229"     "286940"   
## [109] "192176"    "68794"     "14281"     "17300"     "14234"     "14302"    
## [115] "14419"     "74246"     "22122"     "272551"    "14620"     "11605"    
## [121] "76854"     "15360"     "26557"     "15452"     "15460"     "18415"    
## [127] "80888"     "15902"     "269951"    "15926"     "16010"     "209268"   
## [133] "50905"     "16195"     "114663"    "57444"     "68048"     "229504"   
## [139] "217837"    "16451"     "54721"     "16452"     "16529"     "19348"    
## [145] "16600"     "16598"     "69540"     "56538"     "16663"     "16665"    
## [151] "16669"     "16782"     "226519"    "16795"     "228366"    "217325"   
## [157] "16897"     "54135"     "17002"     "71775"     "22041"     "26415"    
## [163] "29857"     "17762"     "17242"     "17294"     "56335"     "74407"    
## [169] "243864"    "266815"    "17434"     "17863"     "226101"    "26903"    
## [175] "83762"     "17937"     "17965"     "20602"     "20185"     "56183"    
## [181] "18166"     "268903"    "56488"     "237082"    "56177"     "229759"   
## [187] "13603"     "107586"    "18426"     "23972"     "23971"     "18546"    
## [193] "18569"     "53318"     "59020"     "64058"     "18667"     "56460"    
## [199] "225845"    "56096"     "20873"     "235611"    "140571"    "18846"    
## [205] "18845"     "18844"     "140570"    "67784"     "243743"    "105675"   
## [211] "19088"     "19087"     "19116"     "76453"     "19218"     "64292"    
## [217] "15170"     "106572"    "19334"     "54189"     "268480"    "225182"   
## [223] "19713"     "69724"     "20112"     "110651"    "20111"     "67071"    
## [229] "20202"     "545541"    "20778"     "12492"     "20276"     "56788"    
## [235] "18690"     "20347"     "20704"     "20703"     "20701"     "20700"    
## [241] "20702"     "68348"     "194604"    "16625"     "20716"     "271047"   
## [247] "20717"     "238393"    "20714"     "20715"     "74069"     "628900"   
## [253] "238395"    "268591"    "55948"     "20393"     "20439"     "20501"    
## [259] "55963"     "20520"     "56517"     "30805"     "94249"     "238384"   
## [265] "13521"     "231583"    "26458"     "225579"    "63959"     "56017"    
## [271] "20539"     "26941"     "65962"     "71982"     "20322"     "20675"    
## [277] "20681"     "20682"     "19143"     "20446"     "20460"     "54200"    
## [283] "100043194" "76971"     "638251"    "434121"    "629203"    "434264"   
## [289] "629219"    "20859"     "21420"     "21784"     "21786"     "21789"    
## [295] "21823"     "21844"     "24001"     "27375"     "140765"    "50528"    
## [301] "21924"     "22057"     "21973"     "21983"     "21987"     "17229"    
## [307] "100503895" "72169"     "66109"     "22117"     "246221"    "22235"    
## [313] "22249"     "208898"    "22393"     "22433"     "74335"     "22695"    
## 
## $HALLMARK_ANDROGEN_RESPONSE
##   [1] "239273"    "54608"     "74205"     "50790"     "109711"    "60595"    
##   [7] "11474"     "11472"     "11504"     "23794"     "30806"     "101401"   
##  [13] "235130"    "223838"    "56436"     "100043022" "83397"     "11651"    
##  [19] "11652"     "23797"     "56847"     "19378"     "26358"     "11668"    
##  [25] "72535"     "11669"     "11732"     "66884"     "71371"     "12007"    
##  [31] "12010"     "14595"     "12167"     "12166"     "207565"    "55984"    
##  [37] "12443"     "12444"     "12445"     "218294"    "12571"     "72155"    
##  [43] "13167"     "74754"     "27362"     "13714"     "192657"    "68801"    
##  [49] "54326"     "76267"     "60527"     "56473"     "228151"    "14229"    
##  [55] "14679"     "14677"     "14678"     "333433"    "14555"     "14782"    
##  [61] "60596"     "14958"     "73998"     "15357"     "208715"    "15360"    
##  [67] "26557"     "15446"     "66065"     "319554"    "234515"    "269180"   
##  [73] "231070"    "544963"    "404710"    "16410"     "241226"    "16402"    
##  [79] "16612"     "16619"     "16615"     "16624"     "16623"     "16622"    
##  [85] "16617"     "16616"     "16613"     "13646"     "13648"     "18048"    
##  [91] "18050"     "16618"     "13647"     "16669"     "16691"     "16880"    
##  [97] "18414"     "70361"     "235416"    "17132"     "16658"     "17152"    
## [103] "56542"     "17761"     "17289"     "26362"     "67268"     "67938"    
## [109] "27057"     "17988"     "59007"     "18095"     "18813"     "56376"    
## [115] "67399"     "109785"    "56469"     "17344"     "229615"    "19012"    
## [121] "65112"     "19229"     "24000"     "19250"     "19341"     "19342"    
## [127] "110651"    "20111"     "67071"     "20112"     "107094"    "20229"    
## [133] "20250"     "20249"     "30049"     "329065"    "69608"     "218811"   
## [139] "20363"     "20393"     "13521"     "231583"    "67760"     "20603"    
## [145] "671878"    "20322"     "76687"     "76219"     "76976"     "30051"    
## [151] "20807"     "66384"     "22184"     "22183"     "117167"    "53416"    
## [157] "108737"    "71817"     "77975"     "50528"     "140765"    "106869"   
## [163] "21985"     "21807"     "107652"    "22196"     "56228"     "30960"    
## [169] "22596"     "14375"     "229055"    "328365"    "52915"    
## 
## $HALLMARK_MYOGENESIS
##   [1] "226251"    "231148"    "319713"    "11423"     "14081"     "433256"   
##   [7] "216739"    "11459"     "11468"     "11464"     "11475"     "238880"   
##  [13] "11461"     "11472"     "60595"     "109711"    "11474"     "11489"    
##  [19] "11492"     "11515"     "11568"     "55987"     "56264"     "77559"    
##  [25] "11603"     "11636"     "11652"     "23797"     "56642"     "107765"   
##  [31] "78321"     "23796"     "11815"     "11820"     "11937"     "11938"    
##  [37] "53313"     "54411"     "12017"     "12062"     "20893"     "30948"    
##  [43] "58226"     "12291"     "239556"    "12299"     "12323"     "108058"   
##  [49] "12325"     "12322"     "12372"     "12373"     "12391"     "12491"    
##  [55] "12554"     "12575"     "11537"     "11435"     "11443"     "11449"    
##  [61] "12709"     "12715"     "76722"     "12716"     "12759"     "71994"    
##  [67] "12797"     "12819"     "12822"     "12842"     "12829"     "12828"    
##  [73] "107581"    "53867"     "71355"     "94216"     "373864"    "12824"    
##  [79] "12825"     "12826"     "12827"     "12830"     "12831"     "12832"    
##  [85] "12836"     "12843"     "74320"     "12834"     "12833"     "12835"    
##  [91] "68553"     "245026"    "12862"     "12865"     "12908"     "12647"    
##  [97] "12955"     "13009"     "13019"     "13143"     "13144"     "76954"    
## [103] "209773"    "13346"     "19132"     "22352"     "13405"     "22288"    
## [109] "13497"     "13400"     "13527"     "13528"     "13644"     "13682"    
## [115] "13681"     "53975"     "13808"     "13845"     "270190"    "13844"    
## [121] "13846"     "13835"     "13840"     "13842"     "13848"     "13841"    
## [127] "13836"     "13838"     "13837"     "13839"     "13867"     "13869"    
## [133] "13649"     "13866"     "14077"     "12140"     "14074"     "110196"   
## [139] "14173"     "14199"     "14202"     "14226"     "14248"     "54601"    
## [145] "14313"     "56188"     "14387"     "69983"     "93739"     "17873"    
## [151] "14613"     "14681"     "14778"     "75512"     "14780"     "227753"   
## [157] "20259"     "11567"     "22349"     "15200"     "15184"     "56233"    
## [163] "208727"    "15464"     "69253"     "80888"     "15982"     "15983"    
## [169] "16000"     "16009"     "16011"     "29817"     "16404"     "16400"    
## [175] "16412"     "192897"    "16419"     "16416"     "16420"     "16510"    
## [181] "238271"    "16511"     "170738"    "192775"    "16582"     "16581"    
## [187] "12224"     "16773"     "16795"     "228366"    "24131"     "14245"    
## [193] "64899"     "16985"     "29857"     "26415"     "100732"    "17189"    
## [199] "17258"     "17260"     "17261"     "17259"     "17532"     "17868"    
## [205] "233199"    "109272"    "53311"     "68753"     "17878"     "17879"    
## [211] "17884"     "17880"     "17886"     "17883"     "17882"     "17885"    
## [217] "544791"    "71960"     "77579"     "140781"    "668940"    "17888"    
## [223] "17901"     "17906"     "17907"     "17897"     "17896"     "216459"   
## [229] "17904"     "17898"     "107589"    "17913"     "17928"     "17929"    
## [235] "17930"     "242702"    "59011"     "78286"     "260315"    "215690"   
## [241] "17967"     "17968"     "18125"     "18126"     "18127"     "18128"    
## [247] "18129"     "18104"     "18105"     "77090"     "18563"     "83679"    
## [253] "75216"     "67399"     "18642"     "56421"     "18641"     "56012"    
## [259] "18648"     "18693"     "18767"     "140570"    "18846"     "18845"    
## [265] "18844"     "235611"    "140571"    "67784"     "243743"    "68507"    
## [271] "327814"    "233977"    "53412"     "19122"     "19165"     "19223"    
## [277] "19245"     "19293"     "19309"     "110078"    "110095"    "19645"    
## [283] "52250"     "225362"    "19769"     "19762"     "20190"     "20192"    
## [289] "20191"     "20250"     "20249"     "30049"     "329065"    "30953"    
## [295] "100505386" "20391"     "24052"     "24053"     "244431"    "20399"    
## [301] "50795"     "212531"    "56726"     "64383"     "102857"    "66402"    
## [307] "29856"     "276829"    "20657"     "20411"     "20410"     "20692"    
## [313] "30051"     "11790"     "20698"     "20740"     "20739"     "16651"    
## [319] "20856"     "225115"    "20973"     "21345"     "21393"     "21679"    
## [325] "21676"     "21803"     "21924"     "21925"     "21952"     "21953"    
## [331] "21954"     "21955"     "21956"     "21957"     "21987"     "22004"    
## [337] "59069"     "621054"    "22084"     "22354"     "97064"    
## 
## $HALLMARK_PROTEIN_SECRETION
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "11487"     "66471"     "68981"     "11765"     "71770"     "11764"    
##  [13] "11773"     "232910"    "11774"     "11775"     "11777"     "213827"   
##  [19] "11840"     "11841"     "66251"     "211673"    "99371"     "99889"    
##  [25] "11928"     "98660"     "232975"    "11944"     "27222"     "192113"   
##  [31] "110935"    "11966"     "108664"    "11977"     "11979"     "12068"    
##  [37] "12176"     "12390"     "12512"     "12725"     "12727"     "211286"   
##  [43] "12757"     "74325"     "67300"     "76332"     "70349"     "50797"    
##  [49] "59042"     "13032"     "74006"     "320615"    "70028"     "13518"    
##  [55] "13649"     "13869"     "13866"     "13867"     "66366"     "14420"    
##  [61] "107338"    "11605"     "14683"     "14680"     "54214"     "56494"    
##  [67] "15893"     "16004"     "16561"     "16560"     "16668"     "16784"    
##  [73] "70361"     "235416"    "17113"     "26413"     "26417"     "67074"    
##  [79] "108124"    "17957"     "108123"    "320634"    "16330"     "18484"    
##  [85] "19063"     "68365"     "19334"     "106572"    "59021"     "76338"    
##  [91] "271457"    "56382"     "67830"     "110651"    "20111"     "67071"    
##  [97] "20112"     "107767"    "24045"     "69938"     "20333"     "69608"    
## [103] "218811"    "69162"     "208449"    "20404"     "20405"     "20408"    
## [109] "20619"     "67804"     "20655"     "16651"     "20844"     "100226"   
## [115] "228960"    "53331"     "68581"     "100042773" "56334"     "100862175"
## [121] "72736"     "71943"     "21985"     "22088"     "216350"    "56041"    
## [127] "22319"     "53330"     "20955"     "22365"     "20479"     "116733"   
## [133] "77929"     "56418"     "26951"    
## 
## $HALLMARK_INTERFERON_ALPHA_RESPONSE
##   [1] "56417"     "12010"     "74481"     "69550"     "317677"    "50908"    
##   [7] "12362"     "12370"     "54199"     "16423"     "16149"     "22169"    
##  [13] "74157"     "12799"     "12977"     "15945"     "56066"     "234311"   
##  [19] "80861"     "19106"     "13709"     "108670"    "14469"     "14468"    
##  [25] "229900"    "55932"     "236573"    "76074"     "100702"    "634650"   
##  [31] "626578"    "17472"     "66355"     "229003"    "67138"     "73998"    
##  [37] "15013"     "15040"     "14972"     "14990"     "15006"     "14964"    
##  [43] "14991"     "15007"     "15018"     "630294"    "14963"     "14985"    
##  [49] "110696"    "333715"    "224753"    "224754"    "399549"    "667977"   
##  [55] "100529082" "240095"    "15015"     "110557"    "15043"     "15039"    
##  [61] "224761"    "14997"     "224756"    "15024"     "14980"     "15019"    
##  [67] "110558"    "52668"     "217845"    "76933"     "65972"     "70110"    
##  [73] "99899"     "15061"     "71586"     "15958"     "15959"     "667370"   
##  [79] "68713"     "66141"     "74482"     "80876"     "213002"    "69147"    
##  [85] "73835"     "16168"     "16190"     "16196"     "16362"     "16363"    
##  [91] "54123"     "16391"     "100038882" "57444"     "68048"     "229504"   
##  [97] "239739"    "66988"     "19039"     "67168"     "17069"     "17454"    
## [103] "73711"     "17858"     "17857"     "211329"    "170719"    "64685"    
## [109] "53312"     "23960"     "246730"    "243262"    "100535"    "114643"   
## [115] "246729"    "231699"    "23961"     "231655"    "23962"     "72075"    
## [121] "243771"    "547253"    "80285"     "22038"     "18828"     "78459"    
## [127] "71701"     "19124"     "19167"     "16913"     "16912"     "19186"    
## [133] "19188"     "621823"    "192656"    "268749"    "58185"     "67775"    
## [139] "209086"    "20343"     "246696"    "109032"    "434484"    "20684"    
## [145] "624083"    "101056250" "102638047" "102633783" "100041057" "671917"   
## [151] "546061"    "677525"    "20847"     "21354"     "100121"    "212943"   
## [157] "74645"     "68487"     "231712"    "74735"     "20821"     "217069"   
## [163] "67606"     "22670"     "224762"    "667823"    "319236"    "94088"    
## [169] "209387"    "20128"     "76681"     "94094"     "434218"    "434219"   
## [175] "56338"     "74153"     "22201"     "56791"     "24110"     "22375"    
## 
## $HALLMARK_INTERFERON_GAMMA_RESPONSE
##   [1] "56417"     "71939"     "71371"     "11861"     "319974"    "12010"    
##   [7] "242248"    "74481"     "12183"     "69550"     "12226"     "194735"   
##  [13] "436199"    "12227"     "667277"    "50909"     "66686"     "317677"   
##  [19] "50908"     "12362"     "12367"     "12363"     "12369"     "12370"    
##  [25] "20293"     "20296"     "20292"     "20306"     "20304"     "60533"    
##  [31] "12494"     "12182"     "21939"     "12515"     "16149"     "12524"    
##  [37] "12575"     "14962"     "12628"     "214403"    "545366"    "12265"    
##  [43] "14747"     "22169"     "74157"     "12984"     "12983"     "16190"    
##  [49] "15945"     "56066"     "17329"     "230073"    "234311"    "80861"    
##  [55] "19106"     "66892"     "108670"    "14102"     "79201"     "14129"    
##  [61] "14190"     "14293"     "14289"     "14294"     "14291"     "14290"    
##  [67] "321020"    "55932"     "229900"    "236573"    "76074"     "100702"   
##  [73] "634650"    "626578"    "17472"     "14528"     "110168"    "14938"    
##  [79] "229003"    "67138"     "73998"     "15251"     "13819"     "15006"    
##  [85] "15013"     "14972"     "15040"     "14990"     "15007"     "15018"    
##  [91] "14964"     "14991"     "14963"     "15015"     "110557"    "630294"   
##  [97] "667977"    "240095"    "15043"     "14985"     "110696"    "333715"   
## [103] "224753"    "224754"    "399549"    "100529082" "15039"     "224756"   
## [109] "15024"     "224761"    "14997"     "69717"     "14980"     "15019"    
## [115] "110558"    "14998"     "14960"     "381091"    "14969"     "15894"    
## [121] "15898"     "15930"     "52668"     "217845"    "76933"     "65972"    
## [127] "70110"     "99899"     "15061"     "71586"     "667373"    "112419"   
## [133] "15957"     "15958"     "15959"     "667370"    "80876"     "66141"    
## [139] "68713"     "74482"     "213002"    "69147"     "73835"     "15976"    
## [145] "16154"     "16168"     "16169"     "16068"     "16185"     "16193"    
## [151] "16196"     "16362"     "16363"     "16364"     "27056"     "54123"    
## [157] "15900"     "16391"     "100038882" "57444"     "68048"     "229504"   
## [163] "66307"     "16421"     "16412"     "16414"     "16452"     "54721"    
## [169] "16451"     "27007"     "381816"    "66988"     "50523"     "16798"    
## [175] "16822"     "19039"     "17069"     "70082"     "72925"     "71664"    
## [181] "70152"     "380975"    "668178"    "554292"    "17750"     "17748"    
## [187] "17768"     "78388"     "17858"     "17857"     "17874"     "59027"    
## [193] "17979"     "17978"     "18033"     "18034"     "18035"     "434341"   
## [199] "64685"     "107607"    "71805"     "246728"    "246727"    "231655"   
## [205] "23962"     "72075"     "140795"    "243771"    "547253"    "18578"    
## [211] "238871"    "110385"    "18577"     "67245"     "93834"     "56421"    
## [217] "18641"     "18642"     "18712"     "223775"    "18783"     "22038"    
## [223] "18828"     "78459"     "18854"     "667034"    "18950"     "71701"    
## [229] "19166"     "19167"     "19171"     "26445"     "16913"     "16912"    
## [235] "19186"     "19188"     "621823"    "19225"     "19224"     "19246"    
## [241] "19255"     "15170"     "192786"    "76089"     "24105"     "19766"    
## [247] "192656"    "672511"    "268749"    "58185"     "67775"     "209086"   
## [253] "56045"     "209588"    "58210"     "20344"     "12258"     "75345"    
## [259] "246696"    "12703"     "12702"     "20656"     "109032"    "434484"   
## [265] "20684"     "624083"    "101056250" "102638047" "102633783" "100041057"
## [271] "671917"    "546061"    "677525"    "66552"     "237958"    "73218"    
## [277] "109552"    "16651"     "20454"     "20452"     "20846"     "20848"    
## [283] "20849"     "20847"     "21354"     "21356"     "100121"    "21928"    
## [289] "21929"     "21930"     "22035"     "30934"     "30931"     "231712"   
## [295] "74735"     "20821"     "217069"    "67606"     "22670"     "224762"   
## [301] "56338"     "56791"     "22271"     "76654"     "24110"     "53620"    
## [307] "22320"     "22329"     "22375"     "327959"    "16963"     "58203"    
## [313] "98999"    
## 
## $HALLMARK_APICAL_JUNCTION
##   [1] "11459"     "11468"     "11464"     "11475"     "238880"    "11461"    
##   [7] "11465"     "109711"    "60595"     "11474"     "11472"     "11490"    
##  [13] "23792"     "11488"     "11502"     "23794"     "11504"     "30806"    
##  [19] "235130"    "11548"     "11550"     "11652"     "23797"     "11688"    
##  [25] "11686"     "23801"     "11689"     "11705"     "229715"    "105827"   
##  [31] "73341"     "54126"     "76709"     "232975"    "27222"     "192113"   
##  [37] "11928"     "98660"     "11944"     "14595"     "108100"    "12153"    
##  [43] "21892"     "24087"     "239857"    "57278"     "94332"     "12308"    
##  [49] "12331"     "69165"     "170779"    "170780"    "170786"    "170776"   
##  [55] "69142"     "70192"     "60533"     "102657"    "12490"     "12524"    
##  [61] "673094"    "12550"     "12560"     "12561"     "12552"     "12564"    
##  [67] "12565"     "12563"     "320873"    "215654"    "104010"    "23836"    
##  [73] "239096"    "241201"    "12555"     "227485"    "264064"    "78334"    
##  [79] "386463"    "99151"     "234407"    "269132"    "18417"     "56173"    
##  [85] "60363"     "56492"     "242653"    "12740"     "57255"     "12739"    
##  [91] "12741"     "54419"     "53624"     "54420"     "239931"    "56863"    
##  [97] "12798"     "12805"     "21367"     "269784"    "53870"     "244682"   
## [103] "18488"     "107581"    "12829"     "12828"     "53867"     "71355"    
## [109] "94216"     "373864"    "12824"     "12825"     "12826"     "12827"    
## [115] "12830"     "12831"     "12832"     "12836"     "12842"     "12843"    
## [121] "12821"     "12839"     "12840"     "12841"     "12908"     "12647"    
## [127] "224912"    "12385"     "12388"     "20312"     "69192"     "13204"    
## [133] "217207"    "64340"     "13383"     "23859"     "13385"     "53310"    
## [139] "13406"     "13505"     "13507"     "13506"     "13649"     "13869"    
## [145] "13866"     "13867"     "13822"     "269587"    "14026"     "20336"    
## [151] "14118"     "14119"     "68794"     "286940"    "192176"    "14086"    
## [157] "238021"    "23880"     "14431"     "14677"     "14678"     "14679"    
## [163] "14786"     "98053"     "15107"     "15461"     "15894"     "15898"    
## [169] "15896"     "78369"     "16151"     "16332"     "16331"     "231070"   
## [175] "16367"     "384783"    "16369"     "213119"    "319480"    "109700"   
## [181] "16398"     "16400"     "104099"    "16412"     "192897"    "83964"    
## [187] "16480"     "12387"     "16511"     "170738"    "192775"    "16660"    
## [193] "16671"     "71888"     "16672"     "16774"     "16780"     "16782"    
## [199] "226519"    "244864"    "100017"    "65970"     "17123"     "65964"    
## [205] "26412"     "225028"    "26411"     "399510"    "19094"     "26416"    
## [211] "26415"     "29857"     "17242"     "17390"     "17395"     "56217"    
## [217] "68481"     "14012"     "17698"     "19684"     "22350"     "192156"   
## [223] "77579"     "71960"     "17880"     "17886"     "17883"     "17882"    
## [229] "17879"     "17885"     "17884"     "544791"    "140781"    "668940"   
## [235] "17888"     "67938"     "67268"     "98932"     "58235"     "19294"    
## [241] "52118"     "58998"     "71740"     "320840"    "268890"    "68810"    
## [247] "18015"     "18016"     "269116"    "216856"    "192167"    "245537"   
## [253] "18175"     "17996"     "18188"     "18190"     "18191"     "18189"    
## [259] "93737"     "58220"     "57342"     "170736"    "18515"     "18516"    
## [265] "18514"     "75599"     "211712"    "54216"     "245578"    "170761"   
## [271] "18613"     "18643"     "18645"     "74769"     "18707"     "18706"    
## [277] "18710"     "18763"     "18803"     "234779"    "269643"    "52432"    
## [283] "71978"     "72930"     "19211"     "14083"     "19264"     "19354"    
## [289] "170758"    "218397"    "23912"     "20130"     "20163"     "20970"    
## [295] "20392"     "20416"     "110380"    "19261"     "668101"    "100038947"
## [301] "320832"    "381484"    "751864"    "54353"     "22784"     "20563"    
## [307] "20564"     "20562"     "20410"     "11790"     "20779"     "20909"    
## [313] "20963"     "22637"     "68188"     "381921"    "216965"    "330177"   
## [319] "21810"     "21827"     "21828"     "12845"     "21825"     "21838"    
## [325] "21843"     "21841"     "21872"     "21873"     "27375"     "242409"   
## [331] "18383"     "22029"     "56191"     "64930"     "64540"     "109246"   
## [337] "103733"    "103768"    "22323"     "22325"     "57257"     "22324"    
## [343] "22329"     "13003"     "22330"     "22371"     "17833"     "17831"    
## [349] "73178"     "22376"     "69847"     "22629"     "22628"     "22793"    
## 
## $HALLMARK_APICAL_SURFACE
##  [1] "11487"  "68465"  "226250" "432442" "11820"  "140494" "11975"  "21871" 
##  [9] "27060"  "54670"  "67331"  "14595"  "12189"  "54215"  "230872" "16328" 
## [17] "11630"  "20312"  "73379"  "13640"  "13846"  "13835"  "13840"  "13842" 
## [25] "270190" "13848"  "13841"  "13836"  "13838"  "13844"  "13837"  "13839" 
## [33] "13845"  "14252"  "14451"  "14462"  "14461"  "58991"  "14866"  "14864" 
## [41] "14867"  "68312"  "14862"  "14863"  "14865"  "15507"  "16185"  "16186" 
## [49] "17096"  "72434"  "17153"  "74762"  "320772" "56406"  "80883"  "171171"
## [57] "100102" "241035" "192190" "18793"  "56315"  "58176"  "237847" "269295"
## [65] "64706"  "268935" "56788"  "110380" "20521"  "20528"  "20525"  "142681"
## [73] "51795"  "72043"  "21838"  "242409"
## 
## $HALLMARK_HEDGEHOG_SIGNALING
##  [1] "11423"  "14766"  "27494"  "12569"  "12571"  "12614"  "53883"  "12804" 
##  [9] "12933"  "22240"  "12934"  "26757"  "23872"  "14632"  "15213"  "15214" 
## [17] "16728"  "269116" "12661"  "16825"  "17886"  "17880"  "17883"  "17882" 
## [25] "17879"  "17885"  "17884"  "544791" "71960"  "77579"  "140781" "668940"
## [33] "17888"  "18015"  "18096"  "14912"  "74561"  "319504" "18186"  "18187" 
## [41] "94190"  "18815"  "18854"  "19206"  "19207"  "218397" "104001" "20254" 
## [49] "20423"  "13363"  "16147"  "20562"  "20563"  "20564"  "21838"  "21885" 
## [57] "21888"  "21887"  "22253"  "107448" "107449" "22339"  "22359"  "16835" 
## 
## $HALLMARK_COMPLEMENT
##   [1] "11472"     "60595"     "109711"    "11474"     "11502"     "11552"    
##   [7] "56697"     "11727"     "11731"     "219033"    "503844"    "630952"   
##  [13] "11730"     "11747"     "11808"     "66809"     "80287"     "11812"    
##  [19] "11927"     "268936"    "223770"    "78783"     "12259"     "12262"    
##  [25] "667277"    "50909"     "66686"     "317677"    "50908"     "12263"    
##  [31] "12266"     "12268"     "15139"     "12279"     "230558"    "12274"    
##  [37] "109828"    "110382"    "12349"     "12313"     "12315"     "12314"    
##  [43] "12362"     "12367"     "12363"     "12369"     "12371"     "208650"   
##  [49] "20304"     "12491"     "21947"     "17221"     "13136"     "13137"    
##  [55] "333883"    "12509"     "72269"     "12554"     "12569"     "12608"    
##  [61] "14962"     "12628"     "214403"    "545366"    "12759"     "12827"    
##  [67] "107581"    "53867"     "71355"     "94216"     "373864"    "12824"    
##  [73] "12825"     "12826"     "12830"     "12831"     "12832"     "12836"    
##  [79] "12842"     "12843"     "12829"     "12828"     "12870"     "15203"    
##  [85] "70574"     "54381"     "12946"     "64817"     "12902"     "13007"    
##  [91] "13030"     "13032"     "13033"     "13036"     "13039"     "26898"    
##  [97] "56092"     "56094"     "56835"     "58518"     "70202"     "214639"   
## [103] "64139"     "104002"    "117066"    "218275"    "229445"    "13040"    
## [109] "13038"     "14825"     "20310"     "330122"    "20309"     "110197"   
## [115] "13139"     "380921"    "227333"    "210293"    "75974"     "238130"   
## [121] "208869"    "105445"    "13482"     "14089"     "240672"    "67603"    
## [127] "235584"    "69181"     "226419"    "13660"     "57440"     "98878"    
## [133] "259300"    "14058"     "14071"     "14061"     "14066"     "14067"    
## [139] "14068"     "14069"     "14127"     "14134"     "14133"     "14148"    
## [145] "14268"     "14360"     "22612"     "14191"     "20779"     "14462"    
## [151] "14461"     "227960"    "63985"     "63986"     "14678"     "14677"    
## [157] "14679"     "14693"     "14696"     "14688"     "14702"     "14710"    
## [163] "14723"     "54368"     "14571"     "14784"     "71520"     "14938"    
## [169] "14939"     "14940"     "14942"     "14944"     "14943"     "14941"    
## [175] "245839"    "17231"     "14945"     "15378"     "170638"    "26950"    
## [181] "193740"    "15511"     "15481"     "15482"     "14828"     "15512"    
## [187] "16193"     "16362"     "16363"     "54123"     "16409"     "381924"   
## [193] "16411"     "16424"     "16426"     "16452"     "54721"     "16451"    
## [199] "80906"     "56461"     "16563"     "73470"     "73804"     "16612"    
## [205] "16624"     "16619"     "16615"     "16623"     "16622"     "16617"    
## [211] "16616"     "16613"     "13646"     "13648"     "18048"     "18050"    
## [217] "16618"     "13647"     "16621"     "109821"    "70789"     "320858"   
## [223] "16784"     "66988"     "16818"     "17096"     "15162"     "16822"    
## [229] "16854"     "19141"     "16889"     "16971"     "16973"     "16974"    
## [235] "94217"     "228357"    "14725"     "16993"     "17002"     "71775"    
## [241] "22041"     "17133"     "17436"     "109264"    "107029"    "17381"    
## [247] "17386"     "17387"     "17388"     "17389"     "17391"     "17394"    
## [253] "83995"     "83996"     "27361"     "17751"     "18132"     "18128"    
## [259] "18129"     "18131"     "108078"    "381816"    "26875"     "100102"   
## [265] "18591"     "381511"    "18643"     "18645"     "18675"     "18706"    
## [271] "18707"     "74769"     "30955"     "320207"    "18712"     "223775"   
## [277] "18783"     "27226"     "18791"     "18793"     "56193"     "18815"    
## [283] "22038"     "18828"     "78459"     "19053"     "19052"     "56420"    
## [289] "67857"     "72461"     "72843"     "19072"     "18753"     "18761"    
## [295] "22074"     "114228"    "103964"    "22073"     "22072"     "100040233"
## [301] "436523"    "436522"    "67373"     "386551"    "77613"     "214531"   
## [307] "19164"     "16912"     "98710"     "110157"    "11836"     "109880"   
## [313] "19419"     "240168"    "78287"     "19671"     "56212"     "19822"    
## [319] "20196"     "20202"     "545541"    "20255"     "20704"     "20703"    
## [325] "20701"     "20700"     "20702"     "68348"     "194604"    "18788"    
## [331] "11905"     "18787"     "12258"     "16923"     "50721"     "94214"    
## [337] "20909"     "21789"     "21857"     "21858"     "71753"     "21929"    
## [343] "59025"     "14479"     "236733"    "22258"     "74112"     "84092"    
## [349] "70675"     "22376"     "73178"     "170750"    "21417"     "24136"    
## [355] "22762"    
## 
## $HALLMARK_UNFOLDED_PROTEIN_RESPONSE
##   [1] "56454"     "228998"    "27053"     "11910"     "11911"     "226641"   
##   [7] "11972"     "29810"     "23825"     "12317"     "20293"     "20296"    
##  [13] "20292"     "20306"     "12608"     "12611"     "69065"     "54124"    
##  [19] "624855"    "72068"     "53621"     "104625"    "231464"    "211948"   
##  [25] "74322"     "75901"     "70640"     "13191"     "74747"     "77591"    
##  [31] "245474"    "58233"     "27362"     "100037258" "234699"    "192193"   
##  [37] "13629"     "20624"     "13666"     "13665"     "13681"     "13682"    
##  [43] "53975"     "192170"    "668137"    "434080"    "13684"     "218268"   
##  [49] "13685"     "13688"     "208643"    "78943"     "26918"     "50527"    
##  [55] "66482"     "66583"     "50912"     "227715"    "109075"    "27998"    
##  [61] "50911"     "231997"    "233908"    "276919"    "56494"     "15270"    
##  [67] "319173"    "621893"    "319176"    "319191"    "319162"    "232440"   
##  [73] "319171"    "15267"     "319192"    "319163"    "319164"    "319165"   
##  [79] "319166"    "319167"    "319168"    "319169"    "319170"    "665433"   
##  [85] "319172"    "64209"     "22027"     "15516"     "15519"     "14828"    
##  [91] "15481"     "15482"     "15512"     "193740"    "15526"     "12282"    
##  [97] "105148"    "667373"    "112419"    "15957"     "16006"     "102462"   
## [103] "105785"    "66913"     "68137"     "16549"     "16573"     "16582"    
## [109] "16572"     "16574"     "67207"     "50783"     "17768"     "72198"    
## [115] "109019"    "69917"     "18044"     "18045"     "52530"     "70769"    
## [121] "75416"     "67134"     "18148"     "218693"    "74108"     "72599"    
## [127] "71853"     "66161"     "50907"     "107272"    "20044"     "27966"    
## [133] "231452"    "56529"     "66286"     "69162"     "28146"     "72661"    
## [139] "20416"     "55963"     "69048"     "20539"     "69019"     "76687"    
## [145] "76219"     "76976"     "67398"     "20818"     "107513"    "20856"    
## [151] "110960"    "272396"    "71807"     "381801"    "52808"     "218343"   
## [157] "22151"     "227613"    "73710"     "22154"     "22153"     "22152"    
## [163] "545486"    "67951"     "22339"     "22393"     "52639"     "74781"    
## [169] "22433"     "73192"     "68090"     "77254"     "22631"     "22642"    
## 
## $HALLMARK_PI3K_AKT_MTOR_SIGNALING
##   [1] "107476"    "100705"    "66713"     "74117"     "242894"    "210044"   
##   [7] "104110"    "11513"     "11514"     "11512"     "11651"     "11652"    
##  [13] "23797"     "67605"     "11773"     "11840"     "11841"     "192662"   
##  [19] "56378"     "11908"     "100040260" "12912"     "12283"     "69008"    
##  [25] "12317"     "12326"     "12534"     "12566"     "12567"     "12575"    
##  [31] "12576"     "12631"     "12632"     "67300"     "13001"     "12767"    
##  [37] "26377"     "13198"     "72349"     "13555"     "26940"     "13649"    
##  [43] "13869"     "13866"     "13867"     "13684"     "218268"    "14103"    
##  [49] "14171"     "14172"     "14179"     "67112"     "14177"     "14675"    
##  [55] "14672"     "14682"     "14699"     "66066"     "14784"     "71520"    
##  [61] "110355"    "320129"    "56637"     "15461"     "22027"     "15516"    
##  [67] "15519"     "16186"     "16189"     "266632"    "16439"     "16438"    
##  [73] "16440"     "16818"     "17096"     "15162"     "26397"     "26399"    
##  [79] "26409"     "26413"     "26417"     "26414"     "26419"     "26420"    
##  [85] "227743"    "17346"     "17347"     "17874"     "17973"     "18036"    
##  [91] "18049"     "107607"    "70584"     "228026"    "18643"     "18645"    
##  [97] "18710"     "18711"     "23988"     "241593"    "18741"     "66350"    
## [103] "18795"     "18797"     "18798"     "18796"     "18803"     "234779"   
## [109] "19045"     "19047"     "434233"    "73699"     "51792"     "108079"   
## [115] "105787"    "19082"     "19087"     "19088"     "18751"     "18750"    
## [121] "18752"     "19211"     "19247"     "19353"     "110157"    "11836"    
## [127] "109880"    "64143"     "19766"     "19769"     "19762"     "20111"    
## [133] "20112"     "110651"    "67071"     "74370"     "55948"     "20491"    
## [139] "20525"     "20528"     "20527"     "17126"     "17127"     "18412"    
## [145] "20847"     "56480"     "56489"     "75778"     "21844"     "24001"    
## [151] "21937"     "22030"     "228775"    "22084"     "66105"     "73318"    
## [157] "56550"     "381534"    "93765"     "57257"     "22324"     "22325"    
## [163] "54401"    
## 
## $HALLMARK_MTORC1_SIGNALING
##   [1] "27407"     "107476"    "100705"    "104112"    "74205"     "50790"    
##   [7] "66713"     "74117"     "242894"    "27360"     "11518"     "11519"    
##  [13] "68465"     "11639"     "56248"     "11674"     "79459"     "353204"   
##  [19] "74192"     "27053"     "11938"     "11937"     "11951"     "228033"   
##  [25] "73834"     "20878"     "12035"     "20893"     "12227"     "436199"   
##  [31] "194735"    "12226"     "12235"     "12301"     "12317"     "12330"    
##  [37] "12745"     "12449"     "12450"     "12466"     "12467"     "12527"    
##  [43] "12530"     "12575"     "18636"     "26754"     "12721"     "23789"    
##  [49] "23790"     "107869"    "13032"     "12767"     "66427"     "13121"    
##  [55] "26377"     "13198"     "74747"     "68278"     "53817"     "74754"    
##  [61] "13360"     "13361"     "13595"     "192193"    "66143"     "112407"   
##  [67] "67204"     "100040220" "68801"     "54326"     "170439"    "13806"    
##  [73] "433182"    "13807"     "13808"     "107508"    "50527"     "225363"   
##  [79] "76267"     "60527"     "56473"     "228151"    "14149"     "14190"    
##  [85] "14227"     "14381"     "14380"     "14433"     "100039229" "100042427"
##  [91] "100042025" "622339"    "74185"     "14629"     "74105"     "11605"    
##  [97] "93692"     "229363"    "14718"     "14751"     "56637"     "14782"    
## [103] "14884"     "15277"     "216019"    "212032"    "15275"     "15288"    
## [109] "15357"     "208715"    "15360"     "15452"     "22027"     "15516"    
## [115] "15519"     "15525"     "14828"     "15481"     "15482"     "15512"    
## [121] "193740"    "15526"     "15510"     "15528"     "628438"    "15926"    
## [127] "269951"    "319554"    "65972"     "15982"     "15983"     "16011"    
## [133] "16009"     "76614"     "231070"    "16414"     "16415"     "16412"    
## [139] "16421"     "16828"     "16835"     "22359"     "19141"     "16993"    
## [145] "17113"     "26397"     "26399"     "17216"     "17217"     "17436"    
## [151] "109264"    "107029"    "56772"     "17768"     "665563"    "59027"    
## [157] "18030"     "18036"     "18046"     "63913"     "18107"     "18108"    
## [163] "27275"     "70699"     "56312"     "18451"     "18452"     "231887"   
## [169] "228026"    "18641"     "18655"     "18663"     "72157"     "226041"   
## [175] "236539"    "18710"     "56305"     "18738"     "18817"     "26432"    
## [181] "26433"     "18822"     "66249"     "667034"    "18950"     "67486"    
## [187] "67895"     "268373"    "269569"    "17872"     "18477"     "21672"    
## [193] "107272"    "19167"     "26441"     "19173"     "19181"     "23996"    
## [199] "67089"     "66997"     "23997"     "59029"     "19192"     "56088"    
## [205] "100678"    "110391"    "19324"     "17252"     "19769"     "19762"    
## [211] "68275"     "103963"    "20135"     "382985"    "27966"     "235293"   
## [217] "20250"     "20249"     "30049"     "329065"    "64136"     "56529"    
## [223] "66286"     "28146"     "72661"     "12406"     "108037"    "20425"    
## [229] "54353"     "20491"     "55963"     "20514"     "20525"     "20528"    
## [235] "20527"     "14385"     "21366"     "26570"     "20539"     "26941"    
## [241] "65962"     "20322"     "20775"     "18412"     "78925"     "94224"    
## [247] "107513"    "170459"    "20855"     "20867"     "83671"     "56480"    
## [253] "56489"     "21399"     "21400"     "21753"     "236749"    "245376"   
## [259] "22042"     "73166"     "69071"     "53333"     "21991"     "228775"   
## [265] "22145"     "22143"     "22144"     "22147"     "22146"     "22142"    
## [271] "53857"     "238463"    "103733"    "103768"    "50493"     "232223"   
## [277] "66105"     "73318"     "56550"     "381534"    "56207"     "67890"    
## [283] "22256"     "56041"     "22375"     "22433"     "56418"    
## 
## $HALLMARK_E2F_TARGETS
##   [1] "11637"     "66471"     "68981"     "66403"     "66929"     "70472"    
##   [7] "20878"     "20877"     "20871"     "12021"     "11799"     "12189"    
##  [13] "12190"     "52592"     "12236"     "12419"     "12442"     "12447"    
##  [19] "101565"    "107995"    "12530"     "12531"     "14793"     "52276"    
##  [25] "12534"     "12567"     "12575"     "12576"     "12578"     "12579"    
##  [31] "12580"     "72391"     "229841"    "66570"     "12649"     "50883"    
##  [37] "12704"     "329977"    "54124"     "624855"    "66197"     "58184"    
##  [43] "110750"    "13018"     "51797"     "55936"     "13178"     "140917"   
##  [49] "66422"     "68278"     "53817"     "110052"    "76131"     "56419"    
##  [55] "54004"     "218977"    "13433"     "60364"     "28080"     "72107"    
##  [61] "110074"    "108961"    "13626"     "13665"     "105988"    "69639"    
##  [67] "14056"     "14055"     "69270"     "78833"     "109145"    "14852"    
##  [73] "14853"     "15270"     "319173"    "621893"    "319176"    "319191"   
##  [79] "319162"    "232440"    "319171"    "15267"     "319192"    "319163"   
##  [85] "319164"    "319165"    "319166"    "319167"    "319168"    "319169"   
##  [91] "319170"    "665433"    "319172"    "51788"     "77605"     "15201"    
##  [97] "15361"     "111241"    "15364"     "97165"     "15354"     "619829"   
## [103] "15366"     "71653"     "11991"     "15574"     "210554"    "16201"    
## [109] "20744"     "71777"     "233726"    "320727"    "15374"     "70218"    
## [115] "110033"    "73804"     "16563"     "16571"     "16647"     "100043906"
## [121] "98386"     "16881"     "16906"     "16907"     "16905"     "67684"    
## [127] "17089"     "56150"     "17216"     "17215"     "17217"     "17218"    
## [133] "17219"     "17220"     "17279"     "17345"     "17350"     "212377"   
## [139] "17535"     "17685"     "17768"     "17121"     "17865"     "17864"    
## [145] "17869"     "107771"    "78304"     "53605"     "50927"     "27354"    
## [151] "68298"     "18102"     "70769"     "67134"     "68219"     "103468"   
## [157] "218210"    "70699"     "18393"     "56452"     "18813"     "67054"    
## [163] "103135"    "18538"     "18540"     "100710"    "71521"     "68479"    
## [169] "18817"     "20873"     "18861"     "18949"     "18969"     "18971"    
## [175] "18972"     "67967"     "18973"     "66979"     "74097"     "53892"    
## [181] "100336"    "53381"     "19076"     "19090"     "19139"     "328099"   
## [187] "75456"     "110639"    "101739"    "19183"     "30939"     "26934"    
## [193] "19355"     "19357"     "19360"     "19362"     "114714"    "19384"    
## [199] "19428"     "75471"     "19385"     "245688"    "19646"     "19687"    
## [205] "19718"     "69263"     "69724"     "68275"     "19891"     "68240"    
## [211] "20135"     "382985"    "20425"     "108037"    "20492"     "24061"    
## [217] "140557"    "13006"     "70099"     "67241"     "20638"     "20646"    
## [223] "54141"     "67629"     "66442"     "110809"    "20382"     "245492"   
## [229] "20833"     "20842"     "20843"     "50878"     "16765"     "20937"    
## [235] "56403"     "74326"     "21335"     "21379"     "106795"    "22042"    
## [241] "21853"     "66131"     "21877"     "21917"     "21973"     "22059"    
## [247] "20462"     "69716"     "22154"     "22152"     "545486"    "22153"    
## [253] "22151"     "67951"     "227613"    "73710"     "103733"    "103768"   
## [259] "77891"     "67196"     "66622"     "22256"     "230484"    "106618"   
## [265] "22390"     "103573"    "14375"     "26951"    
## 
## $HALLMARK_MYC_TARGETS_V1
##   [1] "24015"     "11431"     "231872"    "11777"     "11792"     "12237"    
##   [7] "12261"     "69719"     "227231"    "12330"     "12745"     "12417"    
##  [13] "12428"     "12461"     "12462"     "12464"     "12465"     "12468"    
##  [19] "107995"    "12544"     "12566"     "12567"     "12729"     "12785"    
##  [25] "75064"     "26754"     "12858"     "108062"    "83410"     "51797"    
##  [31] "55936"     "26965"     "66445"     "66942"     "56200"     "94213"    
##  [37] "110052"    "13204"     "217207"    "69192"     "110074"    "55949"    
##  [43] "66235"     "13664"     "666806"    "544881"    "435337"    "100861908"
##  [49] "266459"    "627873"    "100039042" "100039076" "100039129" "100039162"
##  [55] "666862"    "100503047" "100039226" "544883"    "100039052" "100042776"
##  [61] "100861898" "13665"     "67204"     "100040220" "27979"     "55944"    
##  [67] "78655"     "100042807" "13681"     "13682"     "53975"     "13684"    
##  [73] "218268"    "13690"     "22384"     "107508"    "13877"     "100042777"
##  [79] "225363"    "66446"     "218236"    "14113"     "237730"    "27041"    
##  [85] "109801"    "30877"     "14719"     "14852"     "14853"     "51788"    
##  [91] "77605"     "15182"     "69692"     "15191"     "15192"     "15382"    
##  [97] "229279"    "545091"    "53379"     "627828"    "668559"    "15381"    
## [103] "11991"     "74326"     "51810"     "15452"     "15516"     "15519"    
## [109] "22027"     "15510"     "15528"     "628438"    "105148"    "15982"    
## [115] "15983"     "67781"     "23918"     "23917"     "100042069" "85305"    
## [121] "16647"     "100043906" "16211"     "16828"     "27756"     "66094"    
## [127] "56150"     "17216"     "17217"     "17218"     "17219"     "17220"    
## [133] "19935"     "78523"     "66973"     "17869"     "107771"    "53605"    
## [139] "433702"    "68092"     "70316"     "102634451" "52530"     "18102"    
## [145] "70769"     "28126"     "67134"     "18148"     "18263"     "18393"    
## [151] "18813"     "18458"     "18459"     "67543"     "381404"    "230721"   
## [157] "23983"     "18538"     "18540"     "18655"     "18663"     "18673"    
## [163] "237880"    "12034"     "18972"     "59001"     "268373"    "269569"   
## [169] "14208"     "11757"     "53381"     "68988"     "110639"    "75456"    
## [175] "328099"    "19139"     "26440"     "19166"     "26441"     "26443"    
## [181] "26444"     "73677"     "26445"     "26446"     "240289"    "23996"    
## [187] "67089"     "70247"     "59029"     "22123"     "17463"     "57296"    
## [193] "56351"     "100043508" "103136"    "14694"     "19359"     "19384"    
## [199] "19428"     "75471"     "19385"     "106344"    "19826"     "67115"    
## [205] "19899"     "19934"     "68436"     "623174"    "619547"    "100043876"
## [211] "19988"     "432502"    "11837"     "667618"    "67097"     "16898"    
## [217] "27050"     "20103"     "20104"     "105244208" "20133"     "27966"    
## [223] "66409"     "20174"     "66870"     "56086"     "67465"     "101943"   
## [229] "18674"     "20588"     "68094"     "53607"     "20639"     "68981"    
## [235] "20641"     "107686"    "67332"     "68011"     "666609"    "20810"    
## [241] "20815"     "20817"     "110809"    "20382"     "245492"    "20383"    
## [247] "100502754" "225027"    "20823"     "381760"    "99138"     "56403"    
## [253] "230908"    "21454"     "21781"     "28185"     "20462"     "21849"    
## [259] "233870"    "100041265" "27366"     "22171"     "108121"    "233073"   
## [265] "50995"     "22194"     "218793"    "22195"     "100042355" "230484"   
## [271] "22327"     "22333"     "22335"     "103573"    "73192"     "14375"    
## [277] "22627"     "22630"     "102634437"
## 
## $HALLMARK_MYC_TARGETS_V2
##  [1] "231872" "53414"  "12417"  "12567"  "66422"  "66942"  "13537"  "27998" 
##  [9] "66590"  "30877"  "101612" "15277"  "216019" "212032" "15275"  "15510" 
## [17] "15528"  "628438" "27993"  "75751"  "76130"  "53608"  "17217"  "17218" 
## [25] "67973"  "69902"  "668455" "434693" "18432"  "17869"  "107771" "68493" 
## [33] "66164"  "100608" "70769"  "28126"  "110109" "67134"  "18148"  "18813" 
## [41] "64934"  "18673"  "237880" "18817"  "20873"  "235036" "226169" "71974" 
## [49] "56361"  "227746" "59028"  "107094" "27966"  "20509"  "116914" "13340" 
## [57] "20322"  "20810"  "338359" "21379"  "21453"  "15278"  "69071"  "22256" 
## [65] "70683"  "72515"  "107071"
## 
## $HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
##   [1] "320712"    "11475"     "11468"     "11459"     "11464"     "238880"   
##   [7] "11461"     "11489"     "11492"     "16790"     "11803"     "11839"    
##  [13] "70350"     "12064"     "12111"     "12153"     "21892"     "24087"    
##  [19] "54725"     "109624"    "12321"     "67252"     "12332"     "16007"    
##  [25] "14219"     "12505"     "333883"    "12509"     "12552"     "12564"    
##  [31] "12565"     "12563"     "320873"    "215654"    "104010"    "23836"    
##  [37] "239096"    "241201"    "12558"     "12550"     "12560"     "12561"    
##  [43] "227485"    "12814"     "12829"     "12828"     "107581"    "53867"    
##  [49] "71355"     "94216"     "373864"    "12824"     "12825"     "12826"    
##  [55] "12827"     "12830"     "12831"     "12832"     "12836"     "12842"    
##  [61] "12843"     "12816"     "12818"     "74320"     "12834"     "12833"    
##  [67] "12835"     "68553"     "245026"    "329941"    "12837"     "234407"   
##  [73] "269132"    "99151"     "12845"     "21828"     "21825"     "21827"    
##  [79] "12847"     "50797"     "12931"     "68588"     "14825"     "20310"    
##  [85] "330122"    "20309"     "20315"     "20311"     "13132"     "13179"    
##  [91] "13380"     "22240"     "12934"     "12933"     "26757"     "13518"    
##  [97] "13601"     "407800"    "13612"     "58859"     "23876"     "13717"    
## [103] "13732"     "13807"     "433182"    "13806"     "13808"     "14089"    
## [109] "13482"     "14102"     "79201"     "14114"     "14115"     "14118"    
## [115] "14119"     "218952"    "108101"    "241639"    "14173"     "192176"   
## [121] "286940"    "68794"     "14264"     "14268"     "14234"     "17300"    
## [127] "14314"     "83554"     "71665"     "14370"     "14367"     "13197"    
## [133] "23882"     "17873"     "14451"     "14579"     "14609"     "414089"   
## [139] "73690"     "69286"     "544736"    "14733"     "67305"     "23892"    
## [145] "56213"     "78558"     "15902"     "16008"     "16009"     "16011"    
## [151] "16010"     "16168"     "16193"     "16323"     "16324"     "16398"    
## [157] "213119"    "319480"    "109700"    "16402"     "241226"    "16399"    
## [163] "16410"     "16412"     "16416"     "16419"     "16420"     "16476"    
## [169] "16477"     "16478"     "16772"     "16773"     "16774"     "226519"   
## [175] "18208"     "18209"     "23928"     "16782"     "16852"     "16948"    
## [181] "16949"     "94352"     "16950"     "67573"     "100862072" "16971"    
## [187] "16973"     "16974"     "94217"     "228357"    "14725"     "74488"    
## [193] "17022"     "107528"    "17181"     "17182"     "17220"     "17294"    
## [199] "50530"     "17313"     "83995"     "83996"     "17394"     "17387"    
## [205] "17388"     "17389"     "17391"     "17390"     "17392"     "17384"    
## [211] "17701"     "17702"     "242050"    "98932"     "107589"    "18074"    
## [217] "18113"     "21743"     "18129"     "18128"     "18132"     "18131"    
## [223] "23959"     "235106"    "330908"    "18430"     "56401"     "210530"   
## [229] "18542"     "76477"     "18596"     "18595"     "30794"     "18645"    
## [235] "18643"     "18793"     "18822"     "26432"     "26433"     "65112"    
## [241] "18858"     "50706"     "19035"     "18933"     "20204"     "103964"   
## [247] "22074"     "22073"     "22072"     "100040233" "436523"    "436522"   
## [253] "114228"    "67373"     "386551"    "19227"     "19288"     "52118"    
## [259] "19294"     "104009"    "19736"     "11852"     "20229"     "20254"    
## [265] "20969"     "20971"     "18787"     "20720"     "12406"     "20377"    
## [271] "54612"     "20379"     "24051"     "24052"     "24053"     "244431"   
## [277] "102857"    "20563"     "20564"     "20562"     "20583"     "20649"    
## [283] "20650"     "20692"     "20745"     "72902"     "20750"     "21345"    
## [289] "21789"     "21803"     "21810"     "21814"     "21817"     "331046"   
## [295] "21826"     "21838"     "21857"     "21859"     "21923"     "21929"    
## [301] "18383"     "27279"     "22003"     "22004"     "326618"    "22329"    
## [307] "13003"     "22339"     "22341"     "22352"     "13346"     "19132"    
## [313] "215280"    "22418"     "22419"    
## 
## $HALLMARK_INFLAMMATORY_RESPONSE
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "11308"     "329165"    "11479"     "269275"    "21812"     "11480"    
##  [13] "11481"     "13733"     "11535"     "11541"     "11540"     "56436"    
##  [19] "100043022" "11622"     "23796"     "64008"     "11938"     "11937"    
##  [25] "67972"     "11941"     "320707"    "381290"    "235574"    "26362"    
##  [31] "17289"     "12061"     "24115"     "69550"     "12227"     "436199"   
##  [37] "194735"    "12226"     "12267"     "12273"     "319430"    "54598"    
##  [43] "12311"     "20295"     "20293"     "20296"     "20292"     "20306"    
##  [49] "20297"     "20299"     "56221"     "20304"     "12775"     "54199"    
##  [55] "12475"     "21939"     "12506"     "13136"     "13137"     "12515"    
##  [61] "21948"     "12521"     "12493"     "12575"     "54371"     "60322"    
##  [67] "23845"     "14747"     "12977"     "12985"     "12986"     "20312"    
##  [73] "15945"     "56066"     "20311"     "20309"     "17329"     "80901"    
##  [79] "13058"     "237038"    "73379"     "50498"     "13614"     "19106"    
##  [85] "13732"     "13874"     "14066"     "233079"    "14293"     "14289"    
##  [91] "14294"     "14291"     "14290"     "321020"    "14367"     "14370"    
##  [97] "54393"     "14528"     "14676"     "14679"     "14677"     "14678"    
## [103] "14723"     "14734"     "56696"     "321019"    "15117"     "15118"    
## [109] "15200"     "15251"     "13819"     "15451"     "15465"     "15894"    
## [115] "15898"     "78369"     "50723"     "230623"    "230613"    "329918"   
## [121] "68713"     "66141"     "74482"     "80876"     "213002"    "69147"    
## [127] "15975"     "15980"     "16153"     "16154"     "16160"     "16168"    
## [133] "16169"     "16173"     "16182"     "16174"     "16175"     "16176"    
## [139] "16177"     "16185"     "16190"     "16193"     "16197"     "16323"    
## [145] "16324"     "108960"    "16362"     "54123"     "16402"     "241226"   
## [151] "16399"     "16410"     "16416"     "320910"    "16491"     "16485"    
## [157] "16490"     "16492"     "16493"     "16494"     "16518"     "72413"    
## [163] "16561"     "16560"     "23849"     "239739"    "16818"     "17096"    
## [169] "15162"     "16822"     "16835"     "22359"     "16878"     "14745"    
## [175] "16992"     "17069"     "17167"     "54483"     "17287"     "17295"    
## [181] "19882"     "17387"     "17388"     "17389"     "17391"     "20288"    
## [187] "17119"     "17869"     "107771"    "59027"     "17986"     "18033"    
## [193] "18034"     "18035"     "216799"    "378425"    "195046"    "637515"   
## [199] "64685"     "14767"     "257632"    "104443"    "108078"    "381816"   
## [205] "18387"     "18413"     "18414"     "16880"     "18438"     "18439"    
## [211] "18442"     "57385"     "54216"     "18578"     "238871"    "110385"   
## [217] "18577"     "14726"     "320207"    "18793"     "50501"     "19164"    
## [223] "19204"     "19217"     "19219"     "19222"     "19267"     "19262"    
## [229] "52118"     "19294"     "110157"    "11836"     "109880"    "19419"    
## [235] "240168"    "19697"     "50778"     "19734"     "56212"     "192656"   
## [241] "218215"    "108089"    "19886"     "67775"     "380713"    "224024"   
## [247] "20266"     "20339"     "109815"    "20343"     "20354"     "18787"    
## [253] "74442"     "27218"     "18174"     "18173"     "20511"     "269346"   
## [259] "381417"    "434203"    "20529"     "20530"     "54403"     "20535"    
## [265] "59033"     "94229"     "232156"    "240215"    "218756"    "11987"    
## [271] "11989"     "11988"     "20698"     "109552"    "192187"    "192188"   
## [277] "21336"     "21338"     "21356"     "21857"     "21897"     "21899"    
## [283] "24088"     "142980"    "279572"    "21930"     "21938"     "21942"    
## [289] "22035"     "326623"    "21950"     "21983"     "22353"    
## 
## $HALLMARK_XENOBIOTIC_METABOLISM
##   [1] "12780"     "76408"     "17250"     "27421"     "20927"     "20928"    
##   [7] "244562"    "239273"    "26874"     "11666"     "66082"     "11429"    
##  [13] "11430"     "93732"     "80911"     "11431"     "11432"     "117147"   
##  [19] "233799"    "272428"    "233801"    "11522"     "26876"     "69117"    
##  [25] "100417514" "11529"     "11532"     "269378"    "11615"     "70861"    
##  [31] "77337"     "83702"     "116852"    "105349"    "105387"    "622402"   
##  [37] "27384"     "432720"    "11655"     "11669"     "72535"     "19378"    
##  [43] "26358"     "11668"     "56847"     "11670"     "56752"     "30924"    
##  [49] "11761"     "71724"     "71872"     "213043"    "22436"     "67489"    
##  [55] "11816"     "64008"     "11846"     "11847"     "59046"     "109900"   
##  [61] "71093"     "11938"     "11937"     "12927"     "12035"     "233016"   
##  [67] "68021"     "12349"     "12368"     "12359"     "12408"     "435489"   
##  [73] "20300"     "12491"     "72269"     "12583"     "104158"    "12623"    
##  [79] "234564"    "382044"    "13884"     "13897"     "75704"     "244595"   
##  [85] "14962"     "66054"     "338403"    "12846"     "791260"    "74114"    
##  [91] "12944"     "66289"     "100504232" "20219"     "246277"    "109672"   
##  [97] "76884"     "20430"     "13074"     "13076"     "13077"     "13082"    
## [103] "104086"    "72082"     "13097"     "13095"     "13096"     "13098"    
## [109] "69888"     "72303"     "107141"    "226105"    "433247"    "545288"   
## [115] "404195"    "13099"     "226143"    "100043108" "13106"     "74519"    
## [121] "13110"     "230459"    "13109"     "242546"    "100066"    "665095"   
## [127] "546837"    "224044"    "74134"     "64385"     "106648"    "631304"   
## [133] "72054"     "70101"     "170716"    "208285"    "677156"    "67880"    
## [139] "12409"     "51793"     "69219"     "13195"     "15186"     "13202"    
## [145] "330817"    "52585"     "66375"     "209183"    "51798"     "68801"    
## [151] "54326"     "13809"     "12499"     "13836"     "13846"     "13845"    
## [157] "13835"     "13840"     "13842"     "270190"    "13848"     "13841"    
## [163] "13838"     "13844"     "13837"     "13839"     "13849"     "13982"    
## [169] "66841"     "23872"     "14058"     "14071"     "109821"    "16621"    
## [175] "14080"     "14085"     "14102"     "79201"     "14114"     "14121"    
## [181] "14120"     "59083"     "14261"     "55990"     "14262"     "226565"   
## [187] "14377"     "14378"     "57436"     "14415"     "14417"     "14450"    
## [193] "14528"     "231103"    "14629"     "14538"     "14711"     "14782"    
## [199] "14854"     "14859"     "14857"     "100042314" "14858"     "100042295"
## [205] "14865"     "14864"     "14866"     "14867"     "68312"     "14862"    
## [211] "14863"     "14873"     "68214"     "14872"     "56794"     "55927"    
## [217] "54426"     "58992"     "15368"     "15378"     "15452"     "94175"    
## [223] "15483"     "15486"     "15902"     "15926"     "269951"    "16000"    
## [229] "16006"     "16010"     "16177"     "15900"     "16424"     "16426"    
## [235] "16427"     "16480"     "12387"     "85305"     "70789"     "16816"    
## [241] "192654"    "259301"    "74142"     "64898"     "14245"     "64899"    
## [247] "17155"     "17156"     "230815"    "17161"     "109731"    "223455"   
## [253] "17195"     "78038"     "50997"     "17750"     "17748"     "108156"   
## [259] "29811"     "18041"     "18081"     "18107"     "18108"     "18145"    
## [265] "237636"    "18104"     "18105"     "23972"     "23971"     "18563"    
## [271] "27273"     "56376"     "67399"     "18618"     "110208"    "53328"    
## [277] "70804"     "68943"     "18815"     "29858"     "18984"     "19015"    
## [283] "19128"     "19171"     "19215"     "64292"     "56351"     "100043508"
## [289] "67103"     "19286"     "209027"    "69051"     "110351"    "380711"   
## [295] "19662"     "19692"     "19693"     "67442"     "66397"     "12401"    
## [301] "18787"     "55942"     "108037"    "20425"     "20498"     "20499"    
## [307] "107723"    "20514"     "20517"     "20518"     "110172"    "108652"   
## [313] "242585"    "70484"     "71706"     "14411"     "14412"     "243616"   
## [319] "102857"    "21366"     "228608"    "20733"     "67437"     "234724"   
## [325] "56720"     "21808"     "225913"    "110213"    "65963"     "69071"    
## [331] "21937"     "22021"     "50500"     "22173"     "22235"     "103149"   
## [337] "22271"     "76654"     "22361"     "26464"     "22370"    
## 
## $HALLMARK_FATTY_ACID_METABOLISM
##   [1] "23923"     "235674"    "113868"    "52538"     "11363"     "11364"    
##   [7] "11409"     "11370"     "224530"    "110460"    "11429"     "171210"   
##  [13] "171281"    "26897"     "217698"    "217700"    "171282"    "170789"   
##  [19] "11430"     "14081"     "433256"    "216739"    "50790"     "20216"    
##  [25] "233799"    "272428"    "233801"    "68738"     "11522"     "26876"    
##  [31] "69117"     "100417514" "11529"     "11532"     "68465"     "11564"    
##  [37] "17025"     "11668"     "26358"     "19378"     "56847"     "72535"    
##  [43] "11669"     "11670"     "11671"     "56752"     "11674"     "79459"    
##  [49] "353204"    "11754"     "237940"    "11792"     "11832"     "11992"    
##  [55] "12040"     "109778"    "12167"     "12166"     "68021"     "12349"    
##  [61] "12351"     "12353"     "12408"     "435489"    "109857"    "381045"   
##  [67] "12479"     "12480"     "12491"     "12613"     "12683"     "14311"    
##  [73] "12892"     "12894"     "12895"     "78070"     "12896"     "12908"    
##  [79] "12647"     "12972"     "13076"     "13077"     "666168"    "100040843"
##  [85] "13117"     "13118"     "13119"     "277753"    "435802"    "230639"   
##  [91] "13120"     "81906"     "98314"     "67460"     "74754"     "13382"    
##  [97] "78920"     "51798"     "93747"     "13177"     "23986"     "69123"    
## [103] "74147"     "68801"     "54326"     "13807"     "433182"    "13806"    
## [109] "13808"     "13849"     "67397"     "66841"     "14080"     "14079"    
## [115] "14104"     "14194"     "14261"     "55990"     "14373"     "57436"    
## [121] "14417"     "14415"     "14447"     "14433"     "270076"    "14645"    
## [127] "14555"     "14571"     "76238"     "14874"     "51788"     "77605"    
## [133] "15107"     "231086"    "56185"     "15159"     "227095"    "15356"    
## [139] "208982"    "208715"    "15360"     "15446"     "15108"     "114664"   
## [145] "243168"    "15488"     "15490"     "72479"     "15519"     "15516"    
## [151] "22027"     "15505"     "15525"     "15926"     "269951"    "170718"   
## [157] "15929"     "243996"    "319554"    "100328588" "14204"     "73988"    
## [163] "100470"    "21743"     "18113"     "67956"     "16828"     "16852"    
## [169] "17001"     "17161"     "109731"    "73724"     "17449"     "17448"    
## [175] "17436"     "109264"    "107029"    "75624"     "23945"     "17319"    
## [181] "56690"     "27354"     "52683"     "18194"     "18207"     "18263"    
## [187] "66357"     "13180"     "72562"     "18597"     "18598"     "68263"    
## [193] "19013"     "11758"     "320769"    "19186"     "19270"     "19283"    
## [199] "19286"     "229877"    "17252"     "107605"    "103142"    "19683"    
## [205] "54150"     "216453"    "216454"    "27400"     "70335"     "13476"    
## [211] "67442"     "20194"     "66945"     "66052"     "66925"     "56442"    
## [217] "26943"     "20520"     "56517"     "30805"     "20603"     "671878"   
## [223] "20916"     "56451"     "20917"     "56720"     "68728"     "56791"    
## [229] "22235"     "22275"     "22276"     "22361"     "26464"     "213742"   
## [235] "22629"     "22628"    
## 
## $HALLMARK_OXIDATIVE_PHOSPHORYLATION
##   [1] "11306"     "235674"    "113868"    "52538"     "11364"     "66885"    
##   [7] "11370"     "110446"    "11429"     "69597"     "114896"    "26926"    
##  [13] "11655"     "104776"    "11931"     "11946"     "11947"     "11949"    
##  [19] "66043"     "67126"     "11951"     "228033"    "67942"     "11958"    
##  [25] "57423"     "27425"     "432491"    "11950"     "71679"     "240853"   
##  [31] "11957"     "28080"     "54411"     "114143"    "11984"     "11974"    
##  [37] "76252"     "66335"     "73834"     "11973"     "66144"     "66290"    
##  [43] "338375"    "108664"    "12028"     "12039"     "69772"     "12369"    
##  [49] "70383"     "69802"     "226139"    "12856"     "12857"     "12858"    
##  [55] "12859"     "100040340" "12861"     "110323"    "12864"     "102640946"
##  [61] "12866"     "20463"     "66142"     "78174"     "12867"     "100504157"
##  [67] "12868"     "12894"     "12895"     "78070"     "12974"     "71832"    
##  [73] "109672"    "109754"    "66445"     "13063"     "672195"    "670717"   
##  [79] "13067"     "67460"     "235339"    "13382"     "78920"     "51798"    
##  [85] "93747"     "13177"     "110842"    "110826"    "66841"     "14148"    
##  [91] "14194"     "14297"     "14661"     "14719"     "14751"     "625249"   
##  [97] "17713"     "97212"     "231086"    "15159"     "15108"     "15526"    
## [103] "64704"     "15926"     "269951"    "67834"     "170718"    "15929"    
## [109] "243996"    "76614"     "69046"     "432732"    "66383"     "16828"    
## [115] "16832"     "72416"     "109731"    "17161"     "17449"     "17448"    
## [121] "170731"    "67414"     "66447"     "55951"     "66419"     "27395"    
## [127] "94065"     "66223"     "67994"     "24030"     "66407"     "64655"    
## [133] "59054"     "211253"    "210009"    "53375"     "54405"     "17991"    
## [139] "66091"     "17992"     "68202"     "67130"     "66416"     "68375"    
## [145] "66108"     "70316"     "102634451" "102631912" "68198"     "66495"    
## [151] "68194"     "100041273" "100042503" "66046"     "230075"    "66916"    
## [157] "67264"     "66377"     "68197"     "227197"    "226646"    "68349"    
## [163] "17993"     "407785"    "623286"    "75406"     "225887"    "17995"    
## [169] "72900"     "18115"     "18105"     "18104"     "18242"     "18293"    
## [175] "239017"    "74143"     "69089"     "18597"     "18598"     "68263"    
## [181] "27402"     "27273"     "381511"    "12034"     "16922"     "66865"    
## [187] "69833"     "18984"     "11757"     "67442"     "59040"     "214952"   
## [193] "66945"     "67680"     "66052"     "66925"     "67863"     "78830"    
## [199] "50799"     "57279"     "18674"     "11739"     "11740"     "20916"    
## [205] "56451"     "338359"    "20930"     "27060"     "11975"     "21871"    
## [211] "140494"    "30059"     "30055"     "21854"     "66525"     "30057"    
## [217] "30056"     "223696"    "28185"     "66152"     "66594"     "67530"    
## [223] "22273"     "67003"     "66694"     "66576"     "100042918" "22272"    
## [229] "22333"     "22334"     "22335"    
## 
## $HALLMARK_GLYCOLYSIS
##   [1] "74104"  "11541"  "11540"  "77559"  "11603"  "56248"  "11639"  "58810" 
##   [9] "110695" "56752"  "11674"  "79459"  "353204" "230163" "208211" "11727" 
##  [17] "11731"  "219033" "503844" "630952" "11730"  "57875"  "52231"  "59046" 
##  [25] "11876"  "20878"  "117592" "76898"  "280645" "72727"  "72297"  "272411"
##  [33] "14595"  "53418"  "56375"  "218271" "12124"  "23827"  "58226"  "12291" 
##  [41] "239556" "12337"  "12368"  "12505"  "12534"  "12615"  "74241"  "100910"
##  [49] "76969"  "59031"  "54371"  "60322"  "26887"  "56773"  "17684"  "12739" 
##  [57] "12740"  "56863"  "76524"  "76332"  "12831"  "12829"  "12828"  "107581"
##  [65] "53867"  "71355"  "94216"  "373864" "12824"  "12825"  "12826"  "12827" 
##  [73] "12830"  "12832"  "12836"  "12842"  "12843"  "50797"  "107869" "12767" 
##  [81] "109672" "13179"  "74747"  "76131"  "13382"  "26757"  "12933"  "22240" 
##  [89] "12934"  "13506"  "13507"  "70601"  "13638"  "13649"  "13869"  "13866" 
##  [97] "13867"  "112407" "13710"  "13806"  "433182" "13807"  "13808"  "50527" 
## [105] "14042"  "14043"  "70186"  "14120"  "14121"  "14228"  "53618"  "14381" 
## [113] "14380"  "53897"  "74246"  "14635"  "69976"  "14447"  "14433"  "14629" 
## [121] "14583"  "14584"  "22122"  "93683"  "93692"  "69080"  "331026" "50798" 
## [129] "26384"  "67980"  "14718"  "14719"  "14733"  "14734"  "14735"  "23888" 
## [137] "84111"  "110006" "14936"  "232493" "23897"  "110611" "211208" "245598"
## [145] "15277"  "216019" "212032" "15275"  "15366"  "71653"  "26556"  "23908" 
## [153] "50786"  "50785"  "50787"  "14828"  "15481"  "15482"  "15512"  "193740"
## [161] "15926"  "269951" "15932"  "15937"  "16009"  "16011"  "16164"  "384783"
## [169] "16369"  "16367"  "57444"  "68048"  "229504" "105785" "66913"  "68137" 
## [177] "19348"  "16563"  "73470"  "73804"  "226413" "16591"  "83379"  "16828" 
## [185] "16833"  "76429"  "76987"  "16876"  "16870"  "17449"  "17448"  "17436" 
## [193] "109264" "107029" "23989"  "17289"  "26362"  "17295"  "19882"  "17319" 
## [201] "56727"  "110119" "17859"  "67311"  "627235" "50927"  "83398"  "64580" 
## [209] "17423"  "78330"  "78688"  "18194"  "23959"  "18451"  "18452"  "18484" 
## [217] "55982"  "18563"  "236900" "18639"  "18640"  "270198" "56421"  "18641" 
## [225] "18642"  "18648"  "56012"  "18655"  "18663"  "66171"  "66681"  "70974" 
## [233] "110094" "18679"  "18746"  "67451"  "18822"  "26432"  "26433"  "54128" 
## [241] "67005"  "68507"  "327814" "233977" "268373" "269569" "19053"  "19052" 
## [249] "19139"  "328099" "75456"  "110639" "23996"  "110078" "19309"  "110095"
## [257] "104009" "104458" "24105"  "66646"  "52187"  "54170"  "60406"  "50724" 
## [265] "20969"  "15529"  "20970"  "66052"  "80879"  "57274"  "27376"  "50799" 
## [273] "229782" "14385"  "20655"  "20682"  "20665"  "20681"  "245865" "57357" 
## [281] "20855"  "20856"  "16765"  "21351"  "21786"  "21802"  "21810"  "83553" 
## [289] "74419"  "21881"  "21983"  "21991"  "22021"  "22166"  "67402"  "216558"
## [297] "13003"  "22339"  "22359"  "16835"  "217119" "233781" "30046"  "109263"
## 
## $HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
##  [1] "17250"     "76408"     "27421"     "27416"     "12780"     "20927"    
##  [7] "20928"     "224814"    "244562"    "239273"    "11927"     "12359"    
## [13] "12581"     "112406"    "13871"     "14159"     "14158"     "14325"    
## [19] "100862446" "434624"    "14337"     "14381"     "14380"     "14629"    
## [25] "14630"     "93692"     "69367"     "14778"     "75512"     "14780"    
## [31] "625249"    "14782"     "15242"     "15369"     "320495"    "16477"    
## [37] "16476"     "16478"     "68576"     "16985"     "17196"     "56615"    
## [43] "17523"     "13861"     "76113"     "110265"    "67130"     "68194"    
## [49] "100041273" "100042503" "226646"    "18104"     "18105"     "108737"   
## [55] "53416"     "54132"     "56421"     "18641"     "18642"     "18477"    
## [61] "21672"     "53381"     "11758"     "320769"    "19122"     "110854"   
## [67] "216161"    "224432"    "109815"    "20655"     "20656"     "76650"    
## [73] "59041"     "22166"     "67402"     "50493"     "232223"    "26462"    
## 
## $HALLMARK_P53_PATHWAY
##   [1] "268860"    "27416"     "244562"    "17250"     "12780"     "20927"    
##   [7] "20928"     "239273"    "105501"    "11479"     "269275"    "21812"    
##  [13] "11486"     "68048"     "57444"     "229504"    "11636"     "11688"    
##  [19] "11686"     "23801"     "11689"     "68558"     "11783"     "11820"    
##  [25] "11910"     "108100"    "12018"     "12028"     "53619"     "12156"    
##  [31] "12226"     "194735"    "436199"    "12227"     "12362"     "12444"    
##  [37] "12443"     "12445"     "12450"     "12454"     "101565"    "12520"    
##  [43] "12521"     "12493"     "12554"     "12569"     "12575"     "12578"    
##  [49] "12579"     "70925"     "12606"     "68755"     "229933"    "12722"    
##  [55] "23844"     "80797"     "99663"     "99709"     "229927"    "67426"    
##  [61] "207785"    "13033"     "56464"     "76884"     "20430"     "67880"    
##  [67] "12409"     "107986"    "13198"     "74747"     "23853"     "13139"    
##  [73] "110197"    "217480"    "99480"     "71712"     "13663"     "230233"   
##  [79] "13836"     "13846"     "13845"     "13835"     "13840"     "13842"    
##  [85] "270190"    "13848"     "13841"     "13838"     "13844"     "13837"    
##  [91] "13839"     "13849"     "98845"     "22592"     "14062"     "70186"    
##  [97] "14102"     "79201"     "50754"     "14149"     "14168"     "14167"    
## [103] "14169"     "14281"     "56484"     "71665"     "13197"     "23882"    
## [109] "216456"    "14660"     "14667"     "14776"     "50708"     "14957"    
## [115] "56702"     "80838"     "50709"     "232440"    "15267"     "319192"   
## [121] "319163"    "319164"    "319165"    "319166"    "319167"    "319168"   
## [127] "319169"    "319170"    "665433"    "319172"    "319173"    "319176"   
## [133] "319191"    "319162"    "319171"    "15270"     "621893"    "15200"    
## [139] "15183"     "192231"    "15254"     "15368"     "15461"     "18415"    
## [145] "15937"     "15939"     "65972"     "16175"     "16324"     "16323"    
## [151] "76500"     "16970"     "16179"     "66383"     "192897"    "16450"    
## [157] "16449"     "16476"     "16477"     "16478"     "16554"     "16600"    
## [163] "16598"     "259277"    "16667"     "68239"     "16664"     "16666"    
## [169] "16832"     "16878"     "102626"    "17164"     "17246"     "17347"    
## [175] "17346"     "17119"     "17122"     "17988"     "18072"     "18081"    
## [181] "70930"     "18128"     "18129"     "214254"    "433241"    "56312"    
## [187] "71839"     "18538"     "18540"     "18590"     "64058"     "27280"    
## [193] "57913"     "71795"     "20620"     "12795"     "140570"    "18846"    
## [199] "18845"     "18844"     "235611"    "140571"    "67784"     "243743"   
## [205] "29858"     "80905"     "107939"    "53892"     "17872"     "19079"    
## [211] "15468"     "19124"     "19250"     "24000"     "19267"     "19262"    
## [217] "19296"     "224624"    "217371"    "14694"     "114714"    "19367"    
## [223] "19730"     "74012"     "19645"     "68098"     "67442"     "19734"    
## [229] "217344"    "13650"     "75234"     "30945"     "19899"     "54217"    
## [235] "626888"    "100043215" "100043718" "20042"     "100034727" "67941"    
## [241] "57294"     "100043813" "56437"     "101867"    "20181"     "20183"    
## [247] "20194"     "20198"     "268686"    "20229"     "20969"     "53421"    
## [253] "57743"     "20724"     "170742"    "140742"    "55948"     "116914"   
## [259] "20509"     "242585"    "70484"     "17254"     "26570"     "12703"    
## [265] "20683"     "20698"     "19143"     "68428"     "13830"     "229277"   
## [271] "21354"     "76281"     "99681"     "21452"     "21802"     "21803"    
## [277] "17112"     "67623"     "21950"     "21952"     "21953"     "21954"    
## [283] "22057"     "22059"     "22061"     "22062"     "21987"     "69786"    
## [289] "22032"     "231712"    "69076"     "228775"    "21807"     "52808"    
## [295] "56338"     "22271"     "76654"     "22320"     "22337"     "67776"    
## [301] "244810"    "59002"     "107568"    "16396"     "66894"     "22591"    
## [307] "235320"    "12192"     "22401"     "216049"   
## 
## $HALLMARK_UV_RESPONSE_UP
##   [1] "18671"     "18669"     "18670"     "27413"     "235674"    "113868"   
##   [7] "239528"    "236511"    "214150"    "11655"     "11674"     "79459"    
##  [13] "353204"    "11702"     "100041585" "232910"    "55938"     "11828"    
##  [19] "216869"    "109689"    "27053"     "11910"     "66335"     "66144"    
##  [25] "12018"     "12125"     "12122"     "12156"     "12215"     "12226"    
##  [31] "194735"    "436199"    "12227"     "12228"     "12349"     "12367"    
##  [37] "12424"     "12445"     "12443"     "12444"     "12447"     "216150"   
##  [43] "111266"    "67615"     "71702"     "668198"    "668213"    "668216"   
##  [49] "668209"    "102635357" "668205"    "668203"    "102635473" "12566"    
##  [55] "12577"     "12579"     "12583"     "12611"     "12660"     "110835"   
##  [61] "12724"     "12723"     "74325"     "12757"     "12799"     "12824"    
##  [67] "12829"     "12828"     "107581"    "53867"     "71355"     "94216"    
##  [73] "373864"    "12825"     "12826"     "12827"     "12830"     "12831"    
##  [79] "12832"     "12836"     "12842"     "12843"     "433375"    "13039"    
##  [85] "26898"     "56092"     "56094"     "56835"     "58518"     "70202"    
##  [91] "214639"    "64139"     "104002"    "117066"    "218275"    "14825"    
##  [97] "20310"     "330122"    "20309"     "66427"     "72017"     "13076"    
## [103] "13077"     "56200"     "94213"     "13350"     "13385"     "15502"    
## [109] "81489"     "13559"     "104394"    "26905"     "26908"     "217869"   
## [115] "13807"     "433182"    "13806"     "13808"     "17075"     "13849"    
## [121] "14156"     "14172"     "14171"     "14179"     "14228"     "14261"    
## [127] "55990"     "14281"     "14282"     "18550"     "18553"     "18551"    
## [133] "18552"     "14419"     "14528"     "14590"     "14660"     "216456"   
## [139] "14778"     "75512"     "14780"     "66168"     "17713"     "15270"    
## [145] "319173"    "621893"    "319176"    "319191"    "319162"    "232440"   
## [151] "319171"    "15267"     "319192"    "319163"    "319164"    "319165"   
## [157] "319166"    "319167"    "319168"    "319169"    "319170"    "665433"   
## [163] "319172"    "15013"     "15040"     "14972"     "14991"     "15006"    
## [169] "15007"     "15018"     "14964"     "14990"     "15015"     "630294"   
## [175] "110557"    "15039"     "100529082" "14963"     "240095"    "15043"    
## [181] "14985"     "110696"    "333715"    "224753"    "224754"    "399549"   
## [187] "667977"    "224756"    "15024"     "224761"    "14997"     "14980"    
## [193] "15019"     "110558"    "15368"     "51810"     "110920"    "15512"    
## [199] "15481"     "14828"     "15482"     "193740"    "15566"     "15587"    
## [205] "15894"     "15898"     "16008"     "16193"     "16195"     "16362"    
## [211] "16477"     "16476"     "16478"     "16511"     "170738"    "192775"   
## [217] "71765"     "16870"     "16876"     "17096"     "17161"     "109731"   
## [223] "60597"     "13728"     "232944"    "226778"    "17308"     "17387"    
## [229] "17388"     "17389"     "17391"     "19935"     "17701"     "17702"    
## [235] "17961"     "17960"     "17962"     "18035"     "18091"     "53324"    
## [241] "18164"     "73340"     "504193"    "15370"     "18213"     "18212"    
## [247] "18211"     "71844"     "53319"     "83454"     "170722"    "56177"    
## [253] "229759"    "15379"     "225631"    "246086"    "11546"     "11545"    
## [259] "231887"    "53318"     "227120"    "224860"    "59001"     "50776"    
## [265] "245841"    "231327"    "105675"    "66849"     "19063"     "18747"    
## [271] "18749"     "18753"     "18761"     "70767"     "19182"     "19266"    
## [277] "19268"     "19280"     "11891"     "80718"     "19419"     "240168"   
## [283] "19713"     "106344"    "11852"     "103963"    "56437"     "20182"    
## [289] "20364"     "20429"     "18391"     "11739"     "11740"     "14411"    
## [295] "14412"     "243616"    "102857"    "21366"     "20656"     "20751"    
## [301] "18412"     "59045"     "20867"     "59041"     "20887"     "53315"    
## [307] "57429"     "57430"     "215895"    "21338"     "21336"     "21354"    
## [313] "110960"    "272396"    "71807"     "99681"     "22042"     "73122"    
## [319] "110213"    "22117"     "246221"    "22145"     "22143"     "22144"    
## [325] "22147"     "22146"     "22142"     "53857"     "238463"    "22174"    
## [331] "26362"     "17289"     "22275"     "22404"     "56418"    
## 
## $HALLMARK_UV_RESPONSE_DN
##   [1] "17250"     "76408"     "27421"     "27416"     "12780"     "20927"    
##   [7] "20928"     "224814"    "244562"    "239273"    "11480"     "11481"    
##  [13] "27360"     "11518"     "11519"     "99633"     "330814"    "319387"   
##  [19] "11541"     "11540"     "66549"     "23797"     "11652"     "218038"   
##  [25] "12306"     "11746"     "11787"     "236915"    "219140"    "226970"   
##  [31] "67972"     "11941"     "320707"    "381290"    "235574"    "11990"    
##  [37] "226255"    "22589"     "20238"     "12040"     "12064"     "20893"    
##  [43] "12166"     "12286"     "12288"     "12290"     "54652"     "12289"    
##  [49] "12292"     "12287"     "67252"     "12389"     "16007"     "14219"    
##  [55] "226751"    "217866"    "240505"    "69562"     "69131"     "12576"    
##  [61] "57810"     "14007"     "13046"     "17684"     "12814"     "12829"    
##  [67] "12828"     "107581"    "53867"     "71355"     "94216"     "373864"   
##  [73] "12824"     "12825"     "12826"     "12827"     "12830"     "12831"    
##  [79] "12832"     "12836"     "12842"     "12843"     "74320"     "13132"    
##  [85] "13170"     "69219"     "51793"     "50768"     "243362"    "236920"   
##  [91] "13383"     "23859"     "13385"     "53310"     "68055"     "19252"    
##  [97] "319520"    "13548"     "216616"    "13866"     "13869"     "13649"    
## [103] "13867"     "14066"     "23876"     "58859"     "14200"     "14360"    
## [109] "22612"     "14191"     "20779"     "57265"     "14362"     "14369"    
## [115] "14537"     "14609"     "414089"    "14773"     "26385"     "14772"    
## [121] "15117"     "15118"     "15893"     "15901"     "16001"     "16011"    
## [127] "16009"     "234515"    "269180"    "231070"    "16367"     "384783"   
## [133] "16369"     "16416"     "545156"    "223435"    "16531"     "16532"    
## [139] "16590"     "12978"     "226519"    "18208"     "18209"     "23928"    
## [145] "16772"     "16782"     "16835"     "22359"     "14745"     "268977"   
## [151] "16997"     "50791"     "14924"     "17755"     "17754"     "23938"    
## [157] "26416"     "19094"     "17295"     "19882"     "23945"     "17314"    
## [163] "252875"    "17389"     "17387"     "17388"     "17391"     "57312"    
## [169] "17748"     "17750"     "116870"    "23942"     "116871"    "17869"    
## [175] "107771"    "59125"     "18028"     "18027"     "18029"     "18032"    
## [181] "18033"     "18034"     "71175"     "18129"     "18128"     "18132"    
## [187] "18131"     "353187"    "14815"     "18186"     "18187"     "18596"    
## [193] "18595"     "56376"     "67399"     "56273"     "213109"    "229615"   
## [199] "17344"     "56469"     "18707"     "74769"     "18706"     "18710"    
## [205] "18798"     "67916"     "18858"     "19016"     "110593"    "19088"    
## [211] "19087"     "18750"     "18751"     "18752"     "18754"     "18755"    
## [217] "19211"     "19220"     "24000"     "19250"     "19274"     "19281"    
## [223] "19272"     "19273"     "114713"    "19414"     "19663"     "71973"    
## [229] "19736"     "74194"     "12394"     "12399"     "12393"     "20181"    
## [235] "20183"     "106583"    "30953"     "100505386" "20273"     "20272"    
## [241] "20264"     "24046"     "20265"     "110876"    "20269"     "20271"    
## [247] "15529"     "18787"     "54650"     "217692"    "74206"     "244668"   
## [253] "18400"     "11987"     "11989"     "11988"     "17127"     "17126"    
## [259] "17131"     "17130"     "20583"     "20747"     "399676"    "212727"   
## [265] "207213"    "399674"    "399675"    "383977"    "229571"    "668359"   
## [271] "100043188" "399673"    "436563"    "668346"    "100042761" "109552"   
## [277] "64009"     "20975"     "104015"    "210106"    "21788"     "21813"    
## [283] "21814"     "21872"     "21873"     "27375"     "328108"    "22325"    
## [289] "57257"     "22324"     "207615"    "231386"    "328365"    "52915"    
## 
## $HALLMARK_ANGIOGENESIS
##  [1] "11818"  "11820"  "12444"  "12443"  "12445"  "12825"  "12829"  "12828" 
##  [9] "107581" "53867"  "71355"  "74320"  "94216"  "373864" "12824"  "12826" 
## [17] "12827"  "12830"  "12831"  "12832"  "12836"  "12842"  "12843"  "20311" 
## [25] "20309"  "14182"  "14183"  "14184"  "14186"  "14314"  "16410"  "241226"
## [33] "16402"  "16449"  "16450"  "16523"  "16956"  "16976"  "17022"  "17701" 
## [41] "17702"  "18186"  "18187"  "108078" "381816" "18590"  "56744"  "21946" 
## [49] "50706"  "19074"  "53856"  "14083"  "20198"  "268686" "268591" "24059" 
## [57] "20750"  "20855"  "21824"  "21857"  "94185"  "22325"  "57257"  "22324" 
## [65] "13003"  "22339"  "22370" 
## 
## $HALLMARK_HEME_METABOLISM
##   [1] "74104"     "26357"     "27405"     "13349"     "11433"     "216739"   
##   [7] "11518"     "27360"     "11519"     "72674"     "68262"     "28169"    
##  [13] "170812"    "17025"     "11656"     "107747"    "216188"    "104776"   
##  [19] "11733"     "11828"     "69632"     "213498"    "107566"    "27053"    
##  [25] "666468"    "102926"    "11975"     "21871"     "140494"    "27060"    
##  [31] "12013"     "57278"     "84004"     "109778"    "233016"    "140780"   
##  [37] "269774"    "12177"     "100043324" "12183"     "12215"     "12227"    
##  [43] "436199"    "194735"    "12226"     "12234"     "103583"    "12266"    
##  [49] "12268"     "15139"     "12346"     "12349"     "12380"     "12359"    
##  [55] "215814"    "12445"     "12443"     "12444"     "217232"    "12585"    
##  [61] "237988"    "66935"     "12725"     "12727"     "12892"     "83429"    
##  [67] "13030"     "13034"     "208846"    "242418"    "28199"     "114893"   
##  [73] "54339"     "102323"    "13829"     "242705"    "15467"     "192657"   
##  [79] "71946"     "269587"    "13822"     "13828"     "13857"     "27028"    
##  [85] "14055"     "78938"     "69754"     "71538"     "14151"     "63828"    
##  [91] "238024"    "60611"     "56484"     "14317"     "66691"     "14460"    
##  [97] "14629"     "14630"     "56209"     "73046"     "229363"    "14934"    
## [103] "71683"     "14958"     "97122"     "326619"    "319155"    "319159"   
## [109] "326620"    "319156"    "319157"    "69386"     "319158"    "319160"   
## [115] "100041230" "320332"    "319161"    "14651"     "68977"     "101488143"
## [121] "100503605" "436003"    "15135"     "15129"     "15130"     "544763"   
## [127] "216635"    "15122"     "110257"    "15126"     "15191"     "15192"    
## [133] "15199"     "15288"     "53415"     "64704"     "78369"     "78908"    
## [139] "69046"     "432732"    "18519"     "338523"    "23925"     "219094"   
## [145] "16596"     "16599"     "75753"     "16784"     "16909"     "64898"    
## [151] "14245"     "64899"     "65107"     "26397"     "26399"     "224703"   
## [157] "71779"     "17169"     "232944"    "105787"    "226778"    "13728"    
## [163] "67216"     "218121"    "52065"     "66447"     "17330"     "54484"    
## [169] "22652"     "68591"     "70380"     "17524"     "17859"     "17896"    
## [175] "67608"     "67563"     "27057"     "59125"     "18022"     "18023"    
## [181] "18115"     "14815"     "71207"     "58242"     "102954"    "71648"    
## [187] "74309"     "76303"     "18452"     "18451"     "18563"     "67182"    
## [193] "66171"     "233489"    "14755"     "19044"     "225849"    "26932"    
## [199] "21672"     "18477"     "67151"     "19358"     "74334"     "110351"   
## [205] "380711"    "56190"     "666794"    "83486"     "236732"    "59028"    
## [211] "19743"     "19746"     "66878"     "84585"     "30945"     "53378"    
## [217] "74136"     "665119"    "20342"     "20341"     "214597"    "320007"   
## [223] "214601"    "18174"     "18173"     "30805"     "20520"     "56517"    
## [229] "67712"     "208638"    "20525"     "20528"     "20527"     "22782"    
## [235] "226781"    "20533"     "20535"     "66943"     "102857"    "14664"    
## [241] "104245"    "26570"     "228608"    "20617"     "20739"     "20740"    
## [247] "20741"     "104015"    "20975"     "21349"     "21399"     "21400"    
## [253] "74645"     "212943"    "211586"    "22042"     "68875"     "330401"   
## [259] "56786"     "66241"     "213988"    "233833"    "217351"    "21961"    
## [265] "319939"    "21969"     "72960"     "70827"     "67095"     "19824"    
## [271] "69097"     "224762"    "216781"    "56224"     "74257"     "70026"    
## [277] "22173"     "98766"     "22228"     "22275"     "22276"     "14479"    
## [283] "236733"    "22258"     "22344"     "22439"     "65246"     "66011"    
## [289] "383295"   
## 
## $HALLMARK_COAGULATION
##   [1] "232345"    "17837"     "17836"     "104681"    "232400"    "11287"    
##   [7] "93732"     "11502"     "11727"     "11731"     "219033"    "503844"   
##  [13] "630952"    "11730"     "16952"     "11806"     "11812"     "11813"    
##  [19] "105886299" "11814"     "11843"     "11844"     "12153"     "21892"    
##  [25] "24087"     "12259"     "667277"    "50909"     "66686"     "317677"   
##  [31] "50908"     "12263"     "12266"     "12268"     "15139"     "230558"   
##  [37] "12279"     "12274"     "109828"    "110382"    "69379"     "12334"    
##  [43] "170725"    "12333"     "12335"     "268958"    "73647"     "12337"    
##  [49] "12371"     "12527"     "14962"     "11537"     "12628"     "214403"   
##  [55] "545366"    "12630"     "12759"     "12845"     "21828"     "21825"    
##  [61] "21827"     "56373"     "93721"     "54381"     "68337"     "114570"   
##  [67] "13007"     "13030"     "13034"     "13036"     "13038"     "13040"    
##  [73] "229445"    "13039"     "26898"     "56092"     "56094"     "56835"    
##  [79] "58518"     "70202"     "214639"    "64139"     "104002"    "117066"   
##  [85] "218275"    "13190"     "13482"     "14089"     "56405"     "67603"    
##  [91] "235584"    "14058"     "14071"     "109821"    "16621"     "58992"    
##  [97] "54426"     "14060"     "14061"     "14064"     "14066"     "14069"    
## [103] "14118"     "14119"     "14161"     "99571"     "14268"     "18550"    
## [109] "18553"     "18551"     "18552"     "14360"     "22612"     "14191"    
## [115] "20779"     "14544"     "14693"     "14696"     "14688"     "14701"    
## [121] "14723"     "54368"     "227753"    "20259"     "11567"     "22349"    
## [127] "15360"     "15378"     "15451"     "94175"     "56213"     "78558"    
## [133] "66383"     "16398"     "213119"    "319480"    "109700"    "16416"    
## [139] "16424"     "16426"     "93691"     "259277"    "16784"     "320202"   
## [145] "13590"     "19141"     "16971"     "16973"     "16974"     "94217"    
## [151] "228357"    "14725"     "16993"     "17133"     "17175"     "230908"   
## [157] "17195"     "17287"     "83995"     "83996"     "17394"     "17384"    
## [163] "17392"     "17385"     "17387"     "17388"     "17389"     "17391"    
## [169] "17390"     "17393"     "17395"     "76467"     "15235"     "108078"   
## [175] "381816"    "18441"     "18591"     "18613"     "67898"     "56744"    
## [181] "20309"     "18791"     "18792"     "56193"     "18815"     "19072"    
## [187] "19123"     "19128"     "66901"     "76453"     "98710"     "19353"    
## [193] "223864"    "56508"     "19733"     "20193"     "20196"     "20704"    
## [199] "20703"     "20701"     "20700"     "20702"     "68348"     "194604"   
## [205] "18788"     "11905"     "18787"     "12258"     "23921"     "64383"    
## [211] "20692"     "22041"     "71775"     "17002"     "21789"     "21824"    
## [217] "21857"     "21859"     "71753"     "236733"    "14479"     "22258"    
## [223] "22371"     "17833"     "17831"     "22388"    
## 
## $HALLMARK_IL2_STAT5_SIGNALING
##   [1] "18671"     "18669"     "18670"     "27413"     "11492"     "11596"    
##   [7] "269378"    "11615"     "66395"     "100041194" "11622"     "11658"    
##  [13] "17117"     "11746"     "11803"     "11861"     "53314"     "381319"   
##  [19] "12043"     "12048"     "20893"     "12156"     "12168"     "12349"    
##  [25] "12332"     "12335"     "268958"    "73647"     "170725"    "12333"    
##  [31] "12334"     "12367"     "12444"     "12443"     "12445"     "12447"    
##  [37] "12773"     "12505"     "12506"     "15985"     "12520"     "12522"    
##  [43] "12524"     "72729"     "57912"     "23834"     "109332"    "12577"    
##  [49] "12700"     "216197"    "12810"     "12833"     "12834"     "12977"    
##  [55] "12981"     "13011"     "12477"     "64138"     "15945"     "20430"    
##  [61] "76884"     "69305"     "19347"     "320560"    "20148"     "381738"   
##  [67] "13601"     "68043"     "13730"     "13808"     "18605"     "209558"   
##  [73] "13813"     "320204"    "18612"     "14064"     "14085"     "213056"   
##  [79] "14190"     "14256"     "18550"     "18553"     "18551"     "18552"    
##  [85] "57436"     "17873"     "319625"    "14460"     "55932"     "229900"   
##  [91] "236573"    "76074"     "100702"    "634650"    "626578"    "17472"    
##  [97] "384009"    "14744"     "14608"     "76206"     "245526"    "625249"   
## [103] "14873"     "68214"     "54195"     "15258"     "15257"     "15259"    
## [109] "15277"     "216019"    "212032"    "15275"     "74318"     "59026"    
## [115] "54167"     "66141"     "68713"     "80876"     "74482"     "213002"   
## [121] "69147"     "73835"     "15979"     "16001"     "16004"     "22779"    
## [127] "22781"     "16153"     "16154"     "16163"     "16182"     "16178"    
## [133] "17082"     "16184"     "16185"     "16188"     "12982"     "16190"    
## [139] "16364"     "54139"     "15900"     "16403"     "16407"     "16410"    
## [145] "241226"    "16402"     "209378"    "23849"     "225010"    "16878"    
## [151] "16206"     "269473"    "320398"    "100604"    "72267"     "231549"   
## [157] "433926"    "241296"    "16994"     "17133"     "26410"     "17760"    
## [163] "17164"     "102626"    "17829"     "17119"     "17869"     "107771"   
## [169] "17913"     "71602"     "17916"     "17979"     "17978"     "14299"    
## [175] "17988"     "18030"     "80859"     "110109"    "18186"     "18187"    
## [181] "23959"     "18263"     "18438"     "18439"     "18451"     "18452"    
## [187] "68079"     "18619"     "21664"     "68770"     "18712"     "223775"   
## [193] "22634"     "18810"     "13518"     "11426"     "11520"     "19012"    
## [199] "22038"     "18828"     "78459"     "667034"    "18950"     "18986"    
## [205] "54637"     "18755"     "18754"     "19122"     "19206"     "19207"    
## [211] "19217"     "19228"     "213527"    "217057"    "56361"     "29809"    
## [217] "227800"    "19734"     "11852"     "74734"     "107702"    "102635744"
## [223] "19883"     "52187"     "54170"     "20193"     "20274"     "110876"   
## [229] "20269"     "20271"     "20272"     "20273"     "20264"     "24046"    
## [235] "20265"     "20343"     "20344"     "20719"     "97848"     "20708"    
## [241] "238568"    "435350"    "11905"     "212531"    "50795"     "56726"    
## [247] "214547"    "20514"     "13340"     "20527"     "20525"     "67547"    
## [253] "57319"     "244962"    "66616"     "12703"     "216233"    "100043256"
## [259] "20750"     "114716"    "24066"     "20443"     "20947"     "20973"    
## [265] "229521"    "21817"     "331046"    "21844"     "24001"     "170743"   
## [271] "170744"    "279572"    "21936"     "21938"     "94185"     "22163"    
## [277] "21941"     "21942"     "22035"     "21943"     "22029"     "69863"    
## [283] "65960"     "80914"     "22245"     "22247"     "68151"     "22433"    
## 
## $HALLMARK_BILE_ACID_METABOLISM
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "27410"     "381072"    "67928"     "320631"    "233810"    "217265"   
##  [13] "76184"     "27404"     "217262"    "217258"    "11666"     "26874"    
##  [19] "19299"     "192663"    "67470"     "14081"     "433256"    "216739"   
##  [25] "11611"     "208665"    "11668"     "26358"     "19378"     "56847"    
##  [31] "72535"     "11669"     "237320"    "56752"     "17117"     "11806"    
##  [37] "64008"     "11835"     "20238"     "170442"    "29815"     "12161"    
##  [43] "12359"     "12642"     "74114"     "104086"    "56050"     "13116"    
##  [49] "13122"     "13123"     "13124"     "74754"     "13370"     "107585"   
##  [55] "13371"     "71877"     "13850"     "76267"     "60527"     "56473"    
##  [61] "228151"    "14149"     "14473"     "14630"     "14711"     "14712"    
##  [67] "76263"     "56794"     "15112"     "114664"    "243168"    "15488"    
##  [73] "27400"     "107605"    "19683"     "54150"     "103142"    "216453"   
##  [79] "216454"    "15494"     "15496"     "15497"     "15492"     "15493"    
##  [85] "15495"     "100043456" "100043461" "101502"    "15926"     "269951"   
##  [91] "319554"    "66307"     "16596"     "16818"     "17096"     "15162"    
##  [97] "16890"     "66887"     "56690"     "17999"     "18145"     "237636"   
## [103] "23957"     "20186"     "18171"     "110784"    "67993"     "71648"    
## [109] "212503"    "111175"    "71382"     "18631"     "69129"     "103737"   
## [115] "72129"     "18633"     "19298"     "74043"     "224824"    "18634"    
## [121] "18642"     "56421"     "18641"     "16922"     "19193"     "67452"    
## [127] "54683"     "19301"     "19659"     "67442"     "20181"     "20183"    
## [133] "20280"     "12401"     "18400"     "20522"     "54338"     "26458"    
## [139] "225579"    "26459"     "63959"     "73836"     "28250"     "28248"    
## [145] "28254"     "108096"    "625716"    "435927"    "28253"     "58807"    
## [151] "223920"    "20655"     "56362"     "54200"     "100043194" "76971"    
## [157] "638251"    "434121"    "629203"    "434264"    "629219"    "20859"    
## [163] "81879"     "22221"     "22139"    
## 
## $HALLMARK_PEROXISOME
##   [1] "18671"     "18669"     "18670"     "27413"     "56325"     "21355"    
##   [7] "27416"     "244562"    "17250"     "12780"     "20927"     "20928"    
##  [13] "239273"    "11666"     "26874"     "19299"     "235674"    "113868"   
##  [19] "170789"    "11430"     "14081"     "433256"    "216739"    "50790"    
##  [25] "11657"     "11668"     "26358"     "19378"     "56847"     "72535"    
##  [31] "11669"     "56752"     "20238"     "12042"     "12287"     "12286"    
##  [37] "12288"     "12290"     "54652"     "12289"     "12292"     "54725"    
##  [43] "12359"     "12572"     "12613"     "76524"     "26889"     "12785"    
##  [49] "75064"     "12903"     "12904"     "12908"     "12647"     "13016"    
##  [55] "13017"     "51797"     "55936"     "74754"     "20148"     "13370"    
##  [61] "107585"    "13385"     "51798"     "23986"     "69123"     "74147"    
##  [67] "68801"     "54326"     "13850"     "13870"     "70333"     "13872"    
##  [73] "13983"     "16204"     "76267"     "60527"     "56473"     "228151"   
##  [79] "110196"    "66437"     "14712"     "76263"     "56185"     "15356"    
##  [85] "208982"    "15461"     "15484"     "114664"    "243168"    "15488"    
##  [91] "101502"    "15492"     "15925"     "15926"     "269951"    "319554"   
##  [97] "66307"     "16413"     "66887"     "56690"     "17685"     "78388"    
## [103] "18171"     "110959"    "18458"     "18459"     "67543"     "381404"   
## [109] "230721"    "18631"     "18632"     "72129"     "56273"     "19302"    
## [115] "19305"     "224824"    "18477"     "21672"     "54683"     "17252"    
## [121] "67442"     "20183"     "20181"     "22287"     "20280"     "20348"    
## [127] "20346"     "20347"     "20349"     "108151"    "12401"     "20437"    
## [133] "20438"     "54338"     "20524"     "67283"     "11739"     "11740"    
## [139] "26458"     "225579"    "73836"     "20588"     "68094"     "20655"    
## [145] "20656"     "20905"     "54200"     "100043194" "76971"     "638251"   
## [151] "434121"    "629203"    "434264"    "629219"    "20859"     "21973"    
## [157] "12257"     "22139"     "71773"     "100559"    "100727"    "112417"   
## [163] "243085"    "231396"    "22238"     "72094"     "552899"    "20479"    
## [169] "116733"    "22629"     "22628"    
## 
## $HALLMARK_ALLOGRAFT_REJECTION
##   [1] "234734"    "24015"     "11308"     "329165"    "11423"     "11480"    
##   [7] "11481"     "11651"     "11652"     "23797"     "11785"     "12010"    
##  [13] "12035"     "12042"     "12051"     "12189"     "12263"     "12332"    
##  [19] "27220"     "20292"     "20306"     "20293"     "20296"     "24047"    
##  [25] "100040035" "100861618" "100039789" "100861647" "100039848" "100039053"
##  [31] "100043918" "100043921" "100039973" "20299"     "20303"     "20304"    
##  [37] "12444"     "12443"     "12445"     "12768"     "12770"     "12772"    
##  [43] "12774"     "12479"     "12480"     "12481"     "12503"     "12487"    
##  [49] "12500"     "12501"     "12502"     "12504"     "21939"     "21947"    
##  [55] "16423"     "12516"     "16149"     "12518"     "12519"     "12524"    
##  [61] "12525"     "12526"     "84544"     "12578"     "12579"     "18636"    
##  [67] "54698"     "12977"     "12988"     "13040"     "13038"     "55985"    
##  [73] "17329"     "12766"     "226414"    "13244"     "619326"    "70059"    
##  [79] "226419"    "69181"     "13649"     "13869"     "13866"     "13867"    
##  [85] "13669"     "55944"     "78655"     "100042807" "230861"    "208643"   
##  [91] "276770"    "50701"     "19152"     "56501"     "13874"     "23871"    
##  [97] "14061"     "14062"     "14102"     "79201"     "14103"     "14130"    
## [103] "14131"     "677296"    "14191"     "14360"     "20779"     "22612"    
## [109] "192176"    "286940"    "68794"     "23880"     "14423"     "271786"   
## [115] "14469"     "14468"     "229900"    "14537"     "170823"    "14744"    
## [121] "14938"     "14939"     "14940"     "14942"     "14944"     "14943"    
## [127] "14941"     "245839"    "17231"     "15163"     "79221"     "15184"    
## [133] "56233"     "208727"    "15251"     "13819"     "15006"     "15013"    
## [139] "14972"     "15040"     "14990"     "15007"     "15018"     "14964"    
## [145] "14991"     "14963"     "15015"     "110557"    "630294"    "667977"   
## [151] "240095"    "15043"     "14985"     "110696"    "333715"    "224753"   
## [157] "224754"    "399549"    "100529082" "15039"     "224756"    "15024"    
## [163] "224761"    "14997"     "69717"     "14980"     "15019"     "110558"   
## [169] "14998"     "15000"     "14999"     "15001"     "15002"     "14961"    
## [175] "14960"     "100504404" "667803"    "15894"     "15898"     "50723"    
## [181] "230623"    "230613"    "329918"    "15976"     "15978"     "15979"    
## [187] "15980"     "80719"     "16150"     "12675"     "16153"     "16156"    
## [193] "16159"     "16160"     "16161"     "16163"     "16168"     "16170"    
## [199] "16173"     "16174"     "16176"     "16183"     "50931"     "16184"    
## [205] "16185"     "16186"     "16189"     "16190"     "16193"     "16196"    
## [211] "16198"     "16323"     "16324"     "16364"     "54123"     "15900"    
## [217] "16408"     "16414"     "16415"     "16412"     "16421"     "16428"    
## [223] "21682"     "12229"     "16452"     "54721"     "16451"     "16643"    
## [229] "16678"     "16681"     "16687"     "16688"     "406220"    "110308"   
## [235] "16818"     "17096"     "15162"     "16822"     "16878"     "16994"    
## [241] "17076"     "17084"     "26409"     "26411"     "17195"     "17395"    
## [247] "94062"     "76784"     "17972"     "17973"     "17086"     "216799"   
## [253] "378425"    "195046"    "637515"    "18102"     "18126"     "18127"    
## [259] "18125"     "18148"     "56744"     "20309"     "18646"     "18751"    
## [265] "18750"     "18752"     "19171"     "15170"     "19264"     "104458"   
## [271] "192656"    "67248"     "68172"     "66211"     "27367"     "20005"    
## [277] "100042823" "194905"    "20085"     "20091"     "100043780" "76846"    
## [283] "54390"     "12703"     "56468"     "20375"     "19073"     "20452"    
## [289] "192187"    "192188"    "20846"     "20848"     "20849"     "21354"    
## [295] "21355"     "56325"     "21356"     "21803"     "21808"     "21838"    
## [301] "21857"     "21897"     "21899"     "24088"     "142980"    "279572"   
## [307] "21926"     "21985"     "22030"     "77647"     "216080"    "75097"    
## [313] "237009"    "93765"     "22375"     "22376"     "73178"     "22637"    
## [319] "20963"    
## 
## $HALLMARK_SPERMATOGENESIS
##   [1] "11421"     "54137"     "11451"     "11471"     "11470"     "21744"    
##   [7] "11495"     "11516"     "15463"     "11643"     "11642"     "11687"    
##  [13] "11685"     "11684"     "11861"     "109979"    "11872"     "20878"    
##  [19] "109880"    "11836"     "110157"    "12235"     "12326"     "12427"    
##  [25] "12442"     "12467"     "12466"     "12534"     "72391"     "12638"    
##  [31] "231600"    "12672"     "12745"     "12330"     "20480"     "74438"    
##  [37] "215890"    "12794"     "72978"     "12812"     "22024"     "11572"    
##  [43] "11571"     "13000"     "12995"     "13012"     "69294"     "27214"    
##  [49] "13176"     "18007"     "30959"     "13206"     "13404"     "50796"    
##  [55] "56691"     "71854"     "319446"    "13479"     "12686"     "14056"    
##  [61] "14055"     "14415"     "14417"     "14447"     "14433"     "14581"    
##  [67] "14582"     "23885"     "627264"    "434725"    "668964"    "668963"   
##  [73] "668960"    "668958"    "630022"    "100040482" "100040533" "100040606"
##  [79] "100040722" "100040732" "100040781" "100042168" "100042254" "100042275"
##  [85] "100861971" "100862067" "100862329" "11536"     "14823"     "268934"   
##  [91] "108073"    "14816"     "108069"    "108071"    "108072"    "14840"    
##  [97] "14866"     "14864"     "14867"     "68312"     "14862"     "14863"    
## [103] "14865"     "107970"    "15126"     "216635"    "544763"    "15122"    
## [109] "110257"    "15407"     "15429"     "15482"     "15481"     "193740"   
## [115] "14828"     "15512"     "15511"     "18415"     "15563"     "15564"    
## [121] "15925"     "21821"     "16162"     "16165"     "27399"     "83964"    
## [127] "73804"     "16563"     "16833"     "14245"     "64899"     "17761"    
## [133] "17776"     "56527"     "328329"    "17288"     "17349"     "17354"    
## [139] "246198"    "17773"     "244701"    "56717"     "97243"     "56292"    
## [145] "117903916" "215387"    "380684"    "18040"     "18005"     "18016"    
## [151] "18125"     "18126"     "18127"     "53885"     "18168"     "53814"    
## [157] "18285"     "69310"     "56522"     "18789"     "216578"    "11546"    
## [163] "11545"     "30052"     "18551"     "18550"     "18598"     "18597"    
## [169] "23980"     "76400"     "18663"     "18655"     "74451"     "71838"    
## [175] "68961"     "17344"     "18976"     "19087"     "19088"     "19119"    
## [181] "56088"     "19356"     "106344"    "68172"     "67248"     "20255"    
## [187] "20394"     "18952"     "214547"    "93759"     "20496"     "20495"    
## [193] "20497"     "56485"     "435818"    "20616"     "67946"     "56324"    
## [199] "20744"     "16201"     "20957"     "21351"     "21463"     "71841"    
## [205] "24084"     "21830"     "71868"     "83553"     "74419"     "21881"    
## [211] "21888"     "21887"     "21885"     "21954"     "21953"     "21952"    
## [217] "21958"     "21959"     "235559"    "22099"     "22115"     "22137"    
## [223] "22144"     "22147"     "22143"     "22146"     "22145"     "22142"    
## [229] "53857"     "238463"    "56734"     "22335"     "53422"     "72350"    
## [235] "75553"     "20834"     "53604"    
## 
## $HALLMARK_KRAS_SIGNALING_UP
##   [1] "18671"     "18669"     "18670"     "27413"     "11421"     "11491"    
##   [7] "11501"     "58860"     "13522"     "78560"     "70693"     "170757"   
##  [13] "83397"     "11652"     "23797"     "19378"     "26358"     "11668"    
##  [19] "56847"     "72535"     "11669"     "56068"     "225339"    "57875"    
##  [25] "11732"     "101772"    "243634"    "228432"    "26359"     "11815"    
##  [31] "11846"     "66795"     "78937"     "11796"     "11797"     "17951"    
##  [37] "17952"     "17940"     "17948"     "12156"     "12183"     "228662"   
##  [43] "12223"     "12267"     "12349"     "69008"     "12402"     "234309"   
##  [49] "30951"     "20297"     "12444"     "12443"     "12445"     "72972"    
##  [55] "12493"     "12521"     "71891"     "14962"     "12628"     "214403"   
##  [61] "545366"    "50702"     "12683"     "14311"     "73149"     "269799"   
##  [67] "26888"     "474145"    "69810"     "381809"    "17474"     "56620"    
##  [73] "14747"     "12876"     "74114"     "12981"     "12982"     "16188"    
##  [79] "13040"     "13038"     "15945"     "12767"     "73379"     "71972"    
##  [85] "94176"     "330662"    "68813"     "67603"     "235584"    "13730"    
##  [91] "13805"     "13823"     "13844"     "13845"     "270190"    "13846"    
##  [97] "13835"     "13840"     "13842"     "13848"     "13841"     "13836"    
## [103] "13838"     "13837"     "13839"     "13874"     "50527"     "23871"    
## [109] "14009"     "18612"     "104156"    "14020"     "213027"    "74145"    
## [115] "331046"    "14063"     "106052"    "14127"     "14180"     "80857"    
## [121] "80903"     "14257"     "14254"     "71665"     "14373"     "14396"    
## [127] "14394"     "14395"     "110886"    "23882"     "13197"     "14425"    
## [133] "207839"    "14584"     "93692"     "66066"     "14699"     "93695"    
## [139] "64297"     "70355"     "60596"     "71683"     "319178"    "319184"   
## [145] "319185"    "319186"    "319187"    "319188"    "319189"    "68024"    
## [151] "69389"     "78303"     "319179"    "319180"    "319181"    "319183"   
## [157] "15200"     "79221"     "15184"     "56233"     "208727"    "216019"   
## [163] "15277"     "212032"    "15275"     "15431"     "15483"     "15902"    
## [169] "16002"     "16009"     "16011"     "22778"     "16154"     "16176"    
## [175] "107527"    "16186"     "77125"     "16197"     "16323"     "16324"    
## [181] "15900"     "16398"     "213119"    "319480"    "109700"    "16414"    
## [187] "16415"     "16412"     "16421"     "223272"    "16480"     "12387"    
## [193] "16534"     "16574"     "16572"     "16573"     "16600"     "16598"    
## [199] "16792"     "56743"     "18826"     "102866"    "102502"    "16878"    
## [205] "17087"     "16658"     "17132"     "228576"    "26401"     "26411"    
## [211] "17761"     "67468"     "75104"     "17384"     "17392"     "17385"    
## [217] "17395"     "14012"     "233315"    "18109"     "17870"     "17954"    
## [223] "18049"     "18080"     "23957"     "20186"     "18186"     "18187"    
## [229] "18546"     "30052"     "58205"     "18613"     "18616"     "18703"    
## [235] "18791"     "18792"     "18793"     "27260"     "84094"     "57349"    
## [241] "20309"     "17872"     "12142"     "66390"     "225655"    "19092"    
## [247] "19091"     "18933"     "20204"     "16913"     "56195"     "68927"    
## [253] "19225"     "19224"     "19279"     "320139"    "29809"     "227800"   
## [259] "19653"     "66704"     "102902673" "19662"     "19699"     "57264"    
## [265] "57263"     "19734"     "20230"     "20255"     "20394"     "20266"    
## [271] "76816"     "20347"     "16625"     "20716"     "271047"    "20717"    
## [277] "238393"    "20714"     "20715"     "74069"     "628900"    "238395"   
## [283] "194604"    "20568"     "20614"     "20616"     "20682"     "20665"    
## [289] "20681"     "13602"     "233744"    "20750"     "24064"     "20440"    
## [295] "268980"    "94186"     "97387"     "21788"     "170744"    "170743"   
## [301] "67888"     "72309"     "66058"     "65963"     "21929"     "21938"    
## [307] "21956"     "21957"     "21955"     "240832"    "21990"     "22029"    
## [313] "211770"    "217410"    "66805"     "66109"     "21912"     "56496"    
## [319] "72088"     "22217"     "69727"     "67776"     "244810"    "74320"    
## [325] "22421"     "22422"     "230734"    "246196"    "67778"    
## 
## $HALLMARK_KRAS_SIGNALING_DN
##   [1] "27413"  "192663" "11464"  "11468"  "11459"  "11475"  "238880" "11461" 
##   [9] "11553"  "14187"  "67861"  "11997"  "11686"  "11688"  "23801"  "11689" 
##  [17] "11698"  "14570"  "74100"  "117589" "11944"  "27222"  "192113" "11928" 
##  [25] "98660"  "232975" "110935" "11966"  "12021"  "12167"  "12166"  "114642"
##  [33] "12227"  "436199" "194735" "12226"  "15139"  "12266"  "54652"  "12288" 
##  [41] "12290"  "12286"  "12289"  "12292"  "12299"  "116903" "12310"  "80796" 
##  [49] "494124" "227541" "52163"  "73647"  "12335"  "170725" "12333"  "12334" 
##  [57] "232821" "12427"  "12776"  "246278" "21947"  "12519"  "12556"  "68916" 
##  [65] "53883"  "12614"  "107934" "11449"  "54371"  "60322"  "12715"  "12709" 
##  [73] "114141" "54420"  "57255"  "239931" "109791" "232370" "64085"  "12804" 
##  [81] "12824"  "12829"  "12828"  "107581" "53867"  "71355"  "94216"  "373864"
##  [89] "12825"  "12826"  "12827"  "12830"  "12831"  "12832"  "12836"  "12842" 
##  [97] "12843"  "56358"  "56447"  "67426"  "232680" "71791"  "76703"  "208922"
## [105] "67579"  "231207" "110115" "13072"  "56050"  "13176"  "18007"  "106565"
## [113] "13528"  "13527"  "13608"  "13614"  "13615"  "98363"  "27984"  "13645" 
## [121] "93685"  "67464"  "13839"  "13837"  "13846"  "13845"  "13835"  "13840" 
## [129] "13842"  "270190" "13848"  "13841"  "13836"  "13838"  "13844"  "80903" 
## [137] "14180"  "80857"  "67112"  "14184"  "75578"  "14308"  "14431"  "14573" 
## [145] "14723"  "67133"  "22242"  "665186" "14760"  "14748"  "70355"  "64297" 
## [153] "14804"  "14803"  "70239"  "21405"  "15484"  "15551"  "15552"  "15932" 
## [161] "15061"  "99899"  "15978"  "16008"  "16160"  "16191"  "23919"  "16370" 
## [169] "16369"  "26549"  "16426"  "16424"  "16427"  "16425"  "16506"  "16508" 
## [177] "56543"  "246133" "16533"  "84036"  "140492" "140493" "16536"  "110862"
## [185] "213417" "23993"  "259277" "381022" "231051" "16678"  "16681"  "16687" 
## [193] "16688"  "406220" "110308" "16663"  "16665"  "16682"  "239673" "109052"
## [201] "77055"  "406223" "16848"  "17305"  "19719"  "16858"  "72434"  "404634"
## [209] "26914"  "54634"  "546071" "56527"  "328329" "17776"  "54483"  "98682" 
## [217] "17687"  "17769"  "17858"  "17857"  "140781" "17888"  "17910"  "58916" 
## [225] "72333"  "64242"  "18125"  "18126"  "18127"  "54631"  "19065"  "18227" 
## [233] "18124"  "14536"  "60345"  "18205"  "102954" "58242"  "71207"  "18429" 
## [241] "11998"  "18440"  "57385"  "18442"  "18505"  "18509"  "18506"  "93872" 
## [249] "93873"  "93874"  "93875"  "93876"  "93877"  "93878"  "93879"  "93880" 
## [257] "93881"  "93882"  "93883"  "93884"  "93885"  "93886"  "93887"  "93888" 
## [265] "93889"  "93890"  "93892"  "93893"  "18566"  "18587"  "110855" "225600"
## [273] "18604"  "18772"  "56711"  "18948"  "50873"  "19125"  "19127"  "19220" 
## [281] "19271"  "50782"  "67747"  "66611"  "58185"  "20190"  "20192"  "20191" 
## [289] "22287"  "20264"  "20272"  "20273"  "24046"  "20265"  "110876" "20269" 
## [297] "20271"  "20363"  "217847" "18788"  "20393"  "20429"  "320007" "214597"
## [305] "20482"  "20497"  "20496"  "20495"  "20503"  "66972"  "71279"  "22784" 
## [313] "76257"  "114479" "56774"  "13162"  "20538"  "66106"  "104069" "20621" 
## [321] "20665"  "20681"  "20682"  "56632"  "20766"  "20754"  "20753"  "20743" 
## [329] "20742"  "80297"  "20741"  "20608"  "50878"  "20843"  "20842"  "104027"
## [337] "57253"  "21415"  "21416"  "21432"  "23964"  "23965"  "23966"  "74645" 
## [345] "212943" "104271" "21419"  "21418"  "81879"  "22221"  "21785"  "21819" 
## [353] "21808"  "21816"  "331046" "232078" "21834"  "21908"  "21954"  "21953" 
## [361] "21952"  "22094"  "71773"  "100559" "100727" "112417" "243085" "231396"
## [369] "22238"  "72094"  "552899" "100647" "22363"  "22362"  "73288"  "93735" 
## [377] "53422"  "106369" "77864"  "235320" "72350"  "57745"  "22756"  "56525" 
## 
## $HALLMARK_PANCREAS_BETA_CELLS
##  [1] "20927"  "20928"  "17250"  "27416"  "244562" "239273" "23797"  "11652" 
##  [9] "12652"  "13193"  "13482"  "14089"  "77766"  "15376"  "56458"  "14378" 
## [17] "14377"  "14526"  "103988" "21405"  "15874"  "16334"  "16333"  "53626" 
## [25] "56856"  "16392"  "104360" "16909"  "16658"  "17132"  "18012"  "11925" 
## [33] "18088"  "18096"  "14912"  "74561"  "18481"  "18479"  "224105" "18506" 
## [41] "18508"  "18548"  "18549"  "18609"  "18770"  "214189" "56529"  "66286" 
## [49] "20526"  "69019"  "20813"  "27058"  "20818"  "20604"  "20910"  "20911" 
## [57] "80976"  "22337"

List to GeneSetCollection

We can convert the list to a GeneSetCollection to take advantage of GSEABase functionality.

We must first create a list of GeneSet objects using GeneSet() constructor and then create GeneSetCollection from list usin GeneSetCollection constructor.

myGeneSetList <- list()
for (i in 1:length(Mm.H)) {
    myGeneSetList[[i]] <- GeneSet(Mm.H[[i]], setName = names(Mm.H)[i])
}
myGeneSetCollection <- GeneSetCollection(myGeneSetList)
myGeneSetCollection
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_HYPOXIA, ..., HALLMARK_PANCREAS_BETA_CELLS (50 total)
##   unique identifiers: 11303, 11304, ..., 80976 (5897 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)

GeneSetCollection to gmt

We can now use the toGmt function to export our GeneSetCollection to gmt formated file for use in other software.

toGmt(myGeneSetCollection, con = "mouse_Hallmarks.gmt")

Testing gene set enrichment


Testing gene sets

We will review two different methods to identify functional groups associated with our condition of interest.

  • The first method will test for any association of our gene set with our a group of interesting genes (differentially expressed genes).
  • The second method will test for any association of our gene set with the ranking of all our genes (ranked by measure of differential expression).

DE results from DESeq2

First lets read in our differential expression results from DESeq2 analysis of activated vs resting T-cells.

Activated_minus_Resting <- read.delim(file = "data/Group_Activated_minus_Resting.csv", 
    sep = ",")
Activated_minus_Resting[1:3, ]
##    ENTREZID  SYMBOL baseMean log2FoldChange    lfcSE      stat   pvalue padj
## 1 100009600   Zglp1 3.685411      0.2755725 1.855514 0.1485154 0.881936   NA
## 2 100009609 Vmn2r65 0.000000             NA       NA        NA       NA   NA
## 3 100009614 Gm10024 0.000000             NA       NA        NA       NA   NA
##   newPadj
## 1       1
## 2      NA
## 3      NA

Background

All GSA methods will require us to filter to genes to those tested for differential expression.

We will therefore filter to all genes which pass our independent filtering step from DESeq2. These will be our genes with no NA in the DESeq2 padj column

Activated_minus_Resting <- Activated_minus_Resting[!is.na(Activated_minus_Resting$padj), 
    ]
Activated_minus_Resting[1:3, ]
##    ENTREZID  SYMBOL baseMean log2FoldChange      lfcSE        stat       pvalue
## 6    100017 Ldlrap1 2752.367    -0.04815446 0.08880811  -0.5422305 5.876598e-01
## 7    100019    Mdn1 2281.866    -1.09612289 0.09214164 -11.8960650 1.240603e-32
## 8 100033459  Ifi208 3282.679    -0.02774770 0.09029354  -0.3073055 7.586109e-01
##           padj      newPadj
## 6 7.416249e-01 1.000000e+00
## 7 7.038705e-31 2.424386e-28
## 8 8.601547e-01 1.000000e+00

goseq package

We can use the goseq package to identify any functional enrichment in a set of interesting genes (i.e. differentially expressed). The goseq package requires a named vector of 1s or 0s indicating whether a gene is upregulated/downregulated.

Here we define a set of genes significantly upregulated in Activated vs Naive T-reg cells (padj <0 05 and log2FC > 0).

UpInAct <- Activated_minus_Resting$padj < 0.05 & Activated_minus_Resting$log2FoldChange > 
    0
UpInAct <- as.integer(UpInAct)
names(UpInAct) <- Activated_minus_Resting$ENTREZID
UpInAct[1:4]
##    100017    100019 100033459 100034251 
##         0         0         0         0
table(UpInAct)
## UpInAct
##     0     1 
## 10883  2450

Gene ontology and functional testing.

We can see which genomes are supported using the supportedGenomes() function.

supGenomes <- supportedGenomes()
supGenomes[1:2, ]
##     db species      date                               name
## 2 hg19   Human Feb. 2009 Genome Reference Consortium GRCh37
## 3 hg18   Human Mar. 2006                    NCBI Build 36.1
##                                                                                                                  AvailableGeneIDs
## 2                                                    ccdsGene,ensGene,exoniphy,geneSymbol,knownGene,nscanGene,refGene,xenoRefGene
## 3 acembly,acescan,ccdsGene,ensGene,exoniphy,geneid,geneSymbol,genscan,knownGene,knownGeneOld3,refGene,sgpGene,sibGene,xenoRefGene

Gene length bias

The goseq package is specifically designed to account for potential length biases in differential expression analysis and so can remove any artefactual enrichment for long and short genes.

The nullp function assess any biases by evaluating the relationship between differential expression and length.

library(goseq)
pwf = nullp(UpInAct, "mm10", "knownGene", plot.fit = TRUE)

igv

Functional Enrichment analysis

Having corrected for any bias we can now use the goseq function to for enrichment of GO or KEGG terms.

We must specify the genome build and ID we are using (here matching our TxDb.UCSC.mm10.knownGene.db) and the categories we wish to test (GO:BP, GO:MF, GO:CC, KEGG).

Here we identify the top enriched functional terms in GO biological processes.

GO_UpInAct <- goseq(pwf, "mm10", "knownGene", test.cats = c("GO:BP"))
GO_UpInAct[1:3, ]
##        category over_represented_pvalue under_represented_pvalue numDEInCat
## 616  GO:0002376            8.286527e-38                        1        545
## 8070 GO:0050896            3.104791e-36                        1       1249
## 1784 GO:0006952            3.035683e-32                        1        340
##      numInCat                  term ontology
## 616      1788 immune system process       BP
## 8070     5188  response to stimulus       BP
## 1784     1002      defense response       BP

Retrieving function groups

We can retrieve the genes in the immune response (GO:0006955) functional group using the select and the org.Mm.eg.db object.

library(org.Mm.eg.db)
ImmuneResponseGenes <- select(org.Mm.eg.db, keytype = "GOALL", keys = "GO:0006955", 
    columns = "ENTREZID")
ImmuneResponseGenes
##           GOALL EVIDENCEALL ONTOLOGYALL  ENTREZID
## 1    GO:0006955         IDA          BP     11350
## 2    GO:0006955         IGI          BP     11350
## 3    GO:0006955         IMP          BP     11350
## 4    GO:0006955         IDA          BP     11465
## 5    GO:0006955         IMP          BP     11486
## 6    GO:0006955         IBA          BP     11490
## 7    GO:0006955         ISO          BP     11490
## 8    GO:0006955         IMP          BP     11491
## 9    GO:0006955         IDA          BP     11501
## 10   GO:0006955         IMP          BP     11513
## 11   GO:0006955         ISO          BP     11516
## 12   GO:0006955         ISO          BP     11535
## 13   GO:0006955         IEA          BP     11537
## 14   GO:0006955         IMP          BP     11537
## 15   GO:0006955         IMP          BP     11541
## 16   GO:0006955         IDA          BP     11542
## 17   GO:0006955         IMP          BP     11542
## 18   GO:0006955         ISO          BP     11596
## 19   GO:0006955         IDA          BP     11600
## 20   GO:0006955         IMP          BP     11628
## 21   GO:0006955         IBA          BP     11634
## 22   GO:0006955         IDA          BP     11634
## 23   GO:0006955         IMP          BP     11634
## 24   GO:0006955         IEA          BP     11658
## 25   GO:0006955         IMP          BP     11687
## 26   GO:0006955         IMP          BP     11689
## 27   GO:0006955         ISO          BP     11692
## 28   GO:0006955         IBA          BP     11727
## 29   GO:0006955         IDA          BP     11727
## 30   GO:0006955         ISO          BP     11727
## 31   GO:0006955         IBA          BP     11730
## 32   GO:0006955         IBA          BP     11731
## 33   GO:0006955         ISO          BP     11745
## 34   GO:0006955         ISO          BP     11765
## 35   GO:0006955         IMP          BP     11793
## 36   GO:0006955         IMP          BP     11801
## 37   GO:0006955         ISO          BP     11806
## 38   GO:0006955         ISO          BP     11807
## 39   GO:0006955         IMP          BP     11808
## 40   GO:0006955         ISO          BP     11808
## 41   GO:0006955         IMP          BP     11816
## 42   GO:0006955         ISO          BP     11820
## 43   GO:0006955         ISO          BP     11829
## 44   GO:0006955         IEA          BP     11846
## 45   GO:0006955         IMP          BP     11846
## 46   GO:0006955         ISO          BP     11846
## 47   GO:0006955         IEA          BP     11847
## 48   GO:0006955         IMP          BP     11847
## 49   GO:0006955         IMP          BP     11891
## 50   GO:0006955         IMP          BP     11977
## 51   GO:0006955         IBA          BP     12007
## 52   GO:0006955         IEA          BP     12010
## 53   GO:0006955         IMP          BP     12010
## 54   GO:0006955         ISO          BP     12010
## 55   GO:0006955         ISO          BP     12014
## 56   GO:0006955         ISO          BP     12028
## 57   GO:0006955         IBA          BP     12029
## 58   GO:0006955         IBA          BP     12042
## 59   GO:0006955         IMP          BP     12042
## 60   GO:0006955         ISO          BP     12042
## 61   GO:0006955         ISO          BP     12043
## 62   GO:0006955         IDA          BP     12047
## 63   GO:0006955         IMP          BP     12051
## 64   GO:0006955         IBA          BP     12053
## 65   GO:0006955         IGI          BP     12053
## 66   GO:0006955         IMP          BP     12053
## 67   GO:0006955         ISO          BP     12062
## 68   GO:0006955         IEA          BP     12142
## 69   GO:0006955         IBA          BP     12143
## 70   GO:0006955         ISO          BP     12143
## 71   GO:0006955         IBA          BP     12145
## 72   GO:0006955         IMP          BP     12151
## 73   GO:0006955         ISO          BP     12161
## 74   GO:0006955         ISO          BP     12166
## 75   GO:0006955         IBA          BP     12169
## 76   GO:0006955         IEA          BP     12229
## 77   GO:0006955         IMP          BP     12229
## 78   GO:0006955         ISO          BP     12229
## 79   GO:0006955         IBA          BP     12231
## 80   GO:0006955         IEA          BP     12258
## 81   GO:0006955         ISO          BP     12258
## 82   GO:0006955         IEA          BP     12259
## 83   GO:0006955         IMP          BP     12259
## 84   GO:0006955         IEA          BP     12260
## 85   GO:0006955         IBA          BP     12261
## 86   GO:0006955         IEA          BP     12261
## 87   GO:0006955         ISO          BP     12261
## 88   GO:0006955         IEA          BP     12262
## 89   GO:0006955         IEA          BP     12263
## 90   GO:0006955         ISO          BP     12263
## 91   GO:0006955         IDA          BP     12265
## 92   GO:0006955         ISO          BP     12265
## 93   GO:0006955         IBA          BP     12266
## 94   GO:0006955         IDA          BP     12266
## 95   GO:0006955         IEA          BP     12266
## 96   GO:0006955         IMP          BP     12266
## 97   GO:0006955         ISO          BP     12266
## 98   GO:0006955         IBA          BP     12267
## 99   GO:0006955         ISO          BP     12267
## 100  GO:0006955         IBA          BP     12268
## 101  GO:0006955         IMP          BP     12268
## 102  GO:0006955         IEA          BP     12269
## 103  GO:0006955         IBA          BP     12273
## 104  GO:0006955         ISO          BP     12273
## 105  GO:0006955         IMP          BP     12274
## 106  GO:0006955         IEA          BP     12279
## 107  GO:0006955         IMP          BP     12297
## 108  GO:0006955         IMP          BP     12298
## 109  GO:0006955         IEA          BP     12326
## 110  GO:0006955         IDA          BP     12332
## 111  GO:0006955         ISO          BP     12362
## 112  GO:0006955         IEA          BP     12363
## 113  GO:0006955         IBA          BP     12458
## 114  GO:0006955         IMP          BP     12458
## 115  GO:0006955         IEA          BP     12475
## 116  GO:0006955         IBA          BP     12477
## 117  GO:0006955         IEA          BP     12477
## 118  GO:0006955         ISO          BP     12477
## 119  GO:0006955         IBA          BP     12478
## 120  GO:0006955         IDA          BP     12478
## 121  GO:0006955         IEA          BP     12478
## 122  GO:0006955         IMP          BP     12478
## 123  GO:0006955         ISO          BP     12478
## 124  GO:0006955         IBA          BP     12479
## 125  GO:0006955         IDA          BP     12479
## 126  GO:0006955         IEA          BP     12479
## 127  GO:0006955         IMP          BP     12479
## 128  GO:0006955         IBA          BP     12480
## 129  GO:0006955         ISO          BP     12482
## 130  GO:0006955         IBA          BP     12483
## 131  GO:0006955         IGI          BP     12483
## 132  GO:0006955         ISO          BP     12483
## 133  GO:0006955         IDA          BP     12484
## 134  GO:0006955         IEA          BP     12484
## 135  GO:0006955         IMP          BP     12484
## 136  GO:0006955         IBA          BP     12487
## 137  GO:0006955         IEA          BP     12487
## 138  GO:0006955         IMP          BP     12487
## 139  GO:0006955         IEA          BP     12491
## 140  GO:0006955         IMP          BP     12491
## 141  GO:0006955         IMP          BP     12493
## 142  GO:0006955         ISO          BP     12494
## 143  GO:0006955         IEA          BP     12500
## 144  GO:0006955         IDA          BP     12501
## 145  GO:0006955         IEA          BP     12501
## 146  GO:0006955         IEA          BP     12502
## 147  GO:0006955         IBA          BP     12503
## 148  GO:0006955         IDA          BP     12503
## 149  GO:0006955         IEA          BP     12503
## 150  GO:0006955         IEA          BP     12504
## 151  GO:0006955         IMP          BP     12504
## 152  GO:0006955         NAS          BP     12505
## 153  GO:0006955         IEA          BP     12506
## 154  GO:0006955         IBA          BP     12509
## 155  GO:0006955         IDA          BP     12509
## 156  GO:0006955         IMP          BP     12509
## 157  GO:0006955         ISO          BP     12509
## 158  GO:0006955         ISO          BP     12511
## 159  GO:0006955         IDA          BP     12514
## 160  GO:0006955         IEA          BP     12516
## 161  GO:0006955         IBA          BP     12518
## 162  GO:0006955         IDA          BP     12518
## 163  GO:0006955         IEA          BP     12518
## 164  GO:0006955         IBA          BP     12519
## 165  GO:0006955         IEA          BP     12520
## 166  GO:0006955         IMP          BP     12520
## 167  GO:0006955         ISO          BP     12520
## 168  GO:0006955         IEA          BP     12523
## 169  GO:0006955         ISO          BP     12523
## 170  GO:0006955         IBA          BP     12524
## 171  GO:0006955         IEA          BP     12524
## 172  GO:0006955         IBA          BP     12525
## 173  GO:0006955         IEA          BP     12525
## 174  GO:0006955         IMP          BP     12525
## 175  GO:0006955         IEA          BP     12526
## 176  GO:0006955         ISO          BP     12539
## 177  GO:0006955         IDA          BP     12540
## 178  GO:0006955         IMP          BP     12557
## 179  GO:0006955         IDA          BP     12611
## 180  GO:0006955         IMP          BP     12611
## 181  GO:0006955         IDA          BP     12628
## 182  GO:0006955         IEA          BP     12628
## 183  GO:0006955         IGI          BP     12628
## 184  GO:0006955         IMP          BP     12628
## 185  GO:0006955         ISO          BP     12628
## 186  GO:0006955         IEA          BP     12630
## 187  GO:0006955         IMP          BP     12630
## 188  GO:0006955         ISO          BP     12652
## 189  GO:0006955         IEA          BP     12703
## 190  GO:0006955         IDA          BP     12705
## 191  GO:0006955         ISO          BP     12721
## 192  GO:0006955         IBA          BP     12765
## 193  GO:0006955         ISO          BP     12765
## 194  GO:0006955         IBA          BP     12766
## 195  GO:0006955         IBA          BP     12767
## 196  GO:0006955         IBA          BP     12768
## 197  GO:0006955         IMP          BP     12768
## 198  GO:0006955         ISO          BP     12768
## 199  GO:0006955         IBA          BP     12769
## 200  GO:0006955         IBA          BP     12770
## 201  GO:0006955         IBA          BP     12771
## 202  GO:0006955         IBA          BP     12772
## 203  GO:0006955          IC          BP     12772
## 204  GO:0006955         IMP          BP     12772
## 205  GO:0006955         IBA          BP     12773
## 206  GO:0006955         IBA          BP     12774
## 207  GO:0006955         IBA          BP     12775
## 208  GO:0006955          IC          BP     12775
## 209  GO:0006955         IMP          BP     12775
## 210  GO:0006955         IBA          BP     12776
## 211  GO:0006955         IBA          BP     12777
## 212  GO:0006955         IBA          BP     12778
## 213  GO:0006955         IBA          BP     12796
## 214  GO:0006955         IMP          BP     12796
## 215  GO:0006955         ISO          BP     12796
## 216  GO:0006955         ISO          BP     12801
## 217  GO:0006955         IMP          BP     12810
## 218  GO:0006955         ISO          BP     12825
## 219  GO:0006955         IEA          BP     12890
## 220  GO:0006955         IEA          BP     12902
## 221  GO:0006955         IEA          BP     12909
## 222  GO:0006955         ISO          BP     12921
## 223  GO:0006955         ISO          BP     12927
## 224  GO:0006955         ISO          BP     12928
## 225  GO:0006955         IDA          BP     12929
## 226  GO:0006955         IBA          BP     12944
## 227  GO:0006955         ISO          BP     12944
## 228  GO:0006955         ISO          BP     12945
## 229  GO:0006955         IEA          BP     12946
## 230  GO:0006955         IMP          BP     12946
## 231  GO:0006955         ISO          BP     12946
## 232  GO:0006955         TAS          BP     12946
## 233  GO:0006955         IEA          BP     12977
## 234  GO:0006955         IEA          BP     12978
## 235  GO:0006955         IEA          BP     12981
## 236  GO:0006955         IEA          BP     12985
## 237  GO:0006955         IBA          BP     12988
## 238  GO:0006955         IEA          BP     12988
## 239  GO:0006955         ISO          BP     12988
## 240  GO:0006955         IBA          BP     13013
## 241  GO:0006955         IDA          BP     13013
## 242  GO:0006955         IGI          BP     13032
## 243  GO:0006955         IGI          BP     13035
## 244  GO:0006955         IMP          BP     13035
## 245  GO:0006955         ISO          BP     13035
## 246  GO:0006955         IGI          BP     13036
## 247  GO:0006955         ISO          BP     13036
## 248  GO:0006955         IBA          BP     13038
## 249  GO:0006955         IBA          BP     13039
## 250  GO:0006955         IBA          BP     13040
## 251  GO:0006955         IBA          BP     13051
## 252  GO:0006955          IC          BP     13051
## 253  GO:0006955         IMP          BP     13051
## 254  GO:0006955         IMP          BP     13057
## 255  GO:0006955         ISO          BP     13057
## 256  GO:0006955         IMP          BP     13058
## 257  GO:0006955         ISO          BP     13058
## 258  GO:0006955         ISO          BP     13115
## 259  GO:0006955         IEA          BP     13136
## 260  GO:0006955         IMP          BP     13136
## 261  GO:0006955         ISO          BP     13136
## 262  GO:0006955         IEA          BP     13137
## 263  GO:0006955         IMP          BP     13144
## 264  GO:0006955         ISO          BP     13144
## 265  GO:0006955         IEA          BP     13169
## 266  GO:0006955         ISO          BP     13205
## 267  GO:0006955         IEA          BP     13211
## 268  GO:0006955         IMP          BP     13211
## 269  GO:0006955         IBA          BP     13214
## 270  GO:0006955         IMP          BP     13214
## 271  GO:0006955         IBA          BP     13215
## 272  GO:0006955         IBA          BP     13216
## 273  GO:0006955         IBA          BP     13218
## 274  GO:0006955         IBA          BP     13219
## 275  GO:0006955         IBA          BP     13221
## 276  GO:0006955         IBA          BP     13222
## 277  GO:0006955         IBA          BP     13226
## 278  GO:0006955         IBA          BP     13229
## 279  GO:0006955         IBA          BP     13230
## 280  GO:0006955         IBA          BP     13232
## 281  GO:0006955         IBA          BP     13233
## 282  GO:0006955         IBA          BP     13234
## 283  GO:0006955         IBA          BP     13235
## 284  GO:0006955         IBA          BP     13236
## 285  GO:0006955         IBA          BP     13237
## 286  GO:0006955         IBA          BP     13238
## 287  GO:0006955         IDA          BP     13238
## 288  GO:0006955         IBA          BP     13239
## 289  GO:0006955         IBA          BP     13240
## 290  GO:0006955         IBA          BP     13241
## 291  GO:0006955         IBA          BP     13242
## 292  GO:0006955         IBA          BP     13243
## 293  GO:0006955         IMP          BP     13383
## 294  GO:0006955         IMP          BP     13388
## 295  GO:0006955         IDA          BP     13419
## 296  GO:0006955         IDA          BP     13421
## 297  GO:0006955         IGI          BP     13423
## 298  GO:0006955         ISO          BP     13482
## 299  GO:0006955         IMP          BP     13489
## 300  GO:0006955         IBA          BP     13586
## 301  GO:0006955         IBA          BP     13587
## 302  GO:0006955         IMP          BP     13601
## 303  GO:0006955         IEA          BP     13607
## 304  GO:0006955         ISO          BP     13667
## 305  GO:0006955         IGI          BP     13709
## 306  GO:0006955         IDA          BP     13731
## 307  GO:0006955         IEA          BP     13733
## 308  GO:0006955         IBA          BP     13813
## 309  GO:0006955         IDA          BP     13813
## 310  GO:0006955         IEA          BP     13813
## 311  GO:0006955         ISO          BP     13813
## 312  GO:0006955         IMP          BP     13848
## 313  GO:0006955         IMP          BP     13870
## 314  GO:0006955         IMP          BP     13874
## 315  GO:0006955         IDA          BP     14026
## 316  GO:0006955         IBA          BP     14038
## 317  GO:0006955         ISO          BP     14061
## 318  GO:0006955         IDA          BP     14063
## 319  GO:0006955         IEA          BP     14063
## 320  GO:0006955         ISO          BP     14063
## 321  GO:0006955         IMP          BP     14082
## 322  GO:0006955         ISO          BP     14082
## 323  GO:0006955         TAS          BP     14082
## 324  GO:0006955         IBA          BP     14083
## 325  GO:0006955         IEA          BP     14102
## 326  GO:0006955         IMP          BP     14102
## 327  GO:0006955         IEA          BP     14103
## 328  GO:0006955         IDA          BP     14109
## 329  GO:0006955         ISO          BP     14109
## 330  GO:0006955         IBA          BP     14125
## 331  GO:0006955         IDA          BP     14125
## 332  GO:0006955         IMP          BP     14125
## 333  GO:0006955         IEA          BP     14126
## 334  GO:0006955         ISO          BP     14126
## 335  GO:0006955         IBA          BP     14127
## 336  GO:0006955         IDA          BP     14127
## 337  GO:0006955         IMP          BP     14127
## 338  GO:0006955         ISO          BP     14127
## 339  GO:0006955         IMP          BP     14128
## 340  GO:0006955         IBA          BP     14129
## 341  GO:0006955         IEA          BP     14129
## 342  GO:0006955         IMP          BP     14129
## 343  GO:0006955         IBA          BP     14130
## 344  GO:0006955         IMP          BP     14130
## 345  GO:0006955         ISO          BP     14130
## 346  GO:0006955         IBA          BP     14131
## 347  GO:0006955         IDA          BP     14131
## 348  GO:0006955         IMP          BP     14131
## 349  GO:0006955         IBA          BP     14132
## 350  GO:0006955         IBA          BP     14133
## 351  GO:0006955         IDA          BP     14133
## 352  GO:0006955         IEA          BP     14133
## 353  GO:0006955         IBA          BP     14134
## 354  GO:0006955         IEA          BP     14134
## 355  GO:0006955         ISO          BP     14134
## 356  GO:0006955         IBA          BP     14158
## 357  GO:0006955         IMP          BP     14158
## 358  GO:0006955         IBA          BP     14159
## 359  GO:0006955         ISO          BP     14159
## 360  GO:0006955         IEA          BP     14161
## 361  GO:0006955         ISO          BP     14161
## 362  GO:0006955         IMP          BP     14190
## 363  GO:0006955         IBA          BP     14191
## 364  GO:0006955         IDA          BP     14191
## 365  GO:0006955         IMP          BP     14191
## 366  GO:0006955         ISO          BP     14225
## 367  GO:0006955         IMP          BP     14245
## 368  GO:0006955         IBA          BP     14289
## 369  GO:0006955         ISO          BP     14289
## 370  GO:0006955         IBA          BP     14290
## 371  GO:0006955         IBA          BP     14291
## 372  GO:0006955         IBA          BP     14293
## 373  GO:0006955         IBA          BP     14294
## 374  GO:0006955         IBA          BP     14302
## 375  GO:0006955         IMP          BP     14347
## 376  GO:0006955         IBA          BP     14360
## 377  GO:0006955         IEA          BP     14360
## 378  GO:0006955         ISO          BP     14360
## 379  GO:0006955         ISO          BP     14367
## 380  GO:0006955         IEA          BP     14375
## 381  GO:0006955         ISO          BP     14375
## 382  GO:0006955         IMP          BP     14389
## 383  GO:0006955         ISO          BP     14433
## 384  GO:0006955         IMP          BP     14456
## 385  GO:0006955         ISO          BP     14461
## 386  GO:0006955         IDA          BP     14462
## 387  GO:0006955         IEA          BP     14462
## 388  GO:0006955         IMP          BP     14462
## 389  GO:0006955         IBA          BP     14468
## 390  GO:0006955         IDA          BP     14468
## 391  GO:0006955         IBA          BP     14469
## 392  GO:0006955         IDA          BP     14469
## 393  GO:0006955         ISO          BP     14469
## 394  GO:0006955         IBA          BP     14525
## 395  GO:0006955         ISO          BP     14525
## 396  GO:0006955         ISO          BP     14528
## 397  GO:0006955         IMP          BP     14728
## 398  GO:0006955         IBA          BP     14747
## 399  GO:0006955         ISO          BP     14756
## 400  GO:0006955         IBA          BP     14762
## 401  GO:0006955         IGI          BP     14775
## 402  GO:0006955         IGI          BP     14776
## 403  GO:0006955         IMP          BP     14824
## 404  GO:0006955         ISO          BP     14824
## 405  GO:0006955         IBA          BP     14825
## 406  GO:0006955         ISO          BP     14825
## 407  GO:0006955         IMP          BP     14939
## 408  GO:0006955         IDA          BP     14960
## 409  GO:0006955         IEA          BP     14960
## 410  GO:0006955         IDA          BP     14961
## 411  GO:0006955         IEA          BP     14961
## 412  GO:0006955         IMP          BP     14961
## 413  GO:0006955         ISO          BP     14961
## 414  GO:0006955         IEA          BP     14962
## 415  GO:0006955         IGI          BP     14962
## 416  GO:0006955         IMP          BP     14962
## 417  GO:0006955         ISO          BP     14962
## 418  GO:0006955         TAS          BP     14962
## 419  GO:0006955         IBA          BP     14963
## 420  GO:0006955         IBA          BP     14964
## 421  GO:0006955         IDA          BP     14964
## 422  GO:0006955         IDA          BP     14969
## 423  GO:0006955         IEA          BP     14969
## 424  GO:0006955         IBA          BP     14972
## 425  GO:0006955         IDA          BP     14972
## 426  GO:0006955         IBA          BP     14980
## 427  GO:0006955         IBA          BP     14985
## 428  GO:0006955         IBA          BP     14990
## 429  GO:0006955         IBA          BP     14991
## 430  GO:0006955         IDA          BP     14991
## 431  GO:0006955         IMP          BP     14991
## 432  GO:0006955         ISO          BP     14991
## 433  GO:0006955         IBA          BP     14997
## 434  GO:0006955         IEA          BP     14998
## 435  GO:0006955         IMP          BP     14998
## 436  GO:0006955         IEA          BP     14999
## 437  GO:0006955         IBA          BP     15006
## 438  GO:0006955         IBA          BP     15007
## 439  GO:0006955         IBA          BP     15013
## 440  GO:0006955         IBA          BP     15015
## 441  GO:0006955         IBA          BP     15018
## 442  GO:0006955         IDA          BP     15018
## 443  GO:0006955         IBA          BP     15019
## 444  GO:0006955         IBA          BP     15024
## 445  GO:0006955         IBA          BP     15039
## 446  GO:0006955         IBA          BP     15040
## 447  GO:0006955         IDA          BP     15040
## 448  GO:0006955         ISO          BP     15040
## 449  GO:0006955         IBA          BP     15042
## 450  GO:0006955         IBA          BP     15043
## 451  GO:0006955         IBA          BP     15061
## 452  GO:0006955         IDA          BP     15061
## 453  GO:0006955         IBA          BP     15064
## 454  GO:0006955         IEA          BP     15064
## 455  GO:0006955         IMP          BP     15064
## 456  GO:0006955         ISO          BP     15064
## 457  GO:0006955         IDA          BP     15101
## 458  GO:0006955         IEA          BP     15139
## 459  GO:0006955         IBA          BP     15162
## 460  GO:0006955         IGI          BP     15170
## 461  GO:0006955         IMP          BP     15170
## 462  GO:0006955         IEA          BP     15216
## 463  GO:0006955         ISO          BP     15216
## 464  GO:0006955         IMP          BP     15223
## 465  GO:0006955         IMP          BP     15227
## 466  GO:0006955         IDA          BP     15275
## 467  GO:0006955         IEA          BP     15275
## 468  GO:0006955         IGI          BP     15284
## 469  GO:0006955         IMP          BP     15284
## 470  GO:0006955         IBA          BP     15289
## 471  GO:0006955         IDA          BP     15289
## 472  GO:0006955         IEA          BP     15289
## 473  GO:0006955         IMP          BP     15289
## 474  GO:0006955         IBA          BP     15354
## 475  GO:0006955         IEA          BP     15354
## 476  GO:0006955         ISO          BP     15368
## 477  GO:0006955         IMP          BP     15452
## 478  GO:0006955         IMP          BP     15458
## 479  GO:0006955         IMP          BP     15461
## 480  GO:0006955         ISO          BP     15481
## 481  GO:0006955         ISO          BP     15510
## 482  GO:0006955         IDA          BP     15894
## 483  GO:0006955         ISO          BP     15894
## 484  GO:0006955         IMP          BP     15900
## 485  GO:0006955         ISO          BP     15900
## 486  GO:0006955         IMP          BP     15930
## 487  GO:0006955         IDA          BP     15944
## 488  GO:0006955         IEA          BP     15944
## 489  GO:0006955         IMP          BP     15944
## 490  GO:0006955         IBA          BP     15945
## 491  GO:0006955         ISO          BP     15945
## 492  GO:0006955         IEA          BP     15950
## 493  GO:0006955         IBA          BP     15951
## 494  GO:0006955         IEA          BP     15957
## 495  GO:0006955         IEA          BP     15958
## 496  GO:0006955         IEA          BP     15959
## 497  GO:0006955         IBA          BP     15962
## 498  GO:0006955         IDA          BP     15962
## 499  GO:0006955         IBA          BP     15964
## 500  GO:0006955         IBA          BP     15965
## 501  GO:0006955         IBA          BP     15967
## 502  GO:0006955         IDA          BP     15967
## 503  GO:0006955         IBA          BP     15968
## 504  GO:0006955         IBA          BP     15969
## 505  GO:0006955         IBA          BP     15970
## 506  GO:0006955         IBA          BP     15972
## 507  GO:0006955         IDA          BP     15972
## 508  GO:0006955         IBA          BP     15974
## 509  GO:0006955         IDA          BP     15975
## 510  GO:0006955         IMP          BP     15975
## 511  GO:0006955         ISO          BP     15975
## 512  GO:0006955         IBA          BP     15976
## 513  GO:0006955         ISO          BP     15976
## 514  GO:0006955         IBA          BP     15977
## 515  GO:0006955         IDA          BP     15977
## 516  GO:0006955         IMP          BP     15977
## 517  GO:0006955         ISO          BP     15977
## 518  GO:0006955         IBA          BP     15978
## 519  GO:0006955         IDA          BP     15978
## 520  GO:0006955         IEA          BP     15978
## 521  GO:0006955         ISO          BP     15978
## 522  GO:0006955         IBA          BP     15985
## 523  GO:0006955         IDA          BP     15985
## 524  GO:0006955         IEA          BP     15985
## 525  GO:0006955         ISO          BP     16001
## 526  GO:0006955         ISO          BP     16002
## 527  GO:0006955         IBA          BP     16016
## 528  GO:0006955         IDA          BP     16016
## 529  GO:0006955         IBA          BP     16017
## 530  GO:0006955         IDA          BP     16017
## 531  GO:0006955         IBA          BP     16019
## 532  GO:0006955         IDA          BP     16019
## 533  GO:0006955         IMP          BP     16019
## 534  GO:0006955         IDA          BP     16020
## 535  GO:0006955         IDA          BP     16021
## 536  GO:0006955         IBA          BP     16033
## 537  GO:0006955         IBA          BP     16061
## 538  GO:0006955         IBA          BP     16068
## 539  GO:0006955         ISO          BP     16068
## 540  GO:0006955         IBA          BP     16069
## 541  GO:0006955         ISO          BP     16069
## 542  GO:0006955         ISS          BP     16069
## 543  GO:0006955         IBA          BP     16071
## 544  GO:0006955         IBA          BP     16098
## 545  GO:0006955         IBA          BP     16136
## 546  GO:0006955         IBA          BP     16142
## 547  GO:0006955         IBA          BP     16149
## 548  GO:0006955          IC          BP     16149
## 549  GO:0006955         IDA          BP     16149
## 550  GO:0006955         IEA          BP     16149
## 551  GO:0006955         IMP          BP     16149
## 552  GO:0006955         NAS          BP     16149
## 553  GO:0006955         IMP          BP     16153
## 554  GO:0006955         ISO          BP     16153
## 555  GO:0006955         IEA          BP     16159
## 556  GO:0006955         IGI          BP     16159
## 557  GO:0006955         ISO          BP     16159
## 558  GO:0006955         IDA          BP     16160
## 559  GO:0006955         IGI          BP     16160
## 560  GO:0006955         IMP          BP     16160
## 561  GO:0006955         ISO          BP     16160
## 562  GO:0006955         ISO          BP     16161
## 563  GO:0006955         IEA          BP     16163
## 564  GO:0006955         IGI          BP     16163
## 565  GO:0006955         IMP          BP     16163
## 566  GO:0006955         IMP          BP     16165
## 567  GO:0006955         IBA          BP     16168
## 568  GO:0006955         IEA          BP     16168
## 569  GO:0006955         IMP          BP     16168
## 570  GO:0006955         IDA          BP     16171
## 571  GO:0006955         IDA          BP     16173
## 572  GO:0006955         IGI          BP     16173
## 573  GO:0006955         IMP          BP     16173
## 574  GO:0006955         ISO          BP     16173
## 575  GO:0006955         ISS          BP     16173
## 576  GO:0006955         TAS          BP     16173
## 577  GO:0006955         IMP          BP     16174
## 578  GO:0006955         IEA          BP     16175
## 579  GO:0006955         IEA          BP     16176
## 580  GO:0006955         ISO          BP     16176
## 581  GO:0006955         ISO          BP     16177
## 582  GO:0006955         IBA          BP     16179
## 583  GO:0006955         IEP          BP     16179
## 584  GO:0006955         ISO          BP     16179
## 585  GO:0006955         IEA          BP     16180
## 586  GO:0006955         IBA          BP     16181
## 587  GO:0006955         IEA          BP     16181
## 588  GO:0006955         IMP          BP     16182
## 589  GO:0006955         ISO          BP     16182
## 590  GO:0006955         IEA          BP     16183
## 591  GO:0006955         IGI          BP     16183
## 592  GO:0006955         IMP          BP     16183
## 593  GO:0006955         ISO          BP     16183
## 594  GO:0006955         ISO          BP     16184
## 595  GO:0006955         IEA          BP     16187
## 596  GO:0006955         IBA          BP     16189
## 597  GO:0006955         IDA          BP     16189
## 598  GO:0006955         IEA          BP     16189
## 599  GO:0006955         IGI          BP     16189
## 600  GO:0006955         IMP          BP     16189
## 601  GO:0006955         ISO          BP     16189
## 602  GO:0006955         IGI          BP     16190
## 603  GO:0006955         IMP          BP     16190
## 604  GO:0006955         IEA          BP     16191
## 605  GO:0006955         IMP          BP     16192
## 606  GO:0006955         IDA          BP     16193
## 607  GO:0006955         IEA          BP     16193
## 608  GO:0006955         IMP          BP     16193
## 609  GO:0006955         ISO          BP     16193
## 610  GO:0006955         IDA          BP     16194
## 611  GO:0006955         IEA          BP     16196
## 612  GO:0006955         IMP          BP     16197
## 613  GO:0006955         IEA          BP     16198
## 614  GO:0006955         IMP          BP     16331
## 615  GO:0006955         ISO          BP     16334
## 616  GO:0006955         IEA          BP     16362
## 617  GO:0006955         IMP          BP     16362
## 618  GO:0006955         TAS          BP     16362
## 619  GO:0006955         IMP          BP     16364
## 620  GO:0006955         IDA          BP     16365
## 621  GO:0006955         IEA          BP     16365
## 622  GO:0006955         ISO          BP     16365
## 623  GO:0006955         IEA          BP     16396
## 624  GO:0006955         ISO          BP     16408
## 625  GO:0006955         ISO          BP     16409
## 626  GO:0006955         ISO          BP     16414
## 627  GO:0006955         ISO          BP     16423
## 628  GO:0006955         IBA          BP     16428
## 629  GO:0006955         IMP          BP     16428
## 630  GO:0006955         IMP          BP     16431
## 631  GO:0006955         ISO          BP     16449
## 632  GO:0006955         IEA          BP     16452
## 633  GO:0006955         ISO          BP     16452
## 634  GO:0006955         IEA          BP     16453
## 635  GO:0006955         IMP          BP     16453
## 636  GO:0006955         ISO          BP     16534
## 637  GO:0006955         IDA          BP     16558
## 638  GO:0006955         IDA          BP     16573
## 639  GO:0006955         IMP          BP     16590
## 640  GO:0006955         ISO          BP     16590
## 641  GO:0006955         ISO          BP     16643
## 642  GO:0006955         IMP          BP     16666
## 643  GO:0006955         ISO          BP     16678
## 644  GO:0006955         IMP          BP     16687
## 645  GO:0006955         IDA          BP     16768
## 646  GO:0006955         IEA          BP     16768
## 647  GO:0006955         IMP          BP     16768
## 648  GO:0006955         ISO          BP     16783
## 649  GO:0006955         IBA          BP     16797
## 650  GO:0006955         IEA          BP     16797
## 651  GO:0006955         ISO          BP     16797
## 652  GO:0006955         IEA          BP     16800
## 653  GO:0006955         IBA          BP     16803
## 654  GO:0006955         IDA          BP     16803
## 655  GO:0006955         IMP          BP     16803
## 656  GO:0006955         ISO          BP     16803
## 657  GO:0006955         IBA          BP     16818
## 658  GO:0006955         IDA          BP     16818
## 659  GO:0006955         IMP          BP     16819
## 660  GO:0006955         ISO          BP     16822
## 661  GO:0006955         IDA          BP     16842
## 662  GO:0006955         ISO          BP     16846
## 663  GO:0006955         IMP          BP     16848
## 664  GO:0006955         IDA          BP     16852
## 665  GO:0006955         IEA          BP     16854
## 666  GO:0006955         IMP          BP     16854
## 667  GO:0006955         ISO          BP     16854
## 668  GO:0006955         IMP          BP     16859
## 669  GO:0006955         IEA          BP     16878
## 670  GO:0006955         IDA          BP     16904
## 671  GO:0006955         IMP          BP     16950
## 672  GO:0006955         IBA          BP     16952
## 673  GO:0006955         IEA          BP     16952
## 674  GO:0006955         ISO          BP     16952
## 675  GO:0006955         IBA          BP     16963
## 676  GO:0006955          IC          BP     16963
## 677  GO:0006955         IDA          BP     16963
## 678  GO:0006955         IEA          BP     16963
## 679  GO:0006955         ISO          BP     16963
## 680  GO:0006955         NAS          BP     16963
## 681  GO:0006955         IGI          BP     16971
## 682  GO:0006955         IMP          BP     16975
## 683  GO:0006955         IEA          BP     16988
## 684  GO:0006955         IEA          BP     16992
## 685  GO:0006955         IGI          BP     16992
## 686  GO:0006955         IMP          BP     16992
## 687  GO:0006955         IEA          BP     16994
## 688  GO:0006955         IEA          BP     17000
## 689  GO:0006955         IBA          BP     17002
## 690  GO:0006955         ISO          BP     17002
## 691  GO:0006955         IDA          BP     17059
## 692  GO:0006955         ISO          BP     17060
## 693  GO:0006955         IBA          BP     17079
## 694  GO:0006955         IEA          BP     17079
## 695  GO:0006955         IMP          BP     17079
## 696  GO:0006955         IGI          BP     17082
## 697  GO:0006955         IEA          BP     17084
## 698  GO:0006955         IEA          BP     17085
## 699  GO:0006955         ISO          BP     17085
## 700  GO:0006955         IEA          BP     17087
## 701  GO:0006955         IEA          BP     17089
## 702  GO:0006955         IBA          BP     17096
## 703  GO:0006955         IDA          BP     17096
## 704  GO:0006955         IEA          BP     17096
## 705  GO:0006955         IGI          BP     17096
## 706  GO:0006955         IMP          BP     17096
## 707  GO:0006955         ISO          BP     17096
## 708  GO:0006955         IMP          BP     17101
## 709  GO:0006955         ISO          BP     17101
## 710  GO:0006955         IMP          BP     17127
## 711  GO:0006955         ISO          BP     17127
## 712  GO:0006955         ISO          BP     17130
## 713  GO:0006955         IMP          BP     17131
## 714  GO:0006955         IEA          BP     17167
## 715  GO:0006955         IBA          BP     17174
## 716  GO:0006955         IEA          BP     17174
## 717  GO:0006955         IMP          BP     17174
## 718  GO:0006955         IBA          BP     17175
## 719  GO:0006955         IDA          BP     17175
## 720  GO:0006955         IEA          BP     17175
## 721  GO:0006955         ISO          BP     17175
## 722  GO:0006955         IEA          BP     17184
## 723  GO:0006955         ISO          BP     17184
## 724  GO:0006955         IDA          BP     17194
## 725  GO:0006955         IEA          BP     17194
## 726  GO:0006955         IGI          BP     17194
## 727  GO:0006955         ISO          BP     17194
## 728  GO:0006955         IDA          BP     17195
## 729  GO:0006955         IEA          BP     17195
## 730  GO:0006955         IGI          BP     17195
## 731  GO:0006955         IMP          BP     17195
## 732  GO:0006955         ISO          BP     17195
## 733  GO:0006955         ISO          BP     17221
## 734  GO:0006955         IMP          BP     17242
## 735  GO:0006955         IMP          BP     17260
## 736  GO:0006955         IMP          BP     17305
## 737  GO:0006955         IEA          BP     17319
## 738  GO:0006955         IMP          BP     17319
## 739  GO:0006955         ISO          BP     17319
## 740  GO:0006955         NAS          BP     17319
## 741  GO:0006955         IBA          BP     17329
## 742  GO:0006955         IGI          BP     17350
## 743  GO:0006955         IMP          BP     17350
## 744  GO:0006955         IMP          BP     17381
## 745  GO:0006955         IDA          BP     17390
## 746  GO:0006955         IMP          BP     17393
## 747  GO:0006955         IBA          BP     17441
## 748  GO:0006955         IEA          BP     17470
## 749  GO:0006955         IBA          BP     17472
## 750  GO:0006955         IDA          BP     17472
## 751  GO:0006955         IDA          BP     17474
## 752  GO:0006955         IMP          BP     17474
## 753  GO:0006955         IEA          BP     17476
## 754  GO:0006955         IDA          BP     17533
## 755  GO:0006955         IBA          BP     17685
## 756  GO:0006955         IGI          BP     17685
## 757  GO:0006955         IMP          BP     17685
## 758  GO:0006955         IGI          BP     17688
## 759  GO:0006955         IMP          BP     17688
## 760  GO:0006955         ISO          BP     17863
## 761  GO:0006955         IBA          BP     17874
## 762  GO:0006955         IMP          BP     17874
## 763  GO:0006955         ISO          BP     17874
## 764  GO:0006955         TAS          BP     17874
## 765  GO:0006955         IDA          BP     17913
## 766  GO:0006955         IMP          BP     17916
## 767  GO:0006955         IEA          BP     17948
## 768  GO:0006955         IEA          BP     17951
## 769  GO:0006955         IEA          BP     17952
## 770  GO:0006955         IMP          BP     17993
## 771  GO:0006955         IMP          BP     17999
## 772  GO:0006955         ISO          BP     18019
## 773  GO:0006955         IEA          BP     18030
## 774  GO:0006955         IMP          BP     18034
## 775  GO:0006955         IMP          BP     18089
## 776  GO:0006955         IEA          BP     18106
## 777  GO:0006955         IMP          BP     18106
## 778  GO:0006955         ISO          BP     18106
## 779  GO:0006955         IMP          BP     18124
## 780  GO:0006955         IDA          BP     18126
## 781  GO:0006955         IGI          BP     18128
## 782  GO:0006955         IGI          BP     18129
## 783  GO:0006955         IMP          BP     18129
## 784  GO:0006955         ISO          BP     18159
## 785  GO:0006955         ISO          BP     18168
## 786  GO:0006955         IDA          BP     18173
## 787  GO:0006955         IMP          BP     18173
## 788  GO:0006955         IMP          BP     18176
## 789  GO:0006955         ISO          BP     18387
## 790  GO:0006955         IEA          BP     18413
## 791  GO:0006955         IMP          BP     18439
## 792  GO:0006955         IMP          BP     18477
## 793  GO:0006955         IBA          BP     18489
## 794  GO:0006955         IEA          BP     18521
## 795  GO:0006955         IMP          BP     18534
## 796  GO:0006955         IBA          BP     18566
## 797  GO:0006955         IEA          BP     18566
## 798  GO:0006955         IMP          BP     18566
## 799  GO:0006955         ISO          BP     18578
## 800  GO:0006955         IEA          BP     18602
## 801  GO:0006955         IEA          BP     18605
## 802  GO:0006955         IEA          BP     18606
## 803  GO:0006955         IMP          BP     18607
## 804  GO:0006955         IEA          BP     18636
## 805  GO:0006955         IMP          BP     18636
## 806  GO:0006955         IDA          BP     18646
## 807  GO:0006955         IMP          BP     18646
## 808  GO:0006955         ISO          BP     18673
## 809  GO:0006955         ISO          BP     18703
## 810  GO:0006955         IEA          BP     18707
## 811  GO:0006955         IEA          BP     18733
## 812  GO:0006955         IMP          BP     18733
## 813  GO:0006955         IEA          BP     18751
## 814  GO:0006955         IMP          BP     18751
## 815  GO:0006955         IMP          BP     18753
## 816  GO:0006955         IMP          BP     18754
## 817  GO:0006955         ISO          BP     18755
## 818  GO:0006955         IEA          BP     18760
## 819  GO:0006955         IMP          BP     18761
## 820  GO:0006955         IMP          BP     18762
## 821  GO:0006955         ISO          BP     18778
## 822  GO:0006955         IMP          BP     18782
## 823  GO:0006955         IMP          BP     18783
## 824  GO:0006955         IMP          BP     18784
## 825  GO:0006955         IDA          BP     18803
## 826  GO:0006955         ISO          BP     18806
## 827  GO:0006955         IEA          BP     18807
## 828  GO:0006955         ISO          BP     18826
## 829  GO:0006955         IBA          BP     18829
## 830  GO:0006955         IEA          BP     18829
## 831  GO:0006955         IBA          BP     18843
## 832  GO:0006955         IMP          BP     18843
## 833  GO:0006955         ISO          BP     18843
## 834  GO:0006955         IDA          BP     18854
## 835  GO:0006955         ISO          BP     18854
## 836  GO:0006955         IMP          BP     18858
## 837  GO:0006955         IGI          BP     18861
## 838  GO:0006955         IMP          BP     18861
## 839  GO:0006955         IBA          BP     18938
## 840  GO:0006955         IMP          BP     18950
## 841  GO:0006955         ISO          BP     18976
## 842  GO:0006955         ISO          BP     18983
## 843  GO:0006955         IMP          BP     18985
## 844  GO:0006955         IMP          BP     18987
## 845  GO:0006955         IEA          BP     19011
## 846  GO:0006955         IMP          BP     19014
## 847  GO:0006955         ISO          BP     19016
## 848  GO:0006955         IMP          BP     19056
## 849  GO:0006955         IEA          BP     19074
## 850  GO:0006955         IEA          BP     19090
## 851  GO:0006955         ISO          BP     19090
## 852  GO:0006955         IEA          BP     19106
## 853  GO:0006955         IMP          BP     19122
## 854  GO:0006955         IGI          BP     19164
## 855  GO:0006955         ISO          BP     19164
## 856  GO:0006955         IGI          BP     19165
## 857  GO:0006955         IMP          BP     19172
## 858  GO:0006955         IEA          BP     19200
## 859  GO:0006955         ISO          BP     19204
## 860  GO:0006955         IDA          BP     19219
## 861  GO:0006955         IBA          BP     19229
## 862  GO:0006955         IEA          BP     19229
## 863  GO:0006955         IMP          BP     19229
## 864  GO:0006955         IMP          BP     19255
## 865  GO:0006955         ISO          BP     19255
## 866  GO:0006955         IBA          BP     19260
## 867  GO:0006955         IEA          BP     19260
## 868  GO:0006955         IMP          BP     19260
## 869  GO:0006955         ISO          BP     19260
## 870  GO:0006955         ISO          BP     19261
## 871  GO:0006955         IGI          BP     19264
## 872  GO:0006955         IMP          BP     19264
## 873  GO:0006955         ISO          BP     19264
## 874  GO:0006955         IMP          BP     19266
## 875  GO:0006955         IDA          BP     19271
## 876  GO:0006955         IGI          BP     19271
## 877  GO:0006955         ISO          BP     19271
## 878  GO:0006955         IBA          BP     19288
## 879  GO:0006955         ISO          BP     19288
## 880  GO:0006955         IBA          BP     19294
## 881  GO:0006955         ISO          BP     19294
## 882  GO:0006955         IDA          BP     19328
## 883  GO:0006955         IMP          BP     19329
## 884  GO:0006955         IDA          BP     19332
## 885  GO:0006955         IMP          BP     19354
## 886  GO:0006955         IBA          BP     19368
## 887  GO:0006955         IBA          BP     19369
## 888  GO:0006955         IDA          BP     19369
## 889  GO:0006955         IBA          BP     19370
## 890  GO:0006955         IBA          BP     19373
## 891  GO:0006955         IMP          BP     19373
## 892  GO:0006955         ISO          BP     19401
## 893  GO:0006955         IMP          BP     19419
## 894  GO:0006955         ISO          BP     19419
## 895  GO:0006955         IMP          BP     19664
## 896  GO:0006955         IBA          BP     19692
## 897  GO:0006955         IBA          BP     19693
## 898  GO:0006955         IBA          BP     19694
## 899  GO:0006955         IBA          BP     19695
## 900  GO:0006955         IDA          BP     19695
## 901  GO:0006955         ISO          BP     19695
## 902  GO:0006955         IBA          BP     19696
## 903  GO:0006955         IBA          BP     19697
## 904  GO:0006955         ISO          BP     19697
## 905  GO:0006955         IBA          BP     19698
## 906  GO:0006955         IMP          BP     19698
## 907  GO:0006955         IBA          BP     19720
## 908  GO:0006955         IDA          BP     19720
## 909  GO:0006955         ISO          BP     19720
## 910  GO:0006955         IBA          BP     19824
## 911  GO:0006955         IDA          BP     19824
## 912  GO:0006955         IEA          BP     19882
## 913  GO:0006955         IMP          BP     19883
## 914  GO:0006955         IDA          BP     19885
## 915  GO:0006955         IMP          BP     19885
## 916  GO:0006955         ISO          BP     19946
## 917  GO:0006955         ISO          BP     20085
## 918  GO:0006955         IGI          BP     20104
## 919  GO:0006955         IMP          BP     20104
## 920  GO:0006955         IBA          BP     20128
## 921  GO:0006955         IEA          BP     20186
## 922  GO:0006955         IEA          BP     20201
## 923  GO:0006955         IBA          BP     20202
## 924  GO:0006955         IEA          BP     20202
## 925  GO:0006955         ISO          BP     20202
## 926  GO:0006955         ISO          BP     20218
## 927  GO:0006955         IBA          BP     20219
## 928  GO:0006955         ISO          BP     20219
## 929  GO:0006955         ISO          BP     20248
## 930  GO:0006955         IBA          BP     20290
## 931  GO:0006955         IEA          BP     20290
## 932  GO:0006955         ISO          BP     20290
## 933  GO:0006955         IBA          BP     20292
## 934  GO:0006955         IEA          BP     20292
## 935  GO:0006955         ISO          BP     20292
## 936  GO:0006955         IBA          BP     20293
## 937  GO:0006955         IEA          BP     20293
## 938  GO:0006955         IBA          BP     20295
## 939  GO:0006955         ISO          BP     20295
## 940  GO:0006955         IBA          BP     20296
## 941  GO:0006955         IDA          BP     20296
## 942  GO:0006955         IEA          BP     20296
## 943  GO:0006955         ISO          BP     20296
## 944  GO:0006955         IBA          BP     20297
## 945  GO:0006955         IEA          BP     20297
## 946  GO:0006955         ISO          BP     20297
## 947  GO:0006955         IBA          BP     20299
## 948  GO:0006955         IEA          BP     20299
## 949  GO:0006955         ISO          BP     20299
## 950  GO:0006955         IBA          BP     20300
## 951  GO:0006955         IEA          BP     20300
## 952  GO:0006955         ISO          BP     20300
## 953  GO:0006955         IBA          BP     20302
## 954  GO:0006955         IEA          BP     20302
## 955  GO:0006955         IBA          BP     20303
## 956  GO:0006955         IEA          BP     20303
## 957  GO:0006955         IBA          BP     20304
## 958  GO:0006955         IEA          BP     20304
## 959  GO:0006955         ISO          BP     20304
## 960  GO:0006955         IBA          BP     20305
## 961  GO:0006955         IEA          BP     20305
## 962  GO:0006955         IBA          BP     20306
## 963  GO:0006955         IEA          BP     20306
## 964  GO:0006955         IBA          BP     20307
## 965  GO:0006955         IEA          BP     20307
## 966  GO:0006955         IBA          BP     20308
## 967  GO:0006955         IEA          BP     20308
## 968  GO:0006955         IBA          BP     20309
## 969  GO:0006955         IBA          BP     20310
## 970  GO:0006955         ISO          BP     20310
## 971  GO:0006955         IBA          BP     20311
## 972  GO:0006955         ISO          BP     20311
## 973  GO:0006955         IBA          BP     20312
## 974  GO:0006955         IEA          BP     20312
## 975  GO:0006955         IEA          BP     20315
## 976  GO:0006955         ISO          BP     20315
## 977  GO:0006955         IEA          BP     20351
## 978  GO:0006955         IMP          BP     20351
## 979  GO:0006955         IBA          BP     20361
## 980  GO:0006955         IDA          BP     20361
## 981  GO:0006955         IMP          BP     20371
## 982  GO:0006955         ISO          BP     20371
## 983  GO:0006955         IEA          BP     20390
## 984  GO:0006955         ISO          BP     20390
## 985  GO:0006955         IEA          BP     20400
## 986  GO:0006955         IGI          BP     20400
## 987  GO:0006955         IMP          BP     20400
## 988  GO:0006955         ISO          BP     20400
## 989  GO:0006955         IBA          BP     20459
## 990  GO:0006955         ISO          BP     20466
## 991  GO:0006955         IBA          BP     20491
## 992  GO:0006955         IBA          BP     20568
## 993  GO:0006955         IMP          BP     20568
## 994  GO:0006955         ISO          BP     20568
## 995  GO:0006955         IDA          BP     20592
## 996  GO:0006955         ISO          BP     20617
## 997  GO:0006955         ISO          BP     20619
## 998  GO:0006955         IDA          BP     20706
## 999  GO:0006955         IEA          BP     20715
## 1000 GO:0006955         IMP          BP     20723
## 1001 GO:0006955         ISO          BP     20723
## 1002 GO:0006955         IBA          BP     20737
## 1003 GO:0006955         IMP          BP     20737
## 1004 GO:0006955         ISO          BP     20737
## 1005 GO:0006955         IBA          BP     20779
## 1006 GO:0006955         IMP          BP     20787
## 1007 GO:0006955         IBA          BP     20811
## 1008 GO:0006955         IBA          BP     20821
## 1009 GO:0006955         ISO          BP     20821
## 1010 GO:0006955         IBA          BP     20846
## 1011 GO:0006955         IDA          BP     20846
## 1012 GO:0006955         IMP          BP     20846
## 1013 GO:0006955         ISO          BP     20846
## 1014 GO:0006955         IBA          BP     20847
## 1015 GO:0006955         IMP          BP     20847
## 1016 GO:0006955         ISO          BP     20847
## 1017 GO:0006955         IMP          BP     20848
## 1018 GO:0006955         ISO          BP     20848
## 1019 GO:0006955         IMP          BP     20850
## 1020 GO:0006955         IMP          BP     20851
## 1021 GO:0006955         IGI          BP     20852
## 1022 GO:0006955         IGI          BP     20869
## 1023 GO:0006955         IMP          BP     20869
## 1024 GO:0006955         IDA          BP     20909
## 1025 GO:0006955         ISO          BP     20909
## 1026 GO:0006955         IDA          BP     20910
## 1027 GO:0006955         ISO          BP     20910
## 1028 GO:0006955         IDA          BP     20911
## 1029 GO:0006955         ISO          BP     20911
## 1030 GO:0006955         IDA          BP     20912
## 1031 GO:0006955         IDA          BP     20913
## 1032 GO:0006955         IMP          BP     20926
## 1033 GO:0006955         IDA          BP     20947
## 1034 GO:0006955         ISO          BP     20955
## 1035 GO:0006955         ISS          BP     20955
## 1036 GO:0006955         IBA          BP     20963
## 1037 GO:0006955         IDA          BP     20963
## 1038 GO:0006955         IMP          BP     20963
## 1039 GO:0006955         ISO          BP     20963
## 1040 GO:0006955         ISO          BP     21333
## 1041 GO:0006955         IEA          BP     21354
## 1042 GO:0006955         ISO          BP     21354
## 1043 GO:0006955         IDA          BP     21355
## 1044 GO:0006955         IEA          BP     21355
## 1045 GO:0006955         IMP          BP     21355
## 1046 GO:0006955         ISO          BP     21355
## 1047 GO:0006955         IEA          BP     21425
## 1048 GO:0006955         IMP          BP     21425
## 1049 GO:0006955         IEA          BP     21632
## 1050 GO:0006955         ISO          BP     21667
## 1051 GO:0006955         IBA          BP     21682
## 1052 GO:0006955         ISO          BP     21682
## 1053 GO:0006955         IDA          BP     21687
## 1054 GO:0006955         IDA          BP     21803
## 1055 GO:0006955         ISO          BP     21803
## 1056 GO:0006955         TAS          BP     21803
## 1057 GO:0006955         ISO          BP     21808
## 1058 GO:0006955         ISO          BP     21809
## 1059 GO:0006955         ISO          BP     21814
## 1060 GO:0006955         IDA          BP     21822
## 1061 GO:0006955         NAS          BP     21822
## 1062 GO:0006955         IBA          BP     21838
## 1063 GO:0006955         IDA          BP     21838
## 1064 GO:0006955         ISO          BP     21838
## 1065 GO:0006955         IBA          BP     21849
## 1066 GO:0006955         IDA          BP     21849
## 1067 GO:0006955         IGI          BP     21849
## 1068 GO:0006955         ISO          BP     21849
## 1069 GO:0006955         IEA          BP     21897
## 1070 GO:0006955         IDA          BP     21898
## 1071 GO:0006955         IMP          BP     21898
## 1072 GO:0006955         ISO          BP     21898
## 1073 GO:0006955         TAS          BP     21898
## 1074 GO:0006955         IEA          BP     21899
## 1075 GO:0006955         IMP          BP     21906
## 1076 GO:0006955         IEA          BP     21926
## 1077 GO:0006955         IGI          BP     21926
## 1078 GO:0006955         IMP          BP     21926
## 1079 GO:0006955         ISO          BP     21926
## 1080 GO:0006955          IC          BP     21929
## 1081 GO:0006955         IMP          BP     21929
## 1082 GO:0006955         NAS          BP     21929
## 1083 GO:0006955         ISO          BP     21934
## 1084 GO:0006955         IEA          BP     21935
## 1085 GO:0006955         IBA          BP     21938
## 1086 GO:0006955         IGI          BP     21938
## 1087 GO:0006955         IMP          BP     21938
## 1088 GO:0006955         ISO          BP     21938
## 1089 GO:0006955         IBA          BP     21939
## 1090 GO:0006955         IDA          BP     21939
## 1091 GO:0006955         IEA          BP     21943
## 1092 GO:0006955         IEA          BP     21944
## 1093 GO:0006955         IEA          BP     21946
## 1094 GO:0006955         IMP          BP     21946
## 1095 GO:0006955         ISO          BP     21946
## 1096 GO:0006955         IDA          BP     21947
## 1097 GO:0006955         IEA          BP     21947
## 1098 GO:0006955         ISO          BP     21947
## 1099 GO:0006955         IEA          BP     21948
## 1100 GO:0006955         ISO          BP     21948
## 1101 GO:0006955         IEA          BP     21949
## 1102 GO:0006955         IEA          BP     21950
## 1103 GO:0006955         ISO          BP     22030
## 1104 GO:0006955         IEA          BP     22031
## 1105 GO:0006955         IMP          BP     22034
## 1106 GO:0006955         ISO          BP     22034
## 1107 GO:0006955         IEA          BP     22035
## 1108 GO:0006955         IMP          BP     22038
## 1109 GO:0006955         ISO          BP     22038
## 1110 GO:0006955         IMP          BP     22040
## 1111 GO:0006955         IBA          BP     22041
## 1112 GO:0006955         ISO          BP     22042
## 1113 GO:0006955         IGI          BP     22059
## 1114 GO:0006955         IMP          BP     22059
## 1115 GO:0006955         IDA          BP     22121
## 1116 GO:0006955         ISO          BP     22121
## 1117 GO:0006955         IMP          BP     22122
## 1118 GO:0006955         IDA          BP     22164
## 1119 GO:0006955         IEA          BP     22164
## 1120 GO:0006955         IMP          BP     22164
## 1121 GO:0006955         NAS          BP     22164
## 1122 GO:0006955         IBA          BP     22165
## 1123 GO:0006955         IMP          BP     22165
## 1124 GO:0006955         ISO          BP     22165
## 1125 GO:0006955         IGI          BP     22174
## 1126 GO:0006955         IBA          BP     22177
## 1127 GO:0006955         IMP          BP     22177
## 1128 GO:0006955         ISO          BP     22217
## 1129 GO:0006955         IMP          BP     22242
## 1130 GO:0006955         IGI          BP     22256
## 1131 GO:0006955         ISO          BP     22284
## 1132 GO:0006955         ISO          BP     22318
## 1133 GO:0006955         IDA          BP     22319
## 1134 GO:0006955         IDA          BP     22320
## 1135 GO:0006955         ISO          BP     22320
## 1136 GO:0006955         IGI          BP     22324
## 1137 GO:0006955         IMP          BP     22324
## 1138 GO:0006955         ISO          BP     22339
## 1139 GO:0006955         ISO          BP     22350
## 1140 GO:0006955         IDA          BP     22352
## 1141 GO:0006955         ISO          BP     22353
## 1142 GO:0006955         IDA          BP     22361
## 1143 GO:0006955         IBA          BP     22362
## 1144 GO:0006955         IPI          BP     22362
## 1145 GO:0006955         IBA          BP     22363
## 1146 GO:0006955         IBA          BP     22364
## 1147 GO:0006955         IEA          BP     22370
## 1148 GO:0006955         IBA          BP     22373
## 1149 GO:0006955         IDA          BP     22376
## 1150 GO:0006955         ISO          BP     22376
## 1151 GO:0006955         ISO          BP     22418
## 1152 GO:0006955         ISO          BP     22433
## 1153 GO:0006955         IEA          BP     22596
## 1154 GO:0006955         ISO          BP     22596
## 1155 GO:0006955         IBA          BP     22612
## 1156 GO:0006955         ISO          BP     22631
## 1157 GO:0006955         IBA          BP     22637
## 1158 GO:0006955         IEA          BP     22637
## 1159 GO:0006955         IMP          BP     22637
## 1160 GO:0006955         ISO          BP     22637
## 1161 GO:0006955         IBA          BP     22670
## 1162 GO:0006955         ISO          BP     22670
## 1163 GO:0006955         IMP          BP     22694
## 1164 GO:0006955         IMP          BP     22724
## 1165 GO:0006955         IDA          BP     22788
## 1166 GO:0006955         ISO          BP     22788
## 1167 GO:0006955         IDA          BP     22793
## 1168 GO:0006955         IBA          BP     23832
## 1169 GO:0006955         IBA          BP     23845
## 1170 GO:0006955         IDA          BP     23845
## 1171 GO:0006955         ISO          BP     23845
## 1172 GO:0006955         IBA          BP     23855
## 1173 GO:0006955         IBA          BP     23880
## 1174 GO:0006955         IEA          BP     23880
## 1175 GO:0006955         IEA          BP     23881
## 1176 GO:0006955         TAS          BP     23882
## 1177 GO:0006955         IEA          BP     23900
## 1178 GO:0006955         IBA          BP     23921
## 1179 GO:0006955         IDA          BP     23921
## 1180 GO:0006955         IMP          BP     23921
## 1181 GO:0006955         ISO          BP     23921
## 1182 GO:0006955         ISO          BP     23947
## 1183 GO:0006955         IEA          BP     23962
## 1184 GO:0006955         IBA          BP     23993
## 1185 GO:0006955         ISO          BP     23993
## 1186 GO:0006955         IBA          BP     24047
## 1187 GO:0006955         IDA          BP     24047
## 1188 GO:0006955         ISO          BP     24047
## 1189 GO:0006955         IDA          BP     24088
## 1190 GO:0006955         IMP          BP     24088
## 1191 GO:0006955         ISO          BP     24088
## 1192 GO:0006955         TAS          BP     24088
## 1193 GO:0006955         IEA          BP     24099
## 1194 GO:0006955         IMP          BP     24099
## 1195 GO:0006955         ISO          BP     24105
## 1196 GO:0006955         IBA          BP     24108
## 1197 GO:0006955         IEP          BP     24108
## 1198 GO:0006955         IEA          BP     26362
## 1199 GO:0006955         IMP          BP     26365
## 1200 GO:0006955         IEA          BP     26408
## 1201 GO:0006955         IEA          BP     26412
## 1202 GO:0006955         IDA          BP     26413
## 1203 GO:0006955         IMP          BP     26416
## 1204 GO:0006955         IMP          BP     26417
## 1205 GO:0006955         IDA          BP     26437
## 1206 GO:0006955         IMP          BP     26440
## 1207 GO:0006955         TAS          BP     26440
## 1208 GO:0006955         IEA          BP     26888
## 1209 GO:0006955         IBA          BP     26898
## 1210 GO:0006955         IBA          BP     26903
## 1211 GO:0006955         IMP          BP     26903
## 1212 GO:0006955         ISO          BP     26903
## 1213 GO:0006955         IDA          BP     26904
## 1214 GO:0006955         IEA          BP     26904
## 1215 GO:0006955         IGI          BP     26904
## 1216 GO:0006955         IMP          BP     26904
## 1217 GO:0006955         IMP          BP     26909
## 1218 GO:0006955         IEA          BP     26939
## 1219 GO:0006955         IEA          BP     26940
## 1220 GO:0006955         ISO          BP     26943
## 1221 GO:0006955         IEA          BP     26971
## 1222 GO:0006955         IBA          BP     27007
## 1223 GO:0006955         IDA          BP     27007
## 1224 GO:0006955         IEA          BP     27007
## 1225 GO:0006955         IMP          BP     27007
## 1226 GO:0006955         ISO          BP     27007
## 1227 GO:0006955         IBA          BP     27028
## 1228 GO:0006955         IEA          BP     27041
## 1229 GO:0006955         ISO          BP     27050
## 1230 GO:0006955         IEA          BP     27056
## 1231 GO:0006955         IMP          BP     27060
## 1232 GO:0006955         IPI          BP     27061
## 1233 GO:0006955         IEA          BP     27103
## 1234 GO:0006955         IMP          BP     27103
## 1235 GO:0006955         IDA          BP     27218
## 1236 GO:0006955         IEA          BP     27218
## 1237 GO:0006955         ISO          BP     27218
## 1238 GO:0006955         IMP          BP     27223
## 1239 GO:0006955         ISO          BP     27223
## 1240 GO:0006955         IMP          BP     27278
## 1241 GO:0006955         NAS          BP     27278
## 1242 GO:0006955         IDA          BP     27354
## 1243 GO:0006955         IMP          BP     27361
## 1244 GO:0006955         ISO          BP     27401
## 1245 GO:0006955         IBA          BP     28040
## 1246 GO:0006955         ISO          BP     28040
## 1247 GO:0006955         IBA          BP     30053
## 1248 GO:0006955         IEA          BP     30925
## 1249 GO:0006955         ISO          BP     30925
## 1250 GO:0006955         IBA          BP     50701
## 1251 GO:0006955         IDA          BP     50701
## 1252 GO:0006955         IGI          BP     50701
## 1253 GO:0006955         IMP          BP     50701
## 1254 GO:0006955         ISO          BP     50701
## 1255 GO:0006955         IBA          BP     50723
## 1256 GO:0006955         IEA          BP     50723
## 1257 GO:0006955         NAS          BP     50723
## 1258 GO:0006955         IEA          BP     50908
## 1259 GO:0006955         IEA          BP     50909
## 1260 GO:0006955         IEA          BP     50928
## 1261 GO:0006955         IEA          BP     50930
## 1262 GO:0006955         IGI          BP     50931
## 1263 GO:0006955         IMP          BP     50931
## 1264 GO:0006955         IBA          BP     51789
## 1265 GO:0006955         IMP          BP     51869
## 1266 GO:0006955         IDA          BP     52055
## 1267 GO:0006955         IMP          BP     52065
## 1268 GO:0006955         ISO          BP     52065
## 1269 GO:0006955         IMP          BP     53314
## 1270 GO:0006955         ISO          BP     53323
## 1271 GO:0006955         IDA          BP     53330
## 1272 GO:0006955         ISO          BP     53331
## 1273 GO:0006955         ISO          BP     53357
## 1274 GO:0006955         ISO          BP     53603
## 1275 GO:0006955         IEA          BP     53610
## 1276 GO:0006955         ISO          BP     53610
## 1277 GO:0006955         IEA          BP     53791
## 1278 GO:0006955         IEA          BP     53856
## 1279 GO:0006955         IDA          BP     53859
## 1280 GO:0006955         IBA          BP     53876
## 1281 GO:0006955         IBA          BP     53877
## 1282 GO:0006955         IEA          BP     54123
## 1283 GO:0006955         IMP          BP     54123
## 1284 GO:0006955         ISO          BP     54123
## 1285 GO:0006955         TAS          BP     54123
## 1286 GO:0006955         IEA          BP     54131
## 1287 GO:0006955         IMP          BP     54131
## 1288 GO:0006955         IBA          BP     54159
## 1289 GO:0006955         IBA          BP     54199
## 1290 GO:0006955         IDA          BP     54215
## 1291 GO:0006955         IEA          BP     54215
## 1292 GO:0006955         IMP          BP     54215
## 1293 GO:0006955         ISO          BP     54215
## 1294 GO:0006955         IEA          BP     54390
## 1295 GO:0006955         IDA          BP     54396
## 1296 GO:0006955         IMP          BP     54396
## 1297 GO:0006955         ISO          BP     54396
## 1298 GO:0006955         IEA          BP     54445
## 1299 GO:0006955         IBA          BP     54448
## 1300 GO:0006955         IEA          BP     54448
## 1301 GO:0006955         IBA          BP     54450
## 1302 GO:0006955         IEA          BP     54450
## 1303 GO:0006955         ISO          BP     54450
## 1304 GO:0006955         IEA          BP     54473
## 1305 GO:0006955         IBA          BP     54483
## 1306 GO:0006955         ISO          BP     54483
## 1307 GO:0006955         IDA          BP     54519
## 1308 GO:0006955         IEA          BP     54633
## 1309 GO:0006955         ISO          BP     54633
## 1310 GO:0006955         IMP          BP     54644
## 1311 GO:0006955         IEA          BP     54652
## 1312 GO:0006955         IBA          BP     54698
## 1313 GO:0006955         IDA          BP     54698
## 1314 GO:0006955         IEA          BP     54698
## 1315 GO:0006955         ISO          BP     54698
## 1316 GO:0006955         ISS          BP     54698
## 1317 GO:0006955         IBA          BP     54725
## 1318 GO:0006955         IDA          BP     54725
## 1319 GO:0006955         ISO          BP     54725
## 1320 GO:0006955         IBA          BP     55932
## 1321 GO:0006955         IDA          BP     55932
## 1322 GO:0006955         IDA          BP     55943
## 1323 GO:0006955         IMP          BP     55982
## 1324 GO:0006955         IBA          BP     55985
## 1325 GO:0006955         ISO          BP     55985
## 1326 GO:0006955         IBA          BP     56045
## 1327 GO:0006955         IEA          BP     56045
## 1328 GO:0006955         IMP          BP     56045
## 1329 GO:0006955         ISO          BP     56045
## 1330 GO:0006955         IDA          BP     56048
## 1331 GO:0006955         IBA          BP     56066
## 1332 GO:0006955         IBA          BP     56092
## 1333 GO:0006955         IBA          BP     56094
## 1334 GO:0006955         IEA          BP     56200
## 1335 GO:0006955         IMP          BP     56200
## 1336 GO:0006955         IBA          BP     56221
## 1337 GO:0006955         IEA          BP     56221
## 1338 GO:0006955         IBA          BP     56275
## 1339 GO:0006955         IEA          BP     56275
## 1340 GO:0006955         ISO          BP     56275
## 1341 GO:0006955         IMP          BP     56310
## 1342 GO:0006955         IEA          BP     56335
## 1343 GO:0006955         ISO          BP     56335
## 1344 GO:0006955         IEA          BP     56399
## 1345 GO:0006955         ISO          BP     56403
## 1346 GO:0006955         IEA          BP     56417
## 1347 GO:0006955         IMP          BP     56417
## 1348 GO:0006955         IDA          BP     56468
## 1349 GO:0006955         IMP          BP     56480
## 1350 GO:0006955         ISO          BP     56480
## 1351 GO:0006955         IDA          BP     56489
## 1352 GO:0006955         IMP          BP     56489
## 1353 GO:0006955         IEA          BP     56501
## 1354 GO:0006955         IGI          BP     56532
## 1355 GO:0006955         IBA          BP     56554
## 1356 GO:0006955         IDA          BP     56554
## 1357 GO:0006955         IDA          BP     56619
## 1358 GO:0006955         IMP          BP     56619
## 1359 GO:0006955         IDA          BP     56620
## 1360 GO:0006955         IEA          BP     56620
## 1361 GO:0006955         IBA          BP     56631
## 1362 GO:0006955         IMP          BP     56632
## 1363 GO:0006955         IDA          BP     56699
## 1364 GO:0006955         IDA          BP     56708
## 1365 GO:0006955         NAS          BP     56708
## 1366 GO:0006955         IDA          BP     56715
## 1367 GO:0006955         IMP          BP     56715
## 1368 GO:0006955         IEA          BP     56743
## 1369 GO:0006955         ISO          BP     56743
## 1370 GO:0006955         ISS          BP     56743
## 1371 GO:0006955         IBA          BP     56744
## 1372 GO:0006955         IMP          BP     56744
## 1373 GO:0006955         ISO          BP     56744
## 1374 GO:0006955         ISO          BP     56792
## 1375 GO:0006955         IBA          BP     56835
## 1376 GO:0006955         IDA          BP     56838
## 1377 GO:0006955         IEA          BP     56838
## 1378 GO:0006955         ISO          BP     56838
## 1379 GO:0006955         ISO          BP     57257
## 1380 GO:0006955         IBA          BP     57266
## 1381 GO:0006955         IDA          BP     57266
## 1382 GO:0006955         IEA          BP     57266
## 1383 GO:0006955         ISO          BP     57266
## 1384 GO:0006955         IMP          BP     57320
## 1385 GO:0006955         IBA          BP     57349
## 1386 GO:0006955         IEA          BP     57444
## 1387 GO:0006955         IMP          BP     57757
## 1388 GO:0006955         IDA          BP     57765
## 1389 GO:0006955         IMP          BP     57765
## 1390 GO:0006955         IDA          BP     57914
## 1391 GO:0006955         IEA          BP     57916
## 1392 GO:0006955         IBA          BP     58185
## 1393 GO:0006955         IEA          BP     58185
## 1394 GO:0006955         IMP          BP     58185
## 1395 GO:0006955         IBA          BP     58203
## 1396 GO:0006955         IDA          BP     58203
## 1397 GO:0006955         IEA          BP     58203
## 1398 GO:0006955         IMP          BP     58203
## 1399 GO:0006955         IBA          BP     58205
## 1400 GO:0006955         IEA          BP     58205
## 1401 GO:0006955         IEA          BP     58210
## 1402 GO:0006955         IGI          BP     58217
## 1403 GO:0006955         IDA          BP     58218
## 1404 GO:0006955         IGI          BP     58218
## 1405 GO:0006955         IMP          BP     58230
## 1406 GO:0006955         IBA          BP     58518
## 1407 GO:0006955         IMP          BP     58861
## 1408 GO:0006955         IEA          BP     59025
## 1409 GO:0006955         IMP          BP     59032
## 1410 GO:0006955         IBA          BP     59289
## 1411 GO:0006955         IEA          BP     60440
## 1412 GO:0006955         IBA          BP     60505
## 1413 GO:0006955         IDA          BP     60505
## 1414 GO:0006955         IEA          BP     60505
## 1415 GO:0006955         IMP          BP     60505
## 1416 GO:0006955         ISO          BP     60505
## 1417 GO:0006955         IBA          BP     60533
## 1418 GO:0006955         IEA          BP     60533
## 1419 GO:0006955         ISO          BP     60533
## 1420 GO:0006955         IMP          BP     63953
## 1421 GO:0006955         IBA          BP     64139
## 1422 GO:0006955         IMP          BP     64297
## 1423 GO:0006955         IEA          BP     64435
## 1424 GO:0006955         TAS          BP     64435
## 1425 GO:0006955         IDA          BP     64685
## 1426 GO:0006955         IEA          BP     64685
## 1427 GO:0006955         IMP          BP     64930
## 1428 GO:0006955         IEA          BP     65099
## 1429 GO:0006955         IMP          BP     65113
## 1430 GO:0006955         IBA          BP     65956
## 1431 GO:0006955         ISO          BP     66102
## 1432 GO:0006955         IBA          BP     66107
## 1433 GO:0006955         IBA          BP     66141
## 1434 GO:0006955         IDA          BP     66141
## 1435 GO:0006955         IEA          BP     66141
## 1436 GO:0006955         ISO          BP     66141
## 1437 GO:0006955         ISO          BP     66214
## 1438 GO:0006955         IDA          BP     66222
## 1439 GO:0006955         IBA          BP     66289
## 1440 GO:0006955         ISO          BP     66294
## 1441 GO:0006955         IBA          BP     66298
## 1442 GO:0006955         IMP          BP     66362
## 1443 GO:0006955         IMP          BP     66406
## 1444 GO:0006955         ISO          BP     66552
## 1445 GO:0006955         ISO          BP     66592
## 1446 GO:0006955         IBA          BP     66597
## 1447 GO:0006955         ISO          BP     66597
## 1448 GO:0006955         IEA          BP     66645
## 1449 GO:0006955         ISO          BP     66645
## 1450 GO:0006955         IBA          BP     66650
## 1451 GO:0006955         IGI          BP     66713
## 1452 GO:0006955         IBA          BP     66755
## 1453 GO:0006955         IMP          BP     66755
## 1454 GO:0006955         IEA          BP     66824
## 1455 GO:0006955         IMP          BP     66824
## 1456 GO:0006955         ISO          BP     66824
## 1457 GO:0006955         IBA          BP     66854
## 1458 GO:0006955         ISO          BP     66854
## 1459 GO:0006955         IBA          BP     66873
## 1460 GO:0006955         IEA          BP     66873
## 1461 GO:0006955         ISO          BP     66873
## 1462 GO:0006955         IEA          BP     66878
## 1463 GO:0006955         ISO          BP     66878
## 1464 GO:0006955         IBA          BP     66949
## 1465 GO:0006955         IDA          BP     66949
## 1466 GO:0006955         IEA          BP     67005
## 1467 GO:0006955         IEA          BP     67065
## 1468 GO:0006955         ISO          BP     67065
## 1469 GO:0006955         ISO          BP     67067
## 1470 GO:0006955         IDA          BP     67070
## 1471 GO:0006955         IMP          BP     67116
## 1472 GO:0006955         ISO          BP     67116
## 1473 GO:0006955         IDA          BP     67133
## 1474 GO:0006955         IMP          BP     67133
## 1475 GO:0006955         IBA          BP     67135
## 1476 GO:0006955         IEA          BP     67138
## 1477 GO:0006955         ISO          BP     67248
## 1478 GO:0006955         IMP          BP     67278
## 1479 GO:0006955         ISO          BP     67313
## 1480 GO:0006955         ISO          BP     67405
## 1481 GO:0006955         IEA          BP     67486
## 1482 GO:0006955         ISO          BP     67486
## 1483 GO:0006955         IBA          BP     67525
## 1484 GO:0006955         ISO          BP     67525
## 1485 GO:0006955         IBA          BP     67596
## 1486 GO:0006955         IMP          BP     67596
## 1487 GO:0006955         IEA          BP     67664
## 1488 GO:0006955         IBA          BP     67701
## 1489 GO:0006955         IEA          BP     67705
## 1490 GO:0006955         IMP          BP     67742
## 1491 GO:0006955         IEA          BP     67781
## 1492 GO:0006955         IEA          BP     67857
## 1493 GO:0006955         IEA          BP     67917
## 1494 GO:0006955         IMP          BP     67917
## 1495 GO:0006955         ISO          BP     67917
## 1496 GO:0006955         IMP          BP     68002
## 1497 GO:0006955         IBA          BP     68009
## 1498 GO:0006955         IDA          BP     68009
## 1499 GO:0006955         ISO          BP     68024
## 1500 GO:0006955         IEA          BP     68038
## 1501 GO:0006955         IDA          BP     68119
## 1502 GO:0006955         IMP          BP     68137
## 1503 GO:0006955         IBA          BP     68221
## 1504 GO:0006955         IEA          BP     68279
## 1505 GO:0006955         ISO          BP     68350
## 1506 GO:0006955         IMP          BP     68585
## 1507 GO:0006955         IEA          BP     68667
## 1508 GO:0006955         ISO          BP     68667
## 1509 GO:0006955         IBA          BP     68668
## 1510 GO:0006955         ISO          BP     68668
## 1511 GO:0006955         IBA          BP     68713
## 1512 GO:0006955         IEA          BP     68713
## 1513 GO:0006955         IEA          BP     68718
## 1514 GO:0006955         IMP          BP     68767
## 1515 GO:0006955         IBA          BP     68891
## 1516 GO:0006955         IEA          BP     68891
## 1517 GO:0006955         ISO          BP     68891
## 1518 GO:0006955         IBA          BP     69068
## 1519 GO:0006955         ISO          BP     69068
## 1520 GO:0006955         IDA          BP     69091
## 1521 GO:0006955         IBA          BP     69097
## 1522 GO:0006955         ISO          BP     69097
## 1523 GO:0006955         IEA          BP     69146
## 1524 GO:0006955         ISO          BP     69150
## 1525 GO:0006955         IBA          BP     69317
## 1526 GO:0006955         IEA          BP     69379
## 1527 GO:0006955         IBA          BP     69550
## 1528 GO:0006955         IDA          BP     69550
## 1529 GO:0006955         IMP          BP     69550
## 1530 GO:0006955         IBA          BP     69583
## 1531 GO:0006955         IEA          BP     69583
## 1532 GO:0006955         IMP          BP     69583
## 1533 GO:0006955         ISO          BP     69583
## 1534 GO:0006955         IEA          BP     69601
## 1535 GO:0006955         IMP          BP     69635
## 1536 GO:0006955         ISO          BP     69635
## 1537 GO:0006955         IBA          BP     69677
## 1538 GO:0006955         IEA          BP     69677
## 1539 GO:0006955         ISO          BP     69727
## 1540 GO:0006955         IEA          BP     69769
## 1541 GO:0006955         ISO          BP     69807
## 1542 GO:0006955         IDA          BP     69834
## 1543 GO:0006955         IBA          BP     70202
## 1544 GO:0006955         IMP          BP     70238
## 1545 GO:0006955         IBA          BP     70312
## 1546 GO:0006955         IEA          BP     70312
## 1547 GO:0006955         ISO          BP     70312
## 1548 GO:0006955         IEA          BP     70408
## 1549 GO:0006955         ISO          BP     70408
## 1550 GO:0006955         IEA          BP     70428
## 1551 GO:0006955         ISO          BP     70428
## 1552 GO:0006955         IMP          BP     70450
## 1553 GO:0006955         ISO          BP     70450
## 1554 GO:0006955         ISO          BP     70481
## 1555 GO:0006955         ISO          BP     70789
## 1556 GO:0006955         IBA          BP     71183
## 1557 GO:0006955         ISO          BP     71183
## 1558 GO:0006955         IMP          BP     71481
## 1559 GO:0006955         ISO          BP     71481
## 1560 GO:0006955         IEA          BP     71514
## 1561 GO:0006955         ISO          BP     71514
## 1562 GO:0006955         IMP          BP     71538
## 1563 GO:0006955         IBA          BP     71586
## 1564 GO:0006955         IMP          BP     71586
## 1565 GO:0006955         IEA          BP     71648
## 1566 GO:0006955         IBA          BP     71660
## 1567 GO:0006955         ISO          BP     71660
## 1568 GO:0006955         IEA          BP     71693
## 1569 GO:0006955         ISO          BP     71693
## 1570 GO:0006955         IEA          BP     71733
## 1571 GO:0006955         IBA          BP     71775
## 1572 GO:0006955         IBA          BP     71779
## 1573 GO:0006955         IEA          BP     71779
## 1574 GO:0006955         IBA          BP     71856
## 1575 GO:0006955         ISO          BP     71890
## 1576 GO:0006955         IBA          BP     71956
## 1577 GO:0006955         IEA          BP     71956
## 1578 GO:0006955         ISO          BP     71956
## 1579 GO:0006955         IEA          BP     72029
## 1580 GO:0006955         IEA          BP     72049
## 1581 GO:0006955         IMP          BP     72049
## 1582 GO:0006955         IMP          BP     72077
## 1583 GO:0006955         IMP          BP     72103
## 1584 GO:0006955         IEA          BP     72162
## 1585 GO:0006955         IMP          BP     72162
## 1586 GO:0006955         IEA          BP     72169
## 1587 GO:0006955         IBA          BP     72349
## 1588 GO:0006955         ISO          BP     72349
## 1589 GO:0006955         ISO          BP     72354
## 1590 GO:0006955         IMP          BP     72432
## 1591 GO:0006955         IMP          BP     72508
## 1592 GO:0006955         IBA          BP     72512
## 1593 GO:0006955         IMP          BP     72512
## 1594 GO:0006955         ISO          BP     72512
## 1595 GO:0006955         IMP          BP     72544
## 1596 GO:0006955         IBA          BP     72699
## 1597 GO:0006955         IDA          BP     72699
## 1598 GO:0006955         IEA          BP     72699
## 1599 GO:0006955         IBA          BP     72925
## 1600 GO:0006955         IDA          BP     72925
## 1601 GO:0006955         ISO          BP     72925
## 1602 GO:0006955         IMP          BP     72993
## 1603 GO:0006955         IEA          BP     73174
## 1604 GO:0006955         ISO          BP     73218
## 1605 GO:0006955         IEA          BP     73670
## 1606 GO:0006955         IBA          BP     73747
## 1607 GO:0006955         ISO          BP     73747
## 1608 GO:0006955         IMP          BP     73914
## 1609 GO:0006955         IEA          BP     73945
## 1610 GO:0006955         IBA          BP     74039
## 1611 GO:0006955         IDA          BP     74039
## 1612 GO:0006955         IMP          BP     74039
## 1613 GO:0006955         IDA          BP     74048
## 1614 GO:0006955         IGI          BP     74117
## 1615 GO:0006955         IBA          BP     74131
## 1616 GO:0006955         IMP          BP     74131
## 1617 GO:0006955         IEA          BP     74136
## 1618 GO:0006955         IMP          BP     74256
## 1619 GO:0006955         ISO          BP     74256
## 1620 GO:0006955         IEA          BP     74414
## 1621 GO:0006955         ISO          BP     74414
## 1622 GO:0006955         IBA          BP     74482
## 1623 GO:0006955         IBA          BP     74556
## 1624 GO:0006955         IDA          BP     74585
## 1625 GO:0006955         ISO          BP     74585
## 1626 GO:0006955         IDA          BP     74732
## 1627 GO:0006955         IMP          BP     74732
## 1628 GO:0006955         IBA          BP     74735
## 1629 GO:0006955         ISO          BP     74735
## 1630 GO:0006955         IMP          BP     74748
## 1631 GO:0006955         IEA          BP     75234
## 1632 GO:0006955         IMP          BP     75234
## 1633 GO:0006955         IEA          BP     75345
## 1634 GO:0006955         IEA          BP     75400
## 1635 GO:0006955         ISO          BP     75454
## 1636 GO:0006955         ISO          BP     75698
## 1637 GO:0006955         IDA          BP     75863
## 1638 GO:0006955         IMP          BP     75863
## 1639 GO:0006955         IMP          BP     75974
## 1640 GO:0006955         IBA          BP     76074
## 1641 GO:0006955         IDA          BP     76074
## 1642 GO:0006955         IBA          BP     76293
## 1643 GO:0006955         IMP          BP     76438
## 1644 GO:0006955         ISO          BP     76438
## 1645 GO:0006955         IEA          BP     76527
## 1646 GO:0006955         IBA          BP     76681
## 1647 GO:0006955         IEA          BP     76854
## 1648 GO:0006955         IDA          BP     77125
## 1649 GO:0006955         IGI          BP     77125
## 1650 GO:0006955         IEA          BP     77647
## 1651 GO:0006955         ISO          BP     77647
## 1652 GO:0006955         IEA          BP     77673
## 1653 GO:0006955         IEA          BP     77674
## 1654 GO:0006955         IBA          BP     77705
## 1655 GO:0006955         IBA          BP     77727
## 1656 GO:0006955         IEA          BP     77727
## 1657 GO:0006955         IMP          BP     77727
## 1658 GO:0006955         IEA          BP     77772
## 1659 GO:0006955         ISO          BP     77772
## 1660 GO:0006955         IBA          BP     77777
## 1661 GO:0006955         IDA          BP     77777
## 1662 GO:0006955         ISO          BP     77777
## 1663 GO:0006955         IEA          BP     77799
## 1664 GO:0006955         ISO          BP     77799
## 1665 GO:0006955         IBA          BP     78128
## 1666 GO:0006955         IBA          BP     78416
## 1667 GO:0006955         IDA          BP     78416
## 1668 GO:0006955         ISO          BP     78416
## 1669 GO:0006955         IEA          BP     78473
## 1670 GO:0006955         ISO          BP     78473
## 1671 GO:0006955         IEA          BP     78781
## 1672 GO:0006955         IMP          BP     78801
## 1673 GO:0006955         IEA          BP     78903
## 1674 GO:0006955         IEA          BP     78929
## 1675 GO:0006955         IBA          BP     79263
## 1676 GO:0006955         IBA          BP     80285
## 1677 GO:0006955         IEA          BP     80285
## 1678 GO:0006955         IMP          BP     80285
## 1679 GO:0006955         ISO          BP     80285
## 1680 GO:0006955         IEA          BP     80287
## 1681 GO:0006955         IDA          BP     80782
## 1682 GO:0006955         IGI          BP     80782
## 1683 GO:0006955         IMP          BP     80859
## 1684 GO:0006955         IBA          BP     80861
## 1685 GO:0006955         IMP          BP     80861
## 1686 GO:0006955         ISO          BP     80861
## 1687 GO:0006955         IBA          BP     80876
## 1688 GO:0006955         IEA          BP     80876
## 1689 GO:0006955         ISO          BP     80876
## 1690 GO:0006955         IEA          BP     80898
## 1691 GO:0006955         IBA          BP     80901
## 1692 GO:0006955         NAS          BP     81600
## 1693 GO:0006955         IBA          BP     81702
## 1694 GO:0006955         ISO          BP     81702
## 1695 GO:0006955         IBA          BP     81897
## 1696 GO:0006955         IDA          BP     81897
## 1697 GO:0006955         IMP          BP     81897
## 1698 GO:0006955         TAS          BP     81897
## 1699 GO:0006955         IBA          BP     83430
## 1700 GO:0006955         IDA          BP     83430
## 1701 GO:0006955         IEA          BP     83430
## 1702 GO:0006955         ISO          BP     83430
## 1703 GO:0006955          IC          BP     83433
## 1704 GO:0006955         IMP          BP     83433
## 1705 GO:0006955         IBA          BP     83813
## 1706 GO:0006955         ISO          BP     83945
## 1707 GO:0006955         IMP          BP     83964
## 1708 GO:0006955         ISO          BP     84095
## 1709 GO:0006955         IMP          BP     84112
## 1710 GO:0006955         IMP          BP     84544
## 1711 GO:0006955         IBA          BP     85305
## 1712 GO:0006955         ISO          BP     85305
## 1713 GO:0006955         IEA          BP     93670
## 1714 GO:0006955         IMP          BP     93675
## 1715 GO:0006955         IDA          BP     93679
## 1716 GO:0006955         ISO          BP     93679
## 1717 GO:0006955         IDA          BP     93694
## 1718 GO:0006955         IGI          BP     93694
## 1719 GO:0006955         IBA          BP     93719
## 1720 GO:0006955         IBA          BP     93725
## 1721 GO:0006955         IBA          BP     93726
## 1722 GO:0006955         IMP          BP     93759
## 1723 GO:0006955         ISO          BP     93759
## 1724 GO:0006955         ISO          BP     93765
## 1725 GO:0006955         ISS          BP     93765
## 1726 GO:0006955         IBA          BP     94088
## 1727 GO:0006955         IMP          BP     94088
## 1728 GO:0006955         ISO          BP     94088
## 1729 GO:0006955         IBA          BP     94091
## 1730 GO:0006955         IDA          BP     94091
## 1731 GO:0006955         ISO          BP     94091
## 1732 GO:0006955         IBA          BP     94094
## 1733 GO:0006955         IMP          BP     94175
## 1734 GO:0006955         IMP          BP     94176
## 1735 GO:0006955         IEA          BP     94178
## 1736 GO:0006955         IBA          BP     94185
## 1737 GO:0006955         IMP          BP     94185
## 1738 GO:0006955         IEA          BP     94212
## 1739 GO:0006955         IEA          BP     94242
## 1740 GO:0006955         IEA          BP     96875
## 1741 GO:0006955         IBA          BP     96935
## 1742 GO:0006955         ISO          BP     96935
## 1743 GO:0006955         IBA          BP     97165
## 1744 GO:0006955         IEA          BP     97165
## 1745 GO:0006955         IMP          BP     97165
## 1746 GO:0006955         IEA          BP     98682
## 1747 GO:0006955         IMP          BP     99138
## 1748 GO:0006955         IEA          BP     99571
## 1749 GO:0006955         IBA          BP     99899
## 1750 GO:0006955         IEA          BP    100340
## 1751 GO:0006955         TAS          BP    100340
## 1752 GO:0006955         IEA          BP    100535
## 1753 GO:0006955         IDA          BP    100689
## 1754 GO:0006955         IMP          BP    100689
## 1755 GO:0006955         IBA          BP    100702
## 1756 GO:0006955         IDA          BP    100702
## 1757 GO:0006955         IMP          BP    101142
## 1758 GO:0006955         ISO          BP    101476
## 1759 GO:0006955         IEA          BP    101540
## 1760 GO:0006955         IMP          BP    101540
## 1761 GO:0006955         ISO          BP    101540
## 1762 GO:0006955         IEA          BP    101613
## 1763 GO:0006955         IMP          BP    101613
## 1764 GO:0006955         IBA          BP    101700
## 1765 GO:0006955         ISO          BP    102570
## 1766 GO:0006955         IBA          BP    102657
## 1767 GO:0006955         IMP          BP    102657
## 1768 GO:0006955         IBA          BP    103213
## 1769 GO:0006955         IMP          BP    103213
## 1770 GO:0006955         IDA          BP    103743
## 1771 GO:0006955         IBA          BP    104002
## 1772 GO:0006955         IDA          BP    104252
## 1773 GO:0006955         IMP          BP    104418
## 1774 GO:0006955         ISO          BP    104709
## 1775 GO:0006955         IEA          BP    104721
## 1776 GO:0006955         IMP          BP    104721
## 1777 GO:0006955         IEA          BP    104759
## 1778 GO:0006955         IMP          BP    105352
## 1779 GO:0006955         ISO          BP    105855
## 1780 GO:0006955         IBA          BP    106759
## 1781 GO:0006955         IEA          BP    106759
## 1782 GO:0006955         IMP          BP    106759
## 1783 GO:0006955         IEA          BP    107035
## 1784 GO:0006955         IEA          BP    107260
## 1785 GO:0006955         IBA          BP    107321
## 1786 GO:0006955         IDA          BP    107321
## 1787 GO:0006955         ISO          BP    107321
## 1788 GO:0006955         ISO          BP    107338
## 1789 GO:0006955         IDA          BP    107508
## 1790 GO:0006955         ISO          BP    107508
## 1791 GO:0006955         IEA          BP    107515
## 1792 GO:0006955         IEA          BP    107527
## 1793 GO:0006955         IEA          BP    107607
## 1794 GO:0006955         ISO          BP    107746
## 1795 GO:0006955         IMP          BP    107823
## 1796 GO:0006955         IEA          BP    107831
## 1797 GO:0006955         IBA          BP    108004
## 1798 GO:0006955         IBA          BP    108005
## 1799 GO:0006955         IBA          BP    108022
## 1800 GO:0006955         IBA          BP    108024
## 1801 GO:0006955         IBA          BP    108037
## 1802 GO:0006955         ISO          BP    108037
## 1803 GO:0006955         ISO          BP    108067
## 1804 GO:0006955         IMP          BP    108138
## 1805 GO:0006955         IDA          BP    108655
## 1806 GO:0006955         IBA          BP    108660
## 1807 GO:0006955         IMP          BP    108723
## 1808 GO:0006955         ISO          BP    108723
## 1809 GO:0006955         IBA          BP    108857
## 1810 GO:0006955         IEA          BP    109032
## 1811 GO:0006955         IEA          BP    109305
## 1812 GO:0006955         ISO          BP    109648
## 1813 GO:0006955         ISO          BP    109815
## 1814 GO:0006955         ISO          BP    109820
## 1815 GO:0006955         IDA          BP    109880
## 1816 GO:0006955         ISO          BP    109905
## 1817 GO:0006955         IGI          BP    109934
## 1818 GO:0006955         IEA          BP    110135
## 1819 GO:0006955         ISO          BP    110135
## 1820 GO:0006955         IGI          BP    110279
## 1821 GO:0006955         IEA          BP    110382
## 1822 GO:0006955         IBA          BP    110557
## 1823 GO:0006955         IBA          BP    110558
## 1824 GO:0006955         IDA          BP    110558
## 1825 GO:0006955         IEA          BP    110612
## 1826 GO:0006955         IBA          BP    110696
## 1827 GO:0006955         IBA          BP    110785
## 1828 GO:0006955         IBA          BP    110786
## 1829 GO:0006955         IBA          BP    110787
## 1830 GO:0006955         IEA          BP    114643
## 1831 GO:0006955         IMP          BP    114774
## 1832 GO:0006955         IBA          BP    117066
## 1833 GO:0006955         IEA          BP    117149
## 1834 GO:0006955         IMP          BP    117149
## 1835 GO:0006955         NAS          BP    117149
## 1836 GO:0006955         ISO          BP    140474
## 1837 GO:0006955         IDA          BP    140792
## 1838 GO:0006955         ISO          BP    140795
## 1839 GO:0006955         ISO          BP    140806
## 1840 GO:0006955         IDA          BP    142980
## 1841 GO:0006955         TAS          BP    142980
## 1842 GO:0006955         IBA          BP    170743
## 1843 GO:0006955         IEA          BP    170743
## 1844 GO:0006955         IBA          BP    170744
## 1845 GO:0006955         IEA          BP    170744
## 1846 GO:0006955         ISO          BP    170744
## 1847 GO:0006955         IEA          BP    171285
## 1848 GO:0006955         IMP          BP    171285
## 1849 GO:0006955         ISO          BP    171285
## 1850 GO:0006955         ISO          BP    171429
## 1851 GO:0006955         IBA          BP    192194
## 1852 GO:0006955         IBA          BP    192200
## 1853 GO:0006955         IBA          BP    192201
## 1854 GO:0006955         IEA          BP    192231
## 1855 GO:0006955         ISO          BP    192231
## 1856 GO:0006955         IBA          BP    192656
## 1857 GO:0006955         IMP          BP    192656
## 1858 GO:0006955         ISO          BP    192656
## 1859 GO:0006955         IEA          BP    195046
## 1860 GO:0006955         IBA          BP    195176
## 1861 GO:0006955         IBA          BP    195180
## 1862 GO:0006955         IBA          BP    195297
## 1863 GO:0006955         IBA          BP    195359
## 1864 GO:0006955         IBA          BP    195564
## 1865 GO:0006955         IBA          BP    208154
## 1866 GO:0006955         IEA          BP    208154
## 1867 GO:0006955         IMP          BP    208154
## 1868 GO:0006955         IMP          BP    208650
## 1869 GO:0006955         ISO          BP    208650
## 1870 GO:0006955         IEA          BP    209200
## 1871 GO:0006955         IBA          BP    209232
## 1872 GO:0006955         ISO          BP    209354
## 1873 GO:0006955         IBA          BP    209387
## 1874 GO:0006955         IEA          BP    209446
## 1875 GO:0006955         IMP          BP    209446
## 1876 GO:0006955         IEA          BP    209558
## 1877 GO:0006955         IMP          BP    209558
## 1878 GO:0006955         IEA          BP    209588
## 1879 GO:0006955         IEA          BP    209590
## 1880 GO:0006955         ISO          BP    209590
## 1881 GO:0006955         IBA          BP    210155
## 1882 GO:0006955         IMP          BP    210293
## 1883 GO:0006955         IBA          BP    210757
## 1884 GO:0006955         IEA          BP    210757
## 1885 GO:0006955         IMP          BP    210757
## 1886 GO:0006955         IEA          BP    210808
## 1887 GO:0006955         ISO          BP    210808
## 1888 GO:0006955         IBA          BP    211331
## 1889 GO:0006955         IBA          BP    211550
## 1890 GO:0006955         ISO          BP    211550
## 1891 GO:0006955         ISO          BP    211948
## 1892 GO:0006955         IBA          BP    213002
## 1893 GO:0006955         IMP          BP    213208
## 1894 GO:0006955         IEA          BP    213541
## 1895 GO:0006955         ISO          BP    213541
## 1896 GO:0006955         IBA          BP    213570
## 1897 GO:0006955         IBA          BP    213684
## 1898 GO:0006955         IBA          BP    214158
## 1899 GO:0006955         IBA          BP    214639
## 1900 GO:0006955         IBA          BP    214763
## 1901 GO:0006955         IDA          BP    214763
## 1902 GO:0006955         IEA          BP    214763
## 1903 GO:0006955         IGI          BP    214763
## 1904 GO:0006955         IMP          BP    214763
## 1905 GO:0006955         ISO          BP    214763
## 1906 GO:0006955         IEA          BP    214855
## 1907 GO:0006955         IMP          BP    214855
## 1908 GO:0006955         IBA          BP    215257
## 1909 GO:0006955         IEA          BP    215257
## 1910 GO:0006955         IBA          BP    215274
## 1911 GO:0006955         IEA          BP    215274
## 1912 GO:0006955         IBA          BP    215919
## 1913 GO:0006955         IBA          BP    216161
## 1914 GO:0006955         IMP          BP    216161
## 1915 GO:0006955         ISO          BP    216161
## 1916 GO:0006955         IMP          BP    216190
## 1917 GO:0006955         IBA          BP    216781
## 1918 GO:0006955         IEA          BP    216799
## 1919 GO:0006955         IMP          BP    216799
## 1920 GO:0006955         ISO          BP    216869
## 1921 GO:0006955         IMP          BP    216892
## 1922 GO:0006955         IDA          BP    217069
## 1923 GO:0006955         ISO          BP    217069
## 1924 GO:0006955         IEA          BP    217203
## 1925 GO:0006955         IDA          BP    217303
## 1926 GO:0006955         ISO          BP    217303
## 1927 GO:0006955         IMP          BP    217370
## 1928 GO:0006955         ISO          BP    217715
## 1929 GO:0006955         IEA          BP    217845
## 1930 GO:0006955         IBA          BP    218275
## 1931 GO:0006955         ISO          BP    218442
## 1932 GO:0006955         IMP          BP    218624
## 1933 GO:0006955         ISO          BP    218832
## 1934 GO:0006955         IBA          BP    219033
## 1935 GO:0006955         IDA          BP    219033
## 1936 GO:0006955         IMP          BP    219131
## 1937 GO:0006955         IDA          BP    223601
## 1938 GO:0006955         IEA          BP    223723
## 1939 GO:0006955         ISO          BP    223723
## 1940 GO:0006955         ISO          BP    224045
## 1941 GO:0006955         IBA          BP    224109
## 1942 GO:0006955         IMP          BP    224109
## 1943 GO:0006955         IEA          BP    224647
## 1944 GO:0006955         ISO          BP    224727
## 1945 GO:0006955         IBA          BP    224753
## 1946 GO:0006955         IBA          BP    224754
## 1947 GO:0006955         IBA          BP    224756
## 1948 GO:0006955         IBA          BP    224761
## 1949 GO:0006955         IBA          BP    224762
## 1950 GO:0006955         IDA          BP    224762
## 1951 GO:0006955         ISO          BP    224762
## 1952 GO:0006955         IBA          BP    224840
## 1953 GO:0006955         IEA          BP    224840
## 1954 GO:0006955         IMP          BP    224840
## 1955 GO:0006955         IMP          BP    224860
## 1956 GO:0006955         ISO          BP    224938
## 1957 GO:0006955         IMP          BP    225160
## 1958 GO:0006955         IEA          BP    225471
## 1959 GO:0006955         IBA          BP    225825
## 1960 GO:0006955         IMP          BP    225825
## 1961 GO:0006955         ISO          BP    225825
## 1962 GO:0006955         IMP          BP    225888
## 1963 GO:0006955         ISO          BP    225913
## 1964 GO:0006955         IDA          BP    226421
## 1965 GO:0006955         ISO          BP    226422
## 1966 GO:0006955         IBA          BP    226695
## 1967 GO:0006955         IEA          BP    226866
## 1968 GO:0006955         IBA          BP    227059
## 1969 GO:0006955         IMP          BP    227059
## 1970 GO:0006955         IBA          BP    227288
## 1971 GO:0006955         IEA          BP    227525
## 1972 GO:0006955         IDA          BP    227753
## 1973 GO:0006955         IMP          BP    228607
## 1974 GO:0006955         ISO          BP    228607
## 1975 GO:0006955         IBA          BP    228801
## 1976 GO:0006955         IEA          BP    228801
## 1977 GO:0006955         ISO          BP    228801
## 1978 GO:0006955         IMP          BP    229096
## 1979 GO:0006955         IEA          BP    229603
## 1980 GO:0006955         IMP          BP    229603
## 1981 GO:0006955         IBA          BP    229898
## 1982 GO:0006955         IDA          BP    229898
## 1983 GO:0006955         IMP          BP    229898
## 1984 GO:0006955         IBA          BP    229900
## 1985 GO:0006955         IDA          BP    229900
## 1986 GO:0006955         IBA          BP    230073
## 1987 GO:0006955         IMP          BP    230073
## 1988 GO:0006955         ISO          BP    230073
## 1989 GO:0006955         IMP          BP    230126
## 1990 GO:0006955         IBA          BP    230396
## 1991 GO:0006955         IBA          BP    230398
## 1992 GO:0006955         IBA          BP    230405
## 1993 GO:0006955         IEA          BP    230558
## 1994 GO:0006955         ISO          BP    230558
## 1995 GO:0006955         IBA          BP    230613
## 1996 GO:0006955         IBA          BP    230622
## 1997 GO:0006955         IBA          BP    230623
## 1998 GO:0006955         IDA          BP    230738
## 1999 GO:0006955         IMP          BP    230738
## 2000 GO:0006955         ISO          BP    230738
## 2001 GO:0006955         IBA          BP    230787
## 2002 GO:0006955         IMP          BP    230787
## 2003 GO:0006955         ISO          BP    230899
## 2004 GO:0006955         IBA          BP    230979
## 2005 GO:0006955         IEA          BP    230979
## 2006 GO:0006955         IMP          BP    230979
## 2007 GO:0006955         ISO          BP    230979
## 2008 GO:0006955         IEA          BP    231655
## 2009 GO:0006955         IMP          BP    231712
## 2010 GO:0006955         IBA          BP    232065
## 2011 GO:0006955         IDA          BP    232210
## 2012 GO:0006955         IMP          BP    232341
## 2013 GO:0006955         ISO          BP    232345
## 2014 GO:0006955         IEA          BP    232371
## 2015 GO:0006955         ISO          BP    232413
## 2016 GO:0006955         IMP          BP    232790
## 2017 GO:0006955         IMP          BP    232811
## 2018 GO:0006955         IBA          BP    232836
## 2019 GO:0006955         ISO          BP    232836
## 2020 GO:0006955         IBA          BP    232972
## 2021 GO:0006955         IEA          BP    233001
## 2022 GO:0006955         IMP          BP    233079
## 2023 GO:0006955         ISO          BP    233079
## 2024 GO:0006955         IMP          BP    233080
## 2025 GO:0006955         IMP          BP    233726
## 2026 GO:0006955         IBA          BP    234199
## 2027 GO:0006955         IDA          BP    234199
## 2028 GO:0006955         IEA          BP    234199
## 2029 GO:0006955         IBA          BP    234329
## 2030 GO:0006955         IMP          BP    234695
## 2031 GO:0006955         IDA          BP    234779
## 2032 GO:0006955         IMP          BP    234779
## 2033 GO:0006955         IDA          BP    235047
## 2034 GO:0006955         IGI          BP    235047
## 2035 GO:0006955         IMP          BP    235587
## 2036 GO:0006955         IMP          BP    235623
## 2037 GO:0006955         IEA          BP    235626
## 2038 GO:0006955         ISO          BP    235626
## 2039 GO:0006955         IBA          BP    235952
## 2040 GO:0006955         IBA          BP    236047
## 2041 GO:0006955         IEA          BP    236312
## 2042 GO:0006955         IBA          BP    236573
## 2043 GO:0006955         IDA          BP    236573
## 2044 GO:0006955         IMP          BP    237625
## 2045 GO:0006955         ISO          BP    237625
## 2046 GO:0006955         IBA          BP    237754
## 2047 GO:0006955         IEA          BP    237868
## 2048 GO:0006955         IMP          BP    237877
## 2049 GO:0006955         IBA          BP    238412
## 2050 GO:0006955         IBA          BP    238418
## 2051 GO:0006955         IBA          BP    238427
## 2052 GO:0006955         IBA          BP    238447
## 2053 GO:0006955         IDA          BP    238447
## 2054 GO:0006955         IBA          BP    238448
## 2055 GO:0006955         IBA          BP    238555
## 2056 GO:0006955         IDA          BP    238555
## 2057 GO:0006955         IBA          BP    238875
## 2058 GO:0006955         IMP          BP    238875
## 2059 GO:0006955         IEA          BP    239081
## 2060 GO:0006955         IEA          BP    239739
## 2061 GO:0006955         IMP          BP    239743
## 2062 GO:0006955         IBA          BP    240095
## 2063 GO:0006955         IBA          BP    240354
## 2064 GO:0006955         IDA          BP    240354
## 2065 GO:0006955         IEP          BP    240354
## 2066 GO:0006955         IMP          BP    240354
## 2067 GO:0006955         ISO          BP    240354
## 2068 GO:0006955         IBA          BP    240754
## 2069 GO:0006955         IEA          BP    240754
## 2070 GO:0006955         IMP          BP    240754
## 2071 GO:0006955         ISO          BP    240754
## 2072 GO:0006955         IBA          BP    240873
## 2073 GO:0006955         IDA          BP    240873
## 2074 GO:0006955         IEA          BP    240873
## 2075 GO:0006955         IMP          BP    240873
## 2076 GO:0006955         IEA          BP    242100
## 2077 GO:0006955         IMP          BP    242100
## 2078 GO:0006955         ISO          BP    242100
## 2079 GO:0006955         IBA          BP    242122
## 2080 GO:0006955         IEA          BP    242122
## 2081 GO:0006955         IBA          BP    242517
## 2082 GO:0006955         IBA          BP    242519
## 2083 GO:0006955         IBA          BP    242594
## 2084 GO:0006955         ISO          BP    242594
## 2085 GO:0006955         IBA          BP    242627
## 2086 GO:0006955         IMP          BP    242700
## 2087 GO:0006955         IBA          BP    243420
## 2088 GO:0006955         IBA          BP    243423
## 2089 GO:0006955         IBA          BP    243428
## 2090 GO:0006955         IBA          BP    243431
## 2091 GO:0006955         IBA          BP    243433
## 2092 GO:0006955         IBA          BP    243439
## 2093 GO:0006955         IBA          BP    243451
## 2094 GO:0006955         IBA          BP    243453
## 2095 GO:0006955         IBA          BP    243461
## 2096 GO:0006955         IEA          BP    243461
## 2097 GO:0006955         IDA          BP    243655
## 2098 GO:0006955         IMP          BP    243655
## 2099 GO:0006955         ISO          BP    243655
## 2100 GO:0006955         IBA          BP    243659
## 2101 GO:0006955         IBA          BP    243864
## 2102 GO:0006955         ISO          BP    243864
## 2103 GO:0006955         IMP          BP    243874
## 2104 GO:0006955         IMP          BP    243910
## 2105 GO:0006955         IEA          BP    243958
## 2106 GO:0006955         IGI          BP    243958
## 2107 GO:0006955         IBA          BP    244183
## 2108 GO:0006955         IEA          BP    244202
## 2109 GO:0006955         IMP          BP    244202
## 2110 GO:0006955         IBA          BP    244448
## 2111 GO:0006955         IEA          BP    245126
## 2112 GO:0006955         IMP          BP    245860
## 2113 GO:0006955         IBA          BP    246079
## 2114 GO:0006955         IBA          BP    246081
## 2115 GO:0006955         IEA          BP    246082
## 2116 GO:0006955         IEA          BP    246084
## 2117 GO:0006955         IBA          BP    246085
## 2118 GO:0006955         IEA          BP    246177
## 2119 GO:0006955         IMP          BP    246177
## 2120 GO:0006955         IBA          BP    246256
## 2121 GO:0006955         IBA          BP    246700
## 2122 GO:0006955         ISO          BP    246700
## 2123 GO:0006955         IEA          BP    246727
## 2124 GO:0006955         IDA          BP    246728
## 2125 GO:0006955         IEA          BP    246728
## 2126 GO:0006955         IBA          BP    246779
## 2127 GO:0006955         IEA          BP    246779
## 2128 GO:0006955         ISO          BP    246779
## 2129 GO:0006955         IBA          BP    252837
## 2130 GO:0006955         IDA          BP    257630
## 2131 GO:0006955         IDA          BP    257632
## 2132 GO:0006955         IMP          BP    257632
## 2133 GO:0006955         ISO          BP    257632
## 2134 GO:0006955         ISO          BP    259301
## 2135 GO:0006955         IBA          BP    260296
## 2136 GO:0006955         IEA          BP    266620
## 2137 GO:0006955         IEA          BP    266632
## 2138 GO:0006955         IBA          BP    266815
## 2139 GO:0006955         IDA          BP    268564
## 2140 GO:0006955         IEA          BP    268564
## 2141 GO:0006955         ISO          BP    268749
## 2142 GO:0006955         IMP          BP    268857
## 2143 GO:0006955         IEA          BP    268973
## 2144 GO:0006955         IMP          BP    268973
## 2145 GO:0006955         ISO          BP    269378
## 2146 GO:0006955         NAS          BP    269855
## 2147 GO:0006955         IEA          BP    270151
## 2148 GO:0006955         IMP          BP    270151
## 2149 GO:0006955         IBA          BP    277146
## 2150 GO:0006955         IBA          BP    277345
## 2151 GO:0006955         IBA          BP    278180
## 2152 GO:0006955         ISO          BP    278180
## 2153 GO:0006955         IDA          BP    279572
## 2154 GO:0006955         IDA          BP    286940
## 2155 GO:0006955         IEA          BP    317677
## 2156 GO:0006955         IBA          BP    319146
## 2157 GO:0006955         ISO          BP    319179
## 2158 GO:0006955         ISO          BP    319180
## 2159 GO:0006955         ISO          BP    319181
## 2160 GO:0006955         ISO          BP    319184
## 2161 GO:0006955         ISO          BP    319185
## 2162 GO:0006955         ISO          BP    319190
## 2163 GO:0006955         IBA          BP    319236
## 2164 GO:0006955         ISO          BP    319278
## 2165 GO:0006955         IEA          BP    319352
## 2166 GO:0006955         IBA          BP    319430
## 2167 GO:0006955         IEA          BP    319579
## 2168 GO:0006955         IMP          BP    319583
## 2169 GO:0006955         IGI          BP    319817
## 2170 GO:0006955         IMP          BP    319817
## 2171 GO:0006955         IMP          BP    319953
## 2172 GO:0006955         IBA          BP    320148
## 2173 GO:0006955         IBA          BP    320640
## 2174 GO:0006955         IMP          BP    320795
## 2175 GO:0006955         IBA          BP    320913
## 2176 GO:0006955         IBA          BP    321019
## 2177 GO:0006955         IMP          BP    321019
## 2178 GO:0006955         IBA          BP    321020
## 2179 GO:0006955         IBA          BP    321021
## 2180 GO:0006955         IEA          BP    326623
## 2181 GO:0006955         IMP          BP    327957
## 2182 GO:0006955         IBA          BP    328483
## 2183 GO:0006955         IBA          BP    328505
## 2184 GO:0006955         IBA          BP    328795
## 2185 GO:0006955         IGI          BP    328795
## 2186 GO:0006955         IBA          BP    328829
## 2187 GO:0006955         IBA          BP    328830
## 2188 GO:0006955         IBA          BP    328833
## 2189 GO:0006955         IBA          BP    329260
## 2190 GO:0006955         IMP          BP    329260
## 2191 GO:0006955         ISO          BP    329260
## 2192 GO:0006955         IBA          BP    329547
## 2193 GO:0006955         ISO          BP    329547
## 2194 GO:0006955         IDA          BP    329693
## 2195 GO:0006955         IGI          BP    329693
## 2196 GO:0006955         IBA          BP    329918
## 2197 GO:0006955         IBA          BP    329919
## 2198 GO:0006955         IBA          BP    330122
## 2199 GO:0006955         IEA          BP    330490
## 2200 GO:0006955         IBA          BP    330496
## 2201 GO:0006955         IDA          BP    330496
## 2202 GO:0006955         IEA          BP    330496
## 2203 GO:0006955         IEA          BP    332579
## 2204 GO:0006955         IMP          BP    332579
## 2205 GO:0006955         IBA          BP    333307
## 2206 GO:0006955         IBA          BP    333715
## 2207 GO:0006955         IBA          BP    333883
## 2208 GO:0006955         IDA          BP    333883
## 2209 GO:0006955         ISO          BP    333883
## 2210 GO:0006955         IBA          BP    338374
## 2211 GO:0006955         IDA          BP    338374
## 2212 GO:0006955         IEA          BP    338374
## 2213 GO:0006955         IBA          BP    353320
## 2214 GO:0006955         IDA          BP    360013
## 2215 GO:0006955         IEA          BP    360211
## 2216 GO:0006955         IBA          BP    360212
## 2217 GO:0006955         IBA          BP    360214
## 2218 GO:0006955         IBA          BP    360217
## 2219 GO:0006955         IBA          BP    378460
## 2220 GO:0006955         IMP          BP    378460
## 2221 GO:0006955         IEA          BP    378700
## 2222 GO:0006955         IBA          BP    379043
## 2223 GO:0006955         IDA          BP    379043
## 2224 GO:0006955         IMP          BP    380732
## 2225 GO:0006955         IBA          BP    380792
## 2226 GO:0006955         IBA          BP    380793
## 2227 GO:0006955         IDA          BP    380793
## 2228 GO:0006955         IBA          BP    380794
## 2229 GO:0006955         IBA          BP    380795
## 2230 GO:0006955         IBA          BP    380797
## 2231 GO:0006955         IDA          BP    380797
## 2232 GO:0006955         IMP          BP    380797
## 2233 GO:0006955         IBA          BP    380808
## 2234 GO:0006955         IBA          BP    380809
## 2235 GO:0006955         IBA          BP    380823
## 2236 GO:0006955         IBA          BP    380824
## 2237 GO:0006955         IMP          BP    380924
## 2238 GO:0006955         IGI          BP    381305
## 2239 GO:0006955         IMP          BP    381305
## 2240 GO:0006955         IBA          BP    381308
## 2241 GO:0006955         IBA          BP    381776
## 2242 GO:0006955         IEA          BP    381776
## 2243 GO:0006955         IBA          BP    381777
## 2244 GO:0006955         IBA          BP    381778
## 2245 GO:0006955         IBA          BP    381782
## 2246 GO:0006955         IBA          BP    381783
## 2247 GO:0006955         IBA          BP    381784
## 2248 GO:0006955         IEA          BP    381812
## 2249 GO:0006955         IBA          BP    381831
## 2250 GO:0006955         IBA          BP    382000
## 2251 GO:0006955         IBA          BP    382059
## 2252 GO:0006955         IBA          BP    382692
## 2253 GO:0006955         IBA          BP    382695
## 2254 GO:0006955         IBA          BP    382696
## 2255 GO:0006955         IBA          BP    383619
## 2256 GO:0006955         IDA          BP    383619
## 2257 GO:0006955         IEA          BP    383619
## 2258 GO:0006955         ISO          BP    383619
## 2259 GO:0006955         IEA          BP    384059
## 2260 GO:0006955         IBA          BP    384309
## 2261 GO:0006955         IDA          BP    384309
## 2262 GO:0006955         IBA          BP    384410
## 2263 GO:0006955         IBA          BP    384411
## 2264 GO:0006955         IBA          BP    384417
## 2265 GO:0006955         IBA          BP    384419
## 2266 GO:0006955         IBA          BP    384514
## 2267 GO:0006955         IBA          BP    384515
## 2268 GO:0006955         IEA          BP    384997
## 2269 GO:0006955         IMP          BP    384997
## 2270 GO:0006955         ISO          BP    384997
## 2271 GO:0006955         IBA          BP    385047
## 2272 GO:0006955         IBA          BP    385109
## 2273 GO:0006955         IBA          BP    385120
## 2274 GO:0006955         IBA          BP    385253
## 2275 GO:0006955         IEA          BP    385253
## 2276 GO:0006955         IBA          BP    385291
## 2277 GO:0006955         IBA          BP    386446
## 2278 GO:0006955         IBA          BP    386454
## 2279 GO:0006955         IDA          BP    387140
## 2280 GO:0006955         IDA          BP    387173
## 2281 GO:0006955         IBA          BP    387510
## 2282 GO:0006955         IBA          BP    399549
## 2283 GO:0006955         IBA          BP    404549
## 2284 GO:0006955         IBA          BP    404711
## 2285 GO:0006955         IDA          BP    404711
## 2286 GO:0006955         IBA          BP    404736
## 2287 GO:0006955         IBA          BP    404743
## 2288 GO:0006955         IBA          BP    408190
## 2289 GO:0006955         IBA          BP    432701
## 2290 GO:0006955         IBA          BP    432702
## 2291 GO:0006955         IBA          BP    432708
## 2292 GO:0006955         IBA          BP    432709
## 2293 GO:0006955         IEA          BP    432763
## 2294 GO:0006955         IBA          BP    432940
## 2295 GO:0006955         ISO          BP    432940
## 2296 GO:0006955         IEA          BP    433693
## 2297 GO:0006955         IBA          BP    434024
## 2298 GO:0006955         IBA          BP    434025
## 2299 GO:0006955         IBA          BP    434028
## 2300 GO:0006955         IBA          BP    434031
## 2301 GO:0006955         IBA          BP    434033
## 2302 GO:0006955         IBA          BP    434034
## 2303 GO:0006955         IBA          BP    434036
## 2304 GO:0006955         IBA          BP    434039
## 2305 GO:0006955         IBA          BP    434040
## 2306 GO:0006955         IBA          BP    434041
## 2307 GO:0006955         IBA          BP    434218
## 2308 GO:0006955         IBA          BP    434219
## 2309 GO:0006955         IBA          BP    434341
## 2310 GO:0006955         IDA          BP    434341
## 2311 GO:0006955         IMP          BP    434341
## 2312 GO:0006955         ISO          BP    434341
## 2313 GO:0006955         IBA          BP    434586
## 2314 GO:0006955         IBA          BP    434609
## 2315 GO:0006955         IBA          BP    435321
## 2316 GO:0006955         IBA          BP    435328
## 2317 GO:0006955         IBA          BP    435653
## 2318 GO:0006955         IMP          BP    435653
## 2319 GO:0006955         IBA          BP    435791
## 2320 GO:0006955         IBA          BP    435900
## 2321 GO:0006955         IMP          BP    436440
## 2322 GO:0006955         IBA          BP    436468
## 2323 GO:0006955         IBA          BP    436539
## 2324 GO:0006955         IBA          BP    436545
## 2325 GO:0006955         IEA          BP    442835
## 2326 GO:0006955         IBA          BP    497114
## 2327 GO:0006955         IBA          BP    503491
## 2328 GO:0006955         IDA          BP    503491
## 2329 GO:0006955         IBA          BP    503844
## 2330 GO:0006955         IBA          BP    503847
## 2331 GO:0006955         IBA          BP    541307
## 2332 GO:0006955         IBA          BP    544896
## 2333 GO:0006955         IEA          BP    545378
## 2334 GO:0006955         IGI          BP    545378
## 2335 GO:0006955         IMP          BP    545378
## 2336 GO:0006955         IEA          BP    545384
## 2337 GO:0006955         IBA          BP    545541
## 2338 GO:0006955         IBA          BP    545645
## 2339 GO:0006955         IBA          BP    545648
## 2340 GO:0006955         IBA          BP    545649
## 2341 GO:0006955         IBA          BP    545650
## 2342 GO:0006955         IBA          BP    545652
## 2343 GO:0006955         IBA          BP    545847
## 2344 GO:0006955         IBA          BP    545848
## 2345 GO:0006955         IBA          BP    545849
## 2346 GO:0006955         IBA          BP    545850
## 2347 GO:0006955         IBA          BP    545851
## 2348 GO:0006955         ISO          BP    546038
## 2349 GO:0006955         IBA          BP    546213
## 2350 GO:0006955         IBA          BP    546244
## 2351 GO:0006955         IBA          BP    547109
## 2352 GO:0006955         IEA          BP    547253
## 2353 GO:0006955         IMP          BP    547253
## 2354 GO:0006955         ISO          BP    547253
## 2355 GO:0006955         IBA          BP    547329
## 2356 GO:0006955         IBA          BP    547424
## 2357 GO:0006955         IBA          BP    547431
## 2358 GO:0006955         IMP          BP    547431
## 2359 GO:0006955         IGI          BP    574402
## 2360 GO:0006955         IMP          BP    574402
## 2361 GO:0006955         IBA          BP    619441
## 2362 GO:0006955         IBA          BP    619806
## 2363 GO:0006955         IBA          BP    619833
## 2364 GO:0006955         IBA          BP    619846
## 2365 GO:0006955         IEA          BP    619846
## 2366 GO:0006955         IBA          BP    619916
## 2367 GO:0006955         IEA          BP    619916
## 2368 GO:0006955         IEA          BP    619960
## 2369 GO:0006955         IBA          BP    619994
## 2370 GO:0006955         IBA          BP    620017
## 2371 GO:0006955         IBA          BP    620050
## 2372 GO:0006955         IBA          BP    620088
## 2373 GO:0006955         IBA          BP    620105
## 2374 GO:0006955         IBA          BP    620126
## 2375 GO:0006955         IBA          BP    620191
## 2376 GO:0006955         IBA          BP    620240
## 2377 GO:0006955         IBA          BP    620297
## 2378 GO:0006955         IBA          BP    620400
## 2379 GO:0006955         IBA          BP    622117
## 2380 GO:0006955         IBA          BP    622728
## 2381 GO:0006955         IBA          BP    624681
## 2382 GO:0006955         IDA          BP    625018
## 2383 GO:0006955         IBA          BP    626347
## 2384 GO:0006955         IBA          BP    626545
## 2385 GO:0006955         IBA          BP    626578
## 2386 GO:0006955         IDA          BP    626578
## 2387 GO:0006955         IBA          BP    626583
## 2388 GO:0006955         IBA          BP    626682
## 2389 GO:0006955         IBA          BP    626708
## 2390 GO:0006955         IBA          BP    627394
## 2391 GO:0006955         IBA          BP    628027
## 2392 GO:0006955         IBA          BP    628056
## 2393 GO:0006955         IBA          BP    628072
## 2394 GO:0006955         IBA          BP    628098
## 2395 GO:0006955         IBA          BP    628127
## 2396 GO:0006955         IBA          BP    628144
## 2397 GO:0006955         IBA          BP    628268
## 2398 GO:0006955         IBA          BP    628398
## 2399 GO:0006955         IBA          BP    628541
## 2400 GO:0006955         IBA          BP    628571
## 2401 GO:0006955         IBA          BP    628614
## 2402 GO:0006955         IBA          BP    629754
## 2403 GO:0006955         IBA          BP    629756
## 2404 GO:0006955         IBA          BP    629761
## 2405 GO:0006955         IBA          BP    629812
## 2406 GO:0006955         IBA          BP    629818
## 2407 GO:0006955         IBA          BP    629822
## 2408 GO:0006955         IBA          BP    629826
## 2409 GO:0006955         IBA          BP    629833
## 2410 GO:0006955         IBA          BP    629842
## 2411 GO:0006955         IBA          BP    629845
## 2412 GO:0006955         IBA          BP    629849
## 2413 GO:0006955         IBA          BP    629859
## 2414 GO:0006955         IBA          BP    629860
## 2415 GO:0006955         IBA          BP    629865
## 2416 GO:0006955         IBA          BP    629866
## 2417 GO:0006955         IBA          BP    629871
## 2418 GO:0006955         IBA          BP    629884
## 2419 GO:0006955         IBA          BP    629893
## 2420 GO:0006955         IBA          BP    629897
## 2421 GO:0006955         IBA          BP    629906
## 2422 GO:0006955         IBA          BP    629908
## 2423 GO:0006955         IBA          BP    629915
## 2424 GO:0006955         IBA          BP    629919
## 2425 GO:0006955         IBA          BP    629925
## 2426 GO:0006955         IBA          BP    629930
## 2427 GO:0006955         IBA          BP    630086
## 2428 GO:0006955         IBA          BP    630294
## 2429 GO:0006955         IBA          BP    630486
## 2430 GO:0006955         IBA          BP    630952
## 2431 GO:0006955         IBA          BP    632126
## 2432 GO:0006955         IBA          BP    632654
## 2433 GO:0006955         IBA          BP    633457
## 2434 GO:0006955         IBA          BP    633568
## 2435 GO:0006955         IBA          BP    634650
## 2436 GO:0006955         IBA          BP    634825
## 2437 GO:0006955         IBA          BP    636260
## 2438 GO:0006955         IBA          BP    636462
## 2439 GO:0006955         IBA          BP    636752
## 2440 GO:0006955         IBA          BP    637227
## 2441 GO:0006955         IEA          BP    637515
## 2442 GO:0006955         IBA          BP    638605
## 2443 GO:0006955         IBA          BP    639510
## 2444 GO:0006955         IBA          BP    639774
## 2445 GO:0006955         IBA          BP    639781
## 2446 GO:0006955         IBA          BP    640046
## 2447 GO:0006955         IBA          BP    640340
## 2448 GO:0006955         IBA          BP    640506
## 2449 GO:0006955         IBA          BP    641178
## 2450 GO:0006955         IEA          BP    654458
## 2451 GO:0006955         IEA          BP    654459
## 2452 GO:0006955         IEA          BP    654460
## 2453 GO:0006955         IBA          BP    654836
## 2454 GO:0006955         IBA          BP    665927
## 2455 GO:0006955         IBA          BP    666731
## 2456 GO:0006955         IBA          BP    666747
## 2457 GO:0006955         IEA          BP    667277
## 2458 GO:0006955         IBA          BP    667281
## 2459 GO:0006955         IPI          BP    667281
## 2460 GO:0006955         IBA          BP    667435
## 2461 GO:0006955         IBA          BP    667449
## 2462 GO:0006955         IBA          BP    667481
## 2463 GO:0006955         IBA          BP    667550
## 2464 GO:0006955         IBA          BP    667681
## 2465 GO:0006955         IBA          BP    667683
## 2466 GO:0006955         IBA          BP    667823
## 2467 GO:0006955         IBA          BP    667859
## 2468 GO:0006955         IBA          BP    667865
## 2469 GO:0006955         IBA          BP    667881
## 2470 GO:0006955         IBA          BP    667899
## 2471 GO:0006955         IBA          BP    667914
## 2472 GO:0006955         IBA          BP    667924
## 2473 GO:0006955         IBA          BP    667928
## 2474 GO:0006955         IBA          BP    667940
## 2475 GO:0006955         IBA          BP    667946
## 2476 GO:0006955         IBA          BP    667977
## 2477 GO:0006955         IBA          BP    668389
## 2478 GO:0006955         IBA          BP    668395
## 2479 GO:0006955         IBA          BP    668421
## 2480 GO:0006955         IBA          BP    668438
## 2481 GO:0006955         IBA          BP    668469
## 2482 GO:0006955         IBA          BP    668474
## 2483 GO:0006955         IBA          BP    668478
## 2484 GO:0006955         IBA          BP    668497
## 2485 GO:0006955         IBA          BP    668517
## 2486 GO:0006955         IBA          BP    668549
## 2487 GO:0006955         IEA          BP    668549
## 2488 GO:0006955         IBA          BP    668589
## 2489 GO:0006955         IBA          BP    668591
## 2490 GO:0006955         IBA          BP    668597
## 2491 GO:0006955         IBA          BP    670558
## 2492 GO:0006955         IPI          BP    670558
## 2493 GO:0006955         IBA          BP    674018
## 2494 GO:0006955         IEA          BP    674018
## 2495 GO:0006955         IBA          BP    677296
## 2496 GO:0006955         IBA          BP    677858
## 2497 GO:0006955         IBA          BP    692152
## 2498 GO:0006955         IBA          BP    692154
## 2499 GO:0006955         IBA          BP    692161
## 2500 GO:0006955         IBA          BP    692165
## 2501 GO:0006955         IBA          BP    692169
## 2502 GO:0006955         IEA          BP    692182
## 2503 GO:0006955         IBA          BP    692187
## 2504 GO:0006955         IBA          BP    692245
## 2505 GO:0006955         IDA          BP    723834
## 2506 GO:0006955         IMP          BP    723834
## 2507 GO:0006955         IDA          BP    723840
## 2508 GO:0006955         IMP          BP    723840
## 2509 GO:0006955         IDA          BP    723890
## 2510 GO:0006955         IDA          BP    723903
## 2511 GO:0006955         IBA          BP    724035
## 2512 GO:0006955         IBA          BP    777685
## 2513 GO:0006955         IBA          BP    777686
## 2514 GO:0006955         IBA          BP    777688
## 2515 GO:0006955         IBA          BP    777780
## 2516 GO:0006955         IBA          BP    780792
## 2517 GO:0006955         IBA          BP    780793
## 2518 GO:0006955         IBA          BP    780794
## 2519 GO:0006955         IBA          BP    780799
## 2520 GO:0006955         IBA          BP    780800
## 2521 GO:0006955         IBA          BP    780801
## 2522 GO:0006955         IBA          BP    780802
## 2523 GO:0006955         IBA          BP    780803
## 2524 GO:0006955         IBA          BP    780804
## 2525 GO:0006955         IBA          BP    780818
## 2526 GO:0006955         IBA          BP    780825
## 2527 GO:0006955         IBA          BP    780829
## 2528 GO:0006955         IBA          BP    780831
## 2529 GO:0006955         IBA          BP    780864
## 2530 GO:0006955         IBA          BP    780883
## 2531 GO:0006955         IBA          BP    780884
## 2532 GO:0006955         IBA          BP    780885
## 2533 GO:0006955         IBA          BP    780891
## 2534 GO:0006955         IBA          BP    780929
## 2535 GO:0006955         IBA          BP    780931
## 2536 GO:0006955         IBA          BP    780932
## 2537 GO:0006955         IBA          BP    780938
## 2538 GO:0006955         IBA          BP    780939
## 2539 GO:0006955         IBA          BP    780956
## 2540 GO:0006955         IBA          BP    780960
## 2541 GO:0006955         IBA          BP    791089
## 2542 GO:0006955         IBA          BP    791090
## 2543 GO:0006955         IEA          BP 100033459
## 2544 GO:0006955         IBA          BP 100034251
## 2545 GO:0006955         IBA          BP 100038862
## 2546 GO:0006955         ISO          BP 100038882
## 2547 GO:0006955         IBA          BP 100038927
## 2548 GO:0006955         ISO          BP 100040048
## 2549 GO:0006955         IBA          BP 100040462
## 2550 GO:0006955         IBA          BP 100041688
## 2551 GO:0006955         IBA          BP 100041759
## 2552 GO:0006955         IBA          BP 100041787
## 2553 GO:0006955         IBA          BP 100041811
## 2554 GO:0006955         IBA          BP 100041895
## 2555 GO:0006955         IBA          BP 100041952
## 2556 GO:0006955         IBA          BP 100042444
## 2557 GO:0006955         IBA          BP 100042493
## 2558 GO:0006955         IBA          BP 100043177
## 2559 GO:0006955         IBA          BP 100043197
## 2560 GO:0006955         IBA          BP 100043322
## 2561 GO:0006955         IBA          BP 100101942
## 2562 GO:0006955         IBA          BP 100113413
## 2563 GO:0006955         IBA          BP 100114901
## 2564 GO:0006955         IBA          BP 100123473
## 2565 GO:0006955         ISO          BP 100124457
## 2566 GO:0006955         IDA          BP 100124488
## 2567 GO:0006955         IBA          BP 100125262
## 2568 GO:0006955         IBA          BP 100125263
## 2569 GO:0006955         IBA          BP 100126451
## 2570 GO:0006955         IBA          BP 100126456
## 2571 GO:0006955         IBA          BP 100126459
## 2572 GO:0006955         IBA          BP 100126463
## 2573 GO:0006955         IBA          BP 100126464
## 2574 GO:0006955         IBA          BP 100294660
## 2575 GO:0006955         IEA          BP 100503878
## 2576 GO:0006955         IMP          BP 100503878
## 2577 GO:0006955         IBA          BP 100503970
## 2578 GO:0006955         IBA          BP 100504232
## 2579 GO:0006955         IEA          BP 100504362
## 2580 GO:0006955         IBA          BP 100529082
## 2581 GO:0006955         IBA          BP 100534273
## 2582 GO:0006955         IBA          BP 100775172
## 2583 GO:0006955         IBA          BP 100775173
## 2584 GO:0006955         IBA          BP 100775174
## 2585 GO:0006955         IBA          BP 100775175
## 2586 GO:0006955         IBA          BP 102639802
## 2587 GO:0006955         IBA          BP 102640920
## 2588 GO:0006955         ISO          BP 102640920
## 2589 GO:0006955         IBA          BP 102902673
## 2590 GO:0006955         IBA          BP 113002583

Retrieving function groups

We can then filter our DE table, with this GO set of immune response GENES and write to file.

IRG_Entrez <- unique(ImmuneResponseGenes$ENTREZID)
IRG_Res <- Activated_minus_Resting[Activated_minus_Resting$ENTREZID %in% IRG_Entrez, 
    ]
write.table(IRG_Res, file = "data/ImmuneResponseGeneTable.csv", sep = ",", row.names = FALSE)
IRG_Res[1:3, ]
##      ENTREZID SYMBOL  baseMean log2FoldChange      lfcSE       stat
## 8   100033459 Ifi208 3282.6785     -0.0277477 0.09029354 -0.3073055
## 9   100034251 Wfdc17   11.0403      1.4619007 1.15353744  1.2673197
## 107 100038882  Isg15  738.5107      0.6976512 0.15748919  4.4298359
##           pvalue         padj   newPadj
## 8   7.586109e-01 8.601547e-01 1.0000000
## 9   2.050410e-01 3.613285e-01 1.0000000
## 107 9.430483e-06 6.656254e-05 0.1686925

GSEA


GSEA

Another popular method for differential expression analysis is the Broad’s GSEA method.

GSEA tests whether our gene set is correlated with the ranking of genes by our differential expression analysis metric using a modified KS-test.

GSEA inputs

We have already seen how we can write gene set collections as gmt format files. The gmt format is the standard input format for GSEA gene sets.

We will also need to produce a ranked table of gene ids and write to a rnk format file. Here will rank by stat column to give sensible measure of differential expression. We could also use log2FoldChange column if we have modified log2 fold changes using lfsShrink() function.

forRNK <- data.frame(Activated_minus_Resting$ENTREZID, Activated_minus_Resting$stat)

forRNK[1:3, ]
##   Activated_minus_Resting.ENTREZID Activated_minus_Resting.stat
## 1                           100017                   -0.5422305
## 2                           100019                  -11.8960650
## 3                        100033459                   -0.3073055

rnk file

We can now write our results to a rnk file for use within GSEA.

write.table(forRNK, file = "data/Activated_minus_Resting.rnk", sep = "\t", col.names = FALSE, 
    row.names = FALSE)

fgsea

The fgsea package provides access to GSEA method within the R framework.

Once installed we can load library in standard way.

library(fgsea)

fgsea

We can make use of gmt files directly by using the gmtPathways() function to read our previous created gmt file of mouse translated gene sets.

mouse_Hallmarks <- gmtPathways("mouse_Hallmarks.gmt")
class(mouse_Hallmarks)
## [1] "list"
names(mouse_Hallmarks)
##  [1] "HALLMARK_TNFA_SIGNALING_VIA_NFKB"          
##  [2] "HALLMARK_HYPOXIA"                          
##  [3] "HALLMARK_CHOLESTEROL_HOMEOSTASIS"          
##  [4] "HALLMARK_MITOTIC_SPINDLE"                  
##  [5] "HALLMARK_WNT_BETA_CATENIN_SIGNALING"       
##  [6] "HALLMARK_TGF_BETA_SIGNALING"               
##  [7] "HALLMARK_IL6_JAK_STAT3_SIGNALING"          
##  [8] "HALLMARK_DNA_REPAIR"                       
##  [9] "HALLMARK_G2M_CHECKPOINT"                   
## [10] "HALLMARK_APOPTOSIS"                        
## [11] "HALLMARK_NOTCH_SIGNALING"                  
## [12] "HALLMARK_ADIPOGENESIS"                     
## [13] "HALLMARK_ESTROGEN_RESPONSE_EARLY"          
## [14] "HALLMARK_ESTROGEN_RESPONSE_LATE"           
## [15] "HALLMARK_ANDROGEN_RESPONSE"                
## [16] "HALLMARK_MYOGENESIS"                       
## [17] "HALLMARK_PROTEIN_SECRETION"                
## [18] "HALLMARK_INTERFERON_ALPHA_RESPONSE"        
## [19] "HALLMARK_INTERFERON_GAMMA_RESPONSE"        
## [20] "HALLMARK_APICAL_JUNCTION"                  
## [21] "HALLMARK_APICAL_SURFACE"                   
## [22] "HALLMARK_HEDGEHOG_SIGNALING"               
## [23] "HALLMARK_COMPLEMENT"                       
## [24] "HALLMARK_UNFOLDED_PROTEIN_RESPONSE"        
## [25] "HALLMARK_PI3K_AKT_MTOR_SIGNALING"          
## [26] "HALLMARK_MTORC1_SIGNALING"                 
## [27] "HALLMARK_E2F_TARGETS"                      
## [28] "HALLMARK_MYC_TARGETS_V1"                   
## [29] "HALLMARK_MYC_TARGETS_V2"                   
## [30] "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"
## [31] "HALLMARK_INFLAMMATORY_RESPONSE"            
## [32] "HALLMARK_XENOBIOTIC_METABOLISM"            
## [33] "HALLMARK_FATTY_ACID_METABOLISM"            
## [34] "HALLMARK_OXIDATIVE_PHOSPHORYLATION"        
## [35] "HALLMARK_GLYCOLYSIS"                       
## [36] "HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"  
## [37] "HALLMARK_P53_PATHWAY"                      
## [38] "HALLMARK_UV_RESPONSE_UP"                   
## [39] "HALLMARK_UV_RESPONSE_DN"                   
## [40] "HALLMARK_ANGIOGENESIS"                     
## [41] "HALLMARK_HEME_METABOLISM"                  
## [42] "HALLMARK_COAGULATION"                      
## [43] "HALLMARK_IL2_STAT5_SIGNALING"              
## [44] "HALLMARK_BILE_ACID_METABOLISM"             
## [45] "HALLMARK_PEROXISOME"                       
## [46] "HALLMARK_ALLOGRAFT_REJECTION"              
## [47] "HALLMARK_SPERMATOGENESIS"                  
## [48] "HALLMARK_KRAS_SIGNALING_UP"                
## [49] "HALLMARK_KRAS_SIGNALING_DN"                
## [50] "HALLMARK_PANCREAS_BETA_CELLS"

fgsea

Similar to goseq package we need to provide a vector of our ranking metric named by gene id. We can create this from our rnk file.

Act_minus_Rest_rnk <- read.delim("data/Activated_minus_Resting.rnk", sep = "\t", 
    h = FALSE, row.names = 1)
Act_minus_Rest_gsea <- Act_minus_Rest_rnk[, 1]
names(Act_minus_Rest_gsea) <- rownames(Act_minus_Rest_rnk)
Act_minus_Rest_gsea[1:3]
##      100017      100019   100033459 
##  -0.5422305 -11.8960650  -0.3073055

fgsea

The fgsea() functions requires our gene sets, named vector of ranking metric, the minimum and maximum sizes of gene sets to be tested (to minSize and maxSize parameters respectively) and the number of permutations to run (nperm parameter).

Act_minus_Rest_gseaRes <- fgsea(mouse_Hallmarks, Act_minus_Rest_gsea, minSize = 15, 
    maxSize = 500, nperm = 1000)
Act_minus_Rest_gseaRes <- Act_minus_Rest_gseaRes[order(Act_minus_Rest_gseaRes$NES, 
    decreasing = T), ]
Act_minus_Rest_gseaRes[1:2, ]
##                               pathway        pval        padj        ES
## 1: HALLMARK_INTERFERON_GAMMA_RESPONSE 0.001050420 0.003985969 0.6602350
## 2: HALLMARK_INTERFERON_ALPHA_RESPONSE 0.001116071 0.003985969 0.6734605
##         NES nMoreExtreme size                              leadingEdge
## 1: 2.284848            0  247 14190,16412,20304,229900,55932,56045,...
## 2: 2.216089            0  144 12977,229900,55932,16149,12362,76933,...

fgsea

We can extract leading edge genes from leadingEdge column as a list. These are the genes driving your enrichment.

Act_minus_Rest_gseaRes$leadingEdge
## [[1]]
##   [1] "14190"     "16412"     "20304"     "229900"    "55932"     "56045"    
##   [7] "16154"     "12367"     "16149"     "15894"     "12362"     "16421"    
##  [13] "15251"     "76933"     "58203"     "16912"     "21354"     "17472"    
##  [19] "20846"     "22320"     "16185"     "108670"    "19188"     "15900"    
##  [25] "67775"     "231712"    "14964"     "15040"     "246727"    "80876"    
##  [31] "16913"     "12363"     "56791"     "15018"     "12010"     "16364"    
##  [37] "621823"    "16362"     "22169"     "19039"     "57444"     "78388"    
##  [43] "243771"    "68713"     "14972"     "21356"     "66141"     "66892"    
##  [49] "53620"     "100702"    "17069"     "70152"     "12575"     "22375"    
##  [55] "16414"     "547253"    "50523"     "14969"     "58185"     "19171"    
##  [61] "27056"     "72075"     "19106"     "626578"    "56421"     "16822"    
##  [67] "20847"     "327959"    "109552"    "18950"     "26445"     "434341"   
##  [73] "14960"     "17857"     "66552"     "18034"     "229003"    "236573"   
##  [79] "60533"     "19246"     "14998"     "19166"     "18577"     "12369"    
##  [85] "100038882" "667373"    "19186"     "64685"     "20821"     "22038"    
##  [91] "75345"     "14991"     "54721"     "17768"     "16391"     "16452"    
##  [97] "76074"     "230073"    "65972"     "22035"     "18712"    
## 
## [[2]]
##  [1] "12977"     "229900"    "55932"     "16149"     "12362"     "76933"    
##  [7] "14469"     "16912"     "21354"     "17472"     "212943"    "246730"   
## [13] "108670"    "19188"     "67775"     "231712"    "14964"     "15040"    
## [19] "80876"     "16913"     "56791"     "15018"     "12010"     "621823"   
## [25] "16362"     "22169"     "19039"     "57444"     "243771"    "67168"    
## [31] "68713"     "14972"     "80285"     "66141"     "100702"    "17069"    
## [37] "54199"     "22375"     "73711"     "547253"    "58185"     "72075"    
## [43] "20128"     "19106"     "16423"     "626578"    "20847"     "74153"    
## [49] "17857"     "229003"    "236573"    "23960"     "100038882" "19186"    
## [55] "64685"     "20821"     "22038"     "22201"     "14991"     "16391"    
## [61] "76074"     "65972"     "23961"     "12799"     "17454"     "71586"    
## [67] "13709"    
## 
## [[3]]
##  [1] "14939"  "12772"  "12766"  "16412"  "20304"  "17395"  "12774"  "12332" 
##  [9] "12977"  "229900" "15979"  "16149"  "16161"  "15894"  "19073"  "16421" 
## [17] "15251"  "14469"  "16174"  "21354"  "20846"  "12516"  "14537"  "20303" 
## [25] "14062"  "16185"  "16186"  "15900"  "12481"  "14964"  "16153"  "15040" 
## [33] "15163"  "15018"  "12010"  "16364"  "12504"  "12445"  "14972"  "21356" 
## [41] "12502"  "13867"  "12501"  "12189"  "56501"  "22375"  "17972"  "13244" 
## [49] "12519"  "12051"  "16414"  "12500"  "19171"  "21355"  "16423"  "11785" 
## [57] "16822"  "19264"  "192176" "17096"  "21899"  "20779"  "11651"  "13866" 
## [65] "13040"  "14960"  "14998"  "15978"  "14991"  "12768"  "54721"  "12444" 
## [73] "16452"  "12487"  "18125"  "14961"  "22376"  "14940"  "20299"  "26411" 
## [81] "234734" "17973"  "14423"  "21803"  "329165" "12503"  "50723"  "667803"
## [89] "13819" 
## 
## [[4]]
##   [1] "17345"  "21973"  "12531"  "12442"  "26934"  "15251"  "15511"  "16551" 
##   [9] "17219"  "12428"  "16906"  "233406" "16905"  "20460"  "16319"  "108907"
##  [17] "12534"  "12615"  "108000" "17218"  "76464"  "72119"  "16571"  "11799" 
##  [25] "110033" "105988" "193740" "23834"  "20877"  "12449"  "73804"  "68612" 
##  [33] "21335"  "19651"  "209737" "15366"  "107823" "12580"  "52033"  "19366" 
##  [41] "12445"  "229841" "107995" "54124"  "17215"  "27221"  "56150"  "18817" 
##  [49] "12544"  "15270"  "242705" "16765"  "71819"  "14211"  "20878"  "12051" 
##  [57] "22137"  "13555"  "18263"  "15481"  "14056"  "72391"  "78733"  "14828" 
##  [65] "18005"  "18973"  "94246"  "12235"  "19359"  "18141"  "73086"  "12649" 
##  [73] "231912" "12530"  "12444"  "17865"  "319166" "98386"  "21781"  "27214" 
##  [81] "21969"  "19891"  "26909"  "18128"  "19291"  "16573"  "19650"  "17118" 
##  [89] "16574"  "21803"  "18854"  "17216"  "77605"  "17748"  "19357"  "67052" 
##  [97] "13819"  "217232" "17127"  "20873"  "56452"  "71514"  "272551" "665433"
## 
## [[5]]
##  [1] "17345"  "20135"  "21973"  "12531"  "12442"  "26934"  "17219"  "16906" 
##  [9] "16905"  "52276"  "12534"  "17218"  "108961" "20492"  "16571"  "11799" 
## [17] "110033" "13178"  "105988" "20877"  "97165"  "73804"  "21335"  "15366" 
## [25] "12580"  "15201"  "67629"  "14793"  "17279"  "12236"  "54141"  "17217" 
## [33] "229841" "107995" "66929"  "12447"  "16881"  "54124"  "17215"  "13433" 
## [41] "12189"  "68275"  "12575"  "106795" "56150"  "18817"  "15270"  "21877" 
## [49] "12704"  "16765"  "20878"  "68298"  "53381"  "66442"  "70472"  "14056" 
## [57] "72391"  "19362"  "70218"  "22390"  "66570"  "18973"  "110074" "17121" 
## [65] "212377" "218977" "69639"  "12649"  "106618" "12530"  "17768"  "56419" 
## [73] "17865"  "76131"  "18538"  "319166" "98386"  "110052" "12419"  "19891" 
## [81] "55936"  "17216"  "77605"  "67967"  "19357"  "67951"  "66422"  "20873" 
## [89] "12578"  "69716"  "56452"  "114714" "665433" "67196"  "72107" 
## 
## [[6]]
##  [1] "16407"  "54167"  "17916"  "14190"  "17082"  "12332"  "66616"  "12977" 
##  [9] "21938"  "229900" "15979"  "19883"  "55932"  "16154"  "12367"  "12773" 
## [17] "12477"  "66395"  "12506"  "18671"  "17472"  "229521" "216233" "16178" 
## [25] "16182"  "22163"  "53314"  "11658"  "12334"  "21936"  "384009" "16185" 
## [33] "15900"  "56726"  "20430"  "16153"  "23834"  "80876"  "18030"  "11622" 
## [41] "17873"  "11746"  "16364"  "20973"  "20527"  "22779"  "225010" "12445" 
## [49] "68713"  "74318"  "66141"  "12447"  "100702" "12505"  "15258"  "14064" 
## [57] "21942"  "102626" "107702" "76884"  "18263"  "626578" "18810"  "17913" 
## [65] "100604" "11803"  "16188"  "18950"  "19347"  "17164"  "18451"  "17119" 
## [73] "12349"  "64138"  "13011"  "236573" "12048"  "381738" "68151"  "12333" 
## [81] "244962" "72729"  "69863"  "11520"  "22038"  "17829"  "16410"  "20893" 
## [89] "12444"  "76074"  "17760"  "57912"  "71602"  "22035"  "18712" 
## 
## [[7]]
##  [1] "14939"  "20304"  "16854"  "19141"  "12367"  "12362"  "15511"  "16912" 
##  [9] "240672" "16784"  "98878"  "13033"  "13030"  "13660"  "16409"  "70574" 
## [17] "193740" "12608"  "12363"  "73804"  "20196"  "16362"  "14678"  "12315" 
## [25] "14784"  "12313"  "63986"  "214531" "14702"  "56193"  "14462"  "56212" 
## [33] "13032"  "14693"  "71520"  "80287"  "19164"  "14688"  "15481"  "16822" 
## [41] "17096"  "14828"  "20779"  "18643"  "12349"  "19072"  "13040"  "11927" 
## [49] "170750" "11502"  "12842"  "19052"  "12369"  "18753"  "22038"  "54721" 
## [57] "16452"  "13007"  "22376"  "18712"  "56420"  "14940"  "18128"  "21858" 
## [65] "235584" "22041"  "50721"  "14945"  "16363"  "12259"  "30955"  "70675" 
## [73] "12262" 
## 
## [[8]]
##  [1] "93692"  "14190"  "16412"  "20135"  "19141"  "63913"  "20491"  "16421" 
##  [9] "13595"  "17113"  "12450"  "12317"  "26397"  "16828"  "22027"  "83671" 
## [17] "193740" "18030"  "18477"  "12449"  "23789"  "19324"  "20527"  "66286" 
## [25] "56248"  "17217"  "74117"  "14751"  "66713"  "68275"  "21991"  "12575" 
## [33] "18817"  "22375"  "13032"  "15357"  "20878"  "16414"  "26441"  "107513"
## [41] "15481"  "228033" "50527"  "14718"  "107272" "242894" "14828"  "103963"
## [49] "64136"  "12721"  "18950"  "18451"  "15452"  "20322"  "68465"  "26377" 
## [57] "13361"  "73834"  "12235"  "23997"  "14381"  "74192"  "50493"  "72661" 
## [65] "170439" "14782"  "26941"  "67895"  "20893"  "11674"  "12530"  "17768" 
## [73] "65972"  "112407" "54353"  "11938"  "14227"  "17216"  "12330"  "56418" 
## [81] "27053"  "100678" "72157"  "21753"  "59029"  "225363" "18036"  "15288" 
## [89] "56529"  "15275"  "100705" "19173"  "12745"  "23790" 
## 
## [[9]]
##  [1] "16854"  "21973"  "14676"  "12531"  "15979"  "12367"  "12362"  "14958" 
##  [9] "13595"  "19165"  "21354"  "16906"  "16905"  "14062"  "58801"  "12481" 
## [17] "80876"  "97165"  "12363"  "17873"  "12257"  "16362"  "57444"  "12445" 
## [25] "68713"  "227753" "66141"  "13867"  "12189"  "16952"  "12575"  "12505" 
## [33] "18797"  "17948"  "19164"  "228355" "15368"  "22390"  "13866"  "16478" 
## [41] "12048"  "223453" "12369"  "14775"  "12633"  "14782"  "20259"  "12444" 
## [49] "12122"  "27061"  "74256"  "22035"  "21858"  "18003"  "18611"  "19401" 
## [57] "11732" 
## 
## [[10]]
##  [1] "20304"  "12977"  "21938"  "14676"  "16154"  "15894"  "15251"  "12521" 
##  [9] "16174"  "12506"  "19219"  "80901"  "16182"  "54371"  "16185"  "67775" 
## [17] "218756" "16153"  "80876"  "11622"  "381290" "16362"  "14678"  "68713" 
## [25] "21356"  "66141"  "11540"  "17069"  "50498"  "54199"  "12575"  "20354" 
## [33] "56212"  "14767"  "26362"  "16491"  "21942"  "12493"  "19164"  "19106" 
## [41] "16822"  "16416"  "17096"  "109552" "21899" 
## 
## [[11]]
##  [1] "20715"  "93692"  "16412"  "17395"  "15902"  "21938"  "12142"  "16154" 
##  [9] "18826"  "16421"  "320139" "12521"  "11501"  "15483"  "17132"  "18671" 
## [17] "16792"  "238393" "16398"  "16186"  "15900"  "16913"  "12445"  "109700"
## [25] "14063"  "11491"  "94176"  "16414"  "211770" "17948"  "12493"  "58205" 
## [33] "50527"  "93695"  "16188"  "66390"  "12349"  "13040"  "71665"  "56743" 
## [41] "83397"  "240832" "12444"  "76816"  "26411"  "16573"  "14425"  "19224" 
## [49] "11732"  "235584" "16574" 
## 
## [[12]]
##  [1] "16412"  "16852"  "12332"  "15902"  "22352"  "326618" "226519" "16398" 
##  [9] "18074"  "17873"  "20650"  "12933"  "215280" "73690"  "109700" "12505" 
## [17] "20649"  "19035"  "20583"  "11839"  "16416"  "192176" "11803"  "18643" 
## [25] "104009" "16478"  "71665"  "12842"  "11461"  "16410"  "65112"  "16782" 
## 
## [[13]]
##  [1] "17916"  "21973"  "12442"  "26934"  "16551"  "16906"  "233406" "16905" 
##  [9] "12540"  "277360" "12334"  "12345"  "16319"  "108907" "12534"  "108000"
## [17] "72119"  "16571"  "11799"  "110033" "105988" "12927"  "73804"  "16328" 
## [25] "209737" "109934" "22627"  "227753" "54141"  "229841" "217944" "68743" 
## [33] "208628" "18817"  "71819"  "94176"  "20878"  "50523"  "22137"  "208084"
## [41] "223254" "11845"  "192176" "74018"  "217866" "18005"  "12235"  "192662"
## [49] "13605"  "17974"  "218977" "12333"  "17698"  "259302" "81910"  "17886" 
## [57] "20259"  "16800"  "70799"  "330177" "231912" "69632"  "75786"  "71602" 
## [65] "22376"  "18128"  "56376"  "68724"  "18003"  "16573"  "17973"  "53860" 
## [73] "17118"  "16574"  "73341"  "67399"  "329165" "27373"  "67052"  "20739" 
## [81] "217232" "242687" "26382" 
## 
## [[14]]
##  [1] "20491"  "12317"  "26397"  "16186"  "12534"  "22027"  "19045"  "20111" 
##  [9] "56378"  "20527"  "14784"  "12631"  "13867"  "74117"  "67300"  "66713" 
## [17] "12575"  "17347"  "18797"  "71520"  "13555"  "54401"  "20847"  "17096" 
## [25] "242894" "19087"  "12283"  "18643"  "11651"  "13866"  "26377"  "11513" 
## [33] "192662" "13001"  "16438"  "26413"  "12326"  "17973"  "19353"  "14682" 
## [41] "110355" "26420"  "11840"  "266632" "17127"  "19247"  "72349"  "18036" 
## [49] "100705" "16189" 
## 
## [[15]]
## [1] "20198" "21946" "12445" "19074" "14182" "12842" "16410" "12444"
## 
## [[16]]
##  [1] "93692"  "54371"  "18746"  "12534"  "12615"  "16828"  "193740" "73804" 
##  [9] "15366"  "12933"  "57444"  "56248"  "13867"  "11540"  "53618"  "21991" 
## [17] "21881"  "80879"  "12505"  "26362"  "16765"  "19348"  "26384"  "20878" 
## [25] "22166"  "21351"  "14719"  "56421"  "74246"  "15481"  "50527"  "83553" 
## [33] "14718"  "14828"  "20970"  "21802"  "18451"  "13866"  "104009" "23827" 
## [41] "57357"  "14381"  "12842"  "19052"  "69976"  "11674"  "54128"  "76131" 
## [49] "16164"  "12337"  "58810"  "17684"  "17449"  "17448"  "112407" "72727" 
## [57] "14583"  "12124"  "229782" "11727"  "109672" "15275"  "71653"  "54170" 
## [65] "66646"  "50799"  "50797"  "66681"  "233781" "216558" "78330"  "74241" 
## [73] "59046"  "239556" "66913"  "67005"  "100910" "15277"  "236900" "15512" 
## [81] "20856"  "27376"  "18655"  "12291"  "18194"  "110006" "56375"  "68137" 
## 
## [[17]]
##  [1] "12977" "21938" "15979" "16161" "20846" "16178" "16182" "16186" "57914"
## [10] "16362" "14784" "16199" "50498" "12505" "71520" "16416" "20847" "15368"
## [19] "16188" "19246" "16478" "12768" "54721" "16391" "16452" "16164" "18712"
## [28] "21803" "12018" "79201" "19247" "15975" "24088" "15945" "12402"
## 
## [[18]]
##  [1] "16854"  "20195"  "19141"  "63913"  "13595"  "11658"  "60599"  "18030" 
##  [9] "14678"  "11465"  "71914"  "15357"  "50762"  "11676"  "11461"  "22038" 
## [17] "51798"  "19016"  "230903"
## 
## [[19]]
##  [1] "17395"  "19141"  "16784"  "13030"  "12334"  "16398"  "20196"  "109700"
##  [9] "227753" "56193"  "16952"  "64383"  "14064"  "14693"  "22388"  "11844" 
## [17] "14688"  "16416"  "20779"  "19072"  "13040"  "11502"  "12333"  "20259" 
## [25] "13007"  "12337"  "18550"  "56405"  "19353"  "235584" "22041"  "12259" 
## [33] "14544"  "259277" "11727"  "14191" 
## 
## [[20]]
##  [1] "20715"  "21973"  "15902"  "19143"  "226519" "53314"  "238393" "20460" 
##  [9] "56460"  "14229"  "23834"  "225845" "20111"  "27375"  "381290" "20393" 
## [17] "57444"  "12445"  "107995" "11898"  "12505"  "217837" "54135"  "19348" 
## [25] "67784"  "74246"  "223254" "11839"  "192176" "13418"  "19087"  "18415" 
## [33] "225182" "12349"  "15452"  "114663" "20322"  "12017"  "26941"  "110826"
## [41] "54721"  "12864"  "12444"  "16452"  "16782"  "94249"  "13521"  "106572"
## [49] "320997" "12700"  "71982"  "22041" 
## 
## [[21]]
##  [1] "20198"  "20194"  "14667"  "12362"  "12521"  "21354"  "12795"  "19143" 
##  [9] "20181"  "22320"  "13033"  "12450"  "14062"  "231712" "20430"  "11688" 
## [17] "57444"  "12445"  "53421"  "75234"  "12575"  "17347"  "15270"  "11783" 
## [25] "102626" "12493"  "15254"  "76884"  "56702"  "29858"  "67784"  "15368" 
## [33] "21802"  "239273" "18415"  "13830"  "17164"  "17119"  "16478"  "71665" 
## [41] "217344" "17254"  "12444"  "18538"  "319166" "65972"  "18128"  "13663" 
## [49] "17988"  "70484"  "21803"  "67623"  "12018"  "22271"  "13650"  "17246" 
## [57] "22062"  "22401"  "79201"  "67941"  "12578"  "114714" "259277" "665433"
## [65] "16554"  "105501" "56437"  "19124"  "16449"  "15461"  "20698"  "12579" 
## [73] "21812"  "19734"  "17122" 
## 
## [[22]]
##  [1] "14958"  "17132"  "14229"  "12571"  "20111"  "12010"  "20393"  "14678" 
##  [9] "544963" "12445"  "67938"  "106869" "67268"  "26362"  "15357"  "69608" 
## [17] "107652" "239273" "192657" "11651"  "20322"  "333433" "83397"  "14782" 
## [25] "16410"  "65112"  "12444"  "20363"  "71817"  "328365" "13167"  "56376" 
## [33] "17988"  "13521"  "11732"  "19341"  "67399"  "72155"  "404710" "19342" 
## [41] "19229"  "20807"  "56228"  "70361"  "218294" "54608"  "20249"  "66065" 
## [49] "76687"  "11474"  "109785"
## 
## [[23]]
##  [1] "20198"  "93692"  "12306"  "19883"  "54371"  "22022"  "231507" "16828" 
##  [9] "193740" "18030"  "17035"  "12933"  "20527"  "57444"  "56248"  "13867" 
## [17] "11540"  "14751"  "21991"  "12575"  "21881"  "15212"  "56421"  "15481" 
## [25] "13008"  "50527"  "83553"  "14828"  "20970"  "15368"  "11676"  "18451" 
## [33] "13866"  "170750" "16478"  "12452"  "12842"  "83397"  "17886"  "11520" 
## [41] "20893"  "11674"  "18712"  "17684"  "17988"  "16573" 
## 
## [[24]]
##  [1] "16412"  "17395"  "17996"  "15894"  "226519" "22323"  "16398"  "11688" 
##  [9] "27375"  "12331"  "22793"  "14678"  "11465"  "67938"  "19354"  "109700"
## [17] "21873"  "13867"  "76709"  "67268"  "22629"  "11928"  "16331"  "19264" 
## [25] "192176" "12385"  "20970"  "20779"  "18643"  "13866"  "16332"  "11502" 
## [33] "60533"  "12842"  "17698"  "11461"  "12908"  "17886"  "330177" "16782" 
## [41] "20130"  "22376"  "18516"  "232975" "26411"  "14786"  "54353"  "73341" 
## [49] "69192"  "12798"  "11490"  "22329" 
## 
## [[25]]
##  [1] "12442"  "15511"  "15925"  "15463"  "12534"  "215387" "193740" "73804" 
##  [9] "21881"  "20878"  "21351"  "22137"  "16162"  "110257" "15481"  "14056" 
## [17] "72391"  "83553"  "12672"  "14828"  "19087"  "18005"  "18415"  "231600"
## [25] "12235"  "12326"  "18125"  "27214"  "56292"  "18550"  "12330"  "74451" 
## [33] "17349"  "12745"  "11861"  "13404"  "22335" 
## 
## [[26]]
##  [1] "20304"  "12977"  "15902"  "15894"  "21354"  "240672" "98878"  "19219" 
##  [9] "26397"  "13660"  "20303"  "56722"  "12608"  "18030"  "17873"  "21847" 
## [17] "381290" "20393"  "16362"  "20527"  "12445"  "14063"  "56193"  "75234" 
## [25] "106869" "54199"  "12575"  "56336"  "12505"  "12519"  "21942"  "12051" 
## [33] "211770" "17948"  "11839"  "19347"  "55991"  "17119"  "18034"  "16478" 
## [41] "12045"  "18577"  "12633"  "18037"  "65112"  "20893"  "12444"  "230073"
## [49] "16596"  "56376"  "71586"  "19224"  "17118" 
## 
## [[27]]
##  [1] "93692"  "18477"  "16985"  "76650"  "53381"  "22166"  "56421"  "68576" 
##  [9] "239273" "11927"  "16478"  "14381"  "50493"  "14782"  "18104"  "76408" 
## 
## [[28]]
##  [1] "21973"  "18671"  "20181"  "15925"  "67283"  "18477"  "20238"  "12257" 
##  [9] "78388"  "11739"  "22629"  "21355"  "11666"  "73836"  "239273" "433256"
## [17] "12908"  "16413"  "51798"  "55936"  "66437" 
## 
## [[29]]
##  [1] "67804"  "16784"  "17113"  "20111"  "208449" "13867"  "67300"  "11928" 
##  [9] "13032"  "69608"  "12757"  "22319"  "108664" "232910" "13866"  "14683" 
## [17] "15893"  "12725"  "26413"  "232975" "11487"  "11774"  "106572" "70349" 
## [25] "56418"  "11840"  "68365"  "67830"  "11764"  "50797"  "70361"  "271457"
## [33] "19063"  "68581" 
## 
## [[30]]
##  [1] "16828"  "12894"  "14751"  "67834"  "11739"  "12868"  "57279"  "12858" 
##  [9] "14719"  "228033" "11974"  "108664" "66916"  "67680"  "12856"  "16922" 
## [17] "73834"  "11973"  "12857"  "12369"  "66108"  "18104"  "110826" "11949" 
## [25] "66152"  "12864"  "51798"  "12866"  "67264"  "110323" "57423"  "66925" 
## [33] "17449"  "17448"  "18293"  "66694"  "11950"  "17992"  "21871"  "67126" 
## [41] "66046"  "68375"  "12861"  "66043"  "11946"  "13177"  "20930"  "109672"
## [49] "30057"  "66144"  "14661"  "22335"  "15159"  "50799"  "66335"  "211253"
## [57] "11957"  "12859"  "225887" "27060"  "22272"  "78830"  "97212"  "12028" 
## [65] "170731" "54405"  "66594"  "407785" "17993"  "170718" "66576"  "72900" 
## [73] "67003"  "11740"  "11958"  "68197"  "11947" 
## 
## [[31]]
##  [1] "16185"  "16186"  "16328"  "12189"  "14462"  "17096"  "68465"  "171171"
##  [9] "11487"  "21871"  "27060"  "21838"  "11630"  "237847" "432442" "13837" 
## 
## [[32]]
##  [1] "12367"  "15894"  "18671"  "21354"  "14964"  "15040"  "193740" "15018" 
##  [9] "66168"  "11891"  "16362"  "110213" "13350"  "12445"  "14972"  "12447" 
## [17] "11739"  "26362"  "15270"  "17075"  "12757"  "15481"  "17308"  "17096" 
## [25] "14828"  "103963" "15368"  "232910" "12349"  "16478"  "12842"  "18753" 
## [33] "12611"  "14991"  "11674"  "12444"  "11828"  "12122"  "216150" "319166"
## [41] "12799"  "19182"  "110920" "18550"  "12018"  "56418"  "27053"  "20364" 
## [49] "14156"  "81489"  "12215"  "665433" "14528"  "667977" "66144"  "56437" 
## [57] "12566"  "66335"  "19063"  "12579"  "246221" "22146"  "216869" "22275" 
## [65] "15512"  "22142"  "18670"  "18412"  "11740"  "319164" "106344" "15007" 
## [73] "630294" "319167" "20656"  "14590"  "66427"  "319172" "15024"  "15015" 
## [81] "13728"  "224860" "232440" "15370" 
## 
## [[33]]
##  [1] "26943"  "16852"  "20194"  "16828"  "22027"  "56791"  "12894"  "13476" 
##  [9] "22629"  "17025"  "18263"  "11363"  "109778" "68728"  "12349"  "433256"
## [17] "68465"  "19186"  "12908"  "11674"  "12892"  "51798"  "66925"  "17449" 
## [25] "17448"  "77605"  "170789" "11409"  "13177"  "22628"  "66357"  "56442" 
## 
## [[34]]
##  [1] "14958"     "68262"     "16784"     "212943"    "13030"     "26397"    
##  [7] "380711"    "18477"     "65107"     "20527"     "12445"     "100503605"
## [13] "140780"    "242705"    "53378"     "17025"     "110257"    "109778"   
## [19] "192657"    "53415"     "18451"     "12349"     "233489"    "224703"   
## [25] "14934"     "66943"     "22228"     "12725"     "107566"    "74136"    
## [31] "69632"     "12444"     "11828"     "12892"     "68591"     "15130"    
## [37] "17896"     "21969"     "16596"     "15467"     "56786"     "64898"    
## [43] "72674"     "71648"     "21871"     "219094"    "27053"     "21349"    
## [49] "12346"     "20739"     "217232"    "12215"     "74257"     "71946"    
## [55] "12183"     "15288"     "67608"     "54484"     "383295"    "19746"    
## [61] "74334"     "74645"     "22439"     "56209"     "20617"     "27060"    
## [67] "14055"     "18173"     "59125"     "11519"     "11656"    
## 
## [[35]]
##  [1] "16412"  "22352"  "19165"  "56726"  "16985"  "17873"  "20973"  "227753"
##  [9] "13867"  "53313"  "12575"  "64383"  "78286"  "67784"  "17913"  "56421" 
## [17] "16404"  "16416"  "29856"  "20399"  "13866"  "433256" "12017"  "12842" 
## [25] "11461"  "12908"  "17886"  "18104"  "20259"  "20893"  "18125"  "17896" 
## [33] "18128"  "11938"  "21803"  "67399"  "13144" 
## 
## [[36]]
##  [1] "15979"  "68262"  "217430" "11804"  "23943"  "109019" "12580"  "13476" 
##  [9] "13350"  "67834"  "21881"  "22629"  "12868"  "21351"  "20168"  "16404" 
## [17] "66148"  "11363"  "83553"  "66588"  "66092"  "66916"  "13830"  "68465" 
## [25] "26379"  "67680"  "11513"  "16922"  "22187"  "108954" "12452"  "12842" 
## [33] "12908"  "11520"  "170439" "22228"  "232941" "11674"  "110826" "66152" 
## [41] "51798"  "18712"  "17448"  "18606"  "26411"  "19016"  "268301" "12861" 
## [49] "72157"  "66375"  "11409" 
## 
## [[37]]
##  [1] "20135"     "27224"     "15163"     "22171"     "22169"     "54208"    
##  [7] "56248"     "18968"     "19361"     "53421"     "16881"     "53378"    
## [13] "59022"     "18950"     "15452"     "110074"    "11513"     "12856"    
## [19] "18577"     "27061"     "18538"     "19075"     "19891"     "330959"   
## [25] "100041294" "26370"     "50773"     "67967"     "14156"     "20930"    
## [31] "68092"     "66914"     "74414"     "19718"     "72151"     "16434"    
## [37] "67665"     "20018"     "18100"     "18969"    
## 
## [[38]]
##  [1] "15902"  "74134"  "15483"  "380711" "15900"  "20430"  "12927"  "110213"
##  [9] "14872"  "12846"  "19171"  "76884"  "29858"  "52585"  "11666"  "15368" 
## [17] "110172" "239273" "12349"  "15452"  "66054"  "110208" "14782"  "18104" 
## [25] "76408"  "51798"  "67437"  "56376"  "70484"  "50997"  "64898"  "11938" 
## [33] "66397"  "67399"  "22271"  "17748"  "69051"  "66375"  "79201"  "14528" 
## [41] "109900" "109672" "74114" 
## 
## [[39]]
##  [1] "12306"  "12393"  "12399"  "20181"  "226519" "14537"  "27375"  "11746" 
##  [9] "381290" "20238"  "21873"  "13867"  "11540"  "71973"  "20583"  "16416" 
## [17] "109552" "20779"  "217866" "19087"  "239273" "219140" "13866"  "18034" 
## [25] "12842"  "15893"  "76408"  "20893"  "23942"  "16782"  "14200"  "12978" 
## [33] "17684"  "328365" "18128"  "56376"  "19016"  "116871" "67399"  "17748" 
## 
## [[40]]
##  [1] "15902"  "11853"  "14225"  "19045"  "27375"  "21847"  "21873"  "15258" 
##  [9] "17948"  "94246"  "16478"  "232941" "65112"  "18550"  "21803"  "106572"
## 
## [[41]]
##  [1] "12317"  "22027"  "193740" "12608"  "109019" "66286"  "54124"  "15270" 
##  [9] "107513" "15481"  "50527"  "107272" "14828"  "67398"  "11972"  "226641"
## [17] "66482"  "667373" "72661"  "12611"  "17768"  "319166" "69019"  "22631" 
## [25] "16573"  "13685"  "16574"  "218343" "27053"  "67951"  "665433" "71853" 
## [33] "78943"  "56529"  "69065"  "18045"  "15957"  "70640"  "20624"  "13665" 
## [41] "66913"  "22154"  "76687"  "56454"  "15512"  "20856" 
## 
## [[42]]
##  [1] "17132"  "66286"  "239273" "69019"  "53626"  "20813"  "56529"  "18548" 
##  [9] "13482"  "16909"  "20910" 
## 
## [[43]]
##  [1] "12776"  "54371"  "212943" "12334"  "11688"  "20393"  "19271"  "27984" 
##  [9] "11928"  "12519"  "58185"  "17857"  "12842"  "12333"  "15978"  "11461" 
## [17] "21819"  "20363"  "18125" 
## 
## [[44]]
##  [1] "17219"  "12428"  "17218"  "16828"  "22027"  "22171"  "22627"  "17217" 
##  [9] "107995" "20133"  "56150"  "12544"  "57296"  "12858"  "53381"  "14719" 
## [17] "22384"  "26441"  "18263"  "26445"  "26440"  "15452"  "110074" "19359" 
## [25] "218236" "19166"  "22195"  "12461"  "18538"  "26444"  "110052" "21781" 
## [33] "55936"  "17216"  "12330"  "77605"  "69192"  "26446" 
## 
## [[45]]
## [1] "207521" "14534"  "18129"  "16450"  "18519"  "21416"  "14357"  "12234" 
## [9] "109689"
## 
## [[46]]
##  [1] "11303"  "19299"  "11669"  "66307"  "224824" "110784" "74043"  "76267" 
##  [9] "103737" "16890"  "72535"  "63959"  "76263" 
## 
## [[47]]
## [1] "16835" "16825" "14766" "21885" "18187" "12614"
## 
## [[48]]
##  [1] "12043"  "17869"  "107771" "101490" "16206"  "268903" "18432"  "22234" 
##  [9] "16001"  "20520"  "22151"  "16763"  "24056"  "14228"  "16195"  "58208" 
## [17] "16598"  "11518"  "20148"  "76199"  "11512"  "107094" "20539"  "20509" 
## [25] "16451"  "97998"  "12614"  "76459"  "21844" 
## 
## [[49]]
##  [1] "21414"  "17869"  "107771" "16842"  "13542"  "14534"  "15182"  "18129" 
##  [9] "212398" "22059" 
## 
## [[50]]
##  [1] "17869"  "107771" "18432"  "13537"  "75751"  "67134"  "72515"  "235036"
##  [9] "226169" "20810"  "27966"  "71974"  "59028"  "101612" "70683"  "67973" 
## [17] "107094" "110109" "76130"  "28126"  "21453"  "30877"  "107071" "20509" 
## [25] "68493"  "18148"  "338359" "70769"  "66942"

fgsea

We can use these leading edge genes to select genes strongly correlated with our condition and within an enriched gene set.

INTERFERON_Response_LE <- Act_minus_Rest_gseaRes$leadingEdge[[1]]
IR_LE <- Activated_minus_Resting[Activated_minus_Resting$ENTREZID %in% INTERFERON_Response_LE, 
    ]
IR_LE[1:2, ]
##       ENTREZID SYMBOL  baseMean log2FoldChange     lfcSE     stat       pvalue
## 107  100038882  Isg15  738.5107      0.6976512 0.1574892 4.429836 9.430483e-06
## 1236    100702   Gbp6 1308.0094      0.8984211 0.1192259 7.535452 4.866453e-14
##              padj      newPadj
## 107  6.656254e-05 1.686925e-01
## 1236 8.937247e-13 9.271079e-10

GSEA plots

We can also produce a GSEA style plot to visualize our enrichment in a pathway of interest using the plotEnrichment() function. We simply provide the pathway to plot and the ranking we used in test.

plotEnrichment(mouse_Hallmarks[["HALLMARK_INTERFERON_GAMMA_RESPONSE"]], Act_minus_Rest_gsea)

Time for an exercise

Link_to_exercises

Link_to_answers